[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intermittent-exotropia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intermittent-exotropia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,68,90,116,140],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100643068","near-vergence-training-for-distance-control-in-intermittent-exotropia-100643068",false,"NCT07642687","Near Vergence Training for Distance Control in Intermittent Exotropia","Evaluating Near Vergence Training for Distance Control in Basic and Divergence Excess Intermittent Exotropia","Inclusion Criteria\n\n* Age and Diagnosis: Participants must be aged 6 to ≤ 25 years at the time of screening, with a confirmed clinical diagnosis of either Basic or Divergence Excess (DE) Intermittent Exotropia (IXT).\n* Ocular Alignment Magnitude: Distance exodeviation measuring between 10 and 40 prism diopters (pd) inclusive, determined by the prism and alternate cover test (PACT).\n* Distance-Near Disparity Limits: Near exodeviation must not exceed the distance exodeviation by more than 10 pd (to exclude Convergence Insufficiency type exotropia).\n* Baseline Distance Control: A baseline distance IXT Office Control Score (OCS) between Grade 2 and Grade 4 inclusive, based on the mean of 3 standardized assessments.\n* Baseline Near Control: A baseline near IXT control score less than or equal to the distance IXT control score, based on the mean of 3 standardized assessments.\n* Visual Acuity: Best-corrected visual acuity (BCVA) of Logarithm of the Minimum Angle of Resolution (logMAR) 0.1 or better in each eye at both distance and near fixation.\n* Sensory Status: Measurable near stereoacuity of 400 arc seconds or better on the Preschool Randot stereoacuity test.\n* Refractive Correction Stability: Compliance with wearing a stable, appropriate spectacle correction for ≥ 4 months prior to formal baseline assessment if the participant meets any of the following refractive thresholds:\n\n  * Myopia \\\u003C -0.50D spherical equivalent (SE) in either eye.\n  * Hyperopia \\> +2.50D SE in either eye.\n  * Anisometropia \\> 1.00 SE.\n  * Astigmatism \\> 1.50D cylinder in either eye.\n* Treatment History: No history of prior non-surgical interventions for IXT, including patching, vision therapy\u002Forthoptics, or overminus lens therapy (≥ 0.50 D).\n* Surgical History: No prior history of strabismus surgery, extraocular muscle botulinum toxin injections, intraocular surgery, or refractive surgery.\n* Trial Commitment: No planned strabismus surgery or conflicting ocular therapies during the 24-week study period.\n\nExclusion Criteria\n\n* Amblyopia and Co-morbid Strabismus: Presence of amblyopia, nystagmus, restrictive strabismus, or paretic strabismus.\n* Vertical Misalignment: Presence of an associated vertical ocular deviation \\> 5 pd.\n* Significant Pathologies: Co-existing significant ocular disease or neurological disorders (e.g., cerebral palsy) that could confound oculomotor or sensory evaluations.\n* Confounding Medications: Regular use of systemic or topical ocular medications known to alter accommodative or vergence function within the 3 months prior to screening (including, but not limited to, atropine, pirenzepine, or systemic anti-epileptic agents).","ALL","6 Years","25 Years",{"count":20,"type":21},42,"ESTIMATED","INTERVENTIONAL",[24],"NA","Intermittent Exotropia (IXT) is a common type of eye misalignment where one eye periodically turns outward, and control is typically much worse when looking at objects far away than close up. However, most currently available training programme are focused on near-viewing tasks. The goal of this clinical trial is to investigate if a new, structured, home-based near eye training program works to improve distance eye alignment control in children and young adults with IXT.\n\nThe main questions the study aims to answer are:\n\n* Does a 12-week near eye training program improve a participant's ability to control their eye alignment when looking at a distance?\n* Does using a special reading glasses during near training help to control distance eye alignment better than doing the training without the reading glasses?\n* Do the benefits of this eye training last after the training has stopped?\n\nThis is a two- phase, single- masked (examiner masked), randomized clinical trial with crossover design. The entire study duration is about 24 weeks. A total sample size of 42 participants, aged 6 to 25 years with diagnosed Basic (distance deviation is within 10 prism diopters of the near deviation) or Divergence excess (distance deviation is at least 10 prism diopters greater than the near deviation) IXT, will be recruited.\n\nIn Phase I (Weeks 0 to 12), participants will be randomly allocated into one of three groups, with 14 individuals in each group:\n\n* Group 1 does eye training while wearing special plus-power reading glasses that remove the need to focus up close, mimicking how the eyes look at a distance.\n* Group 2 does the exact same eye training but wears regular distance glasses without the special reading addition.\n* Group 3 serves as a control group that does not do training during the first 12 weeks, but will receive the training in the second phase.\n\nIn Phase II (Weeks 13 to 24), which is a crossover phase, groups 1 and 2 will stop training to see if the visual improvements last, while group 3 will be re-randomized into two subgroups (group 3A, with special plus-power reading glasses, and group 3B with regular glasses with distance correction) that will undertake daily eye training for 12 weeks to ensure ethical treatment access. All participants will have a final eye exam at 24 weeks.\n\nDuring home training, participants will:\n\n* Wear standard glasses provided by the study.\n* Practice daily, home-based eye exercises for 12 weeks using a standardized software program on a computer or tablet.\n* Complete 3 training sessions every day, lasting 7 minutes per session.\n* Wear red-blue 3D glasses during training and press arrow keys or swipe the screen to play a visual game that dynamically changes in difficulty.\n\nPreliminary test and binocular vision assessment with fixed and uniform sequence will be performed at baseline visit, 6th week interim visit, 12th and 24th week evaluation. All eye examinations will be carried out in The Optometry Centre (A034), the School of Optometry, The Hong Kong Polytechnic University.\n\nThe following data will be statistically analyzed. The primary outcome data is distance Office Control Score (OCS) at 12-week visit. Secondary outcomes data include change in deviation angle, near and distance stereopsis and patient- \u002F parent- reported health-related quality-of-life questions at 12-week.",[27],"Intermittent Exotropia","RECRUITING","2026-06-10",{"date":31,"type":32},"2026-06-11","ACTUAL",{"date":34,"type":21},"2026-06",{"date":36,"type":21},"2028-12",{"name":38,"class":39},"The Hong Kong Polytechnic University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100643616","a-comparative-study-of-the-efficacy-of-myopia-control-lenses-with-different-mechanisms-on-controlling-myopia-progression-in-patients-with-intermittent-exotropia-100643616","NCT07642934","A Comparative Study of the Efficacy of Myopia Control Lenses With Different Mechanisms on Controlling Myopia Progression in Patients With Intermittent Exotropia","Inclusion Criteria:\n\n1. Participants aged 6 to 12 years (6 ≤ age ≤ 12 years). Written informed consent from legal guardians is mandatory.\n2. Patients with basic-type intermittent exotropia (IXT) meeting all the following criteria:\n\n   1. Intermittent or constant exotropia at the distance of 6 meters, and intermittent exotropia or esophoria at the near distance of 33 centimeters;\n   2. Distance exodeviation ≥ 10 prism diopters (PD) measured via the prism and alternate cover test (PACT);\n   3. The difference between near and distance deviation ≤ 10 PD.\n3. Based on cycloplegic spherical equivalent (SE), the myopic refractive error of both eyes ranges from -6.0 D to -0.5 D.\n4. The logMAR value of monocular distance best-corrected visual acuity (BCVA) measured by the ETDRS chart is ≤ 0.2, and no amblyopia is present.\n5. Parents and children are willing to participate in this clinical trial and can complete the entire study protocol.\n6. Children have healthy eyes without organic ocular diseases.\n\nExclusion Criteria:\n\n1. Participants who have worn myopia control glasses or received other myopia interventions, including low-concentration atropine and phototherapy instruments, within the past 6 months (excluding DIMS and DOT glasses).\n2. Those with severe systemic diseases or cognitive impairment that hinders follow-up attendance and clinical examinations.\n\n4\\. Subjects with astigmatism of ≥ 2 diopters (D) in either eye after cycloplegia; individuals enrolled in other interventional trials.\n\n5\\. Patients with active ocular inflammation in either eye. 6. Those diagnosed with ocular diseases or presenting with clinically significant abnormalities on ophthalmic examinations.\n\n7\\. Participants are currently receiving visual function training or other clinical interventions for intermittent exotropia.\n\n8\\. Individuals who decline to complete the 1-year follow-up period.","12 Years",{"count":49,"type":21},120,[24],"The goal of this clinical trial is to compare the efficacy of myopia control lenses with different working principles in patients with intermittent exotropia aged 6 to 12 years. The main questions it aims to answer are:\n\nAre there any differences in the clinical outcomes of DIMS and DOT glasses between children with intermittent exotropia and those with simple myopia (without intermittent exotropia)? Do DIMS and DOT glasses differ in their myopia control efficacy among children with intermittent exotropia? Does wearing DIMS or DOT glasses affect the binocular visual function of children with intermittent exotropia?",[27,53],"Myopia",[55,56,57,58],"Intermittent exotropia","Myopia control","DIMS","DOT","NOT_YET_RECRUITING","2026-06-09",{"date":31,"type":32},{"date":63,"type":21},"2026-06-01",{"date":65,"type":21},"2027-05-31",{"name":67,"class":39},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":40},"100613854","improving-control-of-intermittent-exotropia-100613854","NCT07272005","Improving Control of Intermittent Exotropia","Inclusion Criteria:\n\n* Diagnosis of IXT or XT at Distance \\& IXT or XP at near (Basic or Pseudo Divergence Excess subtype of IXT)\n* No surgery planned for 6 months\n\nExclusion Criteria:\n\n* Prior eye muscle surgery\n* Prior binocular treatment or vision therapy\n* Amblyopia\n* Neurological conditions, seizure disorders, vestibular abnormalities, or frequent headache\n* Other eye conditions (refractive error OK)","4 Years","10 Years",{"count":77,"type":21},40,[24],"To determine whether use of dichoptic movies for 8 weeks may be helpful in improving control alignment in children with intermittent exotropia (IXT), thus allowing IXT to be managed non-surgically",[27],"2026-04-02",{"date":83,"type":32},"2026-04-08",{"date":85,"type":32},"2026-04-01",{"date":87,"type":21},"2028-08",{"name":89,"class":39},"Retina Foundation of the Southwest",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":22,"phases":102,"briefSummary":103,"conditions":104,"keywords":105,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":5},"100399901","trial-of-vision-therapy-for-intermittent-exotropia-100399901","NCT04487249","Trial of Vision Therapy for Intermittent Exotropia","A Pilot Randomized Trial Evaluating Short-Term Effectiveness of Vision Therapy in Children With Intermittent Exotropia","VT-IXT","Major Inclusion Criteria-\n\n* Age 8 - 16 years\n* Intermittent exotropia meeting all of the following:\n\n  * Distance exodeviation of 15∆ to 35∆ by prism alternating cover test (PACT)\n  * IXT, exophoria, or orthophoria at near\n  * Near exodeviation that does not exceed the distance exodeviation by more than 10∆\n  * Mean distance control score of 2 points or more with at least one measure being 3 points or higher\n  * Mean near control score less than 5 points\n* Random dot stereopsis of 200\" or better on Preschool Randot Stereotest\n* Willingness to accept randomization and no plan to relocate in the next 6 months\n\nMajor Exclusion Criteria-\n\n* Treatment for IXT or amblyopia (other than refractive correction) within 3 months prior to enrollment\n* Office-based vision therapy for IXT within 6 months prior to enrollment\n* Prior office-based vision therapy for IXT of ≥10 sessions\n* Prior strabismus, intraocular, or refractive surgery (including BOTOX injection)","8 Years","16 Years",{"count":101,"type":21},58,[24],"The main objective of this randomized trial comparing vision therapy to observation is to determine the short-term effectiveness of vision therapy on distance intermittent exotropia control. The results will help determine whether to proceed to a full-scale, long-term randomized trial.",[27],[27,106],"Vision Therapy","2025-03-04",{"date":109,"type":32},"2025-03-05",{"date":111,"type":32},"2021-10-01",{"date":113,"type":21},"2025-12",{"name":115,"class":39},"Southern California College of Optometry at Marshall B. Ketchum University",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100574652","exercise-training-on-a-mirror-for-intermittent-exotropia-control-post-strabismus-surgery-100574652","NCT06762067","Exercise Training on a Mirror for Intermittent Exotropia Control Post Strabismus Surgery","Exercise Training in Front of a Mirror for Intermittent Exotropia Control Post Strabismus Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n1. 40 boys and girls with ages from 5 to 15 years\n2. History of strabismus surgery from 6 months presence of intermittent exotropia.\n3. Normal sensory and motor fusion, equal visual acuity. Good general health condition.\n4. Ability to understand and do the exercises at home\n\nExclusion Criteria:\n\n1. systemic diseases as myasthenia gravis, multiple sclerosis and diabetes\n2. Optic nerve injury, organic ocular disease, attention disorder and mental disorders\n3. Attention disorder and learning disability","5 Years","15 Years",{"count":77,"type":21},[24],"The study aims to explore the impact of mirror therapy on exodeviation control, near and far strabismus angles, and quality of life in intermittent exotropia control post strabismus surgery, as well as its effects on near and far strabismus angles.",[129,27,130],"Exercise Training","Strabismus","2025-01-04",{"date":133,"type":32},"2025-01-07",{"date":135,"type":21},"2025-02-01",{"date":137,"type":21},"2025-05-01",{"name":139,"class":39},"Cairo University",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100561784","visual-training-for-improving-intermittent-exotropia-visual-function-100561784","NCT06594666","Visual Training for Improving Intermittent Exotropia Visual Function","Clinical Study on the Effectiveness and Safety of Visual Training for Improving Intermittent Exotropia Visual Function","Inclusion Criteria:\n\nAged 6 to 14 years. Intermittent exotropia meeting all of the following criteria: Exodeviation at least 10Δ at distance measured by the prism and alternate cover test, near deviation does not exceed distance deviation by more than 10Δby prism and alternate cover test, mean distance Newcastle Control Score (NCS)≥2 points (mean of 3 assessments during the examination).\n\nRefractive error between -5.00 D \\\u003C spherical equivalents (SEs) ≤ -1.00 D, astigmatism ≤1.50D, anisometropia ≤1.5D, best visual acuity in each eye of 1.0.\n\nNot receiving any other form of strabismus or myopia treatment within 3 months. Willing to follow the research plan and participate in the entire research process.\n\nParticipants and guardians agree to be randomly assigned and sign an informed consent form.\n\nExclusion Criteria:\n\nVertical strabismus; Diagnosed with other eye diseases or visual abnormalities such as strabismus, amblyopia, etc; Existence of cognitive or learning disabilities that may affect the effectiveness of training; patients with neurological disorders; Unable to cooperate with eye examination and follow-up work.","14 Years",{"count":149,"type":21},78,[24],"The goal of this clinical tral is to investigate that if VR\u002FAR visual training can improve the visual function in children with intermittent exotropia.\n\nThe main question it aims to answer is :\n\nDoes the VR\u002FAR visual training can enhance stereoscopic vision function in children with intermittent exotropia.\n\nResearchers will compare intervention group to control group to see if VR\u002FAR visual training could enhance stereoscopic vision function in children with intermittent exotropia.\n\nParticipants will:\n\nThe intervention group will receive 20 minutes of VR\u002FAR visual training once a day for a period of one year.\n\nFollow up check ups at the hospital every 3 months. Keep a diary of the values of stereoscopic vision function and Newcastle Control Score.",[27,153],"Visual Functions",[155,156,157],"visual training","visual function","intermittent exotropia","2024-09-10",{"date":160,"type":32},"2024-09-19",{"date":162,"type":21},"2024-09-15",{"date":164,"type":21},"2026-02-28",{"name":166,"class":39},"Shanghai Eye Disease Prevention and Treatment Center"]