[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intermittent-hypoxia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intermittent-hypoxia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100624439","influence-of-intermittent-hypoxia-on-loop-gain-in-healthy-subjects-100624439",false,"NCT07409649","Influence of Intermittent Hypoxia on Loop Gain in Healthy Subjects","HI-LOOP","Inclusion Criteria:\n\n* Healthy subjects aged 18 to 45\n* BMI between \\[18-25\\] kg\u002Fm2\n* No known sleep disorders\n* Free subjects, not under guardianship or curatorship or subordination\n* Persons affiliated with or beneficiaries of a Social Security scheme\n* Signature of informed consent after clear and honest information about the study\n\nExclusion Criteria:\n\n* Active smoking or cessation within the last 3 months and total consumption \\> 10 pack-years\n* Alcohol or drug addiction\n* Excessive coffee consumption (\\> 3 espressos\u002Fday)\n* History of acute mountain sickness (presence of symptoms such as dizziness, headaches, nausea\u002Fvomiting, and incapacitating fatigue during or after a stay at high altitude)\n* Living at high altitude (above 3,000 meters, continuously for more than 6 months during the last 10 years)\n* History of respiratory and\u002For cardiovascular and\u002For renal and\u002For neurological disease (migraines, epilepsy)\n* Diabetes\n* Anemia, sickle cell anemia\n* Any medication associated with oxygen metabolism and any psychotropic medication (anxiolytics, sedatives, antidepressants, neuroleptics, muscle relaxants, etc.) that may interfere with motor and respiratory control, muscle strength, or sleep quality\n* Women of childbearing age who do not use effective contraception (hormonal\u002Fmechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total ovariectomy)\n* Concurrent participation in another clinical research study affecting respiratory control or respiratory muscles\n* Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, persons staying in a healthcare facility",true,"ALL","18 Years","45 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Sleep apnoea-hypopnoea syndrome (SAHOS), which causes numerous comorbidities, particularly cardiovascular ones, is widespread worldwide today and incurs significant healthcare costs.\n\nCurrent research in this field focuses on identifying different phenotypes in affected patients in order to provide more personalised treatment.\n\nOne of these phenotypes appears to be linked to instability in ventilatory control due to an increase in loop gain (LG) in these subjects.\n\nHowever, the pathophysiology of this ventilatory control instability due to increased LG is not fully understood. It is still difficult to determine whether subjects have an intrinsically high LG or if exposure to intermittent hypoxia during OSA promotes an increase in LG.\n\nIt has also been demonstrated that OSA causes vascular hyperreactivity by increasing oxidative stress through elevated ROS production. This leads to endothelial dysfunction in response to intermittent hypoxia associated with apnoea. Extracellular vesicles (microvesicles and exosomes) have been shown to play a role in this endothelial response. These extracellular vesicles are essential for intercellular communication in both physiological and pathological situations, such as SAHOS.\n\nTherefore, the objective of this research is to determine whether exposure to intermittent hypoxia and changes in microvesicle phenotype could influence LG, which could lead to new therapeutic advances in the context of SAHOS.",[28,29],"Intermittent Hypoxia","Healthy Volunteers",[31],"loop gain","NOT_YET_RECRUITING","2026-05-22",{"date":35,"type":36},"2026-05-27","ACTUAL",{"date":38,"type":22},"2026-07",{"date":40,"type":22},"2027-09",{"name":42,"class":43},"Poitiers University Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":44},"100598552","cpod-patients-tolerance-of-intermittent-exercise-with-inter-exercise-recovery-under-normoxic-hypoxia-100598552","NCT07072975","CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia","HypoChronoPerf","Inclusion Criteria:\n\n* from 40 to 60 years\n* follow-up in the pneumology unit of CHU Amiens - Picardie\n* Chronic Obstructive Pulmonary Disease stade II\n* Body mass index from 20 to 30 kg.m-2\n* Tiffeneau index \\\u003C 70% of predicted value\n* FEV1 from 50 to 80% of predicted values\n* Smoking cessation since at least 1 week\n* Sedentary or physical active\n* Affiliate to social security\n* Written consent\n\nExclusion Criteria:\n\n\\-","40 Years","60 Years",{"count":55,"type":22},50,[25],"Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.\n\nthis randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.\n\nHypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.",[28,59,60,61,62],"Exercise Recovery","Intermittent Exercise","Rating Exertion Perception","Sleep",[64,65,66,67,68],"intermittent hypoxia","exercise recovery","intermittent exercise","rating exertion perception","sleep","2025-09-30",{"date":71,"type":36},"2025-10-01",{"date":73,"type":22},"2025-10",{"date":75,"type":22},"2027-08",{"name":77,"class":43},"Centre Hospitalier Universitaire, Amiens"]