[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intermittent-theta-burst-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intermittent-theta-burst-stimulation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100636118","electrophysiological-biomarkers-and-treatment-response-to-accelerated-transcranial-magnetic-stimulation-in-patients-with-obsessive-compulsive-disorder-100636118",false,"NCT07561528","Electrophysiological Biomarkers and Treatment Response to Accelerated Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder","Investigation of the Relationship Between Electrophysiological Biomarkers and Treatment Response in Patients Diagnosed With Obsessive-Compulsive Disorder Undergoing Transcranial Magnetic Stimulation Therapy","TMS-OCD-EEG","Inclusion Criteria:\n\n* Being between 18 and 65 years of age.\n* Being diagnosed with Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria.\n* Non-responsiveness to at least one Selective Serotonin Reuptake Inhibitor (SSRI) treatment at an adequate dose and duration.\n* Having a Y-BOCS score of ≥20 following the initial evaluation.\n* No change in the current medications within the last 2 months and a commitment to maintaining stable doses throughout the study.\n* Providing informed consent and having no contraindications for TMS.\n\nExclusion Criteria:\n\n* Severe neurological disorders or neurodegenerative diseases.\n* Any condition associated with increased seizure risk\n* History of cochlear implants, metal implants in the head and neck area, cardiac pacemakers, deep brain stimulation, or vagus nerve stimulation.\n* History of neurosurgical intervention.\n* General contraindications for Transcranial Magnetic Stimulation therapy.","ALL","18 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Purpose:\n\nThis study aims to evaluate the effectiveness of an accelerated intermittent Theta Burst Stimulation (iTBS) protocol-a non-invasive brain stimulation technique-targeted at the dorsomedial prefrontal cortex (dmPFC) and anterior cingulate cortex (ACC) in patients with treatment-resistant Obsessive-Compulsive Disorder (OCD). Additionally, the study seeks to identify electrophysiological biomarkers (such as EEG microstates and heart rate variability) that may predict which patients are most likely to benefit from the treatment.\n\nMethodology:\n\nThe study will include 30 patients aged 18-65 diagnosed with OCD according to DSM-5 criteria who have not responded sufficiently to standard treatments. Participants will undergo an intensive 7-day treatment program consisting of 4 iTBS sessions per day (totaling 28 sessions). Clinical symptoms will be assessed before and after the treatment using standardized scales, including the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A). Resting-state EEG measurements and heart rate data will be recorded during and after the sessions to analyze physiological changes.\n\nGoal:\n\nThe findings are expected to contribute to the development of personalized neuromodulation protocols and help identify predictors of treatment response for OCD patients.",[28,29,30,31],"Obsessive - Compulsive Disorder","Transcranial Magnetic Stimilation","Intermittent Theta Burst Stimulation","EEG","RECRUITING","2026-05-07",{"date":35,"type":36},"2026-05-08","ACTUAL",{"date":38,"type":36},"2026-01-01",{"date":40,"type":22},"2027-04-01",{"name":42,"class":43},"Istanbul University - Cerrahpasa","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":44},"100613274","comparison-of-the-efficacy-of-accelerated-intermittent-theta-burst-stimulation-and-accelerated-continuous-theta-burst-stimulation-in-patients-with-treatment-resistant-depression-100613274","NCT07264452","Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression","Inclusion Criteria:\n\n1. 18 to 65 years old\n2. Patients diagnosed with Major Depressive Disorder according to DSM 5 and the severity of their illness\n3. Scoring 7 points or more on the Maudsley staging method\n4. Having depression unresponsive to 2 different antidepressants\n5. No clinical mental retardation\n6. Agree to participate in the study\n7. Hamilton Depression Rating Scale-17 \\[HDRS\\] score of 20 or higher\n8. Montgomery Asberg Depression Rating Scale \\[MADRS\\] score of 20 or above\n9. Being right hand dominant\n10. Having used the same antidepressant at the same dose for the last 4 weeks\n\nExclusion Criteria:\n\n1. Diagnosed with a neurological or metabolic disease that affects cognitive functions (Systemic diseases such as diabetes mellitus, cardiovascular disease, cerebrovascular disease, chronic renal failure, Parkinson's disease, multiple sclerosis, polyneuropathy, inflammatory rheumatologic disease and malignancies)\n2. Having a foreign body such as a pacemaker, intracranial implant that can magnetically interact\n3. Hearing and visual impairments that prevent communication\n4. Unstable or acute medical conditions\n5. Pregnancy or breastfeeding\n6. Having a primary psychiatric disorder other than major depressive disorder\n7. Being diagnosed with severe MDD with psychotic features",true,{"count":53,"type":22},60,[25],"In recent years, research on the effectiveness of transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (RTD) has been steadily increasing. The aim of this study was to examine the effectiveness of accelerated unilateral application of two different forms of theta burst stimulation (TBU), a variation of repetitive TMU (rTMS)-intermittent TBU (iTBU) and continuous TBU (cTBU)-in TDD patients. The study aimed to compare the advantages of iTBU and cTBU protocols on depression, suicidal thoughts, anxiety levels, sleep disturbances, cognitive performance, and overall functioning following a two-week intensive treatment period and a 12-week follow-up period.",[57,58,59,30,60,61],"Treatment Resistant Depression (TRD)","Transcranial Magnetic Stimulation","Accelerated Protocol","Continuous Theta Burst Stimulation","Unilateral rTMS",[57,58,63,64,65,61,66,67],"Accelerated protocol","intermittent theta burst stimulation","Continuous theta burst stimulation","unipolar major depressive disorder","non-invasive brain stimulation","2025-12-02",{"date":70,"type":36},"2025-12-04",{"date":72,"type":36},"2025-11-15",{"date":74,"type":22},"2027-01-15",{"name":76,"class":43},"Ataturk University"]