[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"internal-hemorrhoids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:internal-hemorrhoids":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,77,106,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643064","prospective-hemorrhoidal-embolisation-piles-registry-100643064",false,"NCT07635784","Prospective HemorrhoIdaL EmboliSation (PILES) Registry","Creation Of a Prospective Registry For Hemorrhoid Artery Embolization At The Joint & Vascular Institute","PILES","Inclusion Criteria:\n\n* Adults (≥18 years) with symptomatic bleeding internal hemorrhoids refractory to medical therapy, referred for HAE.\n\nExclusion Criteria:\n\n* Pregnancy, coagulopathy, severe comorbidities, or inability to consent.","ALL","18 Years",{"count":20,"type":21},1200,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of hemorrhoid artery embolization (HAE) for symptomatic bleeding internal hemorrhoids in adults aged 18 years or older that have not responded to medical therapy.\n\nThe main question it aims to answer are:\n\n1\\) Does HAE lead to sustained improvement in bleeding (HDSS scores over 12-36 months?\n\nParticipants will:\n\n* Undergo HAE as part of their routine clinical care.\n* Complete clinical follow-up assessments at 1, 3, 6, 12, 18, 24, and 36 months after treatment, including symptom and quality-of-life questionnaires.\n* Have safety outcomes tracked according to Society of Interventional Radiology guidelines.\n\nThere is no comparison group; results will be analyzed to identify predictors of success and inform best practices for patient selection and treatment.",[26,27,28,29,30],"Hemorrhoid","Internal Hemorrhoids","Hemorrhoid Bleeding","Hemorrhoidal Bleeding","Internal Hemorrhoid",[32,33,34],"bleeding","hemorrhoids","internal hemorrhoids","RECRUITING","2026-06-10",{"date":38,"type":39},"2026-06-12","ACTUAL",{"date":41,"type":39},"2026-01-18",{"date":43,"type":21},"2032-01",{"name":45,"class":46},"Joint & Vascular Institute","INDUSTRY",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100632980","clinical-outcomes-after-laser-hemorrhoidoplasty-100632980","NCT07520734","Clinical Outcomes After Laser Hemorrhoidoplasty","Clinical Outcomes, Pain Scores, and Patient Satisfaction in Patients Undergoing Laser Hemorrhoidoplasty: A Prospective Observational Study","LHP","Inclusion Criteria:\n\n* Age 18 years or older\n* Symptomatic internal hemorrhoidal disease\n* Scheduled to undergo laser hemorrhoidoplasty\n* Willingness to participate and provision of informed consent\n\nExclusion Criteria:\n\n* Grade IV hemorrhoidal disease\n* Acute thrombosed hemorrhoids\n* Additional anorectal pathology such as anal fissure, fistula, or perianal abscess\n* History of inflammatory bowel disease or colorectal malignancy\n* Previous major anal surgery'",{"count":57,"type":21},60,"This single-center prospective observational study aims to evaluate clinical outcomes, postoperative pain scores, complications, and patient satisfaction in adults undergoing laser hemorrhoidoplasty for symptomatic internal hemorrhoidal disease. Additional objectives are to assess the relationship between hemorrhoid stage, dominant presenting symptoms, operative technical details, and postoperative outcomes. No study-specific intervention beyond routine clinical care and follow-up will be performed.",[60,27],"Hemorrhoidal Disease",[62,63,64,65],"Laser hemorrhoidoplasty","Hemorrhoidal disease","Patient satisfaction","Visual Analog Scale","NOT_YET_RECRUITING","2026-04-02",{"date":69,"type":39},"2026-04-09",{"date":71,"type":21},"2026-04-01",{"date":73,"type":21},"2027-04-01",{"name":75,"class":76},"Sanliurfa Education and Research Hospital","OTHER_GOV",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100623043","phase-4-nitroglycerin-ointment-for-pain-relief-after-endoscopic-hemorrhoid-band-ligation-100623043","NCT07391501","Nitroglycerin Ointment for Pain Relief After Endoscopic Hemorrhoid Band Ligation","A Randomized, Double-Blind, Placebo-Controlled Study of Nitroglycerin Ointment for Postoperative Pain Relief After Endoscopic Rubber Band Ligation of Internal Hemorrhoids","Inclusion Criteria:\n\n* Age: 18 to 75 years, male or female\n* Diagnosis\u002Findication: Internal hemorrhoids grade I, II, or III scheduled for endoscopic rubber band ligation\n* Consent: Able and willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Compliance\u002Fassessment: Unable to understand study endpoints or complete study records\u002Fforms\n* Concomitant medications: Current use of oral nitrates or calcium channel blockers\n* Allergy: Known allergy to lactulose oral solution, nitroglycerin ointment, or other study-related medications\n* Pregnancy\u002Flactation: Pregnant or breastfeeding women\n* Procedure tolerance: Unable to tolerate hemorrhoid band ligation, colonoscopy, or bowel preparation\n* Severe comorbidities: Severe cardiac, respiratory, neurologic, or psychiatric disorders\n* Legal capacity: Lacking legal capacity for civil conduct or lacking insight\u002Fjudgment to provide valid consent","75 Years",{"count":86,"type":21},68,"INTERVENTIONAL",[89],"PHASE4","This study is designed to evaluate whether nitroglycerin ointment can reduce pain after endoscopic rubber band ligation for internal hemorrhoids. Endoscopic rubber band ligation is a commonly used, minimally invasive treatment for internal hemorrhoids, but postoperative anal pain is a frequent and sometimes severe complication that can affect daily activities and recovery.\n\nParticipants undergoing endoscopic rubber band ligation will be randomly assigned to receive either nitroglycerin ointment or a placebo ointment applied locally after the procedure. Both participants and investigators will be blinded to the treatment assignment. All participants will receive the same standard perioperative care, and rescue pain medication will be provided when necessary.\n\nThe primary goal of the study is to compare the proportion of patients who require rescue pain medication within 72 hours after the procedure between the two groups. Secondary outcomes include pain intensity at multiple time points, time to complete pain relief, postoperative complications, treatment-related adverse events, and overall treatment effectiveness at 30 days. The results of this study may help identify a safe and effective option for improving pain control after endoscopic treatment of internal hemorrhoids.",[27,92],"Postoperative Pain After Endoscopic Rubber Band Ligation",[27,94,95,96],"Endoscopic Rubber Band Ligation","Postoperative Pain","Nitroglycerin Ointment","2026-02-01",{"date":99,"type":39},"2026-02-05",{"date":97,"type":21},{"date":102,"type":21},"2028-11-30",{"name":104,"class":105},"Ying Zhu","OTHER",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":87,"phases":116,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":47},"100606749","hemorrhoidal-artery-embolization-longitudinal-impact-on-symptoms-helios-100606749","NCT07179601","Hemorrhoidal Artery Embolization: Longitudinal Impact On Symptoms (HELIOS)","HELIOS","Inclusion Criteria:\n\n* Age 18 to 90 years\n* Ability to give written informed consent and to comply with the follow-up visits\n* Symptomatic hemorrhoidal disease with French Bleeding Score (FBS) of at least four out of nine\n* Refusal of or contraindication to surgery\n* Refusal of or contraindication to other minimally invasive hemorrhoid treatments\n* Grade I to III hemorrhoids\n* Previous anoscopy or colonoscopy demonstrating internal hemorrhoids within 1 year\n* Supply of the CCR from either the SRA or MRA on intra-procedural angiogram prior to embolization\n\nExclusion Criteria:\n\n* Asymptomatic patients\n* Patients who ever had previous colorectal surgery\n* Grade IV hemorrhoids\n* Colorectal disease other than hemorrhoids that could result in bleeding\n* Anatomic findings on CTA that would preclude successful embolization\n* Contraindication to iodinated contrast\n* Inability to give written informed consent\n* Active infection or malignancy\n* Recent (within 12 months) or active cigarette use\n* History of inflammatory bowel disease\n* Uncorrectable bleeding diathesis\n* Presence of portal hypertension or rectal varices seen on pre-procedure CTA or anoscopy\u002Fcolonoscopy\n* No SRA or MRA supply to the CCR seen intra-procedural angiogram","90 Years",{"count":115,"type":21},22,[117],"NA","Hemorrhoidal artery embolization (HAE) is a novel treatment for symptomatic internal hemorrhoids. HAE involves the deliberate blockage (embolization) of enlarged rectal or hemorrhoidal arteries leading to reduction of abnormal blood flow to the hemorrhoidal tissue. The aim of HAE is to the improve hemorrhoid related symptoms, especially bleeding. Initial reports of HAE have demonstrated that it both safe and effective. Following an initial clinic visit to determine trial candidacy, enrolled patients will be subsequently treated with HAE. Patients will be followed for a year with clinic follow-up visits at 1, 3, 6 and 12 months.",[27,120],"HAE","2026-01-30",{"date":123,"type":39},"2026-02-02",{"date":125,"type":39},"2025-08-05",{"date":127,"type":21},"2029-09-30",{"name":129,"class":105},"University of California, Los Angeles",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":138,"targetDuration":4,"studyType":87,"phases":139,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":47},"100618547","helo-trial-energy-based-therapies-vs-conventional-hemorrhoidectomy-for-grade-iii-hemorrhoids-100618547","NCT07333040","HELO Trial: Energy-Based Therapies vs. Conventional Hemorrhoidectomy for Grade III Hemorrhoids","Hemorrhoidectomy, Energy-Based, and Laser Outcomes in Grade III Hemorrhoids: A Prospective, Multicenter, Preference-Based Comparative Study","HELO","Inclusion Criteria:\n\n* Diagnosed with Goligher Grade III internal hemorrhoids.\n* Symptomatic with HDSS score \\>= 5.\n* Age 18-75 years.\n* Fit for general anesthesia or sedation.\n* Able to provide informed consent.\n* Agree to pre-operative photo documentation.\n\nExclusion Criteria:\n\n* Other anorectal diseases (fistula, abscess, IBD, malignancy).\n* Prior anorectal surgery within 6 months.\n* Pregnancy or lactation.\n* Contraindications to anesthesia.",{"count":57,"type":21},[117],"This prospective, multicenter study compares the efficacy and functional outcomes of three surgical treatments for symptomatic Goligher Grade III internal hemorrhoids: Laser Hemorrhoidoplasty (LHP), Hemorrhoid Energy Therapy (HET), and conventional closed hemorrhoidectomy (Ferguson technique). Due to strong patient preferences in hemorrhoidal surgery, this study utilizes a pragmatic, preference-tolerant design. Eligible patients will undergo standardized counseling and select their preferred treatment arm. The study aims to evaluate whether minimally invasive energy-based therapies offer superior postoperative pain relief and faster functional recovery compared to conventional hemorrhoidectomy",[142,27,143],"Hemorrhoids Third Degree","Mixed Hemorrhoids",[145,146,95,147,148],"Laser Hemorrhoidoplasty","Hemorrhoid Energy Therapy","Minimally Invasive Surgery","Hemorrhoidectomy","2026-01-01",{"date":151,"type":39},"2026-01-12",{"date":153,"type":21},"2026-03-01",{"date":155,"type":21},"2028-03-01",{"name":157,"class":105},"Chang Gung Memorial Hospital"]