[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"internalizing-mental-health-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:internalizing-mental-health-symptoms":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100636483","early-phase-1-micropractices-for-unhoused-lgbtq-youth-100636483",false,"NCT07566273","Micropractices for Unhoused LGBTQ Youth","Developing and Evaluating Collaboratively Designed Mindfulness and Identity-Affirming Practices for Unhoused LGBTQ Youth","Inclusion Criteria:\n\n* Aged 16 to 26 years\n* Self-identify as LGBTQ\n* Currently or recently experiencing housing instability (within the past six months)\n* Have access to a mobile device with internet capability to complete study activities\n\nExclusion Criteria:\n\n* Unable to complete study procedures (e.g., lack of device access)",true,"ALL","16 Years","26 Years",{"count":21,"type":22},200,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","In the present study, the investigators will conduct a pilot randomized controlled trial to evaluate the feasibility, acceptability, and preliminary efficacy of brief, co-designed mindfulness and identity-affirming micropractices for LGBTQ youth and young adults experiencing housing instability. Participants (n = 200, accounting for anticipated attrition) will be randomly assigned to one of two conditions: (1) a mindfulness and identity-based micropractice condition or (2) a structurally equivalent neutral control condition. The intervention content will be developed using a participatory co-design process with members of the target population and standardized prior to trial implementation. The mindfulness and identity condition integrates brief practices targeting present-moment awareness and identity affirmation, whereas the control condition accounts for time and attention without including these components. Assessments will be conducted at baseline, post-intervention, and three-month follow-up. Primary outcomes include feasibility and acceptability, assessed using standardized implementation outcome measures and indicators of intervention adherence. Secondary outcomes include changes in mental health symptoms, psychological and emotional well-being, and substance use. The investigators will evaluate whether the mindfulness and identity-based condition demonstrates greater improvements in outcomes compared to the control condition and will estimate effect sizes to inform the design of future fully powered trials. The intervention will be delivered via a mobile-accessible platform.",[28,29,30],"Well-Being (Psychological Flourishing)","Internalizing Mental Health Symptoms","Substance Abuse",[32,33,34,30,35,29],"Micropractice","Unhoused","Well-Being","LGBTQ","NOT_YET_RECRUITING","2026-04-29",{"date":39,"type":40},"2026-05-05","ACTUAL",{"date":42,"type":22},"2026-10",{"date":44,"type":22},"2027-01",{"name":46,"class":47},"Cornell University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100504282","students-rising-above-offsetting-the-health-and-mental-health-costs-of-resilience-100504282","NCT05846282","Students Rising Above: Offsetting the Health and Mental Health Costs of Resilience","Project STRIVE (STudents RIsing Above) - Offsetting the Health and Mental Health Costs of Resilience","STRIVE","Inclusion Criteria:\n\n* Enrolled in 10th or 11th grade at a participating high school\n* Black, Latinx, Asian American\u002FPacific Islander, or American Indian\u002FAlaskan Native\n* High achieving (e.g., GPA above 3.5 and\u002For in the top 20% of their grade, enrolled in advanced classes such as AP\u002FIB\u002Fhonors classes)\n\nExclusion Criteria:\n\n* Intellectual Disability","13 Years",{"count":59,"type":22},504,[61],"NA","Students who 'strive' to rise above significant stressors to achieve academic success are considered 'resilient'. However, youths' resilience in one domain (i.e. academic) can come at a cost in other domains including physical and mental health morbidities that are under-identified and under-treated. Previous research suggests that individuals from populations experiencing documented health disparities who exhibit a \"striving persistent behavioral style\" in the face of stress evince later health morbidities. Ironically, the same self-regulatory skills that promote academic achievement amid chronic stress can also result in physiological dysregulation that harms health and mental health. Self-regulatory processes that involve emotion suppression, experiential avoidance, and unmodulated perseverance can culminate in allostatic load which fuels health disparities and internalizing symptoms of depression and anxiety.\n\nThe proposed mechanistic trial will utilize mindfulness training to permit examination of questions about the causal role of emotion regulation strategies linked to the striving persistent behavioral style in driving mental health and health morbidities among individuals from populations experiencing documented health disparities. The proposed Project STRIVE (STudents RIsing aboVE) will identify students who are academically resilient in the face of stress and will offer a tailored mindfulness intervention targeting self-regulation processes as a putative mechanism to interrupt the links between the striving persistent behavioral style and negative health outcomes. Investigators propose a multisite randomized trial randomizing 504 high achieving Black, Latinx, or Asian America\u002FPacific Islander students in 18 schools to receive a mindfulness intervention or an attention control condition focused on study skills. The study will: (1) test the effects of the STRIVE intervention on putative self-regulation mechanisms (emotion suppression, experiential avoidance, and unmodulated perseverance) among identified students, (2) test the effects of the STRIVE intervention on health and mental health outcomes at 12-month post-treatment, including biomarkers of allostatic load (cortisol, blood pressure, body-mass-index, waist\u002Fhip\u002Fneck circumference), health complaints, and internalizing symptoms, and (3) examine the mechanistic model linking striving persistent behavioral style and health outcomes within the STRIVE trial.",[29,64,65],"Allostatic Load","Health Complaints","RECRUITING","2026-03-04",{"date":69,"type":40},"2026-03-06",{"date":71,"type":40},"2023-01-09",{"date":73,"type":22},"2027-06",{"name":75,"class":47},"University of California, Los Angeles"]