[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"internuclear-ophthalmoplegia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:internuclear-ophthalmoplegia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100636077","internuclear-ophthalmoplegia-and-multiple-sclerosis-a-multicenter-retrospective-study-100636077",false,"NCT07560995","Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study","INO&MS","Inclusion criteria:\n\n* Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis\n* Patients hospitalized in a neurology department\n\nExclusion criteria:\n\n\\- Patients under 18 years of age","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS.\n\nThe objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion.\n\nThe study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.",[24,25],"Multiple Sclerosis","Internuclear Ophthalmoplegia","NOT_YET_RECRUITING","2026-05-04",{"date":29,"type":30},"2026-05-08","ACTUAL",{"date":32,"type":20},"2026-05",{"date":34,"type":20},"2027-05",{"name":36,"class":37},"University Hospital, Strasbourg, France","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100548147","head-cancelled-virtual-reality-for-ocular-cranial-nerve-palsies-100548147","NCT06417216","Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies","Head-Cancelled Virtual Reality for Rehabilitation of Ocular Cranial Nerve Palsies","OCNP","OCNP Group Inclusion Criteria:\n\n* Presence of OCNP in one eye with 50% range-of-motion limitation or worse\n* Able to provide informed consent and will be able to fluently read and understand spoken English\n\nOCNP Group Exclusion Criteria:\n\n* Presence of bilateral OCNP\n* Range of motion better than 50%\n* Visual acuity worse than 20\u002F100 in either eye\n* Greater than 4-line difference in visual acuity between the eyes,\n* Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset\n\nParticipants will be excluded if they are unable to participate if inclusion criteria are not met.\n\nNormal Group Inclusion Criteria:\n\n* Absence of OCNP or other neurological or neuro-ophthalmic diseases\n* No strabismus\n* Have normal or near-normal vision with glasses or contact lenses.\n* Be able to provide informed consent and will be able to fluently read and understand spoken English\n\nNormal Group Exclusion Criteria:\n\n* Visual acuity worse than 20\u002F100 in either eye\n* Greater than 4-line difference in visual acuity between the eyes\n* Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset\n* Known inability to tolerate visual testing of at least 20 minutes continuously.",true,{"count":49,"type":20},40,"INTERVENTIONAL",[52],"NA","This study is investigating whether eye exercises for abducens palsy and internuclear ophthalmoplegia increase ocular range of motion in the paretic direction when performed in virtual reality under head-cancelled compared to head-active conditions.",[25,55],"Palsy, Abducens","RECRUITING","2026-04-01",{"date":59,"type":30},"2026-04-06",{"date":61,"type":30},"2024-09-10",{"date":63,"type":20},"2028-06-01",{"name":65,"class":37},"Kevin Houston",2,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100564436","studying-eye-movement-deficits-and-cognitive-impairment-in-patients-with-multiple-sclerosis-using-infrared-eye-tracking-and-cognitive-tests-100564436","NCT06629155","Studying Eye Movement Deficits and Cognitive Impairment in Patients with Multiple Sclerosis Using Infrared Eye Tracking and Cognitive Tests","Disentangling Cognitive Functioning and Visual Scanning Deficits in Cognitive Test Results in Multiple Sclerosis (MS)","VisuMS","Inclusion criteria:\n\n* Diagnosed with clinically definite multiple sclerosis according to the 2017 McDonald criteria\n* At least 18 years old\n* Combined vision with optimal correction \\> 0,6 on Snellen Visual Acuity Test.\n* Providing informed consent.\n\nExclusion criteria:\n\n* Major medical or psychiatric pathology that potentially affects cognitive functioning.\n* A score higher than 63 on the Fatigue Scale for Motor and Cognitive Functions is categorized as severe fatigue\n* Start or switch in immunomodulatory treatment within three months before inclusion.\n* Less than 3 months post exacerbation.\n* Refusing informed consent.",{"count":76,"type":20},50,"The goal of this observational study is to study the relationship between cognitive problems and problems in eye movements in Multiple Sclerosis (MS).\n\nThe main questions it aims to answer are:\n\n* What is the correlation between eye movement parameters (VDI AUC and VDI Pv\u002FAm, left and right) and SDMT scores in patients with MS?\n* What is the number of patients with VDI AUC\\>1.174 and\u002For VDI Pv\u002FAm\\>1.180 assessed by infrared oculography during prosaccades at 15 degrees left or right?\n* What is the correlation between eye movement parameters (VDI AUC and VDI Pv\u002FAm, left and right) and cognitive test scores in patients with MS?\n\nParticipants will perform specific cognitive tests and eye movements will be measured through infrared oculography.\n\nThe primary hypothesis for the study is: participants who exceed the treshold (VDI AUC\\>1.174 and\u002For VDI Pv\u002FAm\\>1.180, left or right) will perform worse on cognitive tests compared to those who don't.",[24,25],[80,24,25,81],"Cognitive impairment","SDMT","2024-11-04",{"date":84,"type":30},"2024-11-06",{"date":86,"type":20},"2025-03-01",{"date":88,"type":20},"2027-02-01",{"name":90,"class":37},"Universitair Ziekenhuis Brussel"]