[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"interstitial-lung-diseases-ild\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:interstitial-lung-diseases-ild":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,69,94,117,144],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100640455","clinical-utility-of-libs-multi-element-imaging-and-the-iff-algorithm-in-chronic-lung-diseases-100640455",false,"NCT07597187","Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm in Chronic Lung Diseases","Evaluation of the Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm for the Etiological and Medico-Legal Management of Chronic Lung Diseases","PNEUMO-LIBS","Inclusion Criteria:\n\n* Adult patient aged 18 years or older.\n* Diagnosis or documented clinical suspicion of chronic lung disease, including interstitial lung disease, pulmonary granulomatosis such as sarcoidosis, or pulmonary emphysema.\n* Availability of a lung tissue biopsy sample obtained during routine medical care and stored as a formalin-fixed paraffin-embedded sample.\n* Sufficient medical record information to document the clinical context, occupational or environmental exposure history, smoking status, imaging, pathology reports, and other relevant routine-care data.\n* No documented objection to the secondary use of health data and biological samples for this research.\n\nExclusion Criteria:\n\n* Documented objection to participation in the study or to the secondary use of health data or biological samples for research.\n* Missing, unavailable, degraded, or technically unusable biopsy sample.\n* Insufficient medical record information to document the clinical context or exposure history.\n* Lung condition outside the scope of the study, such as isolated acute infection, isolated cardiac disease, or primary lung cancer.\n* Patient under legal protection when the applicable legal conditions for non-opposition cannot be fulfilled.","ALL","18 Years",{"count":20,"type":21},70,"ESTIMATED","OBSERVATIONAL","PNEUMO-LIBS is a multicenter, non-interventional observational study designed to evaluate whether multi-element tissue imaging by Laser-Induced Breakdown Spectroscopy (LIBS), combined with an artificial intelligence-based analysis tool called Interesting Features Finder (IFF), may help physicians better understand the possible causes of chronic lung diseases.\n\nThe study focuses on adult patients with chronic lung diseases for which a lung biopsy has already been performed as part of routine medical care. These diseases include diffuse interstitial lung diseases, pulmonary granulomatoses such as sarcoidosis, and emphysema, especially when an environmental or occupational exposure is suspected but not clearly demonstrated.\n\nSome chronic lung diseases may be influenced by inhaled mineral or metallic particles, such as silica, aluminum, titanium, or other metals. However, these exposures are often difficult to document at the individual patient level. Standard clinical, radiological, and pathological investigations do not usually provide direct information on the presence and distribution of such elements within lung tissue.\n\nLIBS is an imaging technique that can detect and map chemical elements directly in tissue samples, including archived formalin-fixed paraffin-embedded biopsy blocks. In this study, lung biopsy samples will be analyzed with LIBS to search for elemental signatures that may be compatible with occupational or environmental exposures. The IFF algorithm will then be used to help interpret the LIBS data and identify rare or unexpected elemental signals.\n\nThe study does not require any additional biopsy, blood test, imaging examination, treatment, or hospital visit for participants. It uses tissue samples and medical data already collected during routine care. The results of LIBS and IFF analyses will be presented to the treating physician or investigator, who will complete standardized online questionnaires at three time points: before receiving the LIBS results, after receiving the LIBS report, and after receiving the IFF-assisted interpretation.\n\nThe main objective is to assess the perceived clinical utility of LIBS imaging for physicians, particularly regarding etiological understanding, possible occupational disease recognition, and prevention-oriented reasoning. Secondary objectives include assessing the added value of the IFF algorithm and evaluating the feasibility of a centralized multicenter workflow for sample transfer, LIBS analysis, IFF processing, result reporting, and questionnaire completion.\n\nThe study aims to include approximately 70 patients across several French hospital centers. Its results may support the development of future diagnostic, occupational health, and environmental medicine approaches, without modifying the medical care of participants during the study.",[25,26,27,28,29,30],"Interstitial Lung Diseases (ILD)","Pulmonary Emphysema","Chronic Lung Diseases","Occupational Lung Diseases","Environmental Exposure","Occupational Exposure","NOT_YET_RECRUITING","2026-05-12",{"date":34,"type":35},"2026-05-19","ACTUAL",{"date":37,"type":21},"2026-07-01",{"date":39,"type":21},"2027-07-01",{"name":41,"class":42},"University Hospital, Grenoble","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100616060","functional-mri-for-monitoring-progression-and-assessing-trends-in-ild-100616060","NCT07300696","Functional MRI for Monitoring Progression and Assessing Trends in ILD","Functional Magnetic Resonance Imaging of the Lung to Detect Regional Reversibility and Progression in Interstitial Lung Disease","IMPACT-ILD","Inclusion Criteria:\n\n* Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up\n* Capacity to consent\n* Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging)\n\nExclusion Criteria:\n\n* Pregnancy and breast feeding\n* Persons under the age of 18 and persons not able to give informed consent\n* Any medical conditions that could hinder the ability to adhere to the protocol\n* Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR \\\u003C 30 ml min\u002F1,73 m2)",{"count":52,"type":21},200,"INTERVENTIONAL",[55],"NA","The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:\n\nDetermine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.\n\nAnalyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.\n\nAssess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.",[25],"RECRUITING","2025-12-17",{"date":61,"type":35},"2025-12-24",{"date":63,"type":35},"2025-11-20",{"date":65,"type":21},"2027-07",{"name":67,"class":42},"University Hospital Heidelberg",2,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":53,"phases":78,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":92,"locationsCount":68},"100564227","treatable-traits-in-interstitial-lung-disease-100564227","NCT06626438","Treatable Traits in Interstitial Lung Disease","TTRILD","Inclusion Criteria: Patients with a new or pre-existing diagnosis of fibrotic ILD who receive care via the Fiona Stanley Hospital (FSH) or Sir Charles Gairdner Hospital (SCGH) ILD service will be invited to participate. This ILD diagnosis must be made through an ILD MDT.\n\nIncluded participants will be aged ≥ 18 years with a physician-confirmed diagnosis of fibrotic ILD. Fibrotic ILD is defined as presence of fibrotic changes on CT in the opinion of the investigator. All ILD subtypes, excluding sarcoidosis, will be included. Participants will need to be able to provide consent to participate and be established on stable ILD treatment for 1 month prior to study initiation.\n\nExclusion Criteria: Participants will be excluded if they have experienced an acute exacerbation 4 weeks prior to starting the study or are expected to experience either a transplant or death during the study period. Active suicidality, severe depression, active psychosis or mania, or other severe psychiatric concerns that require more intensive treatment. Any such participants could be referred for individual therapy and\u002For psychiatric treatment that would be more appropriate for their needs.",{"count":77,"type":21},110,[55],"The goal of this clinical trial is to learn if a personalised treatment model of care \"treatable traits\" can improve quality of life and disease progression in patients with interstitial lung disease.\n\nThe main question it aims to answer is, will providing a treatable traits model of care improve health-related quality of life (HRQoL) (primary outcome), symptoms, anxiety, physical activity, and body composition (secondary outcomes).\n\nResearchers will compare the treatable traits model to standard of care.\n\nParticipants in both arms will complete surveys, a Dual-Energy X-Ray Absorptiometry (DEXA) and whole-body composition scan, lung function and blood tests. Those in the intervention (TT) arm will be seen in a multidisciplinary clinic where they are seen by an ILD doctor, physiotherapist, psychologist, and dietitian.",[25],[82,83,84,85],"treatable traits","interstitial lung disease","pulmonary fibrosis","multidisciplinary","2025-10-01",{"date":88,"type":35},"2025-10-07",{"date":90,"type":35},"2025-09-03",{"date":65,"type":21},{"name":93,"class":42},"The University of Western Australia",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100591964","establishment-of-diagnosis-and-classification-system-for-lung-interstitial-and-airway-diseases-liad-100591964","NCT06987266","Establishment of Diagnosis and Classification System for Lung Interstitial and Airway Diseases (LIAD)","EDCS-LIAD","Inclusion Criteria:\n\n1. age between 40-80 years old;\n2. inpatients with an admission diagnosis of COPD, Idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, patients with the following diagnoses were screened by chest CT (slice thickness ≤1.5 mm) during hospitalization and by in-hospital or prior pulmonary function;\n3. the inpatients could complete pulmonary function and chest CT examination within 1 month after discharge;\n4. among outpatients, patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, COPD with pulmonary interstitial abnormalities, idiopathic pulmonary fibrosis with airway lesions, nonspecific interstitial pneumonia with airway lesions, pulmonary fibrosis with emphysema syndrome were diagnosed through chest CT (layer thickness ≤1.5mm) and lung function;\n5. provide informed consent.\n\nExclusion Criteria:\n\n1. expected survival less than 12 months;\n2. planned lung transplantation or pneumonectomy within 12 months;\n3. pregnant or lactating women.","40 Years","80 Years",{"count":104,"type":21},900,"This study focuses on both hospitalized and outpatient populations. Through a multicenter, retrospective study, it aims to comprehensively characterize:The comorbidity of interstitial lung diseases (ILD) and airway diseases;The comorbidity of ILD with other intrapulmonary diseases;The comorbidity of airway diseases with other intrapulmonary diseases;The comorbidity of ILD and airway diseases with extrapulmonary diseases.Based on these findings, the study seeks to propose classification and diagnostic criteria for ILD and airway disease comorbidities.Additionally, a multicenter, prospective, disease-specific cohort study will be conducted to observe the prognosis of patients with ILD and\u002For airway diseases, identify prognostic factors, and grade the severity of comorbid conditions based on these factors.Finally, the study will analyze the current state of interventions and the medical costs associated with ILD and airway disease comorbidities through a cost-effectiveness analysis, aiming to propose new strategies for integrated disease management.",[25,107],"Airway Disease","2025-05-22",{"date":110,"type":35},"2025-05-23",{"date":112,"type":21},"2025-05-20",{"date":114,"type":21},"2028-11-30",{"name":116,"class":42},"Xiangya Hospital of Central South University",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":143},"100589015","validity-and-reliability-of-6-minute-pegboard-and-ring-test-in-patients-with-interstitial-lung-disease-100589015","NCT06948916","Validity and Reliability of 6-minute Pegboard and Ring Test in Patients With Interstitial Lung Disease","Investigation of the Validity and Reliability of 6-minute Pegboard and Ring Test in Patients With Interstitial Lung Disease","Inclusion Criteria:\n\n* Patients diagnosed with ILD according to ATS\u002FERS criteria,\n* Ages between 18 and 75,\n* Pulmonary infection during the previous month,\n* Participants who voluntarily participated in the study were included.\n\nExclusion Criteria:\n\n* Patients were excluded if they had:\n* Acute pulmonary exacerbation or respiratory infection in the last four weeks\n* Obstructive lung disease\n* Systemic conditions affecting neurological, neuromuscular, orthopedic, or physical functions\n* Recent participation in a planned exercise program (within three months)\n* Cognitive impairment affecting exercise test understanding\n* Contraindications to exercise testing per the American Sports Medicine Association\n* Cancer, renal, or hepatic disease\n* Aortic stenosis, complex arrhythmia, or aortic aneurysm\n* Serious cardiovascular diseases like uncontrolled hypertension, diabetes, heart failure, or arrhythmia","75 Years",{"count":126,"type":21},34,"Interstitial lung diseases (ILD) are a heterogeneous group of chronic respiratory diseases that cause significant mortality and morbidity worldwide, characterized by diffuse inflammation in the lung parenchyma and vascular structures, can progress to fibrosis, have known or unknown etiology, and can develop secondary to systemic autoimmune connective tissue diseases other than diseases where the primary pathology is in the lung. The 6-minute peg-board and ring test, which was first developed to determine the upper extremity exercise capacity of chronic obstructive pulmonary disease patients, is an exercise test used to evaluate upper extremity functional exercise capacity in different lung diseases. It has been determined that there is no study on the validity and reliability of this test in individuals with ILD.",[25,129,130],"Exercise Capacity","Upper Extremity",[132,129,133],"Interstitial lung diseases","Upper extremity","2025-04-22",{"date":136,"type":35},"2025-04-29",{"date":138,"type":35},"2024-12-12",{"date":140,"type":21},"2025-08-12",{"name":142,"class":42},"Gazi University",1,{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":151,"sex":17,"minAge":18,"maxAge":124,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":166,"leadSponsor":168,"locationsCount":143},"100589017","exercise-capacity-muscle-oxygenation-and-physical-activity-between-patients-with-interstitial-lung-disease-100589017","NCT06948942","Exercise Capacity, Muscle Oxygenation, and Physical Activity Between Patients With Interstitial Lung Disease","Comparison of Exercise Capacity, Muscle Oxygenation and Physical Activity Levels Between Patients With Interstitial Lung Disease and Healthy Individuals","Patients who will participate in the study;\n\nInclusion Criteria:\n\n* Patients diagnosed with ILD according to ATS\u002FERS criteria,\n* Ages between 18 and 75,\n* Pulmonary infection during the previous month,\n* Participants who voluntarily participated in the study were included.\n\nExclusion Criteria:\n\n* Patients were excluded if they had:\n* Acute pulmonary exacerbation or respiratory infection in the last four weeks\n* Obstructive lung disease\n* Systemic conditions affecting neurological, neuromuscular, orthopedic, or physical functions\n* Recent participation in a planned exercise program (within three months)\n* Cognitive impairment affecting exercise test understanding\n* Contraindications to exercise testing per the American Sports Medicine Association\n* Cancer, renal, or hepatic disease\n* Aortic stenosis, complex arrhythmia, or aortic aneurysm\n* Serious cardiovascular diseases like uncontrolled hypertension, diabetes, heart failure, or arrhythmia\n\nFor healthy individuals who will participate in the study;\n\nInclusion Criteria:\n\n* No diagnosed chronic disease,\n* Healthy adults between the ages of 45-80\n\nExclusion Criteria:\n\n* Individuals with a Mini Mental State Assessment Scale score of less than 24,\n* A smoking history of at least 10 packs×years or more,\n* Having had COVID-19,\n* A BMI of \\>30 kg\u002Fm2",true,{"count":153,"type":21},40,"Interstitial lung diseases (ILD) are a group of chronic respiratory diseases that cause significant mortality and morbidity worldwide. Although there are studies in the literature comparing different lung disease groups with healthy individuals, it has been determined that there is no study comparing the exercise capacity, muscle oxygenation, physical activity level, respiratory functions, respiratory and peripheral muscle strength, inspiratory muscle endurance, quality of life and sleep quality of individuals diagnosed with ILD with healthy individuals.",[25,156,129,157,158],"Healthy Individuals","Muscle Oxygenation","Physical Activity Level",[132,160,161,162,163],"Healthy individuals","Exercise capacity","Muscle oxygenation","Physical activity level",{"date":136,"type":35},{"date":138,"type":35},{"date":167,"type":21},"2025-09-12",{"name":142,"class":42}]