[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intervertebral-disc-displacement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intervertebral-disc-displacement":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,91,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100622663","biologic-injection-for-adults-with-lumbar-disc-herniation-100622663",false,"NCT07386548","Biologic Injection For Adults With Lumbar Disc Herniation","Bone Marrow Aspirate Concentrate Injection With MRI's - A Prospective Randomized Control Trial","BMAC","Inclusion Criteria:\n\n* Male or female patients ≥ 18 years of age\n* Clinically and\u002For radiographically (MRI) confirmed diagnosis of degenerative disc disease of the lumbar spine, lumbar disc herniation, and indication for lumbar microdiscectomy surgery\n* Unresponsive to conservative\u002Fnon-operative treatment for \\>3 months\n* Psychosocial, mental and physical ability to understand and to adhere to this protocol, especially adhering to the visit schedule follow-ups and observe the treatment plan\n\nExclusion Criteria:\n\n* Prisoners\n* Individuals who are not yet adults (infants, children, teenagers)\n* Individuals who are not able to clearly understand English\n* Adults with diminished capacity to consent\n* Major cognitive impairment causing to inability to understand and provide informed consent\n* Active malignancy\n* Active chronic or acute infection\n* Autoimmune disorder that impacts the lumbar spine (ankylosing spondylitis, lupus e.g.)\n* Bone marrow-derived or non-bone marrow-derived cancer\n* Low platelet count or clotting disorders\n* Prior surgery at the level to be treated or the adjacent level","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation.\n\nThe main questions it aims to answer are:\n\n* Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)?\n* Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone?\n\nParticipants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery.\n\nResearchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit.\n\nParticipants will:\n\n* Have surgery (microdiscectomy) with or without the injection.\n* Complete pain and disability questionnaires at several times over 2 years.\n* Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health.\n* Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.",[27,28,29,30,31,32,33,34,35,36,37],"Degenerative Disc Disease","DDD","Degenerative Disc Disease Lumbar","Degenerative Disc Disease, Lumbar","Lumbar Disc Herniation","Disc Herniation, Lumbar","Bone Marrow Aspirate Concentrate","Intervertebral Disc Displacement","Low Back Pain","Chronic Low Back Pain (CLBP)","CLBP - Chronic Low Back Pain",[39,40,41,42,43],"degenerative disc disease","lumbar disc herniation","bone marrow aspirate concentrate","intervertebral disc displacement","low back pain","NOT_YET_RECRUITING","2026-04-14",{"date":47,"type":48},"2026-04-16","ACTUAL",{"date":50,"type":21},"2026-05-01",{"date":52,"type":21},"2030-12",{"name":54,"class":55},"Weill Medical College of Cornell University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":68,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":56},"100625667","cervical-movement-control-before-and-after-anterior-cervical-discectomy-and-fusion-100625667","NCT07425613","Cervical Movement Control Before and After Anterior Cervical Discectomy and Fusion","Early Changes in Dynamic Cervical Movement Control Following Anterior Cervical Discectomy and Fusion: A Prospective Controlled Longitudinal Study","MOVE-ACDF","Inclusion Criteria\n\nSurgical group:\n\n* Age 18 to 65 years\n* Clinical diagnosis of cervical disc pathology at one segment level (e.g., cervical disc herniation or degenerative disc disease)\n* Scheduled to undergo anterior cervical discectomy and fusion (ACDF) as part of standard clinical care\n* Ability to understand study procedures and provide written informed consent\n\nNon-Surgical neck pain group:\n\n* Age 18 to 65 years\n* Clinical diagnosis of neck pain associated with cervical disc pathology\n* Not undergoing surgical treatment during the study period\n* Ability to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Prior cervical spine surgery\n* Diagnosed neurological disorders unrelated to cervical disc pathology (e.g., multiple sclerosis, Parkinson's disease, stroke)\n* Known vestibular disorders affecting balance\n* Severe uncorrected visual impairment\n* Acute musculoskeletal injury of the neck or upper limb unrelated to the primary cervical condition\n* Inability to perform the head-tracking task\n* Cognitive impairment preventing informed consent","65 Years",{"count":67,"type":21},30,[24],"Degenerative cervical disc disease can cause neck pain, nerve symptoms, dizziness, and problems with balance and head movement control. The neck contains many sensory receptors that provide information about head position and movement to the brain. When cervical discs degenerate or compress nearby structures, this sensory communication may be disrupted. As a result, patients may experience reduced accuracy and coordination of head movements.\n\nAnterior cervical discectomy and fusion (ACDF) is a standard surgical procedure used to relieve nerve or spinal cord compression caused by cervical disc disease. The procedure is effective in reducing pain and neurological symptoms. However, it is not well understood whether ACDF also improves the way the neck and nervous system work together to control head movement.\n\nThe purpose of this study is to evaluate early changes in cervical movement control after ACDF. Patients scheduled for ACDF will be assessed before surgery and again one week after surgery. A group of healthy participants without neck pain will be assessed at the same time interval for comparison.\n\nCervical movement control will be measured using a computer-based head-tracking task. During this task, participants follow a moving target on a screen using controlled head movements. The system records measures of tracking accuracy and timing.\n\nThe primary research question is whether ACDF results in measurable short-term improvements in objective cervical movement control compared with healthy individuals over the same time period.\n\nIt is hypothesized that patients undergoing ACDF will demonstrate improvement in specific movement-control measures after surgery. However, broader patterns of movement-control impairment may not fully normalize in the early postoperative period.\n\nThe results of this study may improve understanding of how cervical spine surgery affects sensorimotor function and may help inform postoperative rehabilitation strategies.",[71,34],"Cervical Vertebral Disc Degeneration",[73,74,75,76,77,78,79,80],"Anterior Cervical Discectomy and Fusion","Cervical Sensorimotor Control","Cervicocephalic Kinaesthesia","Head and neck movement control test","Postoperative Recovery","Cervical Spine Surgery","Movement Control","Neck Proprioception","RECRUITING","2026-02-13",{"date":84,"type":48},"2026-02-23",{"date":86,"type":21},"2026-02-20",{"date":88,"type":21},"2026-03-30",{"name":90,"class":55},"University of Ljubljana",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":22,"phases":102,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":120},"100589611","exercise-therapy-after-caudal-epidural-steroid-injection-100589611","NCT06956664","Exercise Therapy After Caudal Epidural Steroid Injection","Comparative Efficacy of Physiotherapeutic Exercise Regimens Implemented After Caudal Epidural Steroid Injection","CAPER","Inclusion Criteria:\n\n* Age 18 to 70 years.\n* MRI-confirmed lumbar intervertebral disc herniation.\n* Has received a caudal epidural steroid injection (CESI) within the past 2 weeks at Çankırı State Hospital.\n* Low-back or leg pain intensity ≥ 3 cm on a 10-cm Visual Analogue Scale after the injection.\n* Medically cleared for moderate aerobic and core-stabilisation exercise (no cardiac or orthopaedic contraindications).\n* Able to attend supervised physiotherapy three times per week for six weeks.\n* Willing and able to give written informed consent and to comply with study procedures.\n* Sufficient Turkish literacy (minimum primary-school education) to complete questionnaires.\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease (e.g., poorly controlled diabetes mellitus, congestive heart failure, active hepatitis C or other significant liver disease).\n* Neurological red flags such as myelopathy or cauda equina syndrome.\n* Previous lumbar spine surgery at the affected disc level.\n* Current pregnancy or planning pregnancy during the study period.\n* Severe musculoskeletal, cardiovascular, or respiratory condition that precludes safe exercise participation.\n* Use of systemic corticosteroids or opioid analgesics that cannot be stabilised for the duration of the trial.\n* Ongoing litigation or workers' compensation claim related to low-back pain.\n* Inability to communicate effectively with study staff or to follow instructions.","70 Years",{"count":101,"type":21},42,[24],"\\*\\*Brief Summary\\*\\*\n\nLumbar radicular pain arising from intervertebral disc herniation is commonly managed with a caudal epidural steroid injection (CESI), a minimally invasive procedure that delivers anti-inflammatory medication to the sacral hiatus. Although CESI affords short-term analgesia, a sizable proportion of patients continue to experience pain-related disability and diminished quality of life, underscoring the need for optimised post-injection rehabilitation.\n\nThis single-centre, three-arm, parallel-group randomised controlled trial will evaluate the comparative efficacy of two evidence-informed exercise paradigms-moderate-intensity aerobic training and progressive lumbopelvic stabilisation-when each is superimposed upon a standard physiotherapy package of heat, therapeutic ultrasound and transcutaneous electrical nerve stimulation (TENS). Forty-two adults (18-70 years) with MRI-confirmed lumbar disc herniation who have undergone CESI at Çankırı State Hospital will be randomly allocated (1:1:1) to one of the following six-week interventions, initiated two weeks post-injection and delivered thrice weekly under physiotherapist supervision:\n\n1. Conventional physiotherapy alone (heat + ultrasound + TENS).\n2. Conventional physiotherapy plus aerobic exercise (treadmill walking at 55-80 % of age-predicted maximal heart rate with structured warm-up\u002Fcool-down).\n3. Conventional physiotherapy plus core-stabilisation exercise (phased activation of deep trunk musculature progressing to dynamic tasks on unstable surfaces).\n\nPrimary end-points are pain intensity (10 cm Visual Analogue Scale) and back-specific disability (Oswestry Disability Index). Secondary end-points include generic health-related quality of life (SF-12) and lumbar proprioceptive body awareness (Fremantle Back Awareness Questionnaire). Outcomes will be captured at baseline, post-intervention (6 weeks) and at 3- and 6-month follow-up to ascertain both immediate and sustained effects.\n\nStudy Question Does adjunctive aerobic or core-stabilisation exercise confer superior reductions in pain and disability, and greater gains in quality of life and body awareness, compared with conventional physiotherapy alone in adults following CESI for lumbar disc herniation?\n\nIt is hypothesised that both exercise approaches will yield clinically and statistically superior outcomes relative to standard care, with stabilisation training providing the most durable functional benefits. Findings are expected to refine post-CESI rehabilitation algorithms and inform evidence-based clinical guidance for physiotherapists managing lumbar disc pathology.",[34,35,105],"Radiculopathy",[107,35,108,109,110],"Caudal Epidural Injection","Exercise Therapy","Aerobic Exercise","Core Stabilization","2025-08-05",{"date":113,"type":48},"2025-08-08",{"date":115,"type":48},"2025-04-28",{"date":117,"type":21},"2026-02-15",{"name":119,"class":55},"Çankırı Karatekin University",3,{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":56},"100578105","artificial-intelligence-enabled-decision-support-for-selection-of-patients-for-lumbar-spine-surgery-100578105","NCT06806969","Artificial Intelligence Enabled Decision Support for Selection of Patients for Lumbar Spine Surgery","Artificial Intelligence (AI) Enabled Decision Support Tool for Selection of Patients for Lumbar Spine Surgery: a Feasibility Study","Inclusion Criteria:\n\n* Patients with MRI-confirmed LDH or LSS referred to University hospital of North Norway Tromsø for assessment of indication for surgery\n* Specialists and physicians in training (for two years or more) in neurosurgery or orthopedic surgery who evaluate such patients at the neurosurgical outpatient clinic at University hospital of North Norway Tromsø\n\nExclusion Criteria:\n\n* Patients unable to consent because of\n\n  * Age \\\u003C 18 years\n  * Serious drug abuse of severe psychiatric disorders\n  * Language barriers (patients who cannot speak or read Norwegian)\n* Patients with a baseline ODI ≤14 (LDH) or ≤22 (LSS)\n* Patients undergoing non-elective\u002Femergency operations\n* Patients with degenerative conditions other that LDH and LSS, fractures, primary infections, or malignant conditions of the spine\n* Physicians in training with less than two years' experience with spine surgery","100 Years",{"count":130,"type":21},26,[24],"Background One third of patients operated for lumbar disc herniation (LDH) or spinal stenosis (LSS) do not achieve substantial improvement. Studies indicate that well informed shared decision making (SDM) can improve the selection to surgery, and thus the outcomes. Numerous algorithms for outcome prediction have therefore been developed, and some use artificial intelligence (AI). Most are trained on small datasets, few are accurate, all are stand-alone or web-based applications not integrated in the electronic health record (EHR), and none are implemented in routine clinical practice.\n\nThe Norwegian registry for spine surgery (NORspine) comprises a cohort of more than 69,000 cases. The investigators have used AI to analyze the dataset and predict the outcome, and developed a decision support tool (DST) which is seamlessly integrated in the EHR DIPS Arena®.\n\nThe investigators intend to use the tool to inform the SDM between surgeons and patients about the indication for surgery (yes or no), to increase the proportion with a successful outcome. The aim of the study is to assess the safety and feasibility of the DST for use in a subsequent pilot study.\n\nThe device The DST (the device) is an integrate compound of software-solutions. Baseline data are registered by patients and surgeons on questionnaires integrated in DIPS Arena®, and transferred to NORspine. The data are also transferred (de-identified) to the AI-enabled prediction algorithm which operates in a cloud-based model hosting service. The algorithm has been trained and validated on a dataset from NORspine. The area under the curve for prediction of the main outcome (Oswestry disability index after12 months) in receiver operating characteristic analysis is very high (0.85) for LDH and moderate (0.72) for LSS. The model host also calculates outcomes (proportions with substantial, slight, or no improvement, and worsening) for the 50 cases with baseline variables most similar to the present case (\"patients-like-me\"). Finally, the individual prediction and the outcomes for the \"patients-like-me\" are transferred back and displayed in the regular user interface of DIPS Arena® for use in the SDM.\n\nClinical investigations For this feasibility study, the investigators will use convergent qualitative and quantitative mixed methods. The comparator is decision making in routine clinical practice, without use of the DST. The study will include 20 patients with magnetic resonance imaging confirmed LDH or LSS referred for evaluation of the indication for surgery, and six surgeons who do the evaluations. The study will iteratively redesign the user interface of the DST until it is considered safe and feasible for use in a following pilot study.",[34,134,31,135],"Spinal Stenosis Lumbar","Lumbar Spine Degeneration",[137,138,139],"artificial intelligence","decision support","surgery selection","2025-01-30",{"date":142,"type":48},"2025-02-04",{"date":144,"type":21},"2025-02-01",{"date":146,"type":21},"2027-06-30",{"name":148,"class":55},"University Hospital of North Norway"]