[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intestinal-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intestinal-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100376922","effect-of-acupuncture-on-mild-to-moderate-active-crohns-disease-100376922",false,"NCT04187820","Effect of Acupuncture on Mild to Moderate Active Crohn's Disease","Effect of Acupuncture on Crohn's Disease Via the Regulation of Trp-kyn Metabolism in Brain-gut Axis","Inclusion Criteria:\n\n1. aged 16-70;\n2. patients with mild or moderate active disease (150 ≤ CDAI \\\u003C 450);\n3. patients who are not responsive, intolerant, dependent or refused to use at least mesalazine, glucocorticoid, immunomodulator (azathioprine, methotrexate), anti TNF alpha preparation;\n4. patients were not taking medication or were only taking one or more of the following drugs: \\[prednisone ≤15mg\u002Fd, azathioprine (≤1mg\u002Fkg\u002Fd), methotrexate (≤15mg\u002Fw) or mesalazine (≤4g\u002Fd)\\] and prednisone was used for at least 1 month, while azathioprine, methotrexate or mesalazine was used for at least 3 months;\n5. those who did not use anti-TNF alpha and other agents within 3 months before entering the study;\n6. those who have never experienced acupuncture;\n7. patients signing informed consent.\n\nExclusion Criteria:\n\n1. patients who are recently pregnant or in pregnancy or lactation;\n2. patients with serious organic diseases;\n3. patients diagnosed as psychosis;\n4. patients who take antibiotics, probiotics, traditional Chinese medicine and other drugs at the same time, or who suffer from multiple diseases and need to take other drugs for a long time, and may affect the observation of the efficacy of this trial;\n5. severe skin diseases (such as erythema nodosum, pyoderma gangrenosum, etc.), eye diseases (such as iritis, uveitis, etc.), thromboembolic diseases and other serious extraintestinal manifestations;\n6. there are serious intestinal fistula, abdominal abscess, intestinal stenosis and obstruction, perianal abscess, gastrointestinal hemorrhage, intestinal perforation and other complications;\n7. patients with short bowel syndrome who have undergone abdominal or gastrointestinal surgery in the past half a year;\n8. there are skin diseases or defects in the selected area of acupuncture and moxibustion that cannot be performed.",true,"ALL","16 Years","70 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","To observe the clinical effect of acupuncture on Crohn's disease (CD) and its influence on brain function activity and the TRY-KYN metabolism level, and to screen the brain image markers of acupuncture on CD",[28,29,30],"Intestinal Disorder","Inflammatory Bowel Diseases","Crohn Disease",[32,33],"acupuncture","Crohn's disease","RECRUITING","2025-05-13",{"date":37,"type":38},"2025-05-14","ACTUAL",{"date":40,"type":38},"2019-06-01",{"date":42,"type":22},"2026-12-31",{"name":44,"class":45},"Shanghai Institute of Acupuncture, Moxibustion and Meridian","OTHER",2]