[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intestinal-perforation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intestinal-perforation":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":42,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":64},"100625999","saudi-emergency-laparotomy-audit-100625999",false,"NCT07429929","Saudi Emergency Laparotomy Audit","Saudi Emergency Laparotomy Audit (SELA): A National Multicenter Observational Audit of Outcomes Following Emergency Laparotomy in Saudi Arabia","SELA","Inclusion Criteria:\n\n* Age ≥14 years\n* Undergoing an emergency (E1-E4) laparotomy, laparoscopy, or laparoscopically-assisted abdominal operation\n* Procedures involving the stomach, small bowel, large bowel, or rectum for acute pathology (e.g., perforation, ischemia, abscess, bleeding, or obstruction)\n* Washout\u002Fevacuation of intra-peritoneal abscess or hematoma (excluding those secondary to appendicitis or cholecystitis)\n* Bowel resection or repair for obstructed\u002Fincarcerated hernias with acute presentation (incisional, umbilical, inguinal, femoral)\n* Adhesiolysis (open or laparoscopic)\n* Trauma-related emergency abdominal procedures\n* Inoperable pathology where a definitive operative procedure was intended (not purely diagnostic)\n* Return to theatre for major wound dehiscence (\"burst abdomen\")\n* Complications requiring general surgical intervention following interventional radiology procedures\n* Complications requiring general surgical intervention following gynecological oncology surgery\n* Complications following elective or non-elective general\u002Fupper GI surgery, where the above criteria are met\n\nExclusion Criteria:\n\n* Age \\\u003C14 years\n* Elective laparotomy or laparoscopy\n* Diagnostic-only laparotomy or laparoscopy (unless abandoned due to inoperable disease)\n* Appendicectomy or cholecystectomy (including their complications), unless incidental to a more major non-elective gastrointestinal procedure\n* Non-elective hernia repair without bowel resection or adhesiolysis\n* Minor wound dehiscence repair (unless bowel resection is required)\n* Stoma formation via trephine or laparoscopic approach (include only if midline laparotomy is the primary procedure)\n* Vascular, obstetric, gynecological (except gynecological oncology complications requiring general surgery input), transplant, hepatobiliary, urological, renal, pancreatic, or splenic procedures","ALL","14 Years",{"count":20,"type":21},10000,"ESTIMATED","OBSERVATIONAL","The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia. The audit will collect standardized data on patient characteristics, comorbidities, perioperative processes, and postoperative outcomes through a retrospective baseline phase followed by a prospective registry phase. SELA aims to establish national benchmarks, assess applicability of international risk models, support development of a Saudi-specific risk prediction tool, and drive quality improvement through systematic feedback and benchmarking across participating hospitals.",[25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41],"Laparotomy","Laparotomy Surgery","Emergency Treatment","Abdominal Diseases","Gastrointestinal Diseases","Intestinal Obstruction","Intestinal Obstruction and Ileus","Intestinal Perforation","Intestinal Ischemia","Peritonitis Infectious, Gastrointestinal Perforation, Surgical Infection, Postoperative Complications","Peritonitis Bacterial","Peritonitis Caused by Perforated Left-sided Colon Diverticulitis","Peritonitis Infectious","Sepsis","Postoperative Complications After Gastrointestinal Operations","Surgical Procedures, Operative","Mortality",[43,44,45,46,41,47,48,49,50,51],"Emergency laparotomy","Surgical audit","Postoperative outcomes","Perioperative care","Morbidity","Quality improvement","Risk stratification","Retrospective audit","Saudi Arabia","NOT_YET_RECRUITING","2026-02-22",{"date":55,"type":56},"2026-02-24","ACTUAL",{"date":58,"type":21},"2026-06-01",{"date":60,"type":21},"2028-12-31",{"name":62,"class":63},"King Faisal Specialist Hospital & Research Center","OTHER",1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":64},"100574307","necrotizing-enterocolitis-and-bowel-perforation-in-very-preterm-infants---long-term-follow-up-100574307","NCT06757582","Necrotizing Enterocolitis and Bowel Perforation in Very Preterm Infants - Long-term Follow up","NOR-NEC","Inclusion Criteria:\n\n* Case: All Norwegian very preterm infants (gestational age (GA) \\\u003C 32 weeks) born during the 6-year period 2008-2013, diagnosed with surgical NEC or bowel perforation and surviving up to one year of age will be invited to participate as cases.\n* Controls: For each case we will invite two controls matched for important clinical characteristics (e.g. sex, GA, clinical illness score, intracranial pathology, need for oxygen at discharge etc.).\n\nExclusion Criteria:\n\n* not signing informed consent scheme","6 Years","15 Years",{"count":75,"type":21},150,"Necrotizing enterocolitis (NEC) is a gastrointestinal syndrome characterized by transmural inflammation and necrosis of the large and\u002For small bowel and subsequent intramural gas-forming organisms into the intestinal wall. Some preterm infants also develop spontaneous intestinal perforations (SIP) without the classical bowel inflammation\u002Fnecrosis seen in NEC. NEC and SIP can be challenging to differentiate. Severe cases of both conditions require surgery and often bowel resection, but mortality due to SIP seems lower.\n\nStudies looking at \"long-term prognosis\" of infants with NEC and bowel perforation have mainly assessed outcome until 2-7 years of age. The primary school years is a vulnerable period for ex-preterm children. Disruption in learning and social integration is of great importance for their quality of life (QoL), but little data exist in this age group. Moreover, nutritional deficits (e.g. cobalamin- or iron-deficiency may impact cognitive development, but this has not been investigated in this \"high-risk\" population in school age. Authors of a recent systematic review on gastrointestinal sequel after NEC-surgery thus called for \"more high-quality studies assessing long-term follow-up\".\n\nIn this project we will study the long-term impact of surgery for NEC and bowel perforation in preterm infants, both with a quality of life (QoL) perspective and with a focus on development, growth, nutrition and persistent gastrointestinal problems.",[78,32,79],"Necrotizing Enterocolitis","Premature Infant Disease",[81,82,83,84,85],"necrotizing enterocolitis","bowel perforation","preterm infant","long-term follow-up","quality of life","2025-01-02",{"date":88,"type":56},"2025-01-03",{"date":90,"type":21},"2025-02-01",{"date":92,"type":21},"2027-08-01",{"name":94,"class":63},"University Hospital of North Norway"]