[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intestinal-stricture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intestinal-stricture":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100641990","navicam-patency-capsule-to-verify-gastrointestinal-patency-100641990",false,"NCT07649720","NaviCam Patency Capsule to Verify Gastrointestinal Patency","A Prospective, Single Center Clinical Trial Assessing the Efficacy and Safety of the NaviCam Patency Capsule to Verify Gastrointestinal Patency","PATENCY","Inclusion Criteria:\n\n* Patients with suspected or known intestinal stricture (with medical history records, physical examination records, and imaging evidence within the last 6 months.\n* Patients suffering from Crohn's Disease\n* Patients with long-term use of non-steroidal anti-inflammatory drugs.\n* Patients with abdominal symptoms related to intestinal stricture.\n* Patients with chronic inflammatory diseases.\n* Patients with difficulty with balloon-assisted endoscopy (BAE).\n* Patients with a history of small bowel obstruction.\n* Patients with a history of intestinal resection surgery.\n\nExclusion Criteria:\n\n* Patients with esophageal obstruction or swallowing disorder diseases.\n* Patients who are ineligible for surgery or refuse to undergo any abdominal surgery.\n* Patients with known allergies or other contraindications or intolerance to the medications used in this study.\n* Patients with pacemakers or other implanted electronic devices such as cochlear implants, magnetic metal drug infusion pumps, neurostimulators.\n* Pregnant women\n* Patients currently enrolled in another drug or device clinical trial.\n* Other conditions deemed unsuitable for inclusion by the investigator.","ALL","22 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","Participants included in this study will first swallow a patency capsule and then undergo an abdominal X-ray scan within 30 hours after swallowing the capsule to confirm weather the capsule is still in the body.",[27,28,29,30],"Intestinal Stricture","Crohn Disease","NSAID (Non-Steroidal Anti-Inflammatory Drug) Induced Enteropathy","Abdominal Pain","NOT_YET_RECRUITING","2026-06-10",{"date":34,"type":35},"2026-06-16","ACTUAL",{"date":37,"type":21},"2026-06-15",{"date":39,"type":21},"2027-03-15",{"name":41,"class":42},"AnX Robotica Corp.","INDUSTRY",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100468995","efficacy-of-ustekinumab-therapy-in-patients-with-symptomatic-stricturing-crohns-disease-100468995","NCT05387031","Efficacy of Ustekinumab Therapy in Patients With Symptomatic Stricturing Crohn's Disease","Efficacy of Ustekinumab-based Integrated Medicine Therapy in Patients With Symptomatic Stricturing Crohn's Disease: a Multicenter, Prospective, Observational Cohort Study","Inclusion Criteria:\n\n* Clinical diagnosis of moderate to severe Crohn's disease\n* Obstructive symptoms within the last eight weeks\n* A single or several lumen stricture(s) identified by radiological imaging or endoscopy\n* For strictures identified by CT enterograph defined as a lesion with combination of a reduction of luminal narrowing \\>50%, an increase in bowel wall thickness \\>25% relative to non-affected bowel and pre-stricture dilation \\>3.0 cm\n* For strictures identified during endoscopic procedure defined by intestinal strictures with a lumen diameter ≤12 mm or even inability to pass the endoscope across the narrowing\n\nExclusion Criteria:\n\n* Requirement of urgent surgery or endoscopic intervention within 2 months as judged by the clinician\n* Symptoms or signs of perforation such as active perianal sepsis, abdominal abscess, intestinal fistula, and abdominal adhesions\n* Intestinal obstruction caused by surgery, intra-abdominal abscess, isolated intestinal stricture\n* Effective treatments for stricture in the past half a year, such as endoscopic balloon dilatation, intestinal stricture plasty, surgery\u002Fmanual anal dilatation, etc.\n* Unable to eat after using enteral nutrition for more than 2 months\n* History of ustekinumab (UST) or other IL-23 antagonists use in the past 12 months\n* CT enterograph contraindications, such as allergy to contrast media\n* Relative contraindications of biological agents, such as pulmonary tuberculosis-positive chest X-ray or active tuberculosis with strong positive tuberculin skin test, myocardial infarction, heart failure, or demyelinating neurological disease\n* Currently suffering from a solid tumor, lymphoma, or melanoma and undergoing chemotherapy or radiation therapy\n* Combination of intestinal dysplasia (eg, diagnosed with short bowel syndrome), colostomy, or colorectal tumors\n* Combination of active gastrointestinal bleeding, shock, severe diarrhea, refractory vomiting and severe malabsorption syndrome\n* Combination of severe liver and kidney dysfunction\n* Coexistence of bacterial or viral active infection\n* Pregnant or breastfeeding\n* Severe hemodynamics, unstable vital signs or presence of rapidly progressive or end-stage disease, expected to be fatal during the course of the study","18 Years","65 Years",{"count":54,"type":21},239,"OBSERVATIONAL","This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through radiography or endoscopy. After the informed consent of the patients, comprehensive drug therapy with ustekinumab as the mainstay was performed. The basic information and medical history of the patients were collected, and the treatment process of the patients was followed up and recorded, and the drug regimen was adjusted according to the physician's experience and judgment. At different follow-up time points, blood, feces, tissue and other specimens of patients were collected according to the situation, and gastrointestinal endoscopy, imaging examination, laboratory index examination, self-assessment of subjects' symptoms, and nutritional risk screening were performed on the patients. This study evaluated the CD disease activity, obstructive symptoms, and radiographic or endoscopic remission in patients at different follow-up time points, and comprehensively evaluated the efficacy of ustekinumab in relieving stenotic CD and its related factors.",[28,58,27],"Stricture; Bowel",[28,60,61,62,63],"intestinal stricture","Ustekinumab","integrated medicine therapy","cohort study","RECRUITING","2026-02-25",{"date":67,"type":35},"2026-02-27",{"date":69,"type":35},"2024-08-01",{"date":71,"type":21},"2028-08-01",{"name":73,"class":74},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",8]