[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intra-abdominal-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intra-abdominal-infection":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100539510","the-effect-of-continuous-intravenous-infusion-of-lidocaine-on-ppcs-and-prognosis-in-emergency-surgical-patients-with-iai-100539510",false,"NCT06304779","The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI","The Effect of Continuous Intravenous Infusion of Lidocaine on Postoperative Pulmonary Complications and Prognosis in Emergency Surgical Patients With Intra-abdominal Infection","PPCs","Inclusion Criteria:\n\n* Age \\>18 years, any gender.\n* Patients suspected of digestive tract perforation or obstruction based on physical examination, confirmed by imaging, requiring emergency surgical treatment.\n* The anesthesia method is general anesthesia\n* I or the patient's family have carefully read and signed the informed consent form\n* Serum procalcitonin (PCT) at inflammatory levels or leukocytosis (\\>12×109\u002FL) or leukopenia (\\\u003C4×109\u002FL) or \\>10% naive leukocytes\n\nExclusion Criteria:\n\n* Have a history of local anesthesia drug allergy\n* Pregnant patients\n* Patients receiving renal replacement therapy\n* Patients with arrhythmias or heart failure (second or third-degree atrioventricular block or left ventricular ejection fraction（LVEF）\n* Preoperative platelet count\\\u003C80 × 109\u002FL\n* Patients who require secondary surgery for postoperative anastomotic fistula\n* Patients who have participated in other clinical studies","ALL","18 Years","100 Years",{"count":21,"type":22},428,"ESTIMATED","INTERVENTIONAL",[25],"NA","The main purpose of this study is to evaluate the impact of continuous 24-hour intravenous infusion of lidocaine on the incidence of PPCs in patients undergoing emergency laparotomy for intra-abdominal infection (IAI).The secondary objectives of this study are to assess the impact of continuous 24-hour intravenous lidocaine infusion on the proportion of patients requiring mechanical ventilation, protection of important organ function during the perioperative period, length of hospital stay, and outcomes within 30 days postoperatively.",[28,29],"Postoperative Pulmonary Complications","Intra-abdominal Infection",[31,32,33],"intra-abdominal infection","lidocaine","postoperative pulmonary complications","RECRUITING","2026-04-23",{"date":37,"type":38},"2026-04-29","ACTUAL",{"date":40,"type":38},"2023-10-31",{"date":42,"type":22},"2027-11-30",{"name":44,"class":45},"Shanghai Zhongshan Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100600108","rezafungin-peritoneal-diffusion-for-intra-abdominal-candidiasis-100600108","NCT07093203","Rezafungin Peritoneal Diffusion for Intra-abdominal Candidiasis","Pharmacokinetic of Rezafungin in the Plasma and the Peritoneal Fluid of Critically Ill Patients With Intra-abdominal Candidiasis Requiring Abdominal Surgery","REAREZ","Inclusion Criteria:\n\n* age \\> 18 years\n* with a suspected intra-abdominal candidiasis requiring abdominal surgery\n* and receiving the administration of rezafungin as first-line empirical antifungal treatment just before or within 1 hour the abdominal surgery\n* and having abdominal drain for at least 2 days after the surgery\n\nExclusion Criteria:\n\n* death expected within 24h\n* decline to participate",{"count":56,"type":22},20,"OBSERVATIONAL","ntra-abdominal candidiasis is a serious infection common in critically ill patients, often leading to high mortality if not treated quickly. Standard antifungal treatments may be less effective due to growing resistance and poor drug penetration into the abdominal cavity. In critically ill patients, drug levels can vary widely due to factors like surgery, inflammation, fluid resuscitation, or extracorporeal support, increasing the risk of underdosing. Rezafungin is a new antifungal agent with a long half-life and broad activity against Candida species, offering potential advantages in this setting. However, there is currently no data on its concentration or effectiveness in the peritoneal fluid of patients with intra-abdominal sepsis. Its long half-life, coupled with repeated pharmacokinetic variations in critical care settings and the risk of insufficient concentrations, may hinder its use in this population.",[60,61,62,63],"Intra-Abdominal Infection","Candida","Abdominal Surgery Patients","Critically Ill Intensive Care Unit Patients",[65,66,67,68,69],"candida","intra-abdominal candidiasis","abdominal surgery","pharmacokinetics","pharmacodynamics","2026-03-27",{"date":72,"type":38},"2026-04-01",{"date":74,"type":38},"2025-11-14",{"date":76,"type":22},"2026-09-01",{"name":78,"class":45},"Central Hospital, Nancy, France",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":104,"leadSponsor":106,"locationsCount":46},"100602998","innate-immune-response-monitoring-via-monocyte-hla-dr-in-severe-intra-abdominal-infections-at-risk-of-fungal-infection-100602998","NCT07130799","Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal Infection","Evaluation of the Innate Immune Response Through Monocyte HLA-DR Monitoring During Severe Intra-abdominal Candidiasis in the Critically Ill Patients","CANDIRIS","Inclusion Criteria:\n\n* Adult patient (≥ 18 years old)\n* Patient admitted to the ICU or intermediate care unit for a severe intra-abdominal infection requiring urgent abdominal surgery\n* Presence of at least one risk factor for intra-abdominal candidiasis:\n\n  * Abdominal surgery within the last 7 days\n  * Supramesocolic gastrointestinal perforation\n  * Healthcare-associated intra-abdominal infection\n  * Community-acquired intra-abdominal infection in an immunocompromised patient\\*\n  * Intra-abdominal infection complicated by septic shock\n  * Broad-spectrum antibiotic exposure within 72 hours prior to surgery\n* And\u002For a Peritonitis Score ≥ 3 out of 4\n* Patient affiliated with or benefiting from a national health insurance system\n* Patient who has received full information about the clinical study\n\nExclusion Criteria:\n\n* Radiologically guided drainage without surgery\n* Infected acute pancreatitis\n* Limitation or withdrawal of life-sustaining treatments\n* Moribund patient with an expected life expectancy \\\u003C 48 hours\n* Woman of childbearing potential without effective contraception\n* Refusal to participate in the study",{"count":88,"type":22},100,"Intra-abdominal candidiasis (IAC) is a frequent and severe fungal infection in critically ill patients, often diagnosed late. Its pathophysiology remains unclear, particularly regarding why some patients develop invasive infection while others only show benign colonization. A potential explanation lies in the state of innate immunity. Monocyte HLA-DR expression, a recognized marker of immune suppression in critical care, may be transiently but profoundly reduced in non-immunocompromised patients who go on to develop IAC. This observational study aims to evaluate whether patients with IAC have greater innate immune dysfunction-assessed by HLA-DR expression-compared to those with severe bacterial intra-abdominal infections. The goal is to better understand the immune mechanisms involved and improve early risk stratification for IAC.",[29,91,92,93,94],"Critical Illness","Post-Op Infection","Immunization; Sepsis","Candida Sepsis",[31,66,96,97,98,99],"HLA-DR","immunomonitoring","monocyte","critically ill patients","2026-02-05",{"date":102,"type":38},"2026-02-09",{"date":74,"type":38},{"date":105,"type":22},"2027-03-01",{"name":78,"class":45}]