[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intraarticular-injection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intraarticular-injection":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,71,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100643880","intraarticular-injection-of-botox-and-hyaluronic-acid-in-knee-osteoarthritis-100643880",false,"NCT07666347","Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis","Inclusion Criteria:\n\n* Age ≥ 50 years.\n* Both genders.\n* Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.\n* Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.\n\nExclusion Criteria:\n\n* History of intra-articular injection within the last 6 months,\n* History of surgery on the knee joint or major trauma to the lower limb causing fracture.\n* Body mass index (BMI) more than 40 kg\u002Fm2.\n* Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout.\n* Diabetic patient.\n* Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection.\n* Hypersensitivity to Botulinum toxin or hyaluronic acid.","ALL","50 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.",[25,26,27,28],"Intraarticular Injection","Botox","Hyaluronic Acid","Knee Osteoarthritis","RECRUITING","2026-06-24",{"date":32,"type":33},"2026-06-25","ACTUAL",{"date":30,"type":33},{"date":36,"type":19},"2026-12-01",{"name":38,"class":39},"Tanta University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":15,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":40},"100630580","phase-4-arthrosamid-vs-steroid-for-the-management-of-knee-osteoarthritis-100630580","NCT07489521","Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis","A Randomised Control Trial of the Use of an Intraarticular Hydrogel Arthrosamid® vs. Steroid for the Non-operative Management of Knee Osteoarthritis","Inclusion Criteria:\n\n* Adults\n* Symptomatic single side knee pain.\n* Patients with diagnosis of knee osteoarthritis radiographic Kellgren and Lawrence system OA grade II-III-IV on x ray or MRI.\n\nExclusion Criteria:\n\n* Inflammatory conditions,\n* Cancer,\n* acute infection,\n* pregnancy and breastfeeding.\n* Uncontrolled diabetes mellitus,\n* Joint diseases in the knee, such as rheumatoid arthritis or gout, history of knee surgery with metallic implant.\n* If patient has undergone knee arthroscopy in past 6 months.\n* Intra-articular injection of corticosteroids during the previous 3 months, intra-articular injection of other drugs, such as hyaluronic acid over the previous 1 year.\n* Contraindications for intra-articular injection, such as thrombocytopenia, coagulopathy, articular infection of knee, impairment of immunity.",true,"18 Years","100 Years",{"count":52,"type":19},200,[54],"PHASE4","This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.",[57,58,25],"Osteo Arthritis Knee","Osteoarthritis",[58,60,61],"knee","steroid injection","2026-04-23",{"date":64,"type":33},"2026-04-28",{"date":66,"type":33},"2026-01-29",{"date":68,"type":19},"2027-09",{"name":70,"class":39},"Cappagh National Orthopaedic Hospital",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":16,"enrollmentInfo":78,"targetDuration":4,"studyType":20,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":40},"100629108","phase-2-comparison-of-functional-outcomes-following-arthroscopic-acl-reconstruction-with-peroneus-longus-autograft-with-and-without-intra-articular-platelet-rich-plasma-injection-100629108","NCT07470359","Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.","Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection: A Randomized Controlled Trial","Inclusion Criteria: Age between 18 and 50 years. Diagnosis of a primary, complete ACL tear requiring reconstruction. Willingness to undergo arthroscopic ACL reconstruction with peroneus longus autograft.\n\nActive individuals participating in sports or regular physical activity. Willingness to provide informed consent and adhere to the study protocol, including follow-up visits and rehabilitation.\n\nAbility to understand and complete study questionnaires. - Exclusion Criteria: Previous knee surgery on the affected limb. Concomitant ligamentous injuries requiring additional reconstruction (e.g., PCL, MCL, LCL Grade III).\n\nSignificant chondral damage (Outerbridge grade \\> 2 on pre-operative MRI or intra-operative assessment).\n\nPre-existing knee osteoarthritis (Kellgren-Lawrence grade \\> 2). Systemic inflammatory conditions (e.g., rheumatoid arthritis). Bleeding disorders or coagulopathies. Current use of anticoagulants. Corticosteroid injection into the knee within 6 weeks prior to surgery. Pregnancy or lactation. Inability to comply with the rehabilitation protocol. Infection or history of infection in the affected knee. History of previous contralateral ACL injury (to isolate primary injury outcomes).\n\n\\-",{"count":79,"type":19},60,[81],"PHASE2","This prospective RCT investigates if a single 4 ml intra-articular PRP injection improves knee function after ACL reconstruction using peroneus longus autograft. In Pakistan's resource-limited context, 88 patients (18-50 years) with isolated ACL tears receive either PRP or saline during surgery, then randomized equally. KOOS4 scores compared at 3, 6, and 12 months via ANCOVA (adjusted baseline, α=0.05). Positive results could establish affordable enhancement for recovery and guide practice in similar settings.",[84,25,85],"ACL Reconstruction","PRP",[87,88],"Anterior Cruciate Ligament, ACL Reconstruction, Peroneus Longus Autograft, Platelet-Rich Plasma, Intra-articular Injection","Randomized Controlled Trial, KOOS4 Score, Functional Outcomes, Graft Healing, Resource-Limited Settings","2026-03-10",{"date":91,"type":33},"2026-03-13",{"date":93,"type":33},"2026-02-20",{"date":95,"type":19},"2027-11-30",{"name":97,"class":98},"Lahore General Hospital","OTHER_GOV",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":48,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":20,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":4},"100547377","efficacy-of-intra-articular-corticosteroid-injections-on-clinical-outcomes-in-patients-with-operative-distal-radius-fractures-100547377","NCT06407180","Efficacy of Intra-Articular Corticosteroid Injections on Clinical Outcomes in Patients With Operative Distal Radius Fractures","Efficacy of Intra-Articular Corticosteroid Injections on Clinical Outcomes in Patients With Operative Distal Radius Fractures: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age more than 18 years old\n2. Closed unstable distal radius fracture unstable type which need surgical management\n3. Received procedure ORIF with plate and screws at injured wrist\n\nExclusion Criteria:\n\n1. History of corticosteroid allergy\n2. Poor Diabetes controlled (HbA1C) \\> 8\n3. Who need Ritonavir while enter this study\n4. Unable to follow up until the end of projects\n5. Unable to do questionnaires\n6. Infection around injured wrist\n7. Tear tendon at injured wrist\n8. Open fracture of injured wrist",{"count":107,"type":19},58,[22],"The randomized controlled study which compare clinical outcomes (functional score) in patients with distal radius fractures who underwent open reduction with internal fixation and received intra-articular steroid injections to those who received placebo injections.",[111,25],"Wrist Fractures",[111,113,114],"intraarticular injection","corticosteroids","NOT_YET_RECRUITING","2024-05-06",{"date":118,"type":33},"2024-05-09",{"date":120,"type":19},"2024-07-01",{"date":122,"type":19},"2026-12-31",{"name":124,"class":39},"Teeradon Waewworawit"]