[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intracanal-medication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intracanal-medication":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,85,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100642888","phase-1-biological-radiographic-and-clinical-evaluation-of-various-inter-visit-root-canal-dressings-in-retreatment-cases-100642888",false,"NCT07641933","Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases","Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases: A Randomized Controlled Clinical Trial","RCT","Inclusion Criteria:\n\n1. Age: 21-45 years.\n2. Medically free patients. (ASA Class 1)\n3. Gender: males and females\n4. Patients who are cooperative at operation and in attendance at scheduled follow-up visits.\n5. Restorable root canal treated permanent lower first molars with periapical lesions.\n6. Small (\\\u003C5 mm) or medium periapical lesion size (5-10 mm)\n\nExclusion Criteria:\n\n1. Patients with a history of allergic reactions to any of the study materials.\n2. Teeth that become non-restorable after complete caries excavation.\n3. Teeth that have mobility or deep periodontal pockets.\n4. Teeth with internal or external resorption.",true,"ALL","21 Years","45 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"PHASE1","The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications:\n\n1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite\n2. Calcium Silicate\n3. Calcium Hydroxide\n\nIn retreatment cases in terms of:\n\n1. Biological Evaluation: Biomarker (IL 1B)\n2. Radiographic Evaluation: CBCT\n3. Clinical Evaluation: Pain Score (VAS)",[29,30,31,32,33],"Intervention Studies","ASA Physical Status I","Intracanal Medication","Periapical Abscess","Retreatment",[35,36,37,38,39],"intracanal medication","retreatment","inflammatory marker","radiographic","pain score","RECRUITING","2026-06-10",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":44},"2026-06-01",{"date":48,"type":23},"2027-08",{"name":50,"class":51},"Ain Shams University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":24,"phases":64,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":52},"100532011","phase-2-the-antimicrobial-potential-of-diclofenac-sodium-as-an-intracanal-medicament-100532011","NCT06207253","The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament","The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with teeth diagnosed with apical periodontitis\n* Periapical Index (PAI) ≥ 2\n* The teeth are restorable\n\nExclusion Criteria:\n\n* Teeth with immature roots\n* Non restorable teeth\n* Medically compromised patients with systemic complication that would alter the treatment.\n* Teeth with internal\u002Fexternal root resorption\n* Patient with an allergy to diclofenac sodium","18 Years","50 Years",{"count":63,"type":23},48,[65,66],"PHASE2","PHASE3","The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis.\n\nThe main question\\[s\\] it aims to answer are:\n\n• Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.",[69,70,31],"Endodontic Disease","Pulp Disease, Dental",[72,73,74,75],"Sodium diclofenac","Intracanal medication","Calcium hydroxide","Apical periodontitis","2025-05-26",{"date":78,"type":44},"2025-05-30",{"date":80,"type":23},"2025-11",{"date":82,"type":23},"2025-12",{"name":84,"class":51},"British University In Egypt",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":17,"sex":18,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":24,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":52},"100559621","phase-2-effectiveness-of-asiaticoside-as-intracanal-medication-on-infectiousinflammatory-contents-in-teeth-with-apical-periodontitis-100559621","NCT06566508","Effectiveness of Asiaticoside as Intracanal Medication on Infectious\u002FInflammatory Contents in Teeth With Apical Periodontitis","Inclusion Criteria:\n\n• Single-rooted with pulp necrosis and apical periodontitis.\n\nExclusion Criteria:\n\nReceiving antibiotic treatment within the preceding 3 months.\n\n* Reporting systemic disease.\n* Teeth that could not be isolated with rubber dam.\n* Teeth with periodontal pockets deeper than 3 mm.","20 Years","60 Years",{"count":94,"type":23},36,[65,66],"The objective of this study is to investigate \\"clinically\\" the effectiveness of Asiaticoside based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.",[31],[99,100,101],"Inflammation","Asiaticoside","Pulpal necrosis","2024-08-20",{"date":104,"type":44},"2024-08-22",{"date":106,"type":44},"2023-11-20",{"date":108,"type":23},"2025-03-03",{"name":110,"class":51},"Mansoura University",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":17,"sex":18,"minAge":91,"maxAge":92,"enrollmentInfo":118,"targetDuration":4,"studyType":24,"phases":119,"briefSummary":120,"conditions":121,"keywords":122,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":52},"100550916","phase-2-effectiveness-of-glycyrrhizin-as-intracanal-medication-in-root-canal-disinfection-and-inflammatory-cytokines-100550916","NCT06453304","Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines","Clinical Investigation of the Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines","Inclusion Criteria:\n\n* Single-rooted with pulp necrosis and apical periodontitis.\n\nExclusion Criteria:\n\n* Receiving antibiotic treatment within the preceding 3 months.\n* Reporting systemic disease.\n* Teeth that could not be isolated with rubber dam.\n* Teeth with periodontal pockets deeper than 3 mm.",{"count":94,"type":23},[65,66],"The objective of this study is to investigate \"clinically\" the effectiveness of Glycyrrhizin based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.",[31],[123],"Glycirrhizin cytokines antibacterial","2024-07-01",{"date":126,"type":44},"2024-07-03",{"date":128,"type":44},"2022-03-20",{"date":130,"type":23},"2024-07-10",{"name":110,"class":51}]