[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intracranial-atherosclerotic-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intracranial-atherosclerotic-stenosis":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,63,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100603202","multimodal-imaging-evaluation-of-vulnerability-of-atherosclerotic-plaques-a-comparison-of-hr-vwi-oct-and-rws-100603202",false,"NCT07133451","Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS","Prospective Cohort Registry Study on Multimodal Imaging Evaluation of Vulnerability of Intracranial and Extracranial Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS","Inclusion Criteria:\n\n* At least 18 years old;\n* Severe stenosis of intracranial arteries (stenosis degree: 70% \\~ 99%, traditional angiography is required to confirm the degree of stenosis according to the criteria of Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) study);\n* Carry out cerebral angiography and OCT within one week after HR-VWI examination;\n* The patient or the legal representative of the patient is able and willing to sign an informed consent form.\n\nExclusion Criteria:\n\n* Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.;\n* There are contraindications to MRI, such as claustrophobia, metal implants, etc.; Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal);\n* Patients with severe cardiopulmonary diseases were considered unsuitable for this study;\n* Allergy to iodine or gadolinium contrast agent;\n* Participants who were unable to complete the study due to mental illness, cognitive or emotional disorder.","ALL","18 Years",{"count":19,"type":20},561,"ESTIMATED","OBSERVATIONAL","The primary objective of this study is to evaluate the vulnerability of intracranial and extracranial atherosclerotic plaques using HR-VWI, OCT, and RWS technologies, while exploring correlations among these three imaging techniques. Secondary objectives include: 1) Investigating the relationship between RWS and plaque progression and identifying optimal RWS predictors; 2) Further evaluating the clinical value of RWS and HR-VWI in stroke prediction through two-year clinical and HR-VWI follow-up evaluations.",[24],"Intracranial Atherosclerotic Stenosis",[26,27,28,29,30],"high resolution magnetic resonance imaging","intracranial atherosclerotic stenosis","atherosclerotic Plaques","radial Wall Strain","optical Coherence Tomography","NOT_YET_RECRUITING","2025-08-13",{"date":34,"type":35},"2025-08-21","ACTUAL",{"date":37,"type":20},"2025-08-10",{"date":39,"type":20},"2030-06-30",{"name":41,"class":42},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":62,"locationsCount":43},"100602578","high-resolution-magnetic-resonance-vessel-wall-imaging-of-plaques-100602578","NCT07125339","High-resolution Magnetic Resonance Vessel Wall Imaging of Plaques","High-resolution Magnetic Resonance Vessel Wall Imaging of Intracranial and Extracranial Plaques: a Prospective Cohort Registration Study","Inclusion Criteria:\n\n* At least 18 years old;\n* Medium or severe stenosis of the internal carotid artery, middle cerebral artery, V4 segment of vertebral artery or basilar artery \\[stenosis degree: 50% \\~ 99%, confirmed by CTA, MRA or DSA\\];\n* Accept high resolution magnetic resonance angiography; The patient or the legal representative of the patient is able and willing to sign an informed consent form\n\nExclusion Criteria:\n\n* Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.;\n* There are contraindications to MRI, such as claustrophobia, metal implants, etc.;\n* Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal);\n* Patients with severe cardiopulmonary diseases were considered unsuitable for this study;\n* Gadolinium contrast agent allergy;\n* Participants who were unable to complete the study due to mental illness, cognitive or emotional disorder.",{"count":52,"type":20},605,"The primary objective of this study is to investigate the predictive value of High-resolution magnetic resonance vessel wall imaging for future stroke occurrence in patients with moderate to severe intracranial and extracranial artery stenosis.\n\nThe secondary objective is to explore the predictive value of baseline high-resolution magnetic resonance vessel wall imaging for plaque progression.",[24],[56],"high resolution vessel wall imaging",{"date":58,"type":35},"2025-08-15",{"date":37,"type":20},{"date":61,"type":20},"2030-06-01",{"name":41,"class":42},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":78,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":43},"100581957","standardized-procedure-for-intracranial-drug-eluting-stenting-in-the-treatment-of-intracranial-atherosclerotic-stenosis-100581957","NCT06857058","Standardized Procedure for Intracranial Drug-Eluting Stenting in the Treatment of Intracranial Atherosclerotic Stenosis","A Prospective, Multicenter, Registry Study to Evaluate the Safety, Efficacy, and Standardized Procedural Optimization of the Intracranial Drug-Eluting Stent System in Patients with Symptomatic Intracranial Atherosclerotic Stenosis","Inclusion Criteria:\n\n1. Males or females between 18 and 80 years of age\n2. Symptomatic intracranial arteriosclerosis stenosis with reference diameter 2.25-4.00mm\n3. Intracranial artery stenosis ( ≥70%) conformed by DSA\n4. Those who voluntarily participate in the study and sign informed consent form\n\nExclusion Criteria:\n\n1. Those who have surgery within previous 30 days or plan to perform major surgery in the next 90 days (surgery grade 3 and above);\n2. Subjects of acute hemorrhagic stroke within 3 months;\n3. The baseline mRS of disabling stroke is more than 3;\n4. The target vessel is severely calcified and closely related to stenosis;\n5. Non-atherosclerotic diseases (e.g. arterial dissection, Moya Moya disease, vascular inflammatory lesions caused by infection, autoimmune diseases, post-irradiation, postpartum status; developmental or genetic abnormalities such as fibromuscular dysplasia, sickle cell anemia, suspected vasospasm);\n6. It is suspected that the ischemic event is due to embolism or arterial embolism from the extracranial segment (including ipsilateral chest or neck vascular occlusive disease) or potential cardiogenic embolism (e.g. atrial fibrillation, mitral stenosis, patent foramen ovale, left ventricular thrombus, myocardial infarction within 6 weeks, etc.);\n7. The presence of a \\>50% stenosis in the main blood supply artery of the target vessel. For example, when the lesion is located in the middle cerebral artery, the ipsilateral internal carotid artery stenosis by over 50% should be excluded; when the lesion is located in the basilar artery, the dominant side vertebral artery stenosis \\>50% should be excluded;\n8. There are intracranial tumors, or intracranial arteriovenous malformations;\n9. Those who are allergic to heparin, aspirin, clopidogrel, contrast agents, anesthetics, and stent components;\n10. Pregnant and lactating women\n11. Those who are unable to complete follow-up because of mental illness, cognitive or emotional disorders;\n12. Inapplicable for this study at the investigators' viewpoints.","80 Years",{"count":72,"type":20},300,"INTERVENTIONAL",[75],"NA","The primary objective of this trial is to evaluate the Safety, Efficacy, and Standardized Procedural Optimization of the Intracranial Drug-Eluting Stent System in Patients with Symptomatic Intracranial Atherosclerotic Stenosis.",[24],[79],"endovascular therapy, intracranial drug-eluting stent","RECRUITING","2025-03-26",{"date":83,"type":35},"2025-04-01",{"date":85,"type":35},"2024-03-08",{"date":87,"type":20},"2026-06-08",{"name":89,"class":90},"Sino Medical Sciences Technology Inc.","INDUSTRY",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":70,"enrollmentInfo":98,"targetDuration":4,"studyType":73,"phases":100,"briefSummary":101,"conditions":102,"keywords":103,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100526884","clinical-trial-of-biolimus-coated-intracranial-balloon-dilation-catheter-100526884","NCT06140550","Clinical Trial of Biolimus-coated Intracranial Balloon Dilation Catheter","Prospective, Multicenter, Randomized Controlled Clinical Trial to Evaluate the Effectiveness and Safety of Biolimus-coated Intracranial Balloon Dilation Catheter Treatment of Patients With Symptomatic Intracranial Atherosclerotic Stenosis","Inclusion Criteria:\n\n* 18 to 80 years old;\n* Symptomatic intracranial artery stenosis, and the degree of visual stenosis of target blood vessels under intracranial angiography is 70\\~99%(WASID method);\n\nExclusion Criteria:\n\n* Target blood vessels are seriously calcified and distorted, and it is difficult to put the interventional instruments in place or recover;\n* Ischemic cerebral infarction occurred 3 weeks before surgery;\n* Cerebral hemorrhage 3 months before operation;",{"count":99,"type":20},204,[75],"This test took the target lesion restenosis rate 6 months after the operation as the main endpoint to verify the effectiveness of the intracranial balloon expansion catheter of Biolimus coating. After completing the follow-up 6 months after the operation, a clinical summary report was issued for the registration application of the product, and on this basis, 12 months of postoperative follow-up was carried out to evaluate the mid-term curative effect.",[24],[104,105],"Intracranial balloon","stenosis","2023-11-17",{"date":108,"type":35},"2023-11-20",{"date":110,"type":20},"2023-11",{"date":112,"type":20},"2026-12",{"name":114,"class":90},"Bochang"]