[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intracranial-pressure-increase\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intracranial-pressure-increase":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,71,103,135,159,186,210,236,259],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100414330","posterior-fossa-intracranial-pressure-icp-measurement-clinical-study-100414330",false,"NCT04675216","Posterior Fossa Intracranial Pressure (ICP) Measurement: Clinical Study","Posterior Fossa Intracranial Pressure (ICP) Measurement in Cases of Traumatic, Ischemic, or Tumor Pathology (Post-surgical) at This Level: Clinical Study","Postfossa ICP","Inclusion Criteria:\n\n* minimum age of 18 years\n* traumatic, tumor, ischemic, or hemorrhagic pathology of the posterior fossa\n* GCS of 8 or less.\n\nExclusion Criteria:\n\n* coagulation disorders\n* multi-organ failure\n* multiple pathologies\n* open head trauma to the posterior fossa with leakage of nervous tissue","ALL","18 Years","80 Years",{"count":21,"type":22},12,"ESTIMATED","2 Years","OBSERVATIONAL","In modern medicine, doctors attempt to monitor all physiological variables to assess their evolution and to decide, based on their changes, the therapeutic attitudes to adopt. Furthermore, this helps to establish a forecast of the evolution to be expected.\n\nThe measurement of Intracranial Pressure (ICP) has become indispensable for managing brain pathology at the anterior and middle fossa level. Doctors generally carry out this measurement at the frontal level. However, experimental and clinical studies have shown that supra-tentorial ICP measurement does not precisely predict the ICP situation in the posterior fossa.\n\nThe increased ICP in the posterior fossa is directly responsible for the clinical deterioration and eventual death in patients with tumour, hemorrhagic, or ischemic pathology of the posterior fossa structures. Some of these lesions are treatable, and their effects reversible if the increase in ICP in the posterior fossa is controlled by pharmacological or even surgical means, preventing it from reaching high levels. This need for on-time ICP control is genuine in the cerebellar hemispheres' lesions, not so much in lesions involving the brainstem. Therefore, the increase in ICP in the posterior fossa needs to be known and documented to facilitate decision-making regarding the therapy to be adopted, be it medical or surgical.\n\nIt is known what the abnormal ICP levels are at the supratentorial level, but what is not known whether these same levels apply to the posterior fossa. In other words, what it is not know with certainty is whether the same levels of ICP in the posterior fossa and its elevation during the same time are going to have equally pernicious effects or these effects are greater or lesser. Doctors need to have tables of ICP values in the posterior fossa to help them decide when these values are in the physiological range. When posterior fossa intracranial pressure lye in the pathological range, and patients need pharmacological treatment or surgical decompression, knowing for sure the posterior fossa ICP is essential. Finally, when doctors also need to know when any therapeutic attempt is useless.\n\nCurrently, doctors only monitor the ICP at the supra-tentorial level and deduce the changes in the posterior fossa from the CT and MRI images, that is, the size of the lesions, the occlusion of the cisterns, the internal cerebral hernias (cerebellar tonsils, trans-tentorial hernia from bottom to top). However, doctors do not have a tool that can objectify the pathophysiological situation of the posterior fossa's structures in real-time.\n\nMonitoring the posterior fossa ICP will help doctors in decision-making in patients with traumatic, hemorrhagic, ischemic, or tumour pathologies (in the latter case, in the postoperative period of posterior fossa tumours). This posterior fossa ICP measurement will lead to improvements in morbidity\u002Fmortality in this subgroup of patients.",[27],"Intracranial Pressure Increase",[29,30,31,32,33],"Intracranial pressure","Posterior fossa","Posterior fossa tumor","Cerebellar hematoma","Cerebellar infarct","RECRUITING","2026-04-18",{"date":37,"type":38},"2026-04-22","ACTUAL",{"date":40,"type":38},"2019-07-19",{"date":42,"type":22},"2026-12",{"name":44,"class":45},"University of Valencia","OTHER",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100614961","non-invasive-intracranial-pressure-monitoring-in-brain-tumor-patients-100614961","NCT07286396","Non-invasive Intracranial Pressure Monitoring in Brain Tumor Patients","Non-invasive Intracranial Pressure Monitoring in Brain Tumor Patients: A Prospective Observational Study of Optic Nerve Sheath Diameter Dynamics","Inclusion Criteria:\n\n* • Adult patients (\\>21 years) undergoing brain tumor resection surgery.\n\n  * Preoperative imaging-confirmed diagnosis of the tumor.\n  * American Society of Anesthesiologists (ASA) physical status II to IV\n  * Consent to participate in the study.\n\nExclusion Criteria:\n\n* • Preexisting ocular conditions affecting the optic nerve or globe integrity, such as glaucoma, thyroid-associated ophthalmopathy, or other optic nerve diseases.\n\n  * Combined ocular and optic nerve injuries at admission.\n  * History of cranial trauma, prior neurosurgery, or lumbar puncture performed within 2 weeks before the measurement of optic nerve sheath diameter (ONSD).\n  * History of subarachnoid hemorrhage (SAH).\n  * Serious complications that could affect life expectancy, such as hematological disorders or malignancies.\n  * Refusal to participate or withdrawal of consent at any stage.","21 Years",{"count":56,"type":22},60,"This research protocol focuses on the pre- and post-operative evaluation of ICP using non-invasive methods, particularly in the context of surgery for brain tumor removal. By utilizing ocular ultrasound to measure ONSD and ONSD\u002FETD ratios, this study hypothesizes that the utility of these parameters in monitoring ICP pre- and post-operative periods could be effective.",[59,27],"Brain Neoplasm","NOT_YET_RECRUITING","2025-12-02",{"date":63,"type":38},"2025-12-16",{"date":65,"type":22},"2026-01",{"date":67,"type":22},"2027-01",{"name":69,"class":45},"Tanta University",1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":70},"100366073","non-invasive-and-non-contact-intracranial-pressure-waveform-recording-using-dynamic-video-ophthalmoscopy-100366073","NCT04046523","Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy","ICP Waveform","Inclusion Criteria:\n\n* Must be able to sit still and fix their eyes on a target in the VO objective.\n* ICP participants must have an inserted ICP probe for clinical purposes.\n\nExclusion Criteria:\n\n* Diagnosis of glaucoma, retinopathy or head tremor.",true,"4 Years",{"count":81,"type":22},90,"INTERVENTIONAL",[84],"NA","This study will test the use of video ophthalmoscope to provide information about intracranial pressure without the use of invasive methods, anesthesia or contact with the eye.",[27],[88,89,90,91,92,93,94],"video ophthalmoscope","intraocular pressure","electrocardiogram","photoplethysmography","retinal pulsatility","spontaneous venous pulsation","blind source separation","2025-11-24",{"date":61,"type":38},{"date":98,"type":38},"2023-01-31",{"date":100,"type":22},"2030-07-31",{"name":102,"class":45},"University of Minnesota",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":78,"sex":110,"minAge":18,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":82,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":70},"100604868","different-intraperitoneal-pressures-on-optic-nerve-sheath-diameter-in-laparoscopic-surgeries-100604868","NCT07155109","Different Intraperitoneal Pressures on Optic Nerve Sheath Diameter in Laparoscopic Surgeries","The Effects of Different Intraperitoneal Pressures on Optic Nerve Sheath Diameter in Laparoscopic Gyneco-oncologic Surgeries","Inclusion Criteria:\n\n* Laparoscopic gyneco-oncological surgeries\n* Female patients aged 18-65 years\n* ASA physical status classification I-II-III patients\n\nExclusion Criteria:\n\n* Patients with diabetic retinopathy\n* Patients with glaucoma\n* Patients with cerebrovascular disease\n* Pregnant women\n* Patients with known allergy to anaesthetic agents\n* Morbidly obese patients with BMI \\> 40","FEMALE","65 Years",{"count":113,"type":22},100,[84],"The aim of this study is to investigate the effects of low and normal intraperitoneal pressures on intraoperative optic nerve sheath diameter in laparoscopic gyneco-oncologic surgeries.",[27,117,118],"Abdominal Pain","Head Pain",[120,121,122,123,124],"Intracranial Pressure","optic nerve","laparascopy","gyneco-oncologic surgery","low pressure","2025-08-27",{"date":127,"type":38},"2025-09-04",{"date":129,"type":22},"2025-08-30",{"date":131,"type":22},"2025-10-20",{"name":133,"class":134},"Diskapi Yildirim Beyazit Education and Research Hospital","OTHER_GOV",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":70},"100581825","prospective-ocular-imaging-for-intracranial-pressure-evaluation-100581825","NCT06855342","Prospective Ocular Imaging for Intracranial Pressure Evaluation","POICCP","Healthy controls:\n\nInclusion Criteria:\n\n1. Aged ≥18 years\n2. Presumed normal ICP undergoing routine mydriatic ophthalmology OCT scans.\n\nExclusion Criteria:\n\n1. Significant media opacity restricting acquisition of retinal vein imaging and video capture in both eyes.\n2. Current or previous evidence of glaucoma, glaucoma suspect, family history of glaucoma in a 1st degree relative, or non-glaucoma related optic neuropathy in both eyes.\n3. Retinal vein or artery occlusions in both eyes (branch or central).\n4. Active or history of proliferative diabetic retinopathy, or diabetic papillitis in both eyes.\n5. Symptoms and\u002For signs that, in the opinion of the investigator, indicate possible raised intracranial pressure.\n6. Current or previous history of disorders affecting intracranial pressure including, but not limited to, idiopathic intracranial hypertension, hydrocephalus, epilepsy, intracranial bleeds, space occupying lesions or tumours, traumatic brain injury, central nervous system inflammatory or infectious disorders, congenital neuro-cranial disorders, neurosurgical or interventional procedures. Radiologically-confirmed ischaemic stroke is permissible, provided the patient did not develop a subsequent haemorrhagic stroke or require neurosurgical intervention.\n7. Current or recent (6 months) history of medication use affecting intracranial pressure including steroids, vitamin A analogues, tetracyclines, recombinant growth hormone, lithium, nitrofurantoin, nalidixic acid, sulfenazone, cyclosporine, amiodarone.\n8. Bed-bound patients.\n9. Patients who, in the opinion of the investigator, would be unwilling or unable to provide written informed consent, or undergo the testing procedures as described in the protocol.\n\nPatients due to undergo lumbar puncture or intracranial pressure bolt monitoring:\n\nInclusion:\n\n1. Aged ≥18 years.\n2. Patients due to undergo lumbar puncture with measurement of Opening and Closing CSF pressures\n3. Patients due to undergo continuous ICP monitoring\n\nExclusion:\n\n2\\. Current or previous evidence of glaucoma or glaucoma suspect in both eyes.\n\n3\\. Retinal vein or artery occlusions in both eyes (branch or central).\n\n4\\. Bed-bound patients.\n\n5\\. Patients who, in the opinion of the investigator, would be unwilling or unable to provide written informed consent, or undergo the testing procedures as described in the protocol.",{"count":143,"type":22},160,"This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people's eyes - this is a pulse one can see on examination of the back of the eye, originating from the blood vessels around the nerve that connects the eye to the brain (the optic nerve), and is present in most people who have normal pressure around the brain. However, in people with raised pressure in the brain, this pulse disappears as the pressure rises. Many things can cause the pressure around the brain to increase, including tumours, swellings and trauma. The investigators want to test if high-quality images and videos of this pulse, taken using both hand-held and larger, fixed-platform machines, can be used to train a software tool to automatically detect this pulse. The investigators want to collect these images and videos in 2 groups of patients: those with no known or suspected brain pressure problems, and those who are suspected to have raised pressure and\u002For are due to undergo measurement of the pressure around the brain, called lumbar punctures or intracranial pressure bolt monitoring. These tests to check the pressure around the brain are invasive - they involve inserting needles in the back or directly into the brain to measure the pressure, and carry risks. The value of these two groups of people will be to help train the software to reasonably say whether a pulse is present or absent and, hopefully, estimate what the pressure around the brain may be without the need for an invasive test.",[146,27,147],"Idiopathic Intracranial Hypertension","Spontaneous Venous Pulsations",[147,149],"Optic disc videography","2025-08-01",{"date":152,"type":38},"2025-08-03",{"date":154,"type":38},"2025-01-10",{"date":156,"type":22},"2025-11-30",{"name":158,"class":45},"King's College Hospital NHS Trust",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":70},"100555416","correlation-between-noninvasive-blood-vessel-functionality-parameters-and-cerebral-hemodynamics-in-neurocritical-care-patients-100555416","NCT06511804","Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients","Mespere ICP","Inclusion Criteria:\n\nSubjects who meet all the following inclusion criteria may be included:\n\n1. Adults (\\> 18 years of age);\n2. Able and willing to provide written informed consent for participation by self or legally authorized representatives.\n3. Clinical diagnosis of traumatic brain injury (TBI), brain hemorrhage, brain tumor, neurotrauma (including closed head injuries, penetrating head injuries, or other forms of neurotrauma), hemorrhage (intracerebral or subarachnoid), or stroke.\n4. Continuous Blood Pressure Monitoring: Patients must have continuous blood pressure monitoring in place during the study period, obtained from an arterial line. This criterion ensures that we have real-time data on mean arterial pressure (MAP) and systolic pressure (SBP).\n5. Intracranial Pressure (ICP) Monitoring: Patients must have intracranial pressure (ICP) monitoring in place during the study period. This criterion ensures that we can assess the correlation between our blood vessel functionality parameters (VDC, VR, and VRx) and ICP, a key indicator of intracranial dynamics.\n\nExclusion Criteria:\n\n1. Subjects who meet any of the following exclusion criteria will be excluded:\n2. Expected to be at increased risk due to study participation (e.g. due to hemodynamic instability), in the medical opinion of an investigator;\n3. Pregnant as determined per site standard practice;\n4. Previously participated in this study, or are enrolled in another research study that could be expected to interfere with participation, in the opinion of the investigator;\n5. Require or are anticipated to require emergent medical care in which study participation may reasonably delay his\u002Fher medical care or increase risk or unfavorable outcome, in the opinion of the investigator;\n6. Allergy to adhesive tape;\n7. Ongoing photodynamic therapy.","100 Years",{"count":168,"type":22},25,"The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of patients suffering from traumatic brain injury (TBI), stroke, brain tumor, and brain bleeding. This study aims to investigate and establish the correlation between blood vessel functionality parameters-specifically, Vasodilation\u002FConstriction Index (VDC), Vascular Resistance Index (VR), and Volume Reactivity Index (VRx)-with the crucial physiological indicators, Intracranial Pressure (ICP) and Mean Arterial Pressure (MAP). By doing so, the investigators seek to address fundamental questions surrounding cerebral hemodynamics and autoregulation in various neurological conditions.",[171,27,172],"Brain Injuries","Monitoring",[174,175,176],"intracranial pressure","monitoring","noninvasive","2025-05-26",{"date":179,"type":38},"2025-05-30",{"date":181,"type":38},"2024-11-17",{"date":183,"type":22},"2026-06-30",{"name":185,"class":45},"University of Louisville",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":70},"100575357","lung-recruitment-and-peep-effects-on-intracranial-pressure-in-cranial-surgery-100575357","NCT06771232","Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery","Impact of Lung Recruitment Maneuvers and Positive End-Expiratory Pressure (PEEP) on Intracranial Pressure in Patients Undergoing Cranial Surgery","Inclusion Criteria:\n\n* ASA classification I-III.\n* Elective cranial neurosurgery.\n\nExclusion Criteria:\n\n* ASA classification IV or higher.\n* Documented intracranial hypertension.\n* Severe pulmonary disease (e.g., asthma, COPD).\n* Emergency surgery.","75 Years",{"count":195,"type":22},20,"High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.\n\nHowever, individualizing ventilation parameters is essential for each patient. Among protective ventilation strategies, PEEP is key to preventing alveolar collapse. The PEEP level that minimizes alveolar collapse while avoiding overdistension of the pulmonary parenchyma is known as the Best PEEP. This study aims to evaluate the application of Best PEEP in cranial neurosurgery.",[27,198],"Mechanical Ventilation Complication",[200,174],"Positive end expiratory pressure","2025-01-09",{"date":203,"type":38},"2025-01-13",{"date":205,"type":22},"2025-01-01",{"date":207,"type":22},"2026-12-30",{"name":209,"class":45},"University of Chile",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":82,"phases":220,"briefSummary":221,"conditions":222,"keywords":224,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":234,"locationsCount":70},"100538271","asah-treatment-based-on-intraventricular-icp-monitoring-a-prospective-multicenter-randomized-and-controlled-trial-100538271","NCT06288659","aSAH Treatment Based on Intraventricular ICP Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial","Aneurysmal Subarachnoid Hemorrhage Treatment Based on Intraventricular Intracranial Pressure Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial","ASTIM-MT","Inclusion Criteria:\n\n* Confirmed diagnosis of aSAH: presence of SAH symptoms, confirmed by CT scan or lumbar puncture. CTA or DSA confirms ruptured intracranial aneurysm (IA) as the cause. Decision made to perform craniotomy clipping or endovascular treatment within 72 hours aiming for a single procedure to cure the bleeding artery aneurysm;\n* Age ≥ 18 years;\n* The onset of symptoms should occur within 72 hours;\n* The Hunt-Hess grade is between 2 and 4, and the CT imaging findings correspond to a modified Fisher grade of 2 to 4.\n* Obtain the consent of the patient and their family members, and have them sign an informed consent form.\n\nExclusion Criteria:\n\n* Pregnancy or lactation period;\n* Patients presenting with bilateral dilated pupils upon admission;\n* Patients with concurrent tumors, hemorrhagic diseases, or other severe underlying conditions (such as chronic obstructive pulmonary disease, multiple organ dysfunction syndrome, severe diabetes mellitus, congestive heart failure, and chronic kidney disease);\n* Patients with a history of brain disorders or previous brain surgeries;\n* Hemorrhage attributable to causes other than aneurysm;\n* Aneurysmal rupture bleeding concurrent with moyamoya disease;\n* Other underlying conditions that impact prognosis;\n* Patients volunteering for ICP monitoring;\n* Participants in other ongoing clinical trails;\n* Other circumstances deemed inappropriate for inclusion (to be determined by two physicians).",{"count":219,"type":22},372,[84],"ASTIM is a multicenter, prospective, randomised, blinded end-point assessed trial, to investigate the efficacy and safety of treatment based on intracranial pressure monitoring in improving the prognosis of patients with aneurysmal subarachnoid hemorrhage.",[223,27],"Aneurysmal Subarachnoid Hemorrhage",[225,226,227],"Aneurysmal subarachnoid hemorrhage","Intraventricular intracranial pressure monitoring","Multicenter randomized clinical trail","2025-01-04",{"date":230,"type":38},"2025-01-07",{"date":232,"type":38},"2024-05-20",{"date":207,"type":22},{"name":235,"class":45},"Huashan Hospital",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":111,"enrollmentInfo":243,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":70},"100551771","effect-of-lithotomy-position-on-optic-nerve-sheath-diameter-100551771","NCT06464419","Effect of Lithotomy Position on Optic Nerve Sheath Diameter","Ultrasonographic Evaluation of Optic Nerve Sheath Diameter in Patients Undergoing Retrograde Intrarenal Surgery in the Lithotomy Position","Inclusion Criteria:\n\n* Patients who give informed consent\n* Patients who will undergo retrograde intrarenal surgery\n* Patients who are fully oriented and cooperative\n* ASA I-II patients\n* Patients between the ages of 18-65\n\nExclusion Criteria:\n\n* Disoriented and uncooperative patients\n* Patients with BMI\\>30\n* Patients who have had previous intracranial surgery\n* Patients who have had eye surgery before\n* Patients allergic to the pharmacological agents used in the study",{"count":244,"type":22},52,"In this study, the effect of increased venous return and increased intra-abdominal pressure on intracranial pressure in the lithotomy position was evaluated.",[247,27],"Optic Nerve Cup",[249],"ultrasonography, lithotomy position","2024-08-02",{"date":252,"type":38},"2024-08-05",{"date":254,"type":38},"2024-06-10",{"date":256,"type":22},"2024-09-01",{"name":258,"class":134},"Başakşehir Çam & Sakura City Hospital",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":78,"sex":110,"minAge":18,"maxAge":4,"enrollmentInfo":265,"targetDuration":267,"studyType":24,"phases":4,"briefSummary":268,"conditions":269,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":70},"100556222","assessment-of-optic-nerve-sheath-diameter-in-preeclamptic-pregnant-women-using-ultrasonography-and-anesthetic-management-100556222","NCT06522295","Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management","Inclusion Criteria:\n\n* asa 2-3 Individuals Aged 18 and Above Individuals with Gestational Age of 37 Weeks and Above pregnancy with health, mild preeclampsia, severe preeclampsia\n\nExclusion Criteria:\n\n* Multiple pregnancies Fetal anomalies Patients with contraindications to ocular ultrasound (allergy to ultrasound gel, ocular injury or infection, facial fracture) Conditions known to increase cerebral pressure (idiopathic intracranial hypertension, brain tumor, recent history of brain trauma) Conditions potentially leading to edema (heart failure, glomerulonephritis or nephrotic syndrome, liver failure, malnutrition, hypothyroidism) Ophthalmic conditions that may affect optic nerve sheath diameter measurement (glaucoma, cataracts, previous eye surgery) Chronic hypertension",{"count":266,"type":22},38,"3 Days","Preeclampsia is a serious condition associated with complications such as pulmonary edema, placental abruption, hemolysis, thrombocytopenia, and cardiac, renal, and neurological complications, occurring at a rate of 2.7-8% in pregnant women (1,2). Neurological complications are believed to be associated with reversible cerebral vasoconstriction syndrome (3,4) and\u002For posterior leukoencephalopathy syndrome (4,5,6), sharing a common pathophysiology. Cerebral edema is primarily vasogenic, potentially linked to hyperperfusion resulting from impaired cerebral autoregulation, blood-brain barrier disruption, and endothelial cell dysfunction. In some eclampsia cases, computed tomography and magnetic resonance imaging may reveal signs consistent with significantly increased intracranial pressure (ICP) (7). However, the true incidence of elevated ICP in preeclampsia is unknown, clinical symptoms are nonspecific, and interpretation, especially during pregnancy and preeclampsia, can be challenging (2).\n\nCesarean section, currently one of the most frequently performed surgeries worldwide, is conducted in 21.1% of women (8). Anesthesia for cesarean section can be divided into neuraxial and general anesthesia. The choice of anesthesia technique in conditions that may increase intracranial pressure, such as cerebral edema, may vary based on balancing risks and benefits. Neuraxial analgesia and anesthesia are the first choice in healthy pregnancies, but may be contraindicated in cases with intracranial lesions or increased bleeding risk (9). The presence of focal neurological deficits may favor general anesthesia for cesarean delivery (10). General anesthesia in these patients may result in an increased hemodynamic response to laryngoscopy. Agents used in induction and maintenance can also affect cerebral autoregulation (11). Anesthesia induction and maintenance for these patients should be planned to minimize the increase in intracranial pressure.\n\nThe optic nerve, a part of the central nervous system, is surrounded by a dural sheath and a subarachnoid space containing cerebrospinal fluid. Three millimeters behind the ocular globe, the optic nerve is solely surrounded by fat, and the dural sheath can retract within its fatty environment, particularly in conditions of increased pressure in the cerebrospinal fluid (2). Recent clinical studies have reported that ultrasonographic measurements of the optic nerve sheath diameter (ONSD) are correlated with increased intracranial pressure symptoms and may serve as a non-invasive reliable indicator of ICP (12,13). Studies have reported high inter-observer reliability for ONSD measurements (14,15). ONSD measurement is easy, repeatable at the bedside, rapid, inexpensive, and does not involve radiation.\n\nCompared to healthy pregnant women, preeclamptic women are considered to have higher intracranial pressure during the childbirth process. Anesthetic management for delivery in these women can be complex and controversial. The aim of this study is to evaluate ultrasonographic measurements of optic nerve sheath diameter during the perioperative period, independent of anesthesia management, in healthy and preeclamptic pregnant women undergoing cesarean section. We believe that these assessments will contribute to more reliable anesthesia planning for preeclamptic pregnancies.",[270,27,271],"Preeclampsia","Pregnancy; Anesthesia, Adverse Effect, Central Nervous System","2024-07-22",{"date":274,"type":38},"2024-07-26",{"date":276,"type":22},"2024-09-22",{"date":278,"type":22},"2025-06-30",{"name":280,"class":45},"Kocaeli University"]