[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intracranial-pressure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intracranial-pressure":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,42,70,90,116,149,185,206,234,259,281,306],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100644207","jugular-gating-for-upright-level-adjustment-and-targeted-enhancement-of-cerebral-perfusion-100644207",false,"NCT07665606","JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion","JUGULATE","Inclusion Criteria:\n\n* Patients ≥ 18 years old\n* Hospitalized in the neurocritical care unit or the trauma unit\n* Scheduled for nursing care requiring a supine position.\n* Arterial catheter allowing continuous measurement of mean arterial pressure.\n* Central venous catheter for continuous measurement of central venous pressure.\n* External ventricular drain or intracranial pressure sensor for intracranial pressure monitoring.\n* Bed with controlled inclination capability.\n* Clinically stable condition allowing transient positional changes (as judged by the clinician).\n* Not included, or planned to be included in another trial.\n\nExclusion Criteria:\n\n* Contraindication to trunk mobilization.\n* Being a minor or placed under supervision.\n* Hemodynamic or respiratory instability.\n* Uncontrolled intracranial hypertension, refractory arterial hypertension, or severe dysautonomia.\n* Pregnancy or breastfeeding.\n* Refusal to participate in the study.","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse. This collapse is estimated to occur at the angle where the hydrostatic pressure of the blood column matches the central venous pressure, and it can be assessed using ultrasonography. This approach allows for the determination of an individualized tilt angle, optimizing cerebral perfusion pressure without compromising venous drainage.",[24,25],"Intracranial Pressure","Critical Care",[24,27,28],"jugular vein collapse","Critical care","NOT_YET_RECRUITING","2026-06-18",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":20},"2026-09-01",{"date":37,"type":20},"2027-03-31",{"name":39,"class":40},"University Hospital, Bordeaux","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100642008","remifentanil-vs-esmolol-during-intubation-for-cerebral-aneurysm-coil-embolization-100642008","NCT07660861","Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization","Effects of Remifentanil Versus Esmolol on Optic Nerve Sheath Diameter\u002FEyeball Transverse Diameter Ratio During Endotracheal Intubation in Patients Undergoing Cerebral Aneurysm Coil Embolization: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective cerebral aneurysm coil embolization under general anesthesia\n* Planned endotracheal intubation\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency procedures\n* Hemodynamic instability before induction of anesthesia\n* Severe cardiac conduction abnormalities or clinically significant arrhythmias\n* Contraindication or allergy to remifentanil or esmolol\n* Chronic opioid use or opioid dependence\n* Known orbital disease, ocular trauma, or conditions interfering with optic nerve sheath diameter measurements\n* Anticipated difficult airway\n* Pregnancy\n* Refusal to participate in the study",{"count":50,"type":20},84,"INTERVENTIONAL",[53],"NA","Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.\n\nThis randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter\u002Feyeball transverse diameter ratio (ONSD\u002FETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization.\n\nThe findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.",[56,24],"Cerebral Aneurysm Unruptured",[58,24,59,60,61],"Optic Nerve Sheath Diameter","Remifentanil","Esmolol","Coil Embolization","2026-06-16",{"date":64,"type":33},"2026-06-22",{"date":64,"type":20},{"date":67,"type":20},"2027-07-01",{"name":69,"class":40},"Fatih Sultan Mehmet Training and Research Hospital",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":41},"100601658","non-invasive-icp-monitoring-study-100601658","NCT07113353","Non-Invasive ICP Monitoring Study","Non-Invasive Intracranial Pressure Waveform Dynamics","Inclusion Criteria:\n\n* Adult patients (age \\>18) undergoing craniotomy for any indication requiring hyperosmolar agents as a part of their surgery\n* Adult patients (age \\>18) in the neuro-oncology or neurosurgery clinic who are receiving diagnostic\u002Ftherapeutic lumbar puncture as a part of their ordinary care\n* Adult patients (age \\>18) in the neurosurgery clinic with ventriculo-peritoneal shunts who require adjustments to increase or decrease drainage of cerebrospinal fluid.\n\nExclusion Criteria:\n\n* Age \\\u003C18\n* Lacking capacity to provide informed consent on their own behalf",{"count":19,"type":20},"Measuring the pressure inside the skull, which is called intracranial pressure, is important to treat severe neurological illness. Currently, measuring intracranial pressure requires doctors to place an invasive pressure monitor. Recently, a non-invasive intracranial pressure monitor has been developed. This monitor has a tiny pin that is placed on the head which measures the tiny movements of the skull every time the heart beats. This produces a waveform that looks very similar to an invasive intracranial pressure waveform. However, we don't know enough about how the non-invasive device to make it clinically useful yet.",[24],"RECRUITING","2026-04-18",{"date":83,"type":33},"2026-04-22",{"date":85,"type":33},"2026-04-10",{"date":87,"type":20},"2027-10-01",{"name":89,"class":40},"University of Texas Southwestern Medical Center",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":97,"targetDuration":99,"studyType":21,"phases":4,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":41},"100634499","effect-of-internal-jugular-vein-catheterization-on-intracranial-pressure-and-intracranial-blood-flow-100634499","NCT07540481","Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow","Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Assessed by Optic Nerve Sheath Diameter and Carotid Doppler Ultrasonography: a Prospective Observational Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients undergoing surgery under general anesthesia\n* Patients requiring internal jugular vein catheterization as part of routine clinical care\n* Ability to obtain optic nerve sheath diameter measurements using transorbital ultrasonography\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Known intracranial pathology affecting intracranial pressure\n* Ocular conditions preventing accurate ultrasonographic measurement (e.g., orbital trauma, ocular surgery, infection)\n* Hemodynamic instability\n* Contraindication to internal jugular vein catheterization\n* Inability to obtain adequate ultrasound images",{"count":98,"type":20},61,"1 Day","This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia.\n\nONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization.\n\nSecondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.",[24,102],"Ultrasonography",[104,105,102,58,24,106],"Internal Jugular Vein","Catheterization","General Anesthesia","2026-04-14",{"date":109,"type":33},"2026-04-20",{"date":111,"type":20},"2026-04-15",{"date":113,"type":20},"2027-03-16",{"name":115,"class":40},"Kanuni Sultan Suleyman Training and Research Hospital",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":126,"conditions":127,"keywords":136,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":148},"100544420","comind-early-feasibility-study-100544420","NCT06368648","CoMind Early Feasibility Study","An Early Feasibility Study for the Development of a Model to Non-Invasively Estimate Intracranial Pressure (ICP) and New Metrics of Cerebral Autoregulation (CAR) Using the CoMind One EFS Device","CoMind EFS","Inclusion Criteria:\n\n1. Male or female sex at birth, and aged 18 years or older on the date of enrollment.\n2. Receiving continuous invasive ICP monitoring (Bolt or EVD) as part of standard care.\n3. Invasive ICP monitor catheter penetrating the parenchyma or ventricles.\n4. Receiving continuous invasive ABP monitoring as part of standard care.\n\nExclusion Criteria:\n\n1. Presence of any implant (cosmetic or otherwise) in the frontal bone in such proximity to the CoMind One EFS Sensor that they might physically touch.\n2. Open wounds on the forehead such that CoMind One EFS Sensor cannot be safely placed over an area of intact skin\n3. Presenting with radiographic evidence of a non-intact skull at the recording site on admission.\n4. If patient is enrolled in an intervention\u002Fstudy that may interfere with SoC ICP measurements or the CoMind One EFS device measurement then the patient is ineligible.\n5. Patients with decompressive craniectomy will be excluded unless a CoMind One EFS recording can be made from intact skull.",{"count":125,"type":20},581,"The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around the brain from the outside (this pressure is called intracranial pressure or ICP). Monitoring and managing ICP is an important part of care for patients with conditions such as Traumatic Brain Injury (TBI). However, the current way of measuring ICP requires surgery to drill a hole into the skull, and therefore can introduce additional risks such as infections and pain.\n\nRecent research has shown it may be possible to measure ICP without needing surgery. This technology is in development, but large amounts of data is required to build these new devices.\n\nThrough collecting a large database of information from patients who have both the routine surgical device and the research device applied to their head, the research team will work to develop and test an effective and potentially safer way of monitoring patient ICP.",[24,128,129,130,131,132,133,134,135],"Intracranial Pressure Changes","Traumatic Brain Injury","Intracerebral Hemorrhage","Encephalitis","Encephalopathy","Hydrocephalus","Stroke","Autoregulation",[24,129,137],"Cerebral Autoregulation","2026-02-12",{"date":140,"type":33},"2026-02-13",{"date":142,"type":33},"2024-11-27",{"date":144,"type":20},"2026-11",{"name":146,"class":147},"CoMind Technologies Limited","INDUSTRY",14,{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":51,"phases":159,"briefSummary":160,"conditions":161,"keywords":164,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":184},"100615035","optimal-cerebral-perfusion-pressure-guided-therapy-assessment-of-target-effectiveness---ii-100615035","NCT07287358","Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II","CPPopt Guided Therapy: Assessment of Target Effectiveness - II","Cogitate II","Inclusion Criteria:\n\n* Adult (\\>18 years old)\n* Severe TBI requiring ICP-directed therapy for at least 24 hrs on the assessment of the recruiting intensive care team and\u002For attending neurosurgeon\n* Start randomization within 24 hrs after ICU admission.\n\nExclusion Criteria:\n\n* Known pregnancy\n* Moribund at presentation (e.g. bilaterally absent pupillary responses)\n* Patients with a primary decompressive craniectomy\n* Failure to get final written informed consent",{"count":158,"type":20},60,[53],"After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and patient the same. This study aims to change that. With new technology, 'optimal' blood pressure can be determined for each individual brain and treatment can be tailored accordingly. This personalized approach to neurocritical care has never been tested in a randomized controlled study before. If effective in showing reduced brain damage biomarkers, it will fundamentally transform brain injury treatment and dramatically improve recovery outcomes for patients worldwide.",[129,162,24,163],"Severe Traumatic Brain Injury","Cerebral Perfusion Pressure",[165,166,167,168,169,170,171,172,173,174],"CPPopt","optimal cerebral perfusion pressure","pressure reactivity index","PRx","Intracranial pressure","cerebral perfusion pressure","traumatic brain injury","severe traumatic brain injury","cogitate","cogitate-II","2025-12-31",{"date":177,"type":33},"2026-01-06",{"date":179,"type":20},"2026-05-01",{"date":181,"type":20},"2028-05-15",{"name":183,"class":40},"Maastricht University Medical Center",4,{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":51,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":41},"100610072","non-invasive-intracranial-pressure-estimation-by-measurement-of-the-occlusion-pressure-of-the-isolated-periorbital-vein-100610072","NCT07222826","Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein","Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein (NICE-ICP)","Inclusion Criteria:\n\n* Male or female\n* Age \\> 18\n* Equipped with an invasive ICP monitor as part of standard of care\n\nExclusion Criteria:\n\n* Presence of facial and\u002For skull trauma that could hinder placement of the pneumatic mask or contraindicate ultrasound on the forehead\n* History of recent cranial surgery or hemicraniectomy\n* Active bleeding (proven or suspected)\n* History or known pathological condition or injury linked to the orbital socket influencingvenous outflow (e.g. Grave disease, tumor, inflammation, trauma, glaucoma, etc.)\n* History, or known vein stenosis in ophthalmic veins\u002Fcavernous sinus\n* Any other condition that would interfere with measurement technique and routine clinical care according to the judgment of the investigator.",{"count":193,"type":20},15,[53],"Elevated intracranial pressure is a common complication of brain injury which means that the pressure within the skull rises above normal levels. The negative impact of increased intracranial pressure (ICP) on the prognosis of patients has been strongly shown in numerous studies and ICP-based treatment is associated with an important reduction of risk of death. Invasive ICP measurement methods are nowadays a standard of care in severe brain injury. The two available ways of measuring ICP require neurosurgical procedure to implant a catheter and probes within the brain and present risks and complications for the patient, such as infections and intracranial bleeding. In addition, invasive recording of ICP requires neurosurgical expertise and intensive care unit (ICU) facilities, limiting the application of ICP measurements to patients of the acute neuro-ICU (neuro-Intensive Care Unit) with acute brain damage requiring close surveillance to prevent further deterioration of neural tissue and disability. Non-invasive ICP monitoring benefits include no risk of complications seen in invasive monitoring, helping in deciding which patient needs invasive ICP monitoring, and providing ongoing long-term measurements of ICP without having to insert a new device every time. Although many non-invasive ICP measurement methods have been explored, to date, none of them have shown clinical success or usefulness. One under-explored window to ICP is the orbital vein, a small blood vessel located near your eye, which we think could provide a direct link to the intracranial pressure. The study device, called the CPMX3 system, is a non-invasive method to measure pressure in a superficial periorbital vein.",[24,128],"2025-10-28",{"date":199,"type":33},"2025-10-30",{"date":201,"type":33},"2025-09-30",{"date":203,"type":20},"2026-09-30",{"name":205,"class":147},"Compremium AG",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":213,"minAge":17,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":51,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":41},"100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736","NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.","FEMALE","65 Years",{"count":216,"type":20},90,[53],"This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[220,221,222,24,223,224],"Sevoflurane","Lidocaine","Propofol","Cerebral Oxygenation","Laparoscopic Hysterectomy","2025-07-02",{"date":227,"type":33},"2025-07-14",{"date":229,"type":33},"2025-02-01",{"date":231,"type":20},"2027-02-01",{"name":233,"class":40},"Tanta University",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":241,"enrollmentInfo":242,"targetDuration":244,"studyType":21,"phases":4,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":258},"100593388","ai-based-ultrasound-prediction-model-for-intracranial-pressure-and-prognosis-in-lung-cancer-patients-with-leptomeningeal-metastasis-a-dual-center-study-100593388","NCT07005791","AI-Based Ultrasound Prediction Model for Intracranial Pressure and Prognosis in Lung Cancer Patients With Leptomeningeal Metastasis: A Dual-Center Study","基于人工智能的视神经鞘超声视频构建肺癌软脑膜转移患者颅内压预测模型及多模态临床预后模型的双中心临床研究","Inclusion Criteria:\n\n1- Age: Participants must be aged 18 years or older. 2、Diagnosis: Patients must have a histologically confirmed diagnosis of non-small cell lung cancer (NSCLC) with clinically or pathologically confirmed leptomeningeal metastases (LM), and at least one measurable lesion.\n\n3、Lumbar Puncture and Intrathecal Chemotherapy: Patients must have undergone lumbar puncture and intrathecal chemotherapy in the study center.\n\n4、ECOG Performance Status: Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 3.\n\n5、Blood Tests: Neutrophil count ≥ 1.5 × 10⁹\u002FL. Hemoglobin ≥ 9 g\u002FdL. Platelet count ≥ 100 × 10⁹\u002FL. 6、Biochemical Tests: Total bilirubin ≤ 1.5 times the upper limit of normal (ULN). AST (aspartate aminotransferase) and ALT (alanine aminotransferase) \\< 1.5 times ULN.\n\nCreatinine clearance ≥ 60 ml\u002Fmin. 7、No Significant Bleeding or Thrombosis: Patients must not have significant bleeding symptoms, bleeding disorders, or active thrombosis.\n\n8、Reproductive Health: Women of childbearing age must use appropriate contraception and have a negative pregnancy test prior to enrollment.\n\n9、Informed Consent: All patients must have signed the informed consent form and be willing to comply with the study procedures and follow-up schedule.\n\nExclusion Criteria:\n\n* 1、Histological Type: Patients with squamous cell carcinoma or small cell lung cancer are excluded.\n\n  2、Recent Radiotherapy: Patients who have received local radiotherapy for intracranial lesions within the past two weeks are excluded.\n\n  3、ECOG Performance Status: Patients with an ECOG performance score greater than 3 are excluded.\n\n  4、Uncontrolled Seizures: Patients with uncontrolled seizures are excluded. 5、Other Tumor History: Patients with a current or past history of other tumors are excluded.\n\n  6、Bleeding or Thrombotic Disorders: Patients with known hereditary or acquired bleeding or thrombotic tendencies (e.g., hemophilia, coagulation disorders, thrombocytopenia) or with abnormal coagulation function (INR \\> 2.0, PT \\> 16s) are excluded. Those on thrombolytic or anticoagulant therapy are also excluded, except for patients on preventive doses of low-dose aspirin or low-molecular-weight heparin.\n\n  7、Recent Trauma or Surgery: Patients with a history of severe trauma or surgery within the last month, or significant bleeding events within the past three months, are excluded.\n\n  8、Severe Organ Dysfunction: Patients with severe hepatic or renal dysfunction, HIV infection, HCV infection, asthma, or uncontrolled cerebrovascular disease are excluded.\n\n  9、Pregnancy and Breastfeeding: Pregnant or breastfeeding women are excluded. Women of childbearing age must test negative for pregnancy within seven days prior to enrollment.\n\n  10、Thrombotic Events: Patients with arterial or venous thrombotic events (e.g., stroke, transient ischemic attack, brain hemorrhage, deep vein thrombosis, or pulmonary embolism) within the past six months are excluded.\n\n  11、Safety Concerns: Any other conditions or factors that the investigator deems unsuitable for inclusion, including issues that might compromise the patient\\'s safety or compliance, will result in exclusion.","75 Years",{"count":243,"type":20},142,"2 Years","This study focuses on developing an innovative, artificial intelligence-based model using optic nerve sheath ultrasound videos to predict intracranial pressure in lung cancer patients with leptomeningeal metastasis. The study also aims to create a multimodal clinical prognosis model that can help improve patient outcomes. By analyzing ultrasound data from patients at two major medical centres, the research seeks to provide more accurate and early predictions of complications related to elevated intracranial pressure, ultimately improving treatment and management strategies for these patients.",[247,248,24],"Lung Cancer (NSCLC)","Leptomeningeal Metastasis","2025-06-03",{"date":251,"type":33},"2025-06-05",{"date":253,"type":20},"2025-07-01",{"date":255,"type":20},"2027-12-30",{"name":257,"class":40},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",2,{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":214,"enrollmentInfo":266,"targetDuration":4,"studyType":51,"phases":267,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":280,"locationsCount":41},"100582980","phase-3-role-of-non-selective-beta-adrenergic-blocker-in-severe-tbi-100582980","NCT06870370","Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI","Role of Non-Selective Beta-Adrenergic Blocker in Severe Traumatic Brain Injury","Inclusion Criteria:\n\n* Patients aged between 18and 65 years old\n* Patients who have Severe traumatic brain injury\n* Glascow outcome scale ≤ 8\n\nExclusion Criteria:\n\n* Patients have pre-existing heart disease.\n* If there are contraindications to β blocker.\n* penetrating traumatic brain injury.\n* pre-injury brain dysfunction.\n* β-blocker or α2-agonist use before trauma.",{"count":158,"type":20},[268],"PHASE3","The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury",[271,24,272,273],"Traumatic Brain Injury (TBI) Patients","Intensive Care Unit","Mortality","2025-03-06",{"date":276,"type":33},"2025-03-11",{"date":278,"type":20},"2025-09-20",{"date":278,"type":20},{"name":233,"class":40},{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":288,"sex":16,"minAge":289,"maxAge":214,"enrollmentInfo":290,"targetDuration":4,"studyType":51,"phases":291,"briefSummary":292,"conditions":293,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":41},"100558153","effects-of-different-anesthesia-machine-modalities-on-bariatric-surgery-patients-a-prospective-randomized-controlled-study-100558153","NCT06547411","Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study","Effects of Different Ventilation Modes on Intracranial Pressure and Carbon Dioxide Partial Pressure During Bariatric Surgery: a Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective bariatric surgery.\n* Age between 16 and 65 years.\n* Continuous weight gain for more than 5 years with a BMI ≥ 35.\n* ASA-PS (American Society of Anesthesiologists Physical Status) categorization of Grade II or III.\n\nExclusion Criteria:\n\n* Patients who were dependent on alcohol or opioids.\n* Patients with severe mental or intellectual disabilities.\n* Patients with severe ocular conditions, such as ocular trauma, optic nerve tumors, or those wearing ocular prostheses.",true,"16 Years",{"count":216,"type":20},[53],"The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients. The main questions it aims to answer are：\n\n* Do different ventilation patterns affect intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Does PRVC mode reduce intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Whether intracranial pressure can be quickly measured by monitoring a patient's optic nerve sheath diameter (ONSD)？ Researchers randomized bariatric surgery patients into PC, VC, and PRVC groups for comparison, looking at breathing mechanics, PaCO2, and ICP.\n\nParticipants will:\n\n* take PC mode ventilation, VC mode ventilation, and PRVC mode ventilation\n* monitor Respiratory mechanics, PaCO2, and ONSD",[294,295,24,296],"Ventilation","Bariatric Surgery","Carbon Dioxide","2025-02-28",{"date":299,"type":33},"2025-03-05",{"date":301,"type":33},"2024-03-01",{"date":303,"type":20},"2025-03-30",{"name":305,"class":40},"Yu-Long Jia",{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":214,"enrollmentInfo":313,"targetDuration":4,"studyType":51,"phases":315,"briefSummary":316,"conditions":317,"keywords":321,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":4},"100559087","evaluation-of-postoperative-intracranial-pressure-in-patients-undergoing-intracranial-tumor-surgery-100559087","NCT06559566","Evaluation of Postoperative Intracranial Pressure in Patients Undergoing Intracranial Tumor Surgery","Comparison of Two Methods Used to Asses Postoperative Intracranial Pressure in Patients Undergoing Intracranial Tumor Surgery","Inclusion Criteria:\n\n* Patients over 18 -65 years\n* Brain malignant neoplasm tumor\n* Brain benign neoplasm supratentorial\n* Brain benign neoplasm infratentorial information\n\nExclusion Criteria:\n\n* Patients who cannot provide adequate image quality in ocular ultrasonography\n* Who are unconscious or have a Glasgow coma scale of less than 15\n* Pseudotumor cerebri\n* Optic nerve arachnoid cyst\n* Patients with open injuries involving the eyelid and surrounding area\n* Optic nerve malignant neoplasm\n* Injury of the optic nerve and its pathways\n* Systemic Lupus Erythematosis,\n* Scleroderma\n* Multiple Sclerosis, sarcoidosis\n* Thyrotoxicosis (hyperthyroidism)",{"count":314,"type":20},50,[53],"Ultrasonography(USG)-guided optic nerve sheath diameter measurement and its correlation with brain computed tomography in the evaluation of intracranial pressure in patients who underwent intracranial brain tumor surgery.",[318,319,320],"INTRACRANIAL TUMOR","INTRACRANIAL PRESSURE","OPTIC NERVE",[320,319,318,322,323],"INTRACRANIAL TUMOR SURGERY","Intracranial Pressure Change","2024-08-15",{"date":326,"type":33},"2024-08-19",{"date":328,"type":20},"2024-09-15",{"date":330,"type":20},"2025-05-01",{"name":332,"class":333},"Sezen Kumaş Solak","OTHER_GOV"]