[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intranasal-administration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intranasal-administration":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642691","phase-4-intranasal-esketamine-dexmedetomidine-combination-and-postpartum-depression-100642691",false,"NCT07639099","Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression","Impact of Intranasal Esketamine-dexmedetomidine Combination on Postpartum Depression in Parturients With Prenatal Depressive Symptoms: a Randomized, Double-blind, and Placebo-controlled Trial","Inclusion Criteria:\n\n* Pregnant women aged ≥18 years who are preparing for childbirth;\n* Positive prenatal depression screening, defined as a Patient Health Questionnaire-9 (PHQ-9) score ≥5.\n\nExclusion Criteria:\n\n* History of schizophrenia or existence of communication barriers;\n* Severe obstetric complications, including severe preeclampsia, placenta accreta, HELLP syndrome, placenta previa, placental abruption, or ASA physical status classification \\>III;\n* Contraindications to ketamine\u002Fesketamine, including refractory hypertension, severe cardiovascular disease (NYHA class ≥III), or hyperthyroidism;\n* Contraindications to dexmedetomidine, including severe bradycardia (heart rate \\\u003C50 bpm), or second-degree or higher atrioventricular block;\n* Unsuitable for intranasal administration due to nasal cavity diseases (e.g., rhinitis, nasal polyps, or nasal congestion of any cause);\n* Refusal to participate in this study or concurrent participation in another clinical trial.","FEMALE","18 Years",{"count":19,"type":20},164,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Esketamine has rapid-onset antidepressant effects and may reduce postpartum depression in parturients with prenatal depressive symptoms. However, its adverse neuropsychiatric symptoms limits clinical application. Dexmedetomidine can alleviate these adverse symptoms and has independent antidepressant effect. This randomized, double-blind, placebo-controlled trial is designed to evaluate whether intranasal esketamine combined with dexmedetomidine can reduce the prevalence of postpartum depression in women with prenatal depressive symptoms.",[26,27,28,29,30,31],"Parturients","Depressive Symptoms","Esketamine","Dexmedetomidine","Intranasal Administration","Postpartum Depression",[26,33,28,29,34,35],"Prenatal depressive symptoms","Intranasal administration","Postpartum depression","NOT_YET_RECRUITING","2026-06-11",{"date":39,"type":40},"2026-06-15","ACTUAL",{"date":42,"type":20},"2026-06",{"date":44,"type":20},"2029-12",{"name":46,"class":47},"Peking University First Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":48},"100629817","phase-4-intranasal-dexmedetomidine-esketamine-administration-and-postoperative-pain-in-pediatric-patients-100629817","NCT07479602","Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients","Impact of Intranasal Dexmedetomidine-esketamine Administration on Postoperative Pain in Pediatric Patients Undergoing Adenotonsillectomy: a Randomized, Placebo-controlled Trial","Inclusion Criteria:\n\n* Aged 3-7 years old.\n* Scheduled to undergo adenoidectomy and\u002For tonsillectomy under general anesthesia.\n* Provides written informed consent by the guardian.\n\nExclusion Criteria:\n\n* Unsuitable for intranasal administration due to nasal diseases (such as rhinitis, nasal polyps, or any condition causing nasal congestion).\n* Clearly diagnosed cardiovascular and respiratory diseases.\n* Communication barriers due to delayed neurological development or visual or hearing impairments.\n* Traumatic brain injury or neurosurgery.\n* Abnormal liver and kidney function (biomarkers higher than twice of the upper normal limits).\n* Amercian Society of Anesthesiologists classification ≥ III.\n* Body mass index higher than the 95th percentile of the age- and sex-standardized references.\n* Allergic to dexmedetomidine and\u002For esketamine.\n* Any other conditions that are deemed unsuitable for study participation.","ALL","3 Years","7 Years",{"count":60,"type":20},160,[23],"Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain. Currently, there is a lack of clinical strategies to safely and effectively manage postoperative pain in children undergoing adenoid and tonsil surgery. Dexmedetomidine and esketamine can achieve appropriate sedation levels and alleviate postoperative pain when used in children. Both drugs can be administered intranasally, and their pharmacological effects complement each other, reducing side effects. This study aims to investigate whether intranasal administration of dexmedetomidine-esketamine combination can improve postoperative analgesia in children undergoing adenoid and tonsil surgery.",[64,65,30,29,28,66],"Adenotonsillectomy","Children","Postoperative Pain",[64,65,34,29,28,68],"Postoperative pain","RECRUITING","2026-04-08",{"date":72,"type":40},"2026-04-09",{"date":74,"type":40},"2026-04-07",{"date":76,"type":20},"2027-02",{"name":46,"class":47}]