[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intranasal-dexmedetomidine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intranasal-dexmedetomidine":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100634330","phase-2-minimizing-delirium-with-nasal-dexmedetomidine-induced-sleep-middies-100634330",false,"NCT07538284","MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)","Minimizing Delirium With Nasal Dexmedetomidine-Induced Sleep in Older Patients Undergoing Major Abdominal Surgery: : a Randomized, Double-blind, Placebo-controlled Trial","MIDDIES","Inclusion Criteria:\n\n* Aged 65-90 years\n* Scheduled for a major abdominal surgery with estimated surgery time ≥ 2 hours\n\nExclusion Criteria:\n\n* Blind, deafness or the inability to speak mandarin\n* Allergy to dexmedetomidine.\n* Renal and liver failure requiring dialysis or Child-Pugh score \\> 5\n* Follow-up difficulties (i.e. active substance abuse, psychotic disorder, homelessness)\n* Previous major abdominal or cardiac surgery within 1 year of surgical procedure\n* Chronic therapy with benzodiazepines and\u002For antipsychotics. Severe deficit due to structural or anoxic brain damage\n* Body weight \\\u003C 35 kg","ALL","65 Years","90 Years",{"count":21,"type":22},400,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE2","PHASE3","This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.",[29,30,31,32],"Major Abdominal Surgery","Postoperative Delirium (POD)","Sleep Disturbances","Intranasal Dexmedetomidine",[34,35],"dexmedetomidine","intranasal administration","NOT_YET_RECRUITING","2026-04-12",{"date":39,"type":40},"2026-04-20","ACTUAL",{"date":42,"type":22},"2026-05-01",{"date":44,"type":22},"2027-06-30",{"name":46,"class":47},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER"]