[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intraoperative-hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intraoperative-hypotension":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,49,69,92,123,136,165,197,225,248,279,301,326,355,377,398,424,450,474],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053808","pro-stress-trial-proactive-low-dose-norepinephrine-to-reduce-intraoperative-fluid-administration-in-patients-at-high-risk-for-postoperative-pulmonary-complications-undergoing-laparoscopic-abdominal-surgery-100053808",false,"NCT07627360","PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery","Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","PRO STRESS","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours.\n* Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications.\n\nExclusion Criteria:\n\n* Known hypersensitivity to norepinephrine.\n* Severe left ventricular dysfunction with ejection fraction \\\u003C 35%.\n* Significant cardiac arrhythmia.\n* Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg.\n* End-stage renal disease.\n* Requirement for vasopressor support before induction of anesthesia.\n* Emergency surgery.","ALL","18 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications. This randomized double-blind controlled trial evaluates whether proactive administration of fixed low-dose norepinephrine reduces intraoperative crystalloid administration while maintaining hemodynamic stability in high-risk patients undergoing laparoscopic abdominal surgery. One hundred and thirty patients will be randomized to receive either norepinephrine infusion (0.03 µg\u002Fkg\u002Fmin) or placebo from induction until skin closure within a protocolized hemodynamic strategy guided by mean arterial pressure and pulse pressure variation.",[27,28,29],"Intraoperative Hypotension","Postoperative Pulmonary Complications (PPCs)","Fluid Over-load",[31,32,33,34,35],"Norepinephrine","Fluid Therapy","Pulmonary Complications","Abdominal Surgery","Vasopressor","NOT_YET_RECRUITING","2026-07-10",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":21},"2026-07-15",{"date":44,"type":21},"2026-11",{"name":46,"class":47},"Suez Canal University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":48},"100054121","internal-jugular-vein-collapsibility-index-as-a-predictor-of-hypotension-100054121","NCT07692425","Internal Jugular Vein Collapsibility Index as a Predictor of Hypotension","Internal Jugular Vein Collapsibility Index as a Predictor of Hypotension After The Induction of General Anesthesia in Geriatric Patients Undergoing Laparoscopic Colorectal Surgeries: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged ≥ 60 years.\n* Scheduled for elective laparoscopic colorectal surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Patients' refusal of procedure or participation in the study.\n* Severe aortic stenosis, irregular ventricular rhythm (atrial fibrillation or frequent premature ventricular contractions), or any contraindication to perform passive leg raise (PLR).","60 Years",{"count":58,"type":21},70,"OBSERVATIONAL","The internal jugular vein (IJV) collapsibility index has been proposed as a practical alternative of of the inferior vena cava collapsibility index (IVC-CI), as it is easily accessible using bedside ultrasonography. Several studies have demonstrated a correlation between IJV collapsibility and central venous pressure as well as right atrial pressure.",[27],{"date":39,"type":40},{"date":64,"type":21},"2026-07-11",{"date":66,"type":21},"2027-02-11",{"name":68,"class":47},"Ain Shams University",{"id":70,"slug":4,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":48},"100581857","NCT06855758","Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation","Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation, A Double-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with end-stage renal disease aged 18 years or above\n\nExclusion Criteria:\n\n* simultaneous multiple organ transplantation\n* known allergy to study medication\n* known pregnancy status\n* cancellation of surgery due to grafts or personal reasons\n* persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications\n* any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study",{"count":76,"type":21},150,[24],"Prospective double blind randomized controlled trial. By randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed dobutamine group, the investigators compared the effect of intraoperative blood pressure maintenance and the dosage of the vasoactive drug, postoperative graft function, delayed graft function, and other related complications between the two groups, in order to demonstrate whether the use of terlipressin for blood pressure regulation during kidney transplantation is superior to the existing treatments.",[80,81,27],"Kidney Transplant","Delayed Graft Function","RECRUITING","2026-06-16",{"date":85,"type":40},"2026-06-17",{"date":87,"type":40},"2025-03-06",{"date":89,"type":21},"2027-06",{"name":91,"class":47},"Beijing Friendship Hospital",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":101,"targetDuration":102,"studyType":59,"phases":4,"briefSummary":103,"conditions":104,"keywords":108,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":48},"100642441","internal-jugular-vein-ultrasound-and-acute-kidney-injury-after-abdominal-surgery-100642441","NCT07638306","Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery","Dynamic Internal Jugular Vein Assessment During Anesthesia Induction as a Predictor of Hemodynamic Instability and Postoperative Outcomes","PRO-JUGULAR","Inclusion Criteria:\n\n* Elective or Urgent (Non-emergent) major abdominal\u002F visceral surgery under general anesthesia\n* General anesthesia with propofol induction (TCI\u002F manual)\n* Expected surgical duration \\> 60 minutes\n* Continous BP monitoring (Invasive arterial line or non-invasive cuff at 2 minute recording intervals)\n* Serum creatinine and eGFR (CKD-EPI) available within 30 days prior to surgery\n* Written informed consent obtained before surgery\n* Patient accessible by phone 30 days postoperatively\n\nExclusion Criteria:\n\n* Emergency surgery (immediate life-saving, consent unobtainable)\n* End-stage renal disease (eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m²) or dialysis-dependent\n* Concomitant cardiac surgery or carotid endarterectomy\n* Liver transplantation\n* Known Internal Jugular Vein\u002F Inferior Vena Cava thrombosis or Superior Vena Cava syndrome\n* Any anatomical neck abnormalities precluding Internal jugular vein ultrasound\n* Induction with ketamine or etomidate as sole Induction agent\n* Neuraxial anesthesia (spinal or epidural) before propofol induction\n* Active decompensated heart failure (NYHA IV or acute pulmonary edema at time of Surgery)\n* Same-admission reoperation within 30-day study window\n* Withdrawal of consent at any point",true,{"count":76,"type":21},"1 Month","This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are:\n\n1. Can the internal jugular vein collapsibility index before anesthesia predict low blood pressure during induction?\n2. Can the change in internal jugular vein collapsibility from before to just after anesthesia predict low blood pressure during surgery and acute kidney injury after surgery?\n\nParticipants will have routine ultrasound scans of the neck before anesthesia and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests. and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests.",[27,105,106,107],"Jugular Veins","Hypotension on Induction","General Anesthesia With Propofol",[109,110,111,112,113],"Post-induction Hypotension","Internal Jugular Vein","Collapsibility Index","Propofol Induction","Acute Kidney Injury","2026-06-11",{"date":116,"type":40},"2026-06-15",{"date":118,"type":21},"2026-06-01",{"date":120,"type":21},"2027-03-28",{"name":122,"class":47},"Tîrgu Mureș Emergency Clinical County Hospital, Romania",{"id":124,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":25,"conditions":127,"keywords":128,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":135,"locationsCount":48},"100639434",{"count":20,"type":21},[24],[27,28,29],[31,32,33,34,35],"2026-05-31",{"date":131,"type":40},"2026-06-04",{"date":133,"type":21},"2026-05-23",{"date":44,"type":21},{"name":46,"class":47},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":148,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":48},"100616107","hypotension-prediction-index-hpi-and-assisted-fluid-management-afm-for-perioperative-hemodynamic-optimization-in-patients-under-general-anesthesia-100616107","NCT07301307","Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia","The Use of the Hypotension Prediction Index (HPI) Combined With the Assisted Fluid Management (AFM) Software for Perioperative Hemodynamic Optimization in Patients Undergoing General Anesthesia.","Inclusion Criteria:\n\n* Age \\> 18 years\n* Intraoperative monitoring \\> 2 hours or general anesthesia \\> 2 hours\n* Invasive arterial pressure monitoring\n* Target MAP ≥ 65 mm Hg intraoperatively\n* Written informed consent preoperatively\n* ASA Physical Status ≤ 4\n\nExclusion Criteria:\n\n* Target MAP other than 65 mm Hg\n* Severe preoperative hypotension (MAP \\\u003C 65 mm Hg)\n* Severe heart failure (e.g. LVEF \\\u003C 20%)\n* Emergency surgery",{"count":144,"type":21},100,[24],"This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia. The main question is :\n\nDoes the HPI and AFM software reduce the incidence and duration of intraoperative hypotension? Does the HPI and AFM software optimize fluid and vasopressor administration? Does the HPI and AFM software improve perioperative outcomes? Participants will be randomly allocated to either an experimental group receiving goal directed hemodynamic therapy guided by HPI and AFM or a control group receiving conventional hemodynamic management.",[27],[27,149,150,151,152,153,154,155],"Perioperative Hemodynamic Optimization","Goal-Directed Hemodynamic Therapy","Hypotension Prediction Index","Assisted Fluid Management","Invasive Arterial Pressure Monitoring","Artificial Intelligence","Perioperative Care","2026-04-16",{"date":158,"type":40},"2026-04-20",{"date":160,"type":40},"2026-03-15",{"date":162,"type":21},"2027-03",{"name":164,"class":47},"National and Kapodistrian University of Athens",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":173,"targetDuration":175,"studyType":59,"phases":4,"briefSummary":176,"conditions":177,"keywords":181,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":48},"100623438","machine-learning-assisted-management-of-intraoperative-hypotension-for-personalized-treatment-100623438","NCT07396636","Machine Learning-Assisted Management of Intraoperative Hypotension for Personalized Treatment","Machine Learning-Assisted Intraoperative Hypotension Management: Developing Personalized Treatment Recommendations","HYPOGUARD","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled for elective surgical procedures\n* Procedures performed under general anesthesia\n* Availability of continuous invasive arterial blood pressure monitoring during the intraoperative period\n* Planned surgical duration of at least 2 hours\n* Ability to provide written informed consent for participation in the study\n\nExclusion Criteria:\n\n* Emergency surgery\n* Diagnosis of sepsis, septic shock, or advanced cardiogenic shock\n* Cardiac rhythm disturbances that prevent reliable hemodynamic measurements (e.g., atrial fibrillation)\n* Severe left ventricular dysfunction or advanced heart failure (ejection fraction \\\u003C30%)\n* Inability to maintain intraoperative arterial cannulation due to technical or clinical reasons\n* Inability to provide informed consent (e.g., cognitive impairment or refusal to participate)",{"count":174,"type":21},50,"1 Day","Intraoperative hypotension, defined as a drop in blood pressure during surgery, is a frequent event in patients undergoing general anesthesia. Even brief episodes of low blood pressure may reduce blood flow to vital organs such as the brain, heart, and kidneys, and have been associated with an increased risk of postoperative complications, prolonged recovery, and worse clinical outcomes. Despite its clinical importance, the management of intraoperative hypotension is often based on general guidelines and individual clinician experience rather than patient-specific physiological mechanisms.\n\nLow blood pressure during surgery can occur for different underlying reasons, including reduced circulating blood volume, excessive vasodilation caused by anesthetic agents, impaired heart contractility, or abnormalities in heart rate. In routine practice, these mechanisms are not always clearly distinguished, and similar treatment strategies may be applied to patients with different physiological causes of hypotension. As a result, the response to treatment can vary widely between patients.\n\nThis prospective observational study aims to improve the understanding of intraoperative hypotension by collecting detailed hemodynamic data during surgery and analyzing these data using machine learning methods. The study is designed to observe current clinical practice without altering or interfering with routine patient care. All decisions regarding anesthesia management and treatment of hypotension will be made by the attending anesthesiologists according to standard clinical practice. The research team will not provide treatment recommendations during surgery.\n\nAdult patients undergoing elective surgery under general anesthesia with continuous invasive arterial blood pressure monitoring will be included. During the intraoperative period, blood pressure, heart rate, cardiac output, stroke volume, systemic vascular resistance, and other advanced hemodynamic parameters will be continuously recorded at regular intervals. When hypotension occurs, the onset, duration, and severity of the episode will be documented, along with the treatment applied, such as fluid administration, vasopressor agents, or inotropic medications. The time required for blood pressure to recover to an acceptable level will also be recorded.\n\nThe collected data will be analyzed using machine learning techniques to identify distinct subtypes of intraoperative hypotension based on physiological patterns. These subtypes may reflect different underlying mechanisms, such as hypovolemia, vasodilation, myocardial depression, or heart rate-related causes. In addition, the study will evaluate how different treatment strategies perform across these hypotension subtypes and how quickly hemodynamic stability is restored.\n\nPatient-related factors such as age, sex, body mass index, physical status classification, and comorbid conditions will also be examined to determine their relationship with the occurrence, severity, and treatment response of hypotension episodes. By combining patient characteristics, physiological data, and treatment responses, the study aims to generate data-driven insights into personalized hypotension management.\n\nThe ultimate goal of this research is to support the development of individualized treatment recommendations for intraoperative hypotension based on objective physiological data rather than a one-size-fits-all approach. The findings of this study are expected to provide a strong scientific foundation for future clinical decision-support systems that can assist anesthesiologists in selecting the most appropriate treatment strategy for each patient. By improving the precision of blood pressure management during surgery, this approach has the potential to enhance patient safety and perioperative outcomes while maintaining standard clinical workflows.",[27,155,178,179,180],"Hemodynamic Monitoring","Blood Pressure","Anesthesia, General",[182,183,184,185,186],"Intraoperative hypotension","Machine learning","Personalized treatment","Clinical decision support","Hemodynamic instability","2026-04-06",{"date":189,"type":40},"2026-04-09",{"date":191,"type":40},"2026-03-03",{"date":193,"type":21},"2026-09-30",{"name":195,"class":196},"Nevsehir Public Hospital","OTHER_GOV",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":212,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":219,"completionDateStruct":220,"leadSponsor":222,"locationsCount":224},"100602451","ai-assisted-blood-pressure-control-during-anesthesia-100602451","NCT07123675","AI-Assisted Blood Pressure Control During Anesthesia","A Dual-Center, Randomized, Controlled, Proof-of-Concept Trial to Evaluate an AI-Based Decision Support System for Intraoperative Blood Pressure Management","RL-PRAIS PoC","Inclusion Criteria:\n\n* Age 18 to 85 years\n* Scheduled for elective non-cardiac surgery\n* Receiving intravenous-inhalation combined general anesthesia with tracheal intubation\n* ASA physical status I to IV\n* Anesthesia maintenance plan includes propofol for continuous sedation, remifentanil for continuous analgesia, and sevoflurane or desflurane for inhalation anesthesia\n* Continuous invasive arterial blood pressure monitoring during surgery\n* Continuous monitoring of heart rate and Bispectral Index (BIS) during surgery\n* Expected surgical duration of at least 2 hours\n\nExclusion Criteria:\n\n* Emergency surgery\n* Continuous infusion of remifentanil or propofol for less than 30 minutes during surgery\n* Receiving continuous intravenous sedatives other than propofol during the maintenance phase\n* Receiving continuous intravenous analgesics other than remifentanil during the maintenance phase\n* Inhaled anesthetic maintenance concentration not equal to 0.5 MAC\n* Known allergy to propofol or remifentanil\n* Severe obesity (BMI \\>= 35 kg\u002Fm2)\n* Severe cardiovascular disease (NYHA class IV heart failure, unstable angina, or recent myocardial infarction within 30 days)\n* Participation in another interventional clinical trial within 30 days","85 Years",{"count":207,"type":21},40,[24],"This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.\n\nBackground: Intraoperative hypotension is common during general anesthesia and is associated with adverse outcomes including acute kidney injury, myocardial injury, and increased mortality. Current hemodynamic management relies on the individual anesthesiologist's clinical judgment, which can vary in consistency and timeliness. An RL-based system that learns optimal vasoactive agent dosing strategies from clinical data may help standardize and improve real-time hemodynamic decision-making.\n\nPurpose: The primary objective is to evaluate whether the RL-based decision support system can learn intraoperative hemodynamic management decisions comparable to those of experienced anesthesiologists, as measured by the mean absolute error (MAE) between RL-recommended and clinician-executed vasoactive agent doses. The secondary objective is to assess whether RL-guided management improves clinical hemodynamic outcomes, including the time-weighted average of hypotension and the percentage of time with mean arterial pressure within the target range.\n\nParticipants: Adult patients (aged 18 to 85 years, ASA I-IV) scheduled for elective non-cardiac surgery under general anesthesia with continuous invasive arterial blood pressure monitoring.\n\nProcedures: Participants will be randomly assigned (1:1) to one of two groups. In the RL-guided group, the anesthesiologist will receive real-time vasoactive agent dosing recommendations from the decision support system displayed on a bedside screen; the anesthesiologist retains full clinical autonomy over all final decisions. In the standard care group, the anesthesiologist will manage hemodynamics according to institutional standard practice without input from the system. The patient and the outcomes assessor will be masked to group assignment. Data collection covers the intraoperative period and 30-day postoperative follow-up.",[27,211],"Hemodynamic Instability",[213,214,215,154,216],"Reinforcement Learning","Clinical Decision Support System","Depth of Anesthesia","Vasoactive Agent Dosing","2026-04-01",{"date":187,"type":40},{"date":118,"type":21},{"date":221,"type":21},"2027-12-15",{"name":223,"class":47},"Beijing Tsinghua Chang Gung Hospital",2,{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":233,"minAge":18,"maxAge":4,"enrollmentInfo":234,"targetDuration":4,"studyType":22,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":48},"100619789","oscillometric-versus-intraarterial-blood-pressure-monitoring-during-robot-assisted-prostatectomy-100619789","NCT07349186","Oscillometric Versus Intraarterial Blood Pressure Monitoring During Robot-Assisted Prostatectomy","Oscillometric Versus Intraarterial Blood Pressure Monitoring to Reduce Intraoperative Hypotension During Robot-Assisted Prostatectomy: A Non-Inferiority Randomized Trial","PROST-BP","Inclusion Criteria:\n\n* male patient ≥18 years\n* scheduled for elective robot-assisted (Da Vinci) radical prostatectomy in steep Trendelenburg position\n* planned intraarterial blood pressure monitoring\n\nExclusion Criteria:\n\n* patients in whom the attending anesthesiologist considers intraarterial blood pressure monitoring to be mandatory for clinical reasons\n* patients participating in another interventional trial likely to influence intraoperative blood pressure management","MALE",{"count":235,"type":21},210,[24],"The PROST-BP trial is a prospective, single-center, randomized, patient-blinded, non-inferiority trial investigating whether intermittent oscillometric blood pressure monitoring is non-inferior to continuous intraarterial blood pressure monitoring in reducing intraoperative hypotension in patients having robot-assisted radical prostatectomy.",[27],"2026-01-30",{"date":241,"type":40},"2026-02-02",{"date":243,"type":40},"2026-01-29",{"date":245,"type":21},"2027-02",{"name":247,"class":47},"University of Hamburg-Eppendorf",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":256,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":261,"conditions":262,"keywords":265,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":278},"100584125","phase-3-noradrenaline-versus-standard-blood-pressure-management-for-perioperative-hypotension-in-non-cardiac-surgery-100584125","NCT06885268","Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery","The Effect of Noradrenaline Infusion Versus Standard Blood Pressure Management on Perioperative HYPotension in NOn-caRdiac Surgery HYP-NOR Trial","HYP-NOR","Inclusion Criteria:\n\n1. ≥45 years old\n2. Elective or accelerated\\* non-cardiac surgery expected to last ≥1 hour and requiring general, neuraxial, or combined general with neuraxial anesthesia\n3. Expected to stay overnight in the hospital after surgery\n4. Written informed consent to participate in the HYP-NOR Trial provided\n5. American Society of Anesthesiologists (ASA) physical status class II or higher.\n\nExclusion Criteria:\n\n1. Newly diagnosed, untreated, or uncontrolled hypertension -in two measurements on the day before surgery Systolic Blood Pressure (SBP) ≥180 mm Hg or Diastolic Blood Pressure (DBP) ≥110 mm Hg\n2. Persistent difference in recorded SBP between right and left upper limb \\>10 mm Hg\n3. Persistent atrial fibrillation\n4. Have a documented history of dementia\n5. Have language, vision, or hearing impairments that may compromise cognitive assessments\n6. Have a condition that precludes routine blood pressure management such as surgeon request for relative hypotension\n7. Receiving irreversible nonselective monoamine oxidase inhibitors (e.g. tranylcypromine, phenelzine) within 2 weeks preceding study enrolment\n8. The use of tricyclic antidepressants\n9. Have Prinzmetal angina\n10. Have contraindications to noradrenaline per clinician judgement\n11. Noradrenaline infusion started before surgery or plan to use continuous noradrenaline infusion throughout the procedure\n12. Treating physician (surgeon\u002Fanaesthetist) decides on the necessity of extended continuous hemodynamic monitoring during or after surgery\n13. Severe kidney disease (MDRD creatinine clearance \\\u003C15 mL\u002Fmin\u002F1.73m2) or renal replacement therapy\n14. End-stage heart failure: defined as NYHA Class IV - severe limitations in daily activity. Patients experience symptoms even while at rest. Mostly bedbound patients.\n15. Known severe liver disease: defined as the presence of liver cirrhosis or any of the symptoms of severe liver dysfunction: portal hypertension (esophageal varices, ascites), hepatocellular insufficiency (e.g., jaundice, hepatic encephalopathy) and coagulopathy (prolonged INR\u002FAPTT associated with known liver dysfunction).\n16. Emergency and urgent surgery defined as performed within 24 hours of sudden illness\u002Funplanned admission to hospital\n17. Have previously participated in the trial: patient already took a part in the HYP-NOR trial in the past\n18. Pregnant or breastfeeding women.","45 Years",{"count":258,"type":21},750,[260],"PHASE3","The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery.\n\nThe study aims to determine whether perioperative noradrenaline infusion is superior to standard blood pressure management for the occurrence of perioperative hypotension.",[263,27,264],"Blood Pressure Management","Non-cardiac Surgery",[266,267,268],"hypotension","noradrenaline infusion","perioperative care","2026-01-12",{"date":271,"type":40},"2026-01-14",{"date":273,"type":40},"2025-06-25",{"date":275,"type":21},"2027-06-30",{"name":277,"class":47},"Jagiellonian University",5,{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":288,"conditions":289,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":48},"100619042","femoral-vein-diameter-to-predict-intraoperative-hypotension-in-geriatric-patients-undergoing-orthopedic-surgery-under-spinal-anesthesia-100619042","NCT07339475","Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia","Evaluation of Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia: A Prospective Observational Study","Inclusion Criteria:\n\n* Age \\> 60 years.\n* American Society of Anesthesiologists (ASA) physical state I-II.\n* Body mass index (BMI) ≤35 kg\u002Fm². Patients above this value will be excluded because obesity may cause technical difficulty and poor image quality in femoral vein ultrasound assessment.\n* Elective lower-limb orthopedic surgery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Patients refusing to participate.\n* History of psychiatric illness or seizures.\n* Absolute contraindications to spinal anesthesia: infection at the puncture site, severe coagulopathy\u002Fanticoagulation \\[defined as platelet count \\\u003C75,000\u002FµL, International Normalized Ratio (INR) \\>1.5, Activated Partial Thromboplastin Time (aPTT) \\>1.5 times control, or the use of anticoagulants such as warfarin, heparin, low molecular weight heparin, or direct oral anticoagulants within the recommended safety interval for neuraxial anesthesia\\], severe hypovolemia, increased intracranial pressure, or known allergy to local anesthetics.\n* Severe cardiac disease, including left ventricular ejection fraction \\\u003C30%, Severe valvular heart disease (e.g., critical aortic stenosis), clinically significant arrhythmias (atrial fibrillation with uncontrolled ventricular rate \\>120 bpm, frequent ventricular ectopy or sustained ventricular tachyarrhythmia) and congestive heart failure such as New York Heart Association (NYHA) class III-IV.\n* Severe uncontrolled hypertension, defined as persistent mean arterial pressure (MAP) ≥120 mmHg or systolic blood pressure (SBP) ≥180 mmHg and\u002For diastolic blood pressure (DBP) ≥110 mmHg despite medical therapy.\n* Severe respiratory diseases (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage III-IV chronic obstructive pulmonary disease, or forced vital capacity (FVC) \\\u003C50% predicted).\n* Baseline bradycardia (\\\u003C50) or mean arterial blood pressure less than 60mmHg.\n* Emergency surgeries.",{"count":287,"type":21},43,"The study aims to assess whether the transverse diameter of the right common femoral vein (RCFV) in the inguinal region could reflect the degree of post-spinal hypotension during elective orthopedic surgery.",[290,27,291,292],"Femoral Vein Diameter","Orthopedic Surgery","Spinal Anesthesia","2026-01-05",{"date":271,"type":40},{"date":296,"type":40},"2025-12-01",{"date":298,"type":21},"2026-07-01",{"name":300,"class":47},"Cairo University",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":17,"minAge":308,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":313,"conditions":314,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":48},"100589299","phase-4-effect-of-ciprofol-on-intraoperative-hypotension-in-elderly-patients-receiving-renin-angiotensin-system-inhibitors-100589299","NCT06952608","Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors","The Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors: a Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients undergoing elective abdominal surgery under general anesthesia\n2. Duration of surgery exceeding 2 hours\n3. Patients receiving long-term renin-angiotensin system inhibitor therapy (\\>3 months prior to surgery)\n4. Age ≥ 65 years\n5. ASA classification II-III\n6. Informed consent was obtained from patients or their guardians\n\nExclusion Criteria:\n\n1. History of allergy to opioids, propofol, or ciprofol components.\n2. Anticipated difficult airway (limited mouth opening, restricted neck movement, or modified Mallampati grade III-IV) or difficult mask ventilation.\n\n   Body mass index ≤18 or ≥35 kg\u002Fm².\n3. Severe hepatic dysfunction (total bilirubin ≥3.0 mg\u002FdL or AST\u002FALT ≥2 times the upper limit of normal).\n4. Severe renal impairment (creatinine clearance ≤30 mL\u002Fmin).\n5. Cardiac diseases (AV block higher than first-degree, heart rate \\\u003C50 bpm, severe arrhythmias, severe valvular heart disease, heart failure, or unstable angina on the day of surgery).\n6. Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric illness.\n7. Abnormal thyroid-stimulating hormone levels or history of thyroid replacement therapy.\n8. Unstable asthma or history of asthma.\n9. Alcohol abuse, drug abuse, chronic opioid dependence, or analgesic use exceeding 3 months.\n10. Lactating or pregnant women.","65 Years",{"count":310,"type":21},140,[312],"PHASE4","The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors.",[27,315,316],"Ciprofol","Renin-angiotensin System Inhibitors","2025-12-22",{"date":319,"type":40},"2025-12-30",{"date":321,"type":40},"2025-04-10",{"date":323,"type":21},"2026-04-10",{"name":325,"class":47},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":100,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":334,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":335,"conditions":336,"keywords":342,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":48},"100526369","cerebral-autoregulation-in-non-cardiac-surgery-and-relationship-to-postoperative-delirium-state-100526369","NCT06133842","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State - CERBERUS Trial","CERBERUS","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Undergoing any non-cardiac surgeries including but not limited to vascular, hepatobiliary, or complex spine surgeries requiring general anesthesia with arterial catheterization for monitoring\n\nExclusion Criteria:\n\n1. Non-English speaking (Justification: cognitive assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n2. Cognitive impairment as defined by total MoCA score \\\u003C 10 (justification: baseline cognitive dysfunction will confound primary outcome measure)\n3. Significant visual impairment (justification: will be difficult for patients to draw individual components in MOCA score)\n4. Emergent surgery (justification: insufficient time to initiate intervention)\n5. History of stroke within the last 3 months (justification: cognitive dysfunction secondary to stroke can confound outcome measures",{"count":144,"type":21},"The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60 undergoing major non-cardiac surgery. The main question\\[s\\] it aims to answer are:\n\n* Is there a way to tailor the blood pressure to be maintained in such patients during surgery for optimal brain health using non-invasive monitors that check the brains electrical activity, the electroencephalogram(EEG) monitor, and the brain's blood oxygen levels, the cerebral oximetry(CO) monitor?\n* How much does this optimal blood pressure level vary between patients?\n\nParticipants will be asked to:\n\n* Complete a questionnaire at the time they enroll into the study, as well as a daily questionnaire to help determine their level of thinking and brain health. This questionnaire will be administered by a member of the study team.\n* They will also have an EEG and CO monitoring sticker placed on their foreheads. This will be connected to a monitor that will collect this data just before, during, and after their surgery. The data collected through these monitors will help us with our study goals.",[337,338,339,340,27,341],"Perioperative\u002FPostoperative Complications","Postoperative Cognitive Dysfunction","Postoperative Delirium","EEG With Periodic Abnormalities","Cerebral Hypoperfusion",[343,344,345],"EEG","Cerebral Autoregulation","Intraoperative Monitoring","2025-10-27",{"date":348,"type":40},"2025-10-28",{"date":350,"type":40},"2024-04-17",{"date":352,"type":21},"2027-07",{"name":354,"class":47},"Beth Israel Deaconess Medical Center",{"id":356,"slug":357,"hasResults":11,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":362,"maxAge":4,"enrollmentInfo":363,"targetDuration":4,"studyType":22,"phases":365,"briefSummary":366,"conditions":367,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":48},"100523152","effects-of-sufentanil-on-the-intraoperative-hemodynamics-100523152","NCT06091904","Effects of Sufentanil on the Intraoperative Hemodynamics","Effects of Sufentanil on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who undergo elective extracranial-intracranial bypass surgery\n* American Society of Anesthesiologists grade 1,2,3\n* Age \\> 18 years old\n\nExclusion Criteria:\n\n* Refuse to participate to the study\n* American Society of Anesthesiologists grade 4\n* Body Mass Index \\\u003C 18.5 kg\u002Fm2 or \\> 35 kg\u002Fm2\n* Allergic history of opioid\n* pregnant\n* MAO Inhibitor user\n* Severe respiratory insufficiency","19 Years",{"count":364,"type":21},92,[24],"This study is a randomized, controlled trial. A total of 92 patients will be randomized to receive sufentanil or remifentanil during extracranial-intracranial bypass surgery.",[27],"2025-09-10",{"date":370,"type":40},"2025-09-16",{"date":372,"type":40},"2023-11-24",{"date":374,"type":21},"2026-11-01",{"name":376,"class":47},"Seoul National University Hospital",{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":386,"conditions":387,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":396,"locationsCount":48},"100604973","impact-of-intraoperative-blood-pressure-components-on-postoperative-aki-a-phenotype-stratified-analysis-100604973","NCT07156474","Impact of Intraoperative Blood Pressure Components on Postoperative AKI: A Phenotype-Stratified Analysis","Risk Assessment of Postoperative Acute Kidney Injury and Personalized Intraoperative Hypotension Threshold Prediction Based on Blood Pressure Components in Non-Cardiac Surgery Patients","Inclusion Criteria:\n\n1. Patients undergoing non-cardiac surgery\n2. Access to intraoperatively available invasive\u002Fnoninvasive blood pressure monitoring data\n\nExclusion Criteria:\n\n1. Patients for Age \\\u003C 18 yr\n2. Patients without preoperative or postoperative creatinine records\n3. Patients undergoing urinary surgeries\n4. Patients with chronic kidney injury before surgery\n5. ASA grade \\> 5 class\n6. Anesthesia duration \\\u003C 60 min\n7. Patients for non-available lowest blood pressure data during surgery\n8. Hemodynamic records loss more than 25% of the total anesthesia duration\n9. Patients for categorical variables records missing",{"count":385,"type":21},44504,"Postoperative acute kidney injury (AKI) is a serious complication often linked to low blood pressure during surgery. This study aims to better protect patients' kidneys by personalizing how blood pressure is managed during an operation.\n\nThe project has two main goals:\n\nFirst, researchers will analyze data from over 44,000 past surgeries to identify which specific blood pressure measurements are the most critical warning signs for kidney damage.\n\nSecond, using this knowledge, they will build a smart tool (a machine learning model) to predict a unique, safe blood pressure target for each individual patient before their surgery begins.\n\nThis personalized approach is intended to give doctors a specific target to maintain during surgery, helping to prevent kidney injury and improve patient safety.",[388,27],"Postoperative Acute Kidney Injury","2025-09-04",{"date":391,"type":40},"2025-09-05",{"date":393,"type":21},"2025-09-09",{"date":395,"type":21},"2026-12-31",{"name":397,"class":47},"Lanyue Zhu",{"id":399,"slug":400,"hasResults":11,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":405,"targetDuration":175,"studyType":59,"phases":4,"briefSummary":407,"conditions":408,"keywords":409,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":423},"100531656","hypotension-prediction-index-hpi-in-lung-resections-100531656","NCT06202638","Hypotension Prediction Index (HPI) in Lung Resections","An Observational, Prospective, Non-randomized Multi-centre Cohort Feasibility Study of the Hypotension Prediction Index (HPI) in Patients Undergoing Lung Resections With the Use of One-lung Ventilation.","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status II to IV;\n* Planned invasive blood pressure monitoring during general anesthesia expected to last more than 2 hours and planned overnight hospitalization.\n* Procedures: video-assist thoracoscopic (VATS)-lobectomy, open-thoracotomy lobectomy, pneumonectomy.\n* Adults over 18 years old.\n\nExclusion Criteria:\n\n* Urgent\u002Femergency procedures.\n* Patients with known clinically important intracardiac shunts.\n* Moderate to severe valvular disease.\n* Preoperative symptomatic arrhythmias including AF.\n* Congestive heart failure with LV ejection fraction less than 35%.\n* Refusal of participation",{"count":406,"type":21},60,"Perioperative hypotension is a risk factor for perioperative complications. Advances in machine learning and artificial intelligence have produced an algorithm that predicts the occurrence of hypotension episodes by analyzing an arterial pressure waveform. This technology has not been validated in thoracic surgical patients undergoing lung resections with the use of one-lung ventilation (OLV). We planned an observational, prospective multi-centre cohort validation study of the Hypotension Prediction Index (HPI) in patients undergoing lung resection procedures with the use of one-lung ventilation and a lung-protective strategy.",[27],[410,411,412,413],"Hypotension","One Lung Ventilation","Intelligence","Artificial","2025-08-07",{"date":416,"type":40},"2025-08-12",{"date":418,"type":40},"2023-11-11",{"date":420,"type":21},"2025-12-31",{"name":422,"class":47},"John Paul II Hospital, Krakow",3,{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":17,"minAge":431,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":22,"phases":434,"briefSummary":435,"conditions":436,"keywords":440,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":48},"100334058","targeted-blood-pressure-management-and-acute-kidney-injury-after-coronary-artery-bypass-surgery-100334058","NCT03629418","Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery","Impact of Targeted Blood-pressure Management on Incidence of Acute Kidney Injury After Off-pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 50 years;\n* Scheduled to undergo off-pump CABG surgery.\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);\n* Chronic kidney disease with a glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2 or end-stage renal disease requiring renal-replacement therapy;\n* Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease;\n* Requirement of vasopressors\u002Finotropics to maintain blood pressure before surgery;\n* Second or emergency surgery;\n* Expected survival of less than 24 hours.","50 Years",{"count":433,"type":21},612,[24],"Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI. In a recent randomized controlled trial of patients undergoing major noncardiac surgery, intraoperative individualized blood-pressure management reduced the incidence of postoperative organ dysfunction. The investigators hypothesize that, for patients undergoing off-pump CABG, targeted blood-pressure management during surgery may also reduce the incidence of postoperative AKI.",[437,27,113,438,439],"Coronary Artery Bypass, Off-Pump","Preventive Medicine","Intraoperative Care",[437,27,113,438,439],"2025-07-29",{"date":443,"type":40},"2025-07-30",{"date":445,"type":40},"2018-08-14",{"date":447,"type":21},"2026-07",{"name":449,"class":47},"Peking University First Hospital",{"id":451,"slug":452,"hasResults":11,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":456,"eligibilityCriteria":457,"healthyVolunteers":11,"sex":17,"minAge":256,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":22,"phases":459,"briefSummary":460,"conditions":461,"keywords":463,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":48},"100538505","non-invasive-measurement-of-the-hypotension-prediction-index-for-the-reduction-of-intraoperative-hypotension-100538505","NCT06291714","Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension","Prospective Interventional Study Investigating a Goal-directed Therapy Based on Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Hypotension in Patients Undergoing Major Orthopedic and Trauma Surgery","Clearsight","Inclusion Criteria:\n\n* Patients undergoing major trauma or orthopedic surgery in supine position, which is defined as:\n\n  * Reconstructive Surgery of the pelvis (e.g., stabilization of fractures)\n  * Total hip arthroplasty\n  * Surgery of the proximal femur (e.g., stabilization of fractures)\n  * Total knee arthroplasty\n  * Surgery of the spine\n\n    * Performance of general anesthesia with planned duration of \\>90min\n    * Age ≥ 45 years\n\nExclusion Criteria:\n\n\\- Predefined exclusion criteria are:\n\n* Planned invasive blood pressure monitoring\n* Participation in another interventional study\n* Pregnancy and nursing mothers\n* Surgery without controlled mechanical ventilation\n* ASA I or IV\n* Arterial Fibrillation\n* Allergy against gelantine",{"count":76,"type":21},[24],"In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS. However, these studies used an invasive hemodynamic monitoring which offered a continuous surveillance of the blood pressure. In contrast, standard non-invasive blood pressure monitoring results in a blind gap between two measurements (mostly three or five minutes). In order to address this limitation, different continuous non-invasive blood pressure monitoring devices have been introduced. The next evolutional step of non-invasive cardiac output monitoring was to prevent IOH before their onset by using the Hypotension Prediction Index (HPI). Based on the Edward ́s monitoring platform, HPI is a monitoring tool which aims to predict IOH (defined as MAP\\\u003C65 mmHg for at least one minute) up to 15 min before its onset. The underlying machine learning based algorithm uses analyses features from the pressure waveform and was first calculated from a large retrospective data set of surgical patients and subsequently validated in a prospective cohort. In this study HPI showed a sensitivity of 88% and specificity of 87% for predicting IOH 15 min before its onset. Since then, own and studies of other working groups confirmed the effective prevention of IOH by the use of HPI-based GDT. Until today the arterial waveform analysis was dependent on invasive arterial measurement but since Edwards Lifesciences already promoted the start of the HPI on the ClearSight platform a non-invasive measurement will soon be possible.\n\nFurther, until now it has not yet been proven that the perioperative use of a continuous non-invasive blood pressure monitoring has a beneficial effect on the patient´s outcome.\n\nStudy objectives The aim of the study is to investigate whether a hemodynamic protocol based on continuous non-invasive cardiac output monitoring (ClearSight system) compared to standard care can reduce the incidence of IOH, postoperative AKI, and MINS in patients undergoing major trauma and orthopedic surgery.",[27,113,462],"Myocardial Injury After Non-cardiac Surgery",[27,151,464],"Clearsight system","2025-03-31",{"date":467,"type":40},"2025-04-03",{"date":469,"type":40},"2024-08-01",{"date":471,"type":21},"2026-03-31",{"name":473,"class":47},"University of Giessen",{"id":475,"slug":476,"hasResults":11,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":22,"phases":482,"briefSummary":483,"conditions":484,"keywords":485,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":496,"locationsCount":48},"100586008","hypotension-prediction-index-and-intraoperative-hypotension-incidence-100586008","NCT06909786","Hypotension Prediction Index and Intraoperative Hypotension Incidence","Effect of Intraoperative Implementation of the Hypotension Prediction Index (HPI) Guided Management Strategy on Incidents of Intraoperative Hypotension Among Frail Patients Undergoing Major Abdominal Surgery","Inclusion Criteria:\n\n* Age\\> 60 years old\n* Frail score \\> 2\n* ASA≥2\n* Planned to receive general anesthesia\n* Elective laparoscopic or laparotomy major abdominal surgery with an expected duration of \\> 180 minutes\n* Planned to receive an arterial line monitoring intraoperatively\n* Being able to give written informed consent prior to surgery\n\nExclusion Criteria:\n\n* Severe cardiac arrhythmia including atrial fibrillation\n* Severe aortic stenosis\n* Uncontrolled Hypertension (sitting systolic blood pressure ≥ 160 mmHg and\u002For diastolic blood pressure ≥100 mmHg during screening)\n* Significant hypotension before surgery defined as a MAP \\\u003C65mmHg\n* Chronic kidney disease with glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73 m2 or requiring renal-replacement therapy for end-stage renal disease\n* Organ transplant surgery, surgery involving the kidney, liver surgery requiring hilar blockage, surgery requiring controlled hypotension or controlled low central venous pressure",{"count":144,"type":21},[24],"This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery. Investigators hypothesize that the use of this algorithm will alter treatment of hypotension and reduces the amount of hypotension as measured by the time weighted average (TWA) during non-cardiac surgery and to anticipate a reduction of postoperative AKI incidents, to explore the clinical benefits of impact of Acumen guided algorithm hemodynamic management in postoperative intestinal function recovery, and postoperative cardiac complications.",[27],[486,487,488,489],"intraoperative hypotension","hypotension prediction index","frail patient","acute kidney injury","2025-03-27",{"date":492,"type":40},"2025-04-04",{"date":494,"type":21},"2025-04-01",{"date":420,"type":21},{"name":497,"class":47},"First Affiliated Hospital Xi'an Jiaotong University"]