[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intraoperative-monitoring\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intraoperative-monitoring":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100639010","reducing-red-blood-cell-transfusion-requirements-for-adults-undergoing-surgical-resection-of-the-liver---a-quality-improvement-project-100639010",false,"NCT07629648","Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project","Reducing Red Blood Cell Transfusion Requirements for Hepatectomy - A Quality Improvement Project","Inclusion Criteria:\n\n* Liver resection in this study is defined according to the PRICE-2 trial, involving 3 or more liver segments, such as right posterior sectionectomy (of segments VI and VII) as well as central resections involving segments IVb and V, along with expected blood loss of \\>250 mL\n* in patients with known liver cirrhosis, resection of a full segment was included.\n\nExclusion Criteria (defined according to the PRICE-2 trial):\n\n* current cardiac condition (e.g., MI within the last 6 months, hypertrophic cardiomyopathy, severe valvular disease, or other unstable coronary syndromes)\n* history of cerebrovascular disease (CVA within the past 6 months or severe carotid stenosis with more than 70% occlusion)\n* history of significant peripheral vascular disease (not yet revascularized with regular\u002Fongoing claudication)\n* A current pregnancy\n* A documented, patient-declared refusal to undergo phlebotomy and transfusion\n* preoperative autologous blood donation\n* presence of active infection\n* preoperative hemoglobin \\\u003C100 g\u002FL\n* GFR \\\u003C60 mL\u002Fmin\n* platelets count \\\u003C100 × 109\u002FL\n* Uncorrectable coagulopathies or other decompensated cardiac or respiratory conditions that would contraindicate acute volume depletion\n* undergoing emergency surgery\n* planned intraoperative use of cell salvage\n* inability to participate in follow up\n* in the case of repeat liver resections, previous participation in the trial","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","The goal of this clinical trial is to determine if implementing a controlled blood removal protocol (i.e. hypovolemic phlebotomy \\[HP\\] where approximately 10% of the patient's blood is removed and reinfused following hepatic resection as described in the PRICE-2 clinical trial) will reduce the rate of blood transfusions in liver resection surgery at Kingston Health Sciences Centre. Our goals (not included in the PRICE-2 trial) are as follows:\n\n* Improved monitoring of how the body responds during surgery following controlled blood removal. We will conduct blood tests to look at oxygen, carbon dioxide, lactate, and acid (pH) levels in the blood as well as urine output.\n* Standardized guidelines for how fluids and blood pressure medications are used during surgery to reduce blood loss and keep hemodynamics stable.\n* Monitor patients' recovery following surgery to track complications, injury to the heart, length of hospital stay, and outcomes for up to 90 days. We will also compare long-term recurrence rate of liver cancer compared to patients in the past at our site who did not receive the controlled blood removal (i.e., HP) prior to surgery.",[24,25,26,27,28,29],"Hepatectomy","Transfusion Requirements","Intraoperative Bleeding","Intraoperative Monitoring","Blood Cells Transfusion","Phlebotomy",[31,32,33,34,35,36,37,38],"hypovolemic phlebotomy","hepatectomy","Perioperative Care","erythrocyte transfusion","liver resection","transfusion requirements","therapeutic phlebotomy","intraoperative bleeding","NOT_YET_RECRUITING","2026-06-01",{"date":42,"type":43},"2026-06-05","ACTUAL",{"date":45,"type":20},"2026-06",{"date":47,"type":20},"2031-06",{"name":49,"class":50},"Dr. Glenio Mizubuti (MD, PhD, FRCPC)","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":51},"100614511","analysis-of-breath-sounds-during-surgery-100614511","NCT07280546","Analysis of Breath Sounds During Surgery","BREATHSOUND","Inclusion Criteria:\n\n* Age ≥ 20 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective surgery under general anesthesia\n* Provided written informed consent\n\nExclusion Criteria:\n\n* History of respiratory disease (e.g., COPD, severe asthma)\n* Previous airway surgery or anatomical abnormalities that interfere with breath sound assessment\n* Refusal to participate or inability to comply with study procedures","20 Years",{"count":61,"type":20},30,"This study aims to analyze breath sounds during surgery by using electronic stethoscope sensors attached to patients under general anesthesia. The study will evaluate whether breath sound monitoring can provide useful information for respiratory management, assist anesthesiologists in early detection of abnormal breathing events, and support safer perioperative care. A total of 30 adult patients undergoing elective surgery under general anesthesia will be enrolled.",[64,27,65],"General Anesthesia","Respiratory Sounds",[67,68,69,70,71],"Breath sounds","Perioperative care","Airway monitoring","Respiratory complications","Double-lumen endotracheal tube (DLT)","RECRUITING","2025-12-09",{"date":75,"type":43},"2025-12-12",{"date":77,"type":43},"2025-09-03",{"date":79,"type":20},"2026-09-30",{"name":81,"class":82},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":51},"100531850","evaluation-of-new-flexible-high-density-intra-operative-ecog-electrodes-for-epilepsy-surgery--epigrid--100531850","NCT06205160","Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery. ( EpiGrid )","The EpiGrid Study Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery","EpiGrid","Inclusion Criteria:\n\n* Age ≥18 years at the time of enrolment\n* Lesional epilepsy (incl. secondary mesial temporal sclerosis) that is considered a candidate for intra-operative high-density grid recordings (incl. patients who underwent sEEG preceding resective surgery)\n* Provided informed consent for study participation by the subject\n\nExclusion Criteria:\n\n* Occipital lesion\n* Surgeries involving a primary mesial temporal lesion, a disconnection, or hemispherectomy.\n* Planned ioECoG recordings during fully awake surgery and\u002For functional recordings\n* Use of anticoagulants that cannot be discontinued during the perioperative period, or a factor XIII deficiency or any other haematological disease\n* Active participation in another investigational device study\n* Any other condition that in the opinion of the investigator may adversely affect the safety of the subject or would limit the subject's ability to complete the study.\n* Insufficient understanding of Dutch language.",{"count":92,"type":20},12,"INTERVENTIONAL",[95],"NA","The objective of this prospective interventional monocentric clinical investigation is to evaluate the feasibility and performance of the flexible high-density SOFT ECoG electrode grids, manufactured by Neurosoft Bioelectronics SA (test device; TD), in comparison to regular high-density electrode grids (ADTech, CE-marked) (control device; CD) routinely used at the investigation site during epilepsy surgery.\n\nSubjects will undergo ≥ 2 additional intracranial recordings pre- and post-resection with the TD next to the standard recordings with the CD during ECoG-tailored epilepsy surgery.",[98,27],"Focal Epilepsy",[100,101,102,103,104,105,106],"intra-operative electrocorticography","HFO","epileptic biomarkers","high frequency oscillations","epilepsy surgery","flexible ECoG","subdural electrode",{"date":108,"type":43},"2025-12-10",{"date":110,"type":43},"2025-01-01",{"date":112,"type":20},"2027-03",{"name":114,"class":115},"Neurosoft Bioelectronics SA","INDUSTRY"]