[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intraoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intraoperative":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,70,94,119,139,163],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100634172","deep-learning-framework-for-continuous-depth-of-anesthesia-forecasting-100634172",false,"NCT07536230","Deep Learning Framework for Continuous Depth of Anesthesia Forecasting","Validation of a Deep Learning Framework for Continuous Forecasting of Pharmacodynamic Responses and Physiological Trajectories During General Anesthesia","Inclusion Criteria:\n\n* Patients scheduled for elective surgery requiring general anesthesia.\n* Procedures requiring continuous depth of anesthesia monitoring (BIS).\n\nExclusion Criteria:\n\n\\- Procedures where the primary anesthetic plan does not involve continuous electronic data capture.",true,"ALL",{"count":19,"type":20},115,"ESTIMATED","1 Day","OBSERVATIONAL","The integration of Artificial Intelligence (AI) in anesthesiology offers the potential to shift patient monitoring from reactive to predictive. Deep learning architectures, specifically Long Short-Term Memory (LSTM) networks, excel at processing complex, time-series data to forecast future clinical states.\n\nWhile standard PK\u002FPD models (such as the state of the art Eleveld model for Propofol and Remifentanil) estimate target-site drug concentrations (Ce), they do not account for real-time, patient-specific dynamic responses. This study aims to deploy an AI framework designed to predict future physiological states.",[25,26,27,28,29,30,31,32],"BIS","BIS-EEG","Artifical Intelligence","Intraoperative","Machine Learning","Anesthesia","Anesthesia Awareness","Predictive Model","NOT_YET_RECRUITING","2026-04-10",{"date":36,"type":37},"2026-04-17","ACTUAL",{"date":39,"type":20},"2026-06-01",{"date":41,"type":20},"2026-09-01",{"name":43,"class":44},"Universitair Ziekenhuis Brussel","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100623471","clinical-accuracy-validation-of-the-moni-patc-temperature-monitoring-patch-during-surgery-compared-with-esophageal-and-bladder-temperature-100623471","NCT07397065","Clinical Accuracy Validation of the Moni-Patc Temperature Monitoring Patch During Surgery (Compared With Esophageal and Bladder Temperature)","Moni-Patc Temperature Monitoring Patch System Clinical Accuracy Validation","Moni-Patch OR","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Subject is undergoing an elective surgical procedure expected to require at least 60min of general anesthesia and during which routine esophageal (Teso) and bladder (Tbld) temperature monitoring is expected.\n3. Subjects are expected to remain hospitalized at least overnight after surgery.\n4. Subject specifically agrees to temperature Sensor placement on the neck prior to surgery.\n5. Must be able to attach the Sensor away from the operative field (neck) with uninterrupted wireless connection between the Sensor and the Receiver (as close as possible).\n6. Use environment must meet both of the following parameters:\n\n   1. Temperature 15-40⁰ C\u002F59-104⁰ F\n   2. Humidity 30-75% RH (non-condensing)\n7. For non-English speaking subjects, a translator must be present at the time of consent.\n\nExclusion Criteria:\n\n1. Subjects unable to provide their own consent. Consent from family or LOR is not acceptable.\n2. Subjects undergoing surgical procedures who have conditions of the esophagus or bladder that contraindicate placement of these monitoring probes\u002Fsensor.\n3. Subjects whose surgery does not involve the monitoring of esophageal or bladder temperature.\n4. Subjects undergoing surgery that prohibits placement of an esophageal temperature monitoring probe\u002Fsensor (e.g. neck surgery).\n5. Subjects with medical conditions such as inflammation, scratches, redness, rash at the Sensor placement site.\n6. Subjects for whom the sensor cannot be securely adhered to the skin without floating or detaching, or accurately positioned over the carotid artery.\n7. Not for use in MRI or CT facilities.\n8. Use environment does not meet one or more parameters.","18 Years",{"count":56,"type":20},30,"Moni-Patc Temperature Monitoring Patch System, a non-invasive, continuous temperature monitoring device designed to estimate core body temperature by applying a Sensor to the neck.This clinical accuracy validation study aims to verify the accuracy and repeatability of the Moni-Patch compared with an FDA-cleared continuous esophageal and bladder temperature monitoring device used as the clinical reference.Main ObjectivesTo verify that the Moni-Patch and the reference device(esophageal and bladder) demonstrate acceptable agreement, as defined by Bland-Altman Analyses (bias within ±0.4°C and limits of agreement between -1.0°C and 1.0°C).To verify the consistency and repeatability of temperature measurements obtained from the Moni-Patch during continuous monitoring.",[59,28],"Temperature Monitoring","2026-02-05",{"date":62,"type":37},"2026-02-09",{"date":64,"type":20},"2026-02-06",{"date":66,"type":20},"2026-06-30",{"name":68,"class":69},"Murata Vios, Inc.","INDUSTRY",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":45},"100614868","venous-congestion-and-delirium-after-cardiac-surgery-100614868","NCT07285187","Venous Congestion And Delirium After Cardiac Surgery","Intraoperative Venous Congestion And Delirium After Cardiac Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n1. Patients scheduled to undergo elective cardiac surgery via a midline thoracic incision;\n2. ≥18 years;\n3. A preoperative MMSE score\\>23, without consciousness or language barriers, capable of cooperating with neurological examinations, cognitive function tests, and other assessments of neurological function.\n\nExclusion Criteria:\n\n1. Contraindications for TEE;\n2. Emergency cardiac surgery;\n3. Major vascular surgery;\n4. Redo cardiac surgery;\n5. Severe infection requiring continuous antibiotic therapy;\n6. Severe preoperative heart failure with left ventricular ejection fraction \\\u003C 30%;\n7. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy, mechanical ventilation, or cardiac arrest necessitating resuscitation);\n8. Multi-organ dysfunction;\n9. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow (such as urinary tract obstruction);\n10. Planned cardiac transplantation or ventricular assist device implantation;\n11. Pregnancy;\n12. Insufficient ultrasonographic imaging;\n13. Restarting CPB after first CPB cessation during surgery;\n14. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively;\n15. Neurological or psychiatric diagnoses that may affect cognitive performance or cognitive testing;\n16. Documented delirium before surgery.",{"count":78,"type":20},120,"Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery. The high incidence of up to 52% of POD in cardiac surgery patients lead to a range of adverse clinical outcomes.The brain tissue is enclosed in a rigid anatomical structure; when there is an obstruction to venous return from the brain, intracranial pressure can increase, and blood supply to the brain tissue can decrease, leading to central nervous system dysfunction.\n\nSystemic venous congestion can occur when there is right heart dysfunction or excessive volume load. When right heart failure and\u002For volume overload occurs, changes in right atrial pressure are transmitted to the venous system of organs throughout the body, with dilatation of the inferior vena cava (IVC), obstruction of blood return from the hepatic, portal, and renal veins, and abnormal venous flow signals and altered ultrasound Doppler flow patterns.\n\nThe primary objective of this prospective cohort study is to explore if intraoperative systemic venous congestion is associated with POD after cardiac surgery. This study will also investigate the relationship between intraoperative systemic venous congestion and postoperative complications, and the relationship between each separate venous congestion and POD after cardiac surgery.",[28,81,82,83],"Venous Congestion","Postoperative Delirium (POD)","Cardiac Surgery","RECRUITING","2025-12-16",{"date":87,"type":37},"2025-12-23",{"date":89,"type":37},"2024-11-01",{"date":91,"type":20},"2026-10-31",{"name":93,"class":44},"Zhuan Zhang",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":45},"100616351","effects-of-sevoflurane-versus-desflurane-anesthesia-under-protective-mechanical-ventilation-for-robotic-assisted-surgery-100616351","NCT07304479","Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery","Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study","Inclusion Criteria:\n\n* Age 18 to 87 years\n* Undergoing elective robotic-assisted abdominal surgery\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* ASA IV or V\n* Emergency surgery\n* Renal insufficiency\n* Clinically significant respiratory disease\n* Cardiomyopathy\n* Uncontrolled hypertension","87 Years",{"count":103,"type":20},50,"INTERVENTIONAL",[106],"NA","Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.",[109,28],"Respiratory Mechanics","2025-12-12",{"date":112,"type":37},"2025-12-26",{"date":114,"type":37},"2025-05-01",{"date":116,"type":20},"2026-02-28",{"name":118,"class":44},"National and Kapodistrian University of Athens",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":45},"100610799","venous-congestion-and-cardiac-surgery-associated-acute-kidney-injury-100610799","NCT07232277","Venous Congestion and Cardiac Surgery-Associated Acute Kidney Injury","Intraoperative Venous Congestion and Cardiac Surgery-associated Acute Kidney Injury (CSA-AKI): a Prospective Cohort Study","Inclusion Criteria:\n\n1. Patients scheduled to undergo elective cardiac surgery;\n2. ≥ 18 years.\n\nExclusion Criteria:\n\n1. Contraindications for TEE;\n2. Emergency cardiac surgery;\n3. Major vascular surgery;\n4. Redo cardiac surgery;\n5. Abnormal preoperative renal function;\n6. Severe chronic kidney disease (estimated glomerular filtration rate \\\u003C 15 ml\u002Fmin\u002F1.73 m2 or dialysis);\n7. History of kidney transplantation;\n8. Severe infection requiring continuous antibiotic therapy；\n9. Severe preoperative heart failure with left ventricular ejection fraction \\\u003C 30%;\n10. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy \\[RRT\\], mechanical ventilation, or cardiac arrest necessitating resuscitation);\n11. Multi-organ dysfunction;\n12. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow and renal artery blood flow (such as urinary tract obstruction);\n13. Planned cardiac transplantation or ventricular assist device implantation;\n14. Pregnancy;\n15. Insufficient ultrasonographic imaging;\n16. Restarting CPB after first CPB cessation during surgery;\n17. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively.",{"count":127,"type":20},114,"Venous pressure is often overlooked as an important hemodynamic parameter. Elevated venous pressure and blood stasis in organ tissues can lead to interstitial edema. Intraoperative venous blood stasis can rapidly increase interstitial pressures within organ tissues, especially in organs encapsulated by tissue envelopes, such as the kidney, thereby rapidly reducing effective circulating blood flow to the organ. Systemic venous blood stasis, which tends to occur in patients with right heart failure or pulmonary hypertension, as well as in patients with fluid overload, can lead to intraoperative stasis in multiple organs and tissues, mediating the development of multisystem complications, including acute kidney injury. Therefore, timely, effective, and accurate intraoperative assessment of systemic venous blood stasis is particularly important.\n\nWhen right heart failure and\u002For volume overload occurs in the body, changes in right atrial pressure are transmitted to the venous system of organs throughout the body, with dilatation of the inferior vena cava (IVC), obstruction of blood return from the hepatic, portal, and renal veins, and abnormal venous flow signals and altered ultrasound Doppler flow patterns.\n\nThe primary objective of this prospective cohort study is to explore if intraoperative systemic venous congestion during cardiac surgery is associated with postoperative CSA-AKI. In doing so, we seek to identify a promising physiological marker that can provide cues for the prediction of CSA-AKI. This study will also investigate the relationship between intraoperative systemic venous congestion and postoperative complications, and explore the relationship between each separate venous congestion and AKI after cardiac surgery.",[28,81,130],"Cardiac Surgery-associated Acute Kidney Injury","2025-11-13",{"date":133,"type":37},"2025-11-18",{"date":135,"type":37},"2024-10-15",{"date":137,"type":20},"2026-09-30",{"name":93,"class":44},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":104,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":159,"leadSponsor":161,"locationsCount":45},"100590369","intraoperative-combination-of-ketamine-and-magnesium-sulfate-infusions-on-postoperative-analgesia-in-open-rhinoplasty-100590369","NCT06966518","Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty","Effectiveness of Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Patients Undergoing Open Rhinoplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I - II.\n* Scheduled for rhinoplasty under general anesthesia.\n\nExclusion Criteria:\n\n* Receiving analgesic or any medications since 48 hours before the surgery.\n* Drug addiction.\n* Cardiovascular disease.\n* Respiratory disease, renal, liver, metabolic and neurological disease.\n* Pregnancy or breast feeding.\n* Asthma.","65 Years",{"count":103,"type":20},[106],"The study aims to evaluate the effectiveness of intraoperative combination of ketamine and magnesium sulfate infusions on postoperative analgesia in patients undergoing open rhinoplasty.",[28,151,152,153,154],"Ketamine","Magnesium Sulfate","Postoperative Analgesia","Rhinoplasty","2025-05-12",{"date":157,"type":37},"2025-05-13",{"date":155,"type":37},{"date":160,"type":20},"2025-10-01",{"name":162,"class":44},"Ain Shams University",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":104,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":45},"100563809","pre-operative-phentolamine-vs-intraoperative-esmolol-efficacy-for-hypotensive-anesthesia-in-functional-endoscopic-sinus-surgery-100563809","NCT06620991","Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery","Inclusion Criteria:\n\n* Age from 21 to 50 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n\nExclusion Criteria:\n\n* Patients with a medical condition that contraindicated hypotensive anesthesia, such as peripheral vascular disease, cerebrovascular stroke, carotid artery stenosis, previous myocardial infarction, ischemic heart disease, congestive heart failure, limb ischemia, uncontrolled hypertension and raised intracranial tension\n* Renal disease, liver dysfunction, pregnancy.\n* Patients on hypnotic or narcotic analgesic.\n* History of alcohol or drug abuse.\n* History of allergic reaction to any drug used in this study.\n* Bleeding diathesis.\n* Previous nasal surgery.\n* Patients on Non-steroidal anti-inflammatory drugs (NSAIDs).\n* Patients with peripheral vascular disease.","21 Years","50 Years",{"count":172,"type":20},60,[106],"The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery.",[176,177,28,178,179,180],"Preoperative","Phentolamine","Esmolol","Hypotensive Anesthesia","Functional Endoscopic Sinus Surgery","2024-09-29",{"date":183,"type":37},"2024-10-01",{"date":185,"type":20},"2024-10-10",{"date":187,"type":20},"2025-04-01",{"name":162,"class":44}]