[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intrauterine-devices\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intrauterine-devices":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100596523","methoxyflurane-for-iud-insertion-and-endometrial-biopsy-100596523",false,"NCT07046572","Methoxyflurane for IUD Insertion and Endometrial Biopsy","A Double-blind Placebo-controlled Randomized Controlled Trial (RCT) of 3ml Methoxyflurane for Intrauterine Device (IUD) Insertion and Endometrial Biopsy","Inclusion Criteria\n\n* Any participant ≥18 years and ≤ 65 years presenting for an IUD insertion or endometrial biopsy\n* For IUD insertion, only nulliparous patients\n* English speaking participants only\n* Availability of a ride home from the appointment\n\nExclusion Criteria\n\n* Use of pain medication that is not an NSAID or acetaminophen (e.g. opioids, benzodiazepines) within past 24 hours\n* Misoprostol administration within 24 hours\n* Breastfeeding\n* Any diagnosed chronic pain syndromes (e.g. fibromyalgia, vaginismus)\n* Allergy to methoxyflurane\n* Renal or liver disease\n* Known or genetically susceptible to malignant hyperthermia or a history of severe adverse reactions in either patient or relatives\n* Baseline vital signs of systolic blood pressure \\\u003C100, diastolic blood pressure \\\u003C60 and\u002For pulse \\\u003C60.\n* Previous unsuccessful office attempt of IUD insertion or endometrial biopsy by the same practitioner (note of clarification: previous unsuccessful IUD insertion or biopsy attempt by a different practitioner will still be eligible)\n* Clinically evident respiratory impairment",true,"FEMALE","18 Years","65 Years",{"count":21,"type":22},174,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to determine if 3ml of inhaled Methoxyflurane, in the form of a Penthrox inhaler, reduces pain during IUD insertion and\u002For endometrial biopsy. The proposed study is a double-blind, placebo-controlled RCT.\n\nEach participant will be randomly assigned to one of two arms:\n\n1. Intervention (3ml of Methoxyflurane via a Penthrox inhaler)\n2. Placebo (3ml of normal saline via an identical placebo Penthrox inhaler)\n\nThe primary outcome is global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) 5-minutes following the procedure (endometrial biopsy or IUD insertion).",[28,29],"Endometrial Biopsy","Intrauterine Devices",[31],"methoxyflurane","RECRUITING","2025-07-28",{"date":35,"type":36},"2025-07-30","ACTUAL",{"date":38,"type":36},"2025-07-24",{"date":40,"type":22},"2026-03-01",{"name":42,"class":43},"Mount Sinai Hospital, Canada","OTHER"]