[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intrinsic-capacity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intrinsic-capacity":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,85,112,159],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100640034","sheba-healthspan-research-population-sharp-trial---sheba-longevity-center-diagnostic-and-intervention-protocol-to-lower-biological-age-in-older-adults-100640034",false,"NCT07596576","Sheba Healthspan Research Population (SHARP) Trial - Sheba Longevity Center Diagnostic and Intervention Protocol to Lower Biological Age in Older Adults","Sheba Healthspan Research Population (SHARP) Trial","SHARP","Inclusion Criteria:\n\n* Healthy older adults \\>50 years old men and women\n\nExclusion Criteria:\n\n1. A former diagnostic of a significant cognitive reduction (MoCa score \\\u003C 24 ).\n2. Former diagnosis of neurodegenerative disease as Alzheimer's disease, Parkinson's disease, Lewy body dementia.\n3. Former diagnosis of psychiatric disease.\n4. In the past two years, underwent chemotherapy or radiation therapy.",true,"ALL","50 Years",{"count":21,"type":22},1500,"ESTIMATED","INTERVENTIONAL",[25],"NA","Background: Population aging is accelerating rapidly in Israel and worldwide, necessitating adaptation of the healthcare system and considering new approaches that serve the needs of older adult populations.\n\nWorking hypothesis and aims: We hypothesize that a personalized health and behavior intervention program will decrease the biological age as assessed by several biological aging clocks and improve functional and cognitive performance among older adults.\n\nMethods: We propose to conduct a randomized study among healthy community-dwelling elderly subjects (\\>50 years old). The study will include an extensive aging assessment and imaging protocol (baseline assessment), including comprehensive physical, functional, sensory, cognitive, and mental assessment. Each participant in the intervention group will receive a personalized intervention program based on an integrative systems approach analysis. In addition, a uniquely developed application will track compliance and monitor physiological data through a provided wearable device. The control group will be assessed at baseline without receiving an intervention program. Each participant will visit the center aging after 6 months for a blood test and after 12 months for a second extensive diagnostic protocol, similar to the baseline assessment protocol. About 1,500 subjects will be recruited to participate in the study.\n\nExpected results: Obtaining data at two points will allow us to examine efficiency and compliance with a personalized intervention program based on integrative systems analysis models. We expect biological age, general well-being, and various clinical and psychosocial outcomes in the intervention group will decrease and improve compared to the control group.\n\nStudy importance and relevance: The obtained results may help establish evidence-based healthy aging diagnostics protocols and an effective personalized intervention program that might be applied, with proper modifications, to national healthcare organizations for the general older adult population. In addition, to provides a scientific basis on which policymakers and intervention programs can rely to develop national guidelines for promoting extended health.",[28,29,30,31,32],"Healthy Aging","Healthspan","Biological Age","Intrinsic Capacity","Immunaging",[34,35,36,37,38],"healthy longevity","healthspan","geromedicine","biological age","health trajectories","RECRUITING","2026-05-18",{"date":42,"type":43},"2026-05-19","ACTUAL",{"date":45,"type":43},"2024-03-01",{"date":47,"type":22},"2027-12-01",{"name":49,"class":50},"Sheba Medical Center","OTHER_GOV",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":51},"100629660","optimizing-intrinsic-capacity-for-functional-independence-and-to-impede-frailty-in-older-adults-adaptation-of-the-who-icope-for-healthy-ageing-in-singapore-100629660","NCT07477561","Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore","INFINITY-ICOPE","Inclusion Criteria: (in Phases 1, 2 and 3):\n\n* Any Singaporean or Permanent Resident (PR) aged 60 years and above\n* Able to provide informed consent (or legally acceptable representative available)\n\nExclusion Criteria (in Phases 1, 2 and 3):\n\n* Non-Singaporeans or non-PRs under 60 years of age\n* Residents of sheltered or nursing homes","60 Years",{"count":61,"type":22},600,[25],"The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early identification and targeted interventions can improve health outcomes and support healthy ageing. The main questions it aims to answer are:\n\n* Can combined frailty and intrinsic capacity screening with targeted interventions prevent or reduce functional decline in older adults, as measured by changes in life space mobility?\n* Will at least 80% of screened older adults adhere to recommended care pathways and interventions?\n* Can this screening and intervention programme demonstrate sustainability through continued community participation and recruitment of new partner organizations beyond the initial implementation phase? The investigators will compare an intervention group (receiving immediate assessment and clinical referrals based on identified needs) to a wait-list control group (receiving the same interventions 12 months later) to see if early intervention leads to better health outcomes and quality of life.\n\nParticipants will:\n\n* Attend 4 study visits over 2 years (at 6-monthly intervals in the first year, with final assessment at end of year 2), each lasting up to 2 hours.\n* Undergo comprehensive screening assessments including mobility, cognition, mental health, hearing, vision, and nutritional status.\n* Receive 2 follow-up phone calls at 3-month and 9-month intervals to monitor progress.\n* If in the intervention group: receive personalized referrals for further care (which may include comprehensive geriatric assessment, primary care reviews, rehabilitation, or dietitian consultations) and guidance on using a mobile health monitoring application.\n* If in the wait-list control group: receive the same interventions after their 3rd study visit (12 months later).",[65,31,66,67],"Frailty in Older Adults","Age-related Functional Decline","Healthy Ageing",[69,70,71,72,73,74],"Frailty","Intrinsic capacity decline","Community-dwelling older adults","Age-related functional decline","Healthy ageing","Early identification and management of frailty and functional decline","2026-04-14",{"date":77,"type":43},"2026-04-17",{"date":79,"type":43},"2023-07-17",{"date":81,"type":22},"2028-01-15",{"name":83,"class":84},"Sengkang General Hospital","OTHER",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":51},"100633353","implementation-of-decade-of-healthy-ageing-action-plan-to-screen-and-prevent-decline-in-intrinsic-capacity-in-elders-spice-through-multisectoral-collaboration-in-singapore-100633353","NCT07525583","Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore","SPICE","Inclusion Criteria:\n\n* pre-frail or robust older adults who can provide consent and follow instructions\n\nExclusion Criteria:\n\n* frail or with terminal illness",{"count":93,"type":22},2500,"OBSERVATIONAL","This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore. Using the World Health Organization (WHO) Integrated Care for Older People (ICOPE) framework and digital screening tools, participants will undergo IC domain screening in community settings. Individuals identified with early decline will receive targeted multidomain interventions and\u002For referral to primary or specialist care as indicated. Participants will be followed longitudinally to assess feasibility, uptake, functional trajectories, and implementation outcomes.",[69,31,97],"Lifestyle",[99,100,101,102],"intrinsic capacity","personalized intervention","frailty","geroscience","2026-04-10",{"date":105,"type":43},"2026-04-13",{"date":107,"type":43},"2025-04-01",{"date":109,"type":22},"2027-09-30",{"name":111,"class":84},"National University Hospital, Singapore",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":122,"conditions":123,"keywords":138,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":4},"100590537","project-icope-brazil-assessment-of-intrinsic-capacity-in-brazilian-older-adults-100590537","NCT06968702","Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults","Project ICOPE Brazil: Assessment of Intrinsic Capacity in Older Adults as a Basis for Implementation of the WHO ICOPE Strategy in the Unified Health System.","ICOPE-BR","Inclusion Criteria:\n\n* People aged ≥ 60 years, with no age limit;\n* Being registered (with available contact information) in the participating health care units;\n* Being available to go in person to the data collection sites for the assessments.\n\nExclusion criteria\n\n* Inability to access the data collection site;\n* Severe neurologic and\u002For cognitive impairments that preclude interaction with the evaluators to complete the proposed tests and data collections;\n* Advanced serious illness or under palliative care:\n\nClinical Frailty Scale (CFS)20 score of 8 (severely frail) or 9 (terminally ill).",{"count":121,"type":22},3838,"The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability to execute daily life activities. Tests and questionnaires will be applied to collect data on mobility capacity, cognitive capacity, nutritional status, vision, and hearing (sensorial) capacities, and mental health. These assessments are in consonance with what the World Health Organization proposed in the Integrated Care for Older People Program (ICOPE). Participants will be followed up for three years, and the primary outcomes of interest are loss of intrinsic capacity, mobility impairment, cognitive impairment, incident depressive symptoms, loss of functional ability, incident frailty, incident sarcopenia, incident falls, hospitalization, multimorbidity, and mortality.",[31,69,124,28,125,126,127,128,129,130,131,132,133,134,135,136,137],"Aging","Functional Ability","Mobility and Independence","Cognitive Ability, General","Cognitive Impairment","Sensory Hearing Loss","Sensory Deficits","Visual Acuity","Visual Impairment","Mood Disorders","Depressive Symptoms","Vitality","Nutritional Risk","Nutrition Assessment",[139,125,140,141,142,69,128,143,144,135,145,146,147,148],"Instrinsic Capacity","ICOPE","Aging trends","Older Adults","Mobility","Sensory","Psychological","Cohort","healthy aging","public health","NOT_YET_RECRUITING","2025-05-05",{"date":152,"type":43},"2025-05-13",{"date":154,"type":22},"2025-05-15",{"date":156,"type":22},"2029-11",{"name":158,"class":84},"University of Sao Paulo",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":17,"sex":18,"minAge":166,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":51},"100582470","the-beijing-longitudinal-disability-survey-in-community-elderly-100582470","NCT06863727","The Beijing Longitudinal Disability Survey in Community Elderly","BLINDSCE","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years or older who reside in Beijing.\n* Participants who sign an institutionally approved informed consent.\n\nExclusion Criteria:\n\n* Participants with severe mental disorders and serious medical conditions preventing study investigation\n* Participants undergoing long-term professional treatment for physical function and cognitive functioning, such as hospitalization or rehabilitation.","65 Years",{"count":168,"type":22},1962,"The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for disability and cognitive impairment among community-dwelling adults aged 65 years and over. The main question it aims to answer is:\n\n* What are the high-risk factors able to predict the incidence and advance of disability and cognitive impairment in community-dwelling adults aged 65 years and over?\n* What are the categories of function and cognitive performance trajectory in community-dwelling adults aged 65 years and over?",[171,172,128,69,31],"Ageing","Disability",[171,172,128,174,146],"Community","2025-03-03",{"date":177,"type":43},"2025-03-07",{"date":179,"type":43},"2023-08-07",{"date":181,"type":22},"2028-07-31",{"name":183,"class":84},"Xuanwu Hospital, Beijing"]