[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intrusive-memories-of-traumatic-events\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intrusive-memories-of-traumatic-events":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100633182","a-digital-cognitive-intervention-for-intrusive-memories-after-trauma-100633182",false,"NCT07523360","A Digital Cognitive Intervention for Intrusive Memories After Trauma","A Novel Digital Cognitive Intervention Targeting Intrusive Memories Among Trauma-Exposed Individuals: A Randomised Clinical Trial","Inclusion Criteria:\n\n1. Meet DSM-5 Criterion A for PTSD, which stipulates exposure to an event involving serious injury or a threat to one's own or another's physical well-being, either through direct experience or witnessing.\n2. Participants needed to exhibit symptoms from at least three of the five core PTSD symptom domains outlined in DSM-5: intrusive memories (Criterion B), persistent avoidance of trauma-related stimuli (Criterion C), negative alterations in cognitions and mood (Criterion D), alterations in arousal and reactivity (Criterion E), and symptoms lasting for at least one month (Criterion F).\n3. The total score of CAPS-5 ≥ 33.\n4. Have internet access and have access to a personal computer.\n5. Have not taken part in a previous study of this intervention from this research team.\n\nExclusion Criteria:\n\n1. Fewer than 5 intrusive memories during the baseline week (Week 0).\n2. IQ score lower than 80.\n3. A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.\n4. Have severe substance dependence.","ALL","18 Years","50 Years",{"count":20,"type":21},123,"ESTIMATED","INTERVENTIONAL",[24],"NA","Intrusive traumatic memories frequently trigger severe distress and psychological disorders like PTSD. Traditional therapies require explicit trauma recall, which often causes severe patient distress and leads to treatment avoidance. To address this, our study introduces a novel, less aversive intervention combining unconscious visual processing with bilateral eye movement to mitigate these intrusive memories.\n\nUtilizing a randomized, three-arm design (comparing standardized trauma-related images, patient-provided images, and neutral images, all paired with bilateral eye movements), we plan to recruit participants who have experienced severe trauma and report ≥ 5 intrusive memories weekly, targeting a final sample of 40 patients per arm. The primary outcome is the frequency of intrusive memories. Secondary and additional outcomes include PTSD severity (CAPS-5, PCL-5, IES), depression, anxiety, borderline symptoms, functional improvements, subjective intervention distress, and dropout rates.",[27,28],"Post-Traumatic Stress Disorder (PTSD)","Intrusive Memories of Traumatic Event(s)","NOT_YET_RECRUITING","2026-04-04",{"date":32,"type":33},"2026-04-13","ACTUAL",{"date":35,"type":21},"2026-04-10",{"date":37,"type":21},"2028-05-10",{"name":39,"class":40},"Zhu Zijian","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":58,"leadSponsor":60,"locationsCount":4},"100631072","tetris-intervention-following-subliminal-reactivation-for-intrusive-memories-100631072","NCT07495917","Tetris Intervention Following Subliminal Reactivation for Intrusive Memories","A Tetris Intervention Following Subliminal Reactivation for Reducing Intrusive Memories in Trauma-exposed Individuals: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Meet DSM-5 PTSD Criterion A (eg, exposure to actual or threatened death). Have experienced one or more traumatic events.\n2. Experienced five or more intrusive memories during the baseline week.\n3. Have internet access and have access to a personal computer.\n4. Be willing to provide consent and able to complete study procedures and be contacted by the study team.\n\nExclusion Criteria:\n\n1. Have fewer than five intrusive memories during the baseline week.\n2. A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.\n3. Have severe substance dependence.",{"count":49,"type":21},106,[24],"Post-Traumatic Stress Disorder (PTSD) is characterized by recurrent, intrusive memories of traumatic events that cause significant distress and functional impairment. Although trauma-focused treatments are effective, they typically require deliberate recollection of traumatic experiences, which can be distressing and may contribute to treatment avoidance or dropout.\n\nIn previous experimental studies conducted with healthy participants, we demonstrated that unconscious reactivation of trauma-related cues, followed-after a brief delay corresponding to the memory reconsolidation window-by a visuospatial interference task (Tetris gameplay), reduced the frequency and emotional intensity of intrusive memories. These findings suggest that memory representations may be modifiable during reconsolidation without requiring conscious recall.\n\nBuilding on this work, the present randomized controlled trial (RCT) aims to evaluate the clinical efficacy and tolerability of this reconsolidation-based intervention in trauma-exposed individuals experiencing five or more intrusive memories per week.",[53,28],"Post-traumatic Stress Disorder (PTSD)","2026-03-31",{"date":56,"type":33},"2026-04-06",{"date":35,"type":21},{"date":59,"type":21},"2027-07-30",{"name":61,"class":40},"Shaanxi Normal University",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100565198","phase-2-neuromodulation-of-the-hippocampus-to-reduce-intrusive-re-experiencing-in-ptsd-a-randomized-controlled-trial-100565198","NCT06639061","Neuromodulation of the Hippocampus to Reduce Intrusive Re-Experiencing in PTSD: A Randomized Controlled Trial","Characterization and Modulation of Traumatic Memories in PTSD Patients Using Transcranial Magnetic Stimulation (TMS)","Inclusion Criteria:\n\n* Aged of 20-65 years.\n* Meet a diagnosis of PTSD according to DSM-5 as tested by a structured clinical interview (Clinician-Administered PTSD Scale for DSM-5 - CAPS-5).\n* CAPS-5 total score greater or equal to 33.\n* Endorsement of intrusive symptoms (flashbacks, nightmares, or intrusive memories) with a frequency of at least 3 times a week.\n* Meeting the accepted criteria for inclusion in an MRI examination.\n\nExclusion Criteria:\n\n* Meeting a diagnosis of Complex PTSD or personality disorder.\n* Psychotic disorder, bipolar disorder, or a developmental neuropsychological disorder (autism, mental retardation).\n* Use of psychiatric medications (except for the medications listed in section 4.a of the study protocol if the medication dosage is stable in the last three months and does not change during the study.\n* Exclusion rules in TMS research (see guidelines).\n* Use of the following drugs: imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, amphetamines, cocaine, (MDMA, ecstasy), phencyclidine (PCP, angel's dust), ketamine, gamma- hydroxybutyrate (GHB), alcohol, theophylline\n* Epilepsy or use of anti-epileptic drugs.\n* Traumatic head injuries or head surgery.\n* Implanted metallic body (except fillings\u002Famalgam bites\u002Forthodontic fixations approved for MRI), electrodes or a pacemaker.\n* Migraines\n* Pregnant women\n* Hearing problems\n* Drinking alcohol 24 hours before the TMS session\n* Repeated episodes of fainting with loss of consciousness and\u002For an event of fainting with loss of consciousness in the past year.\n* The accepted exclusion criteria for an MRI examination","20 Years","65 Years",{"count":72,"type":21},60,[74],"PHASE2","The goal of this clinical trial is to learn if non-invasive neurostimulation of memory-related brain areas works to treat intrusive memory symptoms in adults patients with posttraumatic stress disorder (PTSD). It will also learn about the effect of this neuromodulation procedure on reorganization of memory-related brain networks. The main questions it aims to answer are:\n\nDoes neuromodulation lower the number of times and the emotional severity participants intrusive memories? Does neuromodulation reduces the overall severity of PTSD? Researchers will compare neuromodulation targeting the hippocampus (a memory-related brain structure) to a control stimulation in an area not related to memory processes to see if hippocampus neuromodulation works to treat intrusive trauma memories and PTSD.\n\nParticipants will:\n\n1. Undergo magnetic resonance imaging (MRI) scans before and after neuromodulation to: a) determine a personalized neuromodulation target; and b) to measure changes in brain function from before to after treatment.\n2. Receive hippocampus neuromodulation or a control neuromodulation once a week for 5 weeks.\n\nKeep a daily diary of their symptoms and the number of times they experience intrusive trauma memories.",[77,28],"PTSD - Post Traumatic Stress Disorder",[79,80,81],"PTSD","TMS","MRI","RECRUITING","2024-10-31",{"date":85,"type":33},"2024-11-01",{"date":85,"type":33},{"date":88,"type":21},"2028-11",{"name":90,"class":40},"Tel Aviv University",1]