[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intrusive-memories\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intrusive-memories":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100625204","estradiol-and-intrusive-memories-100625204",false,"NCT07419594","Estradiol and Intrusive Memories","The Effect of Estradiol on the Acquisition and Consolidation of Trauma-Associated Memories","EstraMemo","Inclusion Criteria:\n\n* healthy female volunteers\n* German on B1 level\n\nExclusion Criteria:\n\n* former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)\n* any physical illnesses\n* any medication intake (except oral contraceptive)\n* history of traumatic experience, e.g. history of sexual abuse or rape\n* pregnancy or lactation period\n* intake of oral contraceptives\n* follicular phase of menstrual cycle",true,"FEMALE","18 Years","45 Years",{"count":22,"type":23},273,"ESTIMATED","INTERVENTIONAL",[26],"NA","The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma.\n\nA well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls.\n\nThis project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.",[29,30,31,32,33],"PTSD","Intrusive Memories","Intrusion Symptom","Trauma","Intrusion",[35,36,37,38,39,40],"Trauma film","Estradiol","ptsd","intrusive memories","intrusion","estrogen","RECRUITING","2026-02-12",{"date":44,"type":45},"2026-02-19","ACTUAL",{"date":47,"type":45},"2024-08-19",{"date":49,"type":23},"2028-02-29",{"name":51,"class":52},"Charite University, Berlin, Germany","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":19,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":24,"phases":65,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":53},"100552149","theories-of-working-memory-and-consolidationreconsolidation-in-the-process-of-resorption-of-post-traumatic-symptoms-100552149","NCT06469333","Theories of Working Memory and Consolidation\u002FRECOnsolidation in the Process of Resorption of Post-traumatic Symptoms.","Theories of Working Memory and Consolidation\u002FRECOnsolidation in the Process of Resorption of Certain Post-traumatic Symptoms: Interventional, Randomized Single-center Study","Inclusion Criteria:\n\n* Present symptoms of acute stress (score between 22 and 35 on the Impact Event Scale-Revised, IES-R) and\u002For PTSD (higher score or equal to 36 on the IES-R), but at least present moderate to high psychological distress (score equal to or greater than 8 on the Kessler Abbreviated Psychological Distress Scale, K6);\n* Being in need of psychotherapeutic follow-up but not having started it yet;\n* Be aged between 18 and 65 years inclusive;\n* Speak and write French (be able to understand information and complete questionnaires independently);\n* Have good vision (being able to follow the movement of a white point on a screen);\n* Have good hearing and tactile abilities (being able to perceive auditory and tactile tones);\n* Have a computer equipped with a webcam;\n* Be informed and sign informed consent.\n\nExclusion Criteria:\n\n* Be an adult protected under guardianship or curatorship;\n* Be a person subject to a judicial safeguard measure;\n* Present a lack of autonomy implying an impossibility in terms of administering questionnaires and filling out questionnaires;\n* Have a vision defect implying an impossibility of visual tracking of a white dot;\n* Present a hearing defect and\u002For tactile abilities implying an impossibility of perception;\n* Have a neurological condition constituting measurement biases (muscular dysfunctions, perceptual dysfunctions, etc.);\n* Suffer from psychotraumatic and dissociative disorders of complex type (respectively evaluated with regard to the anamestistic data of the patients and with a score greater than 25 on the dissociative experiences scale (Dissociative Experiences Scale, DES);\n* Do not present psychological distress (score less than 8 on the Kessler Abbreviated Psychological Distress Scale, K6) ;\n* Have a drug or alcohol dependence;\n* Benefit from ongoing psychotherapeutic monitoring;\n* Have already benefited from psychotherapeutic follow-up or have participated in studies in the last 6 months, both involving EMDR therapy.","ALL","65 Years",{"count":64,"type":23},150,[26],"EMDR is a psychotherapeutic approach recommended by the World Health Organization (WHO) for the treatment of disorders such as post-traumatic stress disorder, anxiety, depression and, more generally, psychological distress. In all these disorders, intrusions are one of the symptoms leading to intense emotional distress. EMDR therapy, by making intrusions less emotional and less present in the mind (i.e. less vivid), would reduce psychological distress. This symptomatological reduction would be made possible by the therapist's application of alternating bilateral visual (rapid eye movements following a point from left to right), auditory (tones emitted alternately in the right ear and then in the left ear) and\u002For tactile (tapping with fingers on the left and right shoulders alternately) stimulations administered while the patient concentrates on his or her intrusive thoughts. Accordingly, the aim of this research is to investigate the efficacy of self-administration of Alternating Bilateral Stimulations (ABS), on the emotional intensity (emotionality) associated with negative intrusive thoughts (or intrusions).",[68,69,70,71,72,30,73,74],"Working Memory","Consolidation\u002FRecconsolidation Memory","Eye Movement Desensitization and Reprocessing","Alterning Bilateral Stimulation","Stress Disorders, Post-Traumatic","Vividness","Emotivity","2025-11-20",{"date":77,"type":45},"2025-11-26",{"date":79,"type":45},"2024-09-06",{"date":81,"type":23},"2026-06",{"name":83,"class":52},"University of Lorraine"]