[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intubation-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intubation-complications":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,83,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637181","establish-whether-hyperangulated-videolaryngoscopy-havl-can-be-used-to-facilitate-tracheal-intubation-effectively-and-safely-in-unselected-adult-patients-describe-the-population-in-whom-havl-fails-to-facilitate-tracheal-intubation-successfully-identifying-any-contributory-characteristics-100637181",false,"NCT07600502","Establish Whether Hyperangulated Videolaryngoscopy (HAVL) Can be Used to Facilitate Tracheal Intubation Effectively and Safely in Unselected Adult Patients; Describe the Population in Whom HAVL Fails to Facilitate Tracheal Intubation Successfully, Identifying Any Contributory Characteristics.","McGrath X-blade Study","Inclusion Criteria:\n\n* Adult patients undergoing surgical procedures requiring tracheal intubation as part of their routine anaesthetic care\n* Patients undergoing either naso- or oro-tracheal intubation\n* Patients undergoing tracheal intubation with or without administration of neuromuscular blocking agents (e.g. those undergoing surgery where facial nerve or recurrent laryngeal nerve monitoring will be utilised)\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Patients in whom tracheal intubation is not required as part of their routine anaesthetic care\n* Patients in whom tracheal intubation was not planned as part of their routine anaesthetic care, but was required as a rescue technique (e.g. for failed insertion of a supraglottic airway) since appropriate patient consent will not have been obtained · Patients that are physiologically unstable (where clinical care must take priority and\u002For patient is unable to consent for inclusion in the study)",true,"ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","When patients have a general anaesthetic (go to sleep for surgery), the anaesthetist often places a small tube into their windpipe (intubation) to help them breathe. To see exactly where to put the tube, the anaesthetist uses a device called a laryngoscope.\n\nA commonly used laryngoscope is the McGrath videolaryngoscope. It has a small camera and screen to help guide safe placement of the tube. It comes in two different shapes - one shaped in the same way laryngoscopes have been shaped for the last 80 years, and another newer design (McGrath X-blade) that matches the curve of patients' tongues better.\n\nAll different classes of videolaryngoscope have been shown to have benefits to patients; however, the best videolaryngoscope shape has yet to be determined.\n\nThe McGrath X-blade is currently recommended in patients in whom the anaesthetist thinks it might be slightly more difficult to place the tube, but some anaesthetists already prefer to use it in all their patients. This is not a new device or a new technique.\n\nIn this study, the investigators wish to explore if there is any special benefit of using it in all patients, by collecting some information when the device is used.",[27,28,29],"Intubation Skill","Intubation Complications","Intubation With Uncuffed Endotracheal Tube",[31,32,33,34],"videolaryngoscopy","hyperangulated blade","first-pass success","airway management","NOT_YET_RECRUITING","2026-05-13",{"date":38,"type":39},"2026-05-20","ACTUAL",{"date":41,"type":21},"2026-06",{"date":43,"type":21},"2027-09",{"name":45,"class":46},"NHS Lothian","OTHER_GOV",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100574304","a-stepped-wedge-cluster-randomised-trial-of-video-versus-direct-laryngoscopy-for-intubation-of-newborn-infants-100574304","NCT06757543","A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants","NEU-VODE","Inclusion Criteria:\n\n* Infants of any gestational age in whom endotracheal intubation is attempted can be included in this study once there is parental consent to the use their infant's data.\n\nExclusion Criteria:\n\n* Infants will be excluded if parents do not consent for their infants' data to be used.","0 Minutes","1 Month",{"count":58,"type":21},840,[24],"Many newborn babies have difficulty breathing. When babies need a lot of help, a doctor will intubate them - i.e. put a tube into their windpipe (trachea) - so that they can be given support with a breathing machine. Intubation is a difficult procedure, during which many babies have falls in their blood oxygen levels and heart rate. When doctors intubate babies, they use a device called a laryngoscope to identify the entrance to the windpipe. A standard laryngoscope has a light at its tip. When doctors use this device, they insert it into the baby's mouth and then look directly into the mouth to find the entrance (direct laryngoscopy). Less than half of first attempts to insert a tube are successful using this device. More recently, video laryngoscopes have been developed. These devices also have a camera at the tip and display a magnified view of the entrance to the windpipe on a screen. A study at one hospital showed that the doctors there inserted the tube at the first attempt more often when they used a video laryngoscope instead of a standard laryngoscope. This study was not large enough to see whether fewer babies had low oxygen levels or heart rate during the procedure.\n\nThe goal of this clinical trial is to see whether more newborn babies are intubated at the first attempt without falls in their blood oxygen levels or heart rate when the doctors use video laryngoscopy compared to direct laryngoscopy.\n\nHospitals where doctors routinely intubate babies by looking directly into the mouth will take part in the NEU-VODE study. From the start of the study, the doctors at each hospital will continue with their usual approach to intubation and collect information about intubation attempts. As the study progresses, the doctors at each participating hospital will switch one--by-one to routinely attempting intubation with a video laryngoscope. The date on which they switch will be determined by chance. By the end of the study, each hospital will have had a study period where babies were routinely intubated using direct laryngoscopy and video laryngoscopy.\n\nAt the end of the study, the information collected from all the babies intubated during the study will be compared to see if more babies were successfully intubated at the first attempt without falls in their blood oxygen levels or heart rate in the video laryngoscopy group.",[62,28,63,64,65],"Intubation","Infant, Newborn","Infant Respiratory Distress Syndrome","Video Laryngoscopy",[67,68,69,70],"infant, newborn","video laryngoscopy","intubation","stepped wedge cluster randomised trial","RECRUITING","2026-04-28",{"date":74,"type":39},"2026-05-04",{"date":76,"type":39},"2025-01-13",{"date":78,"type":21},"2026-08-31",{"name":80,"class":81},"University College Dublin","OTHER",17,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":5},"100622218","comparison-of-peri-intubation-oxygenation-values-and-complications-in-patients-intubated-with-the-delayed-versus-rapid-sequence-intubation-protocols-100622218","NCT07380763","Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols","Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Sequential Intubation (DSI) Versus Rapid Sequence Intubation (RSI) Protocols","DSI vs RSI","Inclusion Criteria:\n\n1. Aged 18 years or older\n2. Presence of spontaneous breathing.\n3. No prediction of a difficult airway prior to intubation.\n4. Requirement for advanced airway management.\n5. Not in cardiac arrest.\n6. Decided to intubate due to non-traumatic etiologies.\n7. Planned intubation using ketamine for sedation and rocuronium for paralysis.\n8. Decision to intubate due to one of the following clinical conditions:\n\n   1. Acute Respiratory Failure: Patients with hypoxic or hypercapnic respiratory failure where adequate oxygenation cannot be achieved despite non-invasive ventilation.\n   2. Inability to Protect the Airway: Altered level of consciousness or increased risk of pulmonary aspiration due to conditions such as upper gastrointestinal bleeding, ileus, volvulus, gastric outlet obstruction, hypersalivation, or hyperemesis.\n   3. Shock States: Patients in any state of shock (hypovolemic, distributive, cardiogenic, obstructive) exhibiting severe altered mental status or declining respiratory status.\n   4. Neuroprotection: Need to terminate ongoing seizures resistant to medical therapy (status epilepticus), or situations requiring strict control of arterial carbon dioxide (PaCO₂) levels to manage increased intracranial pressure (ICP) in non-traumatic conditions (such as intracranial hemorrhage or severe encephalopathy).\n9. Obtaining informed consent from the patient or their legally authorized representative.\n\nExclusion Criteria:\n\n1. Aged under 18 years.\n2. Pregnancy.\n3. Refusal to provide informed consent.\n4. Cardiac arrest prior to intubation.\n5. Anticipated difficult airway.\n6. Intubation required due to traumatic etiologies.\n7. Missing or incomplete patient data.\n8. Patients assigned to the DSI protocol but for whom the decision to intubate was rescinded due to clinical improvement during the preoxygenation phase.\n9. Use of a sedative agent other than ketamine for the RSI protocol.\n10. Intubations performed by practitioners who have not received study-specific training on DSI and RSI protocols.\n11. Duplicate enrollment due to recurrent presentations during the study period.",{"count":92,"type":21},140,[24],"This study compares two different methods of helping patients breathe by placing a tube in their airway (intubation) in an emergency setting. These methods are called Rapid Sequence Intubation (RSI) and Delayed Sequence Intubation (DSI).\n\nThe study focuses on adult patients who are still breathing on their own but need a breathing tube for medical reasons not related to an injury (non-trauma).\n\nThe main goal of the research is to compare:\n\n* Oxygen levels before and after the procedure.\n* The patient's vital signs (such as heart rate and blood pressure).\n* The number of attempts needed to successfully place the tube and the time the procedure takes.\n* Blood gas results and any complications that occur during or shortly after the procedure.\n* Early survival (mortality) rates.\n\nWhile there are previous studies on trauma patients or small observational reports, there is currently no large-scale, multicenter randomized controlled trial that includes all non-trauma adult patients.\n\nWhat makes this study unique? Confirmation of Tube Placement: Researchers will use a specific measurement called end-tidal CO2 (etCO2) to confirm the tube is in the right place, a method not used in similar previous studies.\n\nAssessing Difficulty: This study will use the Cormack-Lehane classification system to measure how difficult the intubation was for each patient.\n\nStandardization: For the first time, breathing machine (ventilator) settings will be standardized for all patients in this type of study.\n\nReal-World Practice: By involving all emergency department physicians as practitioners, the study aims to show how these methods work across a wide range of medical teams.",[96,97,62,28,98],"Delayed Sequence Intubation","Rapid Sequence Induction and Intubation","Intubation, Endotracheal",[100,101,102,103],"delayed sequence intubation","rapid sequence intubation","RSI","DSI","2026-01-24",{"date":106,"type":39},"2026-02-02",{"date":108,"type":39},"2025-10-29",{"date":110,"type":21},"2026-06-29",{"name":112,"class":81},"Kanuni Sultan Suleyman Training and Research Hospital",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":16,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100587132","ramped-versus-supine-position-for-emergent-endotracheal-intubation-in-adult-patients-prospective-randomized-comparative-study-100587132","NCT06924411","Ramped Versus Supine Position for Emergent Endotracheal Intubation in Adult Patients; Prospective, Randomized, Comparative Study","Inclusion Criteria:\n\n\\- Adult patients ≥18 years old and indicated for intubation with variable presentations.\n\nExclusion Criteria:\n\n* Patients unstable to be positioned in semi setting as spine trauma and polytraumatized patients.","14 Years",{"count":121,"type":21},100,[24],"Endotracheal intubation is a life saving procedure for critically unwell and injured patients presenting to the emergency department. Prolonged time to successful intubation and multiple failed attempts are associated with a higher incidence of life-threatening adverse events such as hypoxia and hypotension.\n\nOptimal head and neck positioning and clinical experience are important factors for successful endotracheal intubation in patients especially with a difficult airway. This study aims to investigate the rate of successful endotracheal intubation between ramped and supine positions in patients planned for intubation.\n\nThe ramped position, where the bed is kept half-flat and the head is elevated up to 35°, is planned to prove that it improves glottic view and facilitate intubation and ventilation.\n\nVarying bed angles and heights during ramped position intubation may explain conflicting evidence regarding the effect of ramped position on intubation success in acute care settings.\n\nTherefore, it seems that finding a simple alternative method for the classic supine technique that can create conditions like the proposed standard conditions for laryngoscopy would be a suitable solution for intubating patients with higher difficulty.\n\nThe patient's anatomy and the technique employed for laryngoscopy have a significant effect on the laryngeal view. The technique itself is influenced by a variety of factors including the laryngoscopic force and the skills, experience, and training of the physicians.",[28],[126,127,128,129,130,131],"Ramped intubation","Non-supine intubation","Semi-setting intubation","Intubation without aspiration","Ramped versus supine intubation","Intubation with less complications","2025-04-06",{"date":134,"type":39},"2025-04-11",{"date":136,"type":21},"2025-05",{"date":138,"type":21},"2025-09",{"name":140,"class":81},"Sohag University"]