[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intubation-endotracheal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intubation-endotracheal":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100622218","comparison-of-peri-intubation-oxygenation-values-and-complications-in-patients-intubated-with-the-delayed-versus-rapid-sequence-intubation-protocols-100622218",false,"NCT07380763","Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols","Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Sequential Intubation (DSI) Versus Rapid Sequence Intubation (RSI) Protocols","DSI vs RSI","Inclusion Criteria:\n\n1. Aged 18 years or older\n2. Presence of spontaneous breathing.\n3. No prediction of a difficult airway prior to intubation.\n4. Requirement for advanced airway management.\n5. Not in cardiac arrest.\n6. Decided to intubate due to non-traumatic etiologies.\n7. Planned intubation using ketamine for sedation and rocuronium for paralysis.\n8. Decision to intubate due to one of the following clinical conditions:\n\n   1. Acute Respiratory Failure: Patients with hypoxic or hypercapnic respiratory failure where adequate oxygenation cannot be achieved despite non-invasive ventilation.\n   2. Inability to Protect the Airway: Altered level of consciousness or increased risk of pulmonary aspiration due to conditions such as upper gastrointestinal bleeding, ileus, volvulus, gastric outlet obstruction, hypersalivation, or hyperemesis.\n   3. Shock States: Patients in any state of shock (hypovolemic, distributive, cardiogenic, obstructive) exhibiting severe altered mental status or declining respiratory status.\n   4. Neuroprotection: Need to terminate ongoing seizures resistant to medical therapy (status epilepticus), or situations requiring strict control of arterial carbon dioxide (PaCO₂) levels to manage increased intracranial pressure (ICP) in non-traumatic conditions (such as intracranial hemorrhage or severe encephalopathy).\n9. Obtaining informed consent from the patient or their legally authorized representative.\n\nExclusion Criteria:\n\n1. Aged under 18 years.\n2. Pregnancy.\n3. Refusal to provide informed consent.\n4. Cardiac arrest prior to intubation.\n5. Anticipated difficult airway.\n6. Intubation required due to traumatic etiologies.\n7. Missing or incomplete patient data.\n8. Patients assigned to the DSI protocol but for whom the decision to intubate was rescinded due to clinical improvement during the preoxygenation phase.\n9. Use of a sedative agent other than ketamine for the RSI protocol.\n10. Intubations performed by practitioners who have not received study-specific training on DSI and RSI protocols.\n11. Duplicate enrollment due to recurrent presentations during the study period.","ALL","18 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study compares two different methods of helping patients breathe by placing a tube in their airway (intubation) in an emergency setting. These methods are called Rapid Sequence Intubation (RSI) and Delayed Sequence Intubation (DSI).\n\nThe study focuses on adult patients who are still breathing on their own but need a breathing tube for medical reasons not related to an injury (non-trauma).\n\nThe main goal of the research is to compare:\n\n* Oxygen levels before and after the procedure.\n* The patient's vital signs (such as heart rate and blood pressure).\n* The number of attempts needed to successfully place the tube and the time the procedure takes.\n* Blood gas results and any complications that occur during or shortly after the procedure.\n* Early survival (mortality) rates.\n\nWhile there are previous studies on trauma patients or small observational reports, there is currently no large-scale, multicenter randomized controlled trial that includes all non-trauma adult patients.\n\nWhat makes this study unique? Confirmation of Tube Placement: Researchers will use a specific measurement called end-tidal CO2 (etCO2) to confirm the tube is in the right place, a method not used in similar previous studies.\n\nAssessing Difficulty: This study will use the Cormack-Lehane classification system to measure how difficult the intubation was for each patient.\n\nStandardization: For the first time, breathing machine (ventilator) settings will be standardized for all patients in this type of study.\n\nReal-World Practice: By involving all emergency department physicians as practitioners, the study aims to show how these methods work across a wide range of medical teams.",[27,28,29,30,31],"Delayed Sequence Intubation","Rapid Sequence Induction and Intubation","Intubation","Intubation Complications","Intubation, Endotracheal",[33,34,35,36],"delayed sequence intubation","rapid sequence intubation","RSI","DSI","RECRUITING","2026-01-24",{"date":40,"type":41},"2026-02-02","ACTUAL",{"date":43,"type":41},"2025-10-29",{"date":45,"type":21},"2026-06-29",{"name":47,"class":48},"Kanuni Sultan Suleyman Training and Research Hospital","OTHER",4,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100611327","two-video-laryngoscopes-laringocel-and-c-mac-for-first-attempt-intubation-in-adults-undergoing-elective-surgery-100611327","NCT07239141","Two Video Laryngoscopes (Laringocel® and C-MAC®) for First-Attempt Intubation in Adults Undergoing Elective Surgery","Estimation of the Non-Inferiority of the Laringocel® Videolaryngoscope Compared With the C-MAC D-BLADE (Karl Storz®) for First-Attempt Intubation in Adult Patients Undergoing Elective Surgery","LARINGOCOL","Inclusion Criteria:\n\n* Patients 18 years of age or older\n* Patients scheduled for elective surgery under general anesthesia\n* Patients requiring single-lumen orotracheal intubation\n* Patients compliant with the anesthetic indication and standard preoperative fasting requirements\n\nExclusion Criteria:\n\n* Patients with an anticipated difficult airway (more than two anatomical risk factors for difficult airway)\n* Patient refusal to participate in the study via informed consent",true,{"count":60,"type":21},252,[24],"This study will test two video laryngoscopes that help doctors place a breathing tube during surgery. A breathing tube is needed for people who receive general anesthesia so they can breathe safely. Video laryngoscopes use a small camera to give a better view of the throat and vocal cords, which may help the tube go in on the first try.\n\nThe purpose of this research is to find out if a Colombian device called Laringocel® works as well as the widely used international device C-MAC D-Blade® (Karl Storz). If Laringocel® performs similarly, it could be a more affordable option for hospitals with limited resources.\n\n252 adults (126 in each group) who need elective surgery at Alma Máter Hospital de Antioquia (Medellín, Colombia) will take part. Each participant will be randomly assigned, like flipping a coin, to have their breathing tube placed with either Laringocel® or C-MAC D-Blade®. Only trained anesthesiologists will perform the procedure.\n\nThe study will look at:\n\nMain goal: how often the tube goes in correctly on the first attempt.\n\nOther goals: overall success within 3 attempts, how well the airway is seen, how long the intubation takes, how satisfied the doctor is with the device, and possible side effects such as sore throat, dental injury, or oral injury.\n\nParticipation will not change the usual care people receive during anesthesia. Both devices are already approved for clinical use. Risks are the same as with any standard intubation, and participants will be checked after surgery for any problems.\n\nBy comparing these two devices, researchers hope to learn if Laringocel® can provide safe and effective intubation at lower cost, improving access to advanced airway tools.",[64,31],"Airway Management",[66],"Videolaryngoscopy","2025-12-09",{"date":69,"type":41},"2025-12-11",{"date":71,"type":41},"2025-12-04",{"date":73,"type":21},"2026-04",{"name":75,"class":48},"Mario Zamudio",1]