[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intubation-intratracheal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intubation-intratracheal":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,90,119,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100642471","phase-4-fentanyl-and-rocuronium-for-tracheal-intubation-in-newborns-100642471",false,"NCT07650552","Fentanyl and Rocuronium for Tracheal Intubation in Newborns","Effect of the Association of Fentanyl and Rocuronium on First-Attempt Success Rate of Tracheal Intubation in Newborns: A Randomized Clinical Trial","NEORIN","Inclusion Criteria:\n\n* Newborns admitted to the NICU, ≤28 postnatal days OR corrected gestational age \\\u003C44 weeks\n* Indication for non-emergent orotracheal intubation (≥5 minutes between decision to intubate and start of laryngoscopy)\n* Informed consent signed by legal guardians\n\nExclusion Criteria:\n\n* Upper airway malformations\n* Use of neuromuscular blocking agent in the 24 hours prior to enrollment\n* Known hypersensitivity to fentanyl or rocuronium\n* Severe hemodynamic instability (ongoing shock)\n* Anticipated difficult airway (micrognathia, cleft palate, or similar)\n* Cyanotic congenital heart disease with critical instability\n* Neonatal abstinence syndrome\n* Concurrent enrollment in another interventional clinical trial","ALL","1 Minute","28 Days",{"count":21,"type":22},102,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen desaturation, bradycardia, and airway trauma - are frequent. Premedication with neuromuscular blocking agents has been associated with improved intubation conditions and fewer adverse events in neonates.\n\nThis randomized, double-blind, parallel-group clinical trial (NEORIN) aims to evaluate whether the addition of rocuronium (0,6 mg\u002Fkg IV) to standard fentanyl premedication (1 mcg\u002Fkg IV) improves first-attempt success rates of tracheal intubation in newborns admitted to the NICU of Maternidade Ana Braga, Manaus, Brazil. The control group will receive fentanyl plus saline placebo. Sugammadex (16 mg\u002Fkg IV) is available as a reversal agent in case of prolonged neuromuscular blockade.\n\nA secondary aim is to assess neonatologists' and residents' knowledge of and barriers to the use of neuromuscular blocking agents in neonatal intubation.",[28,29,30,31],"Infant, Premature","Intubation, Intratracheal","Respiratory Distress Syndrome, Newborn","Apnea of Prematurity",[33,34,35,36,37,38,39,40],"neonatal intubation","rocuronium","premedication","neuromuscular blocking agent","sugammadex","first-attempt success","NICU","newborn","NOT_YET_RECRUITING","2026-06-29",{"date":44,"type":45},"2026-07-01","ACTUAL",{"date":47,"type":22},"2026-09",{"date":49,"type":22},"2029-02",{"name":51,"class":52},"UEA - Universidade Do Estado Do Amazonas","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":53},"100644051","oral-protect-i-oral-asepsis-preventing-transmission-during-intubation-100644051","NCT07669064","ORAL-PROTECT I: Oral Asepsis Preventing Transmission During Intubation","ORAL-PROTECT I: Oral Asepsis for Preoperative Reduction Of Tracheal Bacterial Establishment, Colonization, and Transmission","ORAL-PROTECT I","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Elective surgery under general anesthesia with endotracheal intubation\n* Expected duration of surgery ≥ 2 hours\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Systemic antibiotic therapy within 7 days before surgery\n* Planned postoperative systemic antibiotic therapy\n* Known hypersensitivity or allergy to chlorhexidine\n* Pneumonia or clinically relevant respiratory infection within 7 days before surgery\n* Inability to perform the study intervention as intended\n* Preoperative oral hygiene on the day of surgery, less than four hours prior to induction of the general anesthesia","60 Years",{"count":64,"type":22},60,[66],"NA","Postoperative respiratory complications, such as bacterial pneumonia, are common and serious problems after general anesthesia. They can lead to longer hospital stays, more complications, and increased mortality. One possible cause is that bacteria from the mouth and throat enter the lower airways during tracheal intubation.\n\nThe mouth and throat naturally contain many bacteria, including potentially harmful microorganisms. During general anesthesia, coughing and swallowing reflexes are reduced or absent. When a tracheal tube is inserted, secretions from the mouth and throat may be carried into the trachea. The tube may also support the movement of contaminated fluid into the lower airways.\n\nORAL-PROTECT I is a prospective, randomized, controlled study. It investigates whether simple oral hygiene before surgery can reduce the transfer of bacteria into the trachea during airway management under general anesthesia.\n\nThe study includes patients aged 60 years or older undergoing elective surgery under general anesthesia with tracheal intubation. Participants are randomly assigned to an intervention group or a control group. The intervention group performs oral hygiene immediately before anesthesia. This includes brushing the teeth and tongue for about 3 minutes, followed by rinsing and gargling for about 1 minute with a chlorhexidine antiseptic solution. The control group receives standard care without additional oral hygiene.\n\nOral, pharyngeal, and tracheal swabs will be collected at predefined time points. The primary outcome is based on the perioperative tracheal bacterial load, sampled every 30 minutes and assessed at two hours after induction of anesthesia. The co-primary outcome is based on the oral bacterial load immediately before endotracheal intubation.\n\nSecondary outcomes include changes in oral and tracheal bacterial load over time and identification of the microorganisms detected. The study aims to clarify early bacterial transfer during airway management and to evaluate whether a simple preoperative oral hygiene measure can reduce this process.",[69,70,71],"Bacterial Transmission","Intubation Intratracheal","Chlorhexidine",[73,74,75,76,77,78,79,80],"anesthesia, general","oral hygiene","bacterial load","oropharyngeal","respiratory mucosa","chlorhexidine","tracheal intubation","mouth rinsing","2026-06-21",{"date":83,"type":45},"2026-06-25",{"date":85,"type":22},"2026-06-20",{"date":87,"type":22},"2027-05-01",{"name":89,"class":52},"University Hospital Ulm",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":107,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":116,"leadSponsor":117,"locationsCount":4},"100619603","evaluation-of-anterior-neck-ultrasound-in-predicting-difficult-airway-in-obese-patients-100619603","NCT07346768","Evaluation of Anterior Neck Ultrasound in Predicting Difficult Airway in Obese Patients","Ultrasound Assessment of Anterior Neck Soft Tissue Thickness to Predict Difficult Airway Risk in Obese Patients Undergoing for Surgery Under General Anesthesia: an Observational Study","Inclusion Criteria:\n\n* Age 18-70 years\n* ASA physical status I-III\n\n  \\* BMI \\>25 kg\u002Fm²\n* Scheduled for elective surgery under general anesthesia\n\nExclusion Criteria:\n\n* Emergency surgery\n* Pregnancy\n* Maxillofacial anomalies or neck masses\n* Rapid sequence induction\n* Previous history of difficult intubation\n* BMI \\>60 kg\u002Fm²","18 Years","70 Years",{"count":100,"type":22},52,"OBSERVATIONAL","Obese patients are at increased risk of difficult airway management due to anatomical changes in the anterior neck soft tissues. Accurate preoperative prediction of difficult airway remains challenging using conventional clinical airway assessment tests alone.\n\nThis prospective observational study aims to evaluate the role of ultrasound assessment of anterior neck soft tissue thickness in predicting difficult airway risk in overweight and obese adult patients undergoing elective surgery under general anesthesia. Ultrasound-based anterior neck measurements will be compared with standard clinical airway assessment parameters to determine their diagnostic accuracy for difficult laryngoscopy and intubation.\n\nThe results of this study may contribute to improved preoperative airway risk stratification and safer airway management in obese patients.",[104,105,29,106],"Ultrasonography","Airway Management","Obesity and Overweight",[108,109,110,111],"Obesity","difficult airway","anterior neck ultrasound","ultrasonography","2026-06-12",{"date":114,"type":45},"2026-06-16",{"date":85,"type":22},{"date":85,"type":22},{"name":118,"class":52},"Gaziantep City Hospital",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":127,"sex":17,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":137,"overallStatus":143,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":53},"100619946","pediatric-airway-noninferiority-trial-of-devices-for-intubation-assessment-100619946","NCT07351227","Pediatric Airway: Noninferiority Trial of Devices for Intubation Assessment","Comparison of the Effectiveness and Cost-Effectiveness of McGRATH™ MAC and Besdata Videolaryngoscopes in the Orotracheal Intubation of Children: A Non-Inferiority Randomized Clinical Trial","PANDA","Inclusion Criteria:\n\n* The study will include children aged between 6 months and 3 years who are scheduled for elective surgery under general anesthesia at the Children's Institute (Instituto da Criança - ICr) of the Hospital das Clínicas Complex, University of São Paulo Medical School (HC-FMUSP), provided that informed consent is obtained from their parents or legal guardians.\n\nExclusion Criteria:\n\n* Patients under one year of age will be excluded if informed consent is not obtained from their legal guardians, if they are classified as ASA physical status IV or higher, present with hemodynamic instability, or have craniofacial abnormalities or oral deformities suggestive of a potentially difficult airway.",true,"6 Months","3 Years",{"count":131,"type":22},226,[66],"The goal of this clinical trial is to find out whether the BESDATA BD-DF videolaryngoscope works as well as the McGRATH™ MAC videolaryngoscope for placing a breathing tube in infants during surgery. The study will also compare the costs associated with using each device.\n\nThe main questions this study aims to answer are:\n\nIs the BESDATA BD-DF videolaryngoscope as effective as the McGRATH™ MAC videolaryngoscope for successful placement of a breathing tube on the first attempt in infants?\n\nAre there differences between the two devices in terms of procedure time, number of attempts, airway-related complications, and overall costs?\n\nResearchers will compare infants who are intubated using the BESDATA BD-DF videolaryngoscope with infants who are intubated using the McGRATH™ MAC videolaryngoscope to see whether the two devices perform similarly and whether one is more cost-effective than the other.\n\nParticipants will:\n\nBe randomly assigned to have a breathing tube placed using one of the two videolaryngoscopes;\n\nReceive standard general anesthesia for an elective surgical procedure;\n\nHave information collected during and after the procedure to assess safety, effectiveness, and costs.",[29,105,135,136],"Video Laryngoscope","Cost Effectiveness",[138,139,140,141,142],"Videolaryngoscope","Pediatric orotracheal intubation","Cost effectiveness","McGrath MAC","BESDATA","RECRUITING","2026-03-18",{"date":146,"type":45},"2026-03-20",{"date":148,"type":45},"2026-03-01",{"date":150,"type":22},"2027-12-31",{"name":152,"class":52},"University of Sao Paulo General Hospital",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":162,"conditions":163,"keywords":167,"overallStatus":143,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":53},"100589361","classification-and-prediction-of-difficult-awake-tracheal-intubation-with-flexible-bronchoscopes-100589361","NCT06953414","Classification and Prediction of Difficult Awake Tracheal Intubation With Flexible Bronchoscopes","AirWake","Inclusion Criteria:\n\n* Patients with an anticipated difficult airways scheduled for ATI:FB\n* Consent by the patient\n* Minimum 18 years of age\n\nExclusion Criteria:\n\n* Patients not scheduled for ATI:FB\n* Pregnant or breastfeeding patients\n* Consent not given by the patient",{"count":161,"type":22},313,"Airway management problems are key drivers for anesthesia-related adverse events. Awake tracheal intubation using flexible bronchoscopes with preserved spontaneous breathing (ATI:FB) is a recommended technique to manage difficult tracheal intubation in anesthesia, intensive care and emergency medicine. However, a prospective developed classification for this type of airway management is lacking. Due to the absence of a specifically tailored, validated classification for awake intubation with flexible bronchoscopes, many airway operators and institutions use classification tools that were originally developed for direct laryngoscopy, such as the percentage of glottic opening (POGO) score or Cormack-Lehane classification, although their diagnostic performance for the classification of ATI:FB is unknown. This prospective model development and validation study aims to develop two multivariable prediction models: a diagnostic prediction model to classify difficult ATI:FB after ATI:FB has been performed and a second prognostic prediction model to predict the risk for difficult ATI:FB before ATI:FB is performed. An additional aim is to develop a machine learning algorithm to evaluate ATI:FB.",[164,105,29,165,166],"Anesthesia","Bronchoscopy","Endoscopes",[168,169,170,171,172,173,174],"Airway management","Classification","Flexible endoscopy guided intubation","Fibroptic guided intubation","Respiratory system","Laryngeal diseases","Health records","2025-05-01",{"date":177,"type":45},"2025-05-06",{"date":179,"type":45},"2025-04-30",{"date":181,"type":22},"2026-01-31",{"name":183,"class":52},"Universitätsklinikum Hamburg-Eppendorf"]