[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"invasive-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:invasive-cancer":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,60],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":39,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100542080","advice-of-moderate-drinking-pattern-versus-advice-on-abstention-on-major-disease-and-mortality-100542080",false,"NCT06338215","Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality","A Non-inferiority Randomized Trial Testing an Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality","UNATI","Inclusion Criteria:\n\n* Males aged 50-70 years, Women aged 55-75 years\n* Drinkers of any alcoholic beverage initially consuming 3 or more but 40 or less drinks\u002Fwk\n* Projected life expectancy more than 5 years (according to the judgment of their attending physician)\n* Willing to receive advice during up to 4 years on how to improve their alcohol intake making it healthier\n\nExclusion Criteria:\n\n1. Participants without smartphone or a computer (or tablet) with Internet connection.\n2. Drinkers of less than 30 g of pure alcohol\u002Fwk or more than 400 g of pure alcohol\u002Fwk\n3. Illiteracy, inability\u002Funwillingness to give written consent or communicate with study staff, or inadequate abilities for the use of on-line technologies\n4. Participants with any sever psychiatric condition or with a diagnosis of cognitive impairment or dementia.\n5. Participants with liver cirrhosis or prior liver cancer.\n6. Patients with a recent diagnosis of breast cancer (diagnosed in the last 10 years).\n7. Patients under habitual use of high-dose medications that completely preclude any use of alcohol. Most of these patients will be already excluded by the second or fourth exclusion criteria.",true,"ALL","50 Years","75 Years",{"count":22,"type":23},10000,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).\n\nThe main question it aims to answer is to test the non-inferiority advice of a moderate alcohol drinking pattern on all-cause mortality and other chronic disease like cardiovascular disease, cancer or type 2 diabetes.\n\nParticipants will receive during 4 years an advice to drink alcohol following a Mediterranean Alcohol Drinking Pattern (MADP): consuming alcohol in moderation, avoidance of binge drinking and preference for red wine.\n\nResearchers will compare those who will receive a MADP advice with those who will receive an advice on abstention to see if the advice on MADP is not inferior than the abstention advice to prevent all-cause mortality and other chronic diseases.",[29,30,31,32,33,34,35,36,37,38],"All Cause Mortality","Cardiovascular Diseases","Invasive Cancer","Liver Cirrhosis","Type 2 Diabetes","Depression","Dementia","Injury Traumatic","Tuberculosis","Infections",[40,41,42,43,44,45,46],"Alcohol","Drinking Pattern","Abstention","Advice","Clinical Trial","Moderation","Mediterranean Alcohol Drinking Pattern","RECRUITING","2024-12-11",{"date":50,"type":51},"2024-12-12","ACTUAL",{"date":53,"type":51},"2024-05-15",{"date":55,"type":23},"2029-06-30",{"name":57,"class":58},"Clinica Universidad de Navarra, Universidad de Navarra","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":17,"sex":18,"minAge":67,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":59},"100533909","a-prospective-multi-center-clinical-study-to-establish-multi-cancer-early-detection-platform-through-the-analysis-of-whole-genome-sequencing-of-circulating-dna-in-cancer-patients-and-healthy-volunteers-100533909","NCT06231953","A Prospective, Multi-center Clinical Study to Establish Multi-Cancer Early Detection Platform Through the Analysis of Whole Genome Sequencing of Circulating DNA in Cancer Patients and Healthy Volunteers","A Prospective, Multi-center Clinical Study to Establish Multi-Cancer Early Detection Platform Through the Analysis of Whole Genome Sequencing of Circulating DNA in Cancer Patients and Healthy Volunteers.","Inclusion Criteria:\n\n* Aged 19 years or older\n* Subjects who have been diagnosed with stages 1 to 4 of solid tumor or healthy volunteers who have scheduled a cancer screening examination\n* Subjects who have agreed to provide clinical information and blood samples\n* Subjects who have agreed for the storage and secondary use of residual blood samples for research\n* Subjects who have understood the study and are able to provide a written informed consent\n\nExclusion Criteria:\n\n* Subjects who are not appropriate for the study because of intellectual disabilities or severe mental disorders\n* Subjects with a history of HIV, HTLV, or Syphilis infection\n* Subjects with primary site unknown cancer or synchronous or metachronous double primary cancers\n* Subjects who have diagnosed with any other malignant tumor within the past 5 years (except for cured non-melanoma skin cancer, in situ cancer, or thyroid cancer)","19 Years",{"count":69,"type":23},4000,"OBSERVATIONAL","This is a prospective, multi-center clinical study of Multi-Cancer Early Detection (MCED) testing in cancer patients and healthy volunteers. The purpose of this study is to establish MCED platform through the analysis of whole genome sequencing of circulating DNA.\n\nThe study will enroll 4,000 subjects as defined by eligibility criteria at up to 10 clinical institutions in South Korea.",[31,73],"Healthy Volunteer","2024-01-21",{"date":76,"type":51},"2024-01-30",{"date":78,"type":51},"2022-10-13",{"date":80,"type":23},"2026-12",{"name":82,"class":58},"Yonsei University"]