[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"invasive-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:invasive-mechanical-ventilation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,50,79,110,140,168,201,226,253],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100637709","phase-2-ondansetron-for-the-prevention-of-patient-self-inflicted-lung-injury-in-patients-with-ards---pilot-rct-100637709",false,"NCT07588217","Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT","A Pilot, Randomized, Controlled Clinical Trial Evaluating Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury Through Inhibition of Respiratory Drive in Patients With Acute Respiratory Distress Syndrome (OSIRIS-1)","OSIRIS-1","Inclusion Criteria:\n\n* Moderate-to-severe ARDS with all of the following:\n* Hypoxemic respiratory failure with PaO2:FiO2 \\\u003C 200 (on IMV with PEEP ≥ 5)\n* Precipitated within 1 week of an acute condition\n* Bilateral opacities on chest radiography and computed tomography or bilateral B lines and\u002For consolidations on ultrasound not fully explained by effusions, atelectasis, or nodules\u002Fmasses\n* Pulmonary edema not exclusively or primarily attributable to cardiogenic pulmonary edema\u002Ffluid overload\n* Hypoxemia\u002Fgas exchange abnormalities not primarily attributable to atelectasis\n* IMV initiated \\\u003C 96 hours\n* Extubation not anticipated within 24 hours\n\nExclusion Criteria:\n\n* Neuromuscular disease impairing spontaneous breathing\n* Pregnancy\n* Liver cirrhosis (Child B or C) or other severe impairment of hepatic function\n* Bradycardia (baseline pulse\\\u003C50\u002Fmin) on screening day\n* Known long QT syndrome\n* History of sustained ventricular tachycardia\n* Active digestive \u002F abdominal infection44\n* QTc prolongation \\> 470 msec in men and \\> 480 msec in women on screening day\n* On a medication at high risk of QT prolongation (Table 5)50\n* On two or more serotonergic medications (Table 6)51\n* Hypersensitivity \u002F intolerance to 5-HT3 antagonists\n* Patient deemed unlikely to survive past 24 hours or being transitioned to a fully palliative philosophy of care","ALL","18 Years","75 Years",{"count":21,"type":22},76,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE2","PHASE3","Acute Respiratory Distress Syndrome (ARDS) is a serious condition where the lungs become inflamed, leading to severe breathing difficulties. Despite advances in medical care, ARDS remains a life-threatening illness with a high risk of death and long-term complications. One way doctors help ARDS patients is by using special ventilation techniques to protect the lungs from further damage. However, this often requires heavy sedation or even paralyzing medications, which can lead to other problems like delirium, muscle weakness, and longer hospital stays. Allowing patients to breathe on their own might offer benefits, but it also comes with risks. Many ARDS patients have a very strong urge to breathe, which can cause them to overexert their lungs, potentially leading to additional lung damage, known as patient selfinflicted lung injury (P-SILI). Our early research suggests that a medication called ondansetron, commonly used to prevent nausea, might help reduce this strong breathing drive in ARDS patients, possibly preventing further lung injury. The OSIRIS research program is designed to explore whether ondansetron can protect ARDS patients from P-SILI, ultimately improving their chances of survival and reducing long-term complications. The first part of this program, OSIRIS-1, is a small pilot study where we will test the feasibility of running a larger, more definitive trial. We will randomly assign ARDS patients to receive either ondansetron or a placebo, given intravenously four times a day, and monitor their heart rhythms closely to ensure safety. We will also track how well patients stick to the study plan and whether ondansetron helps reduce their breathing drive and lung strain. If successful, this research could lead to new ways of treating ARDS that rely less on heavy sedation, potentially improving outcomes for these critically ill patients and setting the stage for larger, more comprehensive studies in the future.",[29,30,31],"ARDS (Acute Respiratory Distress Syndrome)","Invasive Mechanical Ventilation","Patient-Self Inflicted Lung Injury",[33,34,35,36],"ondansetron","5HT3 antagonist","respiratory drive","respiratory effort","NOT_YET_RECRUITING","2026-05-08",{"date":40,"type":41},"2026-05-14","ACTUAL",{"date":43,"type":22},"2026-10-01",{"date":45,"type":22},"2029-10-01",{"name":47,"class":48},"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100490631","evaluation-and-further-development-of-an-artificial-intelligence-based-algorithm-for-clinical-decision-support-100490631","NCT05668637","Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support","Retrospective Use of Patient Treatment Data for the Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support in Invasive Mechanical Ventilation of Intensive Care Patients","IntelliLung","Inclusion Criteria:\n\n• Subjects who are 18 years or older and receive invasive mechanical ventilation for \\> 4 hours\n\nExclusion Criteria:\n\n• Patients receiving one-lung ventilation",{"count":59,"type":22},318542,"OBSERVATIONAL","Invasive mechanical ventilation is one of the most important and life-saving therapies in the intensive care unit (ICU). In most severe cases, extracorporeal lung support is initiated when mechanical ventilation is insufficient. However, mechanical ventilation is recognised as potentially harmful, because inappropriate mechanical ventilation settings in ICU patients are associated with organ damage, contributing to disease burden. Studies revealed that mechanical ventilation is often not provided adequately despite clear evidence and guidelines. Variables at the ventilator and extracorporeal lung support device can be set automatically using optimization functions and clinical recommendations, but the handling of experts may still deviate from those settings depending upon the clinical characteristics of individual patients. Artificial intelligence can be used to learn from those deviations as well as the patient's condition in an attempt to improve the combination of settings and accomplish lung support with reduced risk of damage.",[30],[64,65,66,67],"Mechanical ventilation","ventilator-induced lung injury","ARDS","artificial intelligence","RECRUITING","2026-04-16",{"date":71,"type":41},"2026-04-21",{"date":73,"type":41},"2023-01-01",{"date":75,"type":22},"2026-09-01",{"name":77,"class":48},"Technische Universität Dresden",8,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":49},"100626896","evaluation-of-the-clinical-and-prognostic-value-of-non-invasive-analysis-of-mandibular-movements-mm-as-a-marker-of-inspiratory-effort-in-the-spontaneously-breathing-intensive-care-patient-100626896","NCT07441590","Evaluation of the Clinical and Prognostic Value of Non-invasive Analysis of Mandibular Movements (MM) as a Marker of Inspiratory Effort in the Spontaneously Breathing Intensive Care Patient","MM-ICU","Inclusion Criteria:\n\n* Adult patients (≥ 18 years)\n* Admitted to the Intensive Care Unit for acute respiratory failure\n* On invasive mechanical ventilation for more than 24 hours with:\n\n  * A respiratory rate ≤ 35 breaths\u002Fminute;\n  * Adequate oxygenation, defined as either an oxygen saturation of at least 90% (obtained during ventilation with a fraction of inspired oxygen \\[FiO2\\] ≤ 40% and a positive end-expiratory pressure \\[PEEP\\] ≤ 8 cm of water) or an arterial partial pressure of oxygen (PaO2) (measured in mmHg) \u002F FiO2 ratio \\> 150 (obtained during ventilation with a PEEP ≤ 8 cm of water);\n  * Respiratory muscle capacity allowing for an effective cough;\n  * A state of wakefulness, defined as a Richmond Agitation and Sedation Scale (RASS) score of -2 to +1;\n  * No use of continuous sedation;\n  * No use of vasopressors (or use of minimal doses).\n* At high risk of weaning failure defined by at least one of the following criteria (5):\n\n  * Age \\> 65 years\n  * A cardiac comorbidity among: systolic dysfunction (ejection fraction ≤45%), permanent atrial fibrillation, or a history of cardiogenic pulmonary edema or myocardial ischemia\n  * A respiratory comorbidity among: COPD, restrictive lung disease, or obesity hypoventilation syndrome\n* Written informed consent obtained from the patient, or in case of incapacity, from the next of kin\u002Ftrusted person\n* Patient covered by social security\n\nExclusion Criteria:\n\n* Absolute contraindication to NIV (patient refusal, undrained pneumothorax, intractable vomiting, upper airway obstruction, upper gastrointestinal bleeding, severe craniofacial trauma)\n* Absolute contraindication to nasogastric tube placement (upper gastrointestinal bleeding, epistaxis, skull base trauma)\n* Persons referred to in Articles L1121-5 to L1121-8 of the CSP (corresponds to all protected persons: pregnant woman, parturient woman, breastfeeding mother, person deprived of liberty by judicial or administrative decision, persons receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 who do not fall under the provisions of Article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, person subject to a legal protection measure or unable to express their consent).",{"count":87,"type":22},50,[89],"NA","Evaluate the performance for measuring inspiratory effort of non-invasive mandibular movement analysis compared to the reference technique oesophageal pressure (PES) variation, in ventilated and spontaneously breathing Intensive Care Unity (ICU) patients, during weaning from mechanical ventilation and within 48 hours after extubation.\n\nThe investigators hypothesis is that the assessment of respiratory effort by MM analysis could represent a non-invasive and reliable alternative to the measurement of PES in critically ill patients.",[92,93,30],"Acute Respiratory Failure (ARF)","Intensive Care Unit (ICU) Patients",[95,96,97,98,99,100],"intensive care unit","acute respiratory failure","invasive mechanical ventilation","weaning from mechanical ventilation","ventilatory control","Breathing efforts","2026-02-23",{"date":103,"type":41},"2026-03-02",{"date":105,"type":22},"2026-02",{"date":107,"type":22},"2027-04",{"name":109,"class":48},"University Hospital, Grenoble",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":49},"100624125","ultrasound-evaluation-of-respiratory-muscles-during-mechanical-ventilation-weaning-in-icu-patients-100624125","NCT07405567","Ultrasound Evaluation of Respiratory Muscles During Mechanical Ventilation Weaning in ICU Patients","Ultrasonographic Evaluation of Diaphragm and Accessory Respiratory Muscles During Weaning in ICU Patients With Pneumonia","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admission to the intensive care unit with a diagnosis of pneumonia\n* Receiving invasive mechanical ventilation via endotracheal intubation\n* Expected to undergo a weaning process from mechanical ventilation\n* Written informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Known neuromuscular disease affecting respiratory muscles\n* High cervical spinal cord injury\n* History of major neck, thoracic, or diaphragmatic surgery\n* Acute thoracic trauma or pneumothorax\n* Central nervous system pathology affecting respiratory drive\n* Continuous neuromuscular blocking agent use\n* Pregnancy",{"count":118,"type":22},150,"Patients with pneumonia who require invasive mechanical ventilation in the intensive care unit (ICU) often experience difficulties during the process of being separated from the breathing machine (weaning). Failure of weaning is associated with longer ventilation duration, prolonged ICU stay, and increased risk of complications and death. Therefore, simple and reliable bedside tools are needed to better understand respiratory muscle function and to help predict weaning outcomes.\n\nThis prospective, observational, single-center study aims to evaluate respiratory muscle function using bedside ultrasound in adult ICU patients with pneumonia receiving invasive mechanical ventilation. The diaphragm, parasternal intercostal muscles, and anterior scalene muscles will be assessed using ultrasound during the weaning process. Measurements will be performed serially, starting from the first day when patients demonstrate meaningful spontaneous breathing effort and continuing until successful extubation, tracheostomy, or ICU mortality.\n\nUltrasound measurements of muscle thickness and thickening fraction will be analyzed in relation to weaning outcomes. In addition, ventilator parameters and commonly used weaning indices will be recorded at the time of each ultrasound assessment. The findings of this study are expected to improve understanding of respiratory muscle involvement during weaning and may contribute to earlier identification of patients at risk of weaning failure.",[121,30,122,123],"Pneumonia","Weaning From Mechanical Ventilation in Care Unit","Respiratory Muscle Dysfunction",[125,126,127,128,129],"Mechanical Ventilation Weaning","Respiratory Muscle Ultrasound","Diaphragm Ultrasound","Parasternal Intercostal Muscle","Anterior Scalene Muscle","2026-02-05",{"date":132,"type":41},"2026-02-12",{"date":134,"type":22},"2026-02-15",{"date":136,"type":22},"2027-02-15",{"name":138,"class":139},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100581802","phase-1-little-lungs-study-100581802","NCT06855043","Little Lungs Study","Pilot Randomized Controlled Trial of Late Surfactant Therapy With Budesonide for Prevention of Bronchopulmonary Dysplasia","Neonate Inclusion Criteria:\n\n* Gestational age 22 0\u002F7 to 28 6\u002F7 weeks at birth\n* Age 7-14 days\n* Need invasive mechanical ventilatory support and a Fraction of Inspired Oxygen (FiO2) greater than or equal to 0.3\n\nBirthing Parent Inclusion Criteria:\n\n* Have a baby who meets neonate eligibility criteria and enrolls in the study.\n\nNeonate Exclusion Criteria:\n\n* Major congenital anomalies including congenital lung malformations and congenital diaphragmatic hernia and\u002For genetic disorders\n* Alternative, acute clinical etiology of respiratory deterioration or increased ventilatory requirements (e.g., sepsis, pneumonia, etc.)\n* History of pulmonary hemorrhage\n* Antibiotic use within 48 hours\n* Indomethacin or Ibuprofen use within 72 hours\n* Prior treatment with corticosteroids for prevention of lung disease\n* Not expected to survive for greater than 7 days at enrollment\n* Determined to be unstable by the clinical team\n* Enrolled in a conflicting clinical trial\n* Have a birth parent aged less than 18 years\n* Parent\u002Fguardian is unable to provide parental permission in English or Spanish","7 Days","14 Days",{"count":150,"type":22},24,[152,25],"PHASE1","This clinical trial is being done to evaluate the safety and clinical response of late surfactant treatment with budesonide in extremely preterm infants requiring mechanical ventilation at 7-14 days of age.",[30,155],"Severe Respiratory Distress Syndrome",[157],"premature birth","2026-01-23",{"date":160,"type":41},"2026-01-27",{"date":162,"type":22},"2026-09",{"date":164,"type":22},"2029-03",{"name":166,"class":48},"University of Wisconsin, Madison",2,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":185,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":49},"100577981","lung-recruitment-during-chest-physiotherapy-in-mechanically-ventilated-patients-100577981","NCT06805357","Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients","Evaluation of Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients","RECRUTKI","Inclusion Criteria:\n\n* Patient under assisted ventilation (in V-ACV or PSV) triggering all ventilator cycles\n* Patient deemed \" secretive \": requiring ≥ 2 tracheal aspirations every 3 hours\n* Patient (or relative) who has given consent to participate in the research\n* Patient covered by social security\n\nExclusion Criteria:\n\n* Age under 18 years\n* Legal guardian required\n* Recent cardiac and\u002For thoracic and\u002For abdominal surgery (\\\u003C 3 months)\n* Rib fracture(s)\n* Pneumothorax and\u002For presence of a chest drain\n* Recent neurosurgery (\\\u003C 3 months) and\u002For proven or suspected increased intracranial pressure (ICP)\n* Hemodynamic instability defined as: noradrenaline ≥ 1mg\u002Fh, adrenaline ≥ 0.5 mg\u002Fh, dobutamine ≥ 5γ\u002Fkg\u002Fmin.\n* Respiratory instability defined as: PEEP \\> 10 cmH2O and\u002For PaO2\u002FFiO2 \\\u003C 150 mm Hg\n* Pregnancy\n* Hemoptysis\n* Sever skin lesions (e.g., burns, Lyell's syndrome)\n* Patient under foreign health insurance","100 Years",{"count":178,"type":22},40,[89],"In intensive care, respiratory physiotherapy is an integral part of the daily care of patients under invasive mechanical ventilation. Its goals are to improve the clearance of bronchial secretions to allow for the resolution of atelectasis and alveolar recruitment, thereby enhancing respiratory mechanics and gas exchange. The most widespread technique in France is external expiratory compression of the chest.\n\nThe effectiveness of this technique depends on the selection of patients (it seems to be more effective in patients with higher secretion levels) and on the practical implementation of the technique (favoring brief and vigorous compressions at the beginning of expiration). However, the effect of the artificial ventilator settings, particularly the ventilatory mode used during the respiratory physiotherapy session, has never been evaluated. The two most commonly used ventilatory modes worldwide are Volume Assist Control Ventilation (V-ACV) and pressure support ventilation (PSV). In this unit, respiratory physiotherapy under artificial ventilation is performed daily on patients with artificial ventilation with abundant secretions, regardless of the ventilatory mode.",[182,30,183,184],"Intensive Care","Chest Physiotherapy","Airway Clearance",[186,187,188,189,190,191],"ICU","Lung recruitment","Respiratory physiotherapy","Rib Cage Compressions (RCC)","mechanical ventilation","intensive care","2026-01-14",{"date":194,"type":41},"2026-01-15",{"date":196,"type":41},"2024-07-23",{"date":198,"type":22},"2027-06-23",{"name":200,"class":48},"Assistance Publique - Hôpitaux de Paris",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":211,"conditions":212,"keywords":214,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":49},"100590594","evaluation-of-rehabilitation-practices-in-the-intensive-care-unit-100590594","NCT06969443","Evaluation of Rehabilitation Practices in the Intensive Care Unit","Evaluation of Rehabilitation Practices in Patients Undergoing Invasive Mechanical Ventilation in French-speaking Critical Care Units","REHALITE","Inclusion criteria:\n\n* Foreseeable invasive ventilation lasting more than 48 hours.\n* Included within the first five days of an intensive care stay.\n\nExclusion criteria:\n\n* Participation in an interventional study on early rehabilitation in the ICU\n* Moribund patient\n* Pregnant or breastfeeding woman\n* A person deprived of liberty by court order\n* Not being affiliated to a social security scheme",{"count":210,"type":22},1000,"This observational study aims to describe the number of rehabilitation procedures performed per patient during their stay in French-speaking adult intensive care units undergoing invasive mechanical ventilation (average rehabilitation ratio). The study aims to determine the actual rehabilitation ratio, i.e. the number of rehabilitation procedures divided by the number of critical care hospital days (censored at day 28 from the start of invasive mechanical ventilation), provided to patients undergoing invasive mechanical ventilation. The rehabilitation procedure will remain the same, and ICU teams will only record the number of procedures performed per day.",[30,213],"Rehabilitation Exercise of ICU Patients",[186,215,64,216],"Rehabilitation","Observationnal","2025-09-23",{"date":219,"type":41},"2025-09-24",{"date":221,"type":41},"2025-06-17",{"date":223,"type":22},"2026-12",{"name":225,"class":48},"French Society for Intensive Care",{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":49},"100556891","assessment-of-ventilation-parameters-for-extubation-prediction-in-icu-100556891","NCT06531005","Assessment of Ventilation Parameters for Extubation Prediction in ICU","Inclusion Criteria:\n\n* consenting patients who have recently been intubated for acute respiratory failure\n\nExclusion Criteria:\n\n* patients with lung cancer\u002F lung metastasis\n* ECMO\n* death within 24 hours",{"count":233,"type":22},100,"The study aims to research the values of mechanical power, driving pressure, and elastic power in predicting the duration of mechanical ventilation in critically ill patients undergoing invasive mechanical ventilation. This will help determine which patients may be considered for early extubation, which patients should wait for extubation, and the patients where extubation is anticipated to be prolonged, attention should be paid to initiating preparations for alternative treatment methods like tracheostomy early.",[236,30],"Acute Respiratory Failure",[238,239,240,241,242,243],"respiratory failure","extubation","mechanical power","elastic power","repiratory mechanics","outcome","2024-07-28",{"date":246,"type":41},"2024-07-31",{"date":248,"type":41},"2024-04-01",{"date":250,"type":22},"2025-02-01",{"name":252,"class":48},"Ankara University",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":259,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":23,"phases":263,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":4},"100532791","preemptive-treatment-with-acyclovir-in-intubated-and-mechanically-ventilated-patients-with-herpes-pth2-100532791","NCT06217406","Preemptive Treatment With Acyclovir in Intubated and Mechanically Ventilated Patients With Herpes (PTH2)","Preemptive Treatment With Acyclovir in Intubated and Mechanically Ventilated Patients With Herpes Simplex Virus Oropharyngeal Reactivation and One or Less Organ Failure","PTH2","Inclusion Criteria:\n\n* aged ≥ 18 year-old\n* invasive mechanical ventilation(MV) for 96 hours and planned to last for at least 48 hours longer\n* HSV reactivation in the throat (qualitative PCR positive for HSV on a throat swab)\n* Presence of 1 or less organ failure; organ failure being defined as a corresponding-organ SOFA score of 3 or 4 (for example, renal failure will be defined as a renal SOFA score of 3 or 4)\n* Effective contraception for patients of childbearing age, throughout the treatment period\n* Written consent from the patient, from a close relative or from the person of trust previously appointed (or inclusion procedure in emergency situations)\n* Under social security cover\n\nExclusion Criteria:\n\n* Hypersensitivity to acyclovir and excipient\n* Pregnant or breastfeeding (controlled by a blood pregnancy test)\n* Patient who received an antiviral drug active against HSV (acyclovir, valacyclovir, gancyclovir, valgancyclovir, foscavir, cidofovir) in the previous 30 days\n* Duration of ventilation before randomization \\>15 days\n* Neutropenia, defined by an absolute neutrophils count \\\u003C 1,000\u002Fmm3\n* Solid organ or bone-marrow transplant\n* Immunosuppressive treatment (including steroids at a dose \\>0.5 mg\u002Fkg\u002Fday of prednisone or equivalent for \\>1 month)\n* HIV infection\n* Moribund, defined by a Simplified Acute Physiology Score (SAPS) II score at inclusion \\>75 points\n* Decision of withholding\u002Fwithdrawing care",{"count":262,"type":22},246,[89],"This research aims to assess the interest of preemptive treatment with Acyclovir in mechanically ventilated patients with reactivation of Herpes simplex (HSV) in the throat and failure of one organ or less. HSV reactivation is common in patients hospitalized in an intensive care unit (ICU) on invasive mechanical ventilation. It begins at the oropharyngeal level (incidence up to 20-50%), then progresses downward with contamination of the distal airways (reported incidence of 20-65%). HSV reactivation is associated with high mortality. The investigators aim to disable that, in mechanically ventilated patients with HSV reactivation in the throat and failure of one organ or less, preemptive treatment with Acyclovir may reduce mortality.\n\nTo answer the question posed in the research, it is planned to include 246 people hospitalized in intensive care on invasive mechanical ventilation, presenting with HSV reactivation of the throat and one organ failure or less.",[30,266],"HSV Throat Reactivation",[186,97,268,269,270],"HSV","Acyclovir","Preemptive treatment","2024-01-19",{"date":273,"type":41},"2024-01-22",{"date":275,"type":22},"2024-03-01",{"date":277,"type":22},"2027-03-01",{"name":200,"class":48}]