[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"iron-absorption\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:iron-absorption":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,75,106,136,169,196],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100603692","dietary-iron-requirements-100603692",false,"NCT07139821","Dietary Iron Requirements","Dietary Iron Requirements in US Adults","Inclusion Criteria:\n\n* Males and premenopausal females age 18-50 y\n* Previously participated in an iron stable isotope study or willing to consume an oral stable iron isotope and undergo a one-year equilibration period\n* Willing to refrain from iron-containing supplements for the duration of the study\n* Willing to refrain from tobacco smoking for the duration of the study\n* Have not donated blood 3 months prior to the start of the study and willing to refrain from donating blood for the duration of the study\n* Willing to have blood stored for future use\n* Able and willing to comply with study requirements and consent to participate\n\nExclusion Criteria:\n\n* Females: pregnant or lactating or plans to become pregnant during the study period\n* Inability to provide informed consent and engage in informed consent procedures\n* Plans to relocate outside the study area",true,"ALL","18 Years","50 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies in European populations. This research study will determine iron needs in a representative sample of adults living in the US using the iron isotope dilution technique. Following administration and equilibration of a stable iron isotope, participants will be followed for a 12 week study period. Blood will be collected every 4 weeks and the isotopic composition will be determined. Results will help update dietary iron guidelines making sure they better match the specific needs of the US population.",[28],"Iron Absorption",[30,31,32,33,34,35],"Iron absorption","Iron losses","Iron requirements","Iron deficiency","Iron deficiency anemia","Iron isotopes","RECRUITING","2026-04-23",{"date":39,"type":40},"2026-04-29","ACTUAL",{"date":42,"type":40},"2026-02-06",{"date":44,"type":22},"2029-05-31",{"name":46,"class":47},"Pennington Biomedical Research Center","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100626711","impact-of-a-cricket-and-black-soldier-fly-larvae-fortified-cracker-on-the-gut-microbiome-and-iron-status-in-malagasy-schoolchildren-100626711","NCT07439185","Impact of a Cricket and Black Soldier Fly Larvae-Fortified Cracker on the Gut Microbiome and Iron Status in Malagasy Schoolchildren","Inclusion criteria for children\n\n* Child (male, female, intersex, non-binary), aged 9 to 13 years old who attends one of the selected schools\n* Caregiver or legal guardian is willing to provide informed consent\n* Child is willing to provide informed assent\n\nExclusion criteria for children\n\n* Child age is outside the preferred age range (9 to 13 years)\n* Not enrolled in the participating schools\n* Unable or unwilling to comply with the study requirements\n* Illness requiring medical treatment, malaria, severe anemia (hemoglobin (Hb) concentration below 8.0 g\u002FdL as indicated by HemoCue 201+ system), severe acute malnutrition, fever, diarrhea, etc.\n* Covid-exposure or symptoms: loss of smell or taste\n* History of food allergies or adverse reactions to any edible insects\n* Chronic severe medical condition or congenital anomalies requiring frequent medical attention or interfering with dietary consumption\n* Caregiver does not give consent, or child does not assent\n\nInclusion criteria for parents • Willing to participate in completing surveys about demographics and household dynamics (assets, housing structure, etc.)\n\nExclusion criteria for parents\n\n• Caregiver does not consent to participate","9 Years","13 Years",{"count":58,"type":22},650,[25],"The purpose of this study is to determine the health impacts of consistent consumption of insect-fortified crackers among school-aged children in Madagascar.\n\nSpecifically, in this RCT, the investigators will assess whether the insect-fortified crackers can improve the health status of Malagasy school children. The investigators' objectives are to: (1) Assess changes in gut microbiome composition that occur after 6 and 14 weeks of cracker consumption through 16S rRNA sequencing. (2) Assess changes in intestinal and systemic inflammation after 6 and 14 weeks of cracker consumption through quantification of fecal calprotectin, lactoferrin, myeloperoxidase (MPO), and alpha-1-antitrypsin (AAT) and circulating pro-inflammatory cytokines. (3) Assess changes in iron status after 14 weeks of cracker consumption through quantification of hemoglobin (Hb), inflammation-adjusted serum ferritin, and soluble transferrin receptor (sTfR).",[62,63,28],"Gut -Microbiota","Inflamation","NOT_YET_RECRUITING","2026-02-23",{"date":67,"type":40},"2026-02-27",{"date":69,"type":22},"2026-02",{"date":71,"type":22},"2026-06",{"name":73,"class":47},"Cornell University",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":74},"100541259","zinc-and-iron-absorption-from-common-beans-in-young-adult-women-100541259","NCT06327529","Zinc and Iron Absorption From Common Beans in Young Adult Women","Inclusion Criteria:\n\n* Healthy eumenorrheic (regular monthly menstrual cycles of 25-30-days in length)\n* BMI 18.5 - 30 kg\u002Fm2\n* Regular consumer of beans, i.e. ≥ 4 servings per month\n* Usual iron intake estimated by Food Frequency Questionnaire to be less than the Recommended Daily Allowance (RDA) of 18 mg\u002Fd (8)\n* Subject is willing and able to comply with the study protocols.\n* Subject is willing to participate in all study procedures.\n\nExclusion Criteria:\n\n* Dislike or allergy to beans\n* Self-reported current or recent pregnancy (within the past 12 months)\n* Self-reported recent termination of pregnancy (3 months if abortion in 1st or 2nd trimester, or 12 months if in 3rd trimester)\n* Self-reported plans to become pregnant during the study period\n* Self-reported cancer\n* Self-reported surgery without the past 12 months\n* Currently taking prescription drugs, other than for contraception, or any nutritional supplements\n* Any daily iron supplementation within the past 12 months.\n* Currently breastfeeding\n* Any medical conditions affecting iron or zinc metabolism (such as hemochromatosis or sickle cell disease)","FEMALE","19 Years","24 Years",{"count":85,"type":22},15,[25],"Fifteen female study participants will be enrolled in a randomized crossover study to measure fractional and total zinc and iron absorption from four common bean (Phaseolus vulgaris) varieties with varying phytate and polyphenolic contents. Phytate, the storage form of phosphorus in plants, and polyphenols, which contribute to the varied colors of common beans, are natural components of the beans and can reduce zinc and iron bioavailability from these foods.",[89,28],"Zinc Absorption",[91,92,93,94,95,96],"zinc","iron","absorption","phytate","polyphenols","beans","2026-02-18",{"date":99,"type":40},"2026-02-20",{"date":101,"type":40},"2024-05-01",{"date":103,"type":22},"2026-12-31",{"name":105,"class":47},"University of California, Davis",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":74},"100603905","determination-of-iron-absorption-and-losses-in-people-living-at-high-altitude-to-investigate-the-requirements-in-this-population-group-using-a-newly-developed-technique-100603905","NCT07142590","Determination of Iron Absorption and Losses in People Living at High Altitude to Investigate the Requirements in This Population Group Using a Newly Developed Technique","Iron Balance in Humans Living at High Altitude: Defining Requirements and Optimal Biomarker Thresholds Using a Novel Body Iron Labelling Technique Based on Stable Iron Isotopes.","ARIA","Inclusion Criteria:\n\n* Females and males aged 18-45 y\n* BMI: 18 to 25 kg\u002Fm2\n* Body weight \\\u003C70 kg for females, \\\u003C85 kg for males\n* Plasma ferritin \\>25 µg\u002FL\n* Signed informed consent\n\nExclusion Criteria:\n\n* Hb \\\u003C12 g\u002FdL (females), Hb \\\u003C13 g\u002FdL (males), corrected for altitude using the 2024 WHO guidance values for hemoglobin adjustments\n* Inflammation (CRP \\> 5 mg\u002FL)1\n* Plasma ferritin \\>150 µg\u002FL for females and \\>200 µg\u002FL for males\n* Chronic disease known to affect iron metabolism\n* Chronic medications (except for oral contraceptives)\n* Pregnancy (tested at screening) or intention to become pregnant during the course of the study\n* Lactation\n* High physical activity (MET-min\u002Fweek \\> 3000 calculated according to the IPAQ, short version, administered at the screening)\n* Difficulty with blood withdrawal\n* Earlier participation in a study using stable iron isotopes or participation in any clinical study within the last 30 days\n* Smoking\n* Blood donation, blood transfusion or significant blood loss (more than 400 mL) over the past 6 months\n* Intention to regularly donate blood during the 2 years duration of the study\n* No residence in the respective location\u002Faltitude for at least the last 2 years\n* No intention to reside in the respective location\u002Faltitude at least for the next 2 years\n* Participants who are planning to spend an extended period (\\>12 weeks) at a different altitude from their residence location\n* Spending more than 2 nights per week at a different location from residence location\n* Inability to understand the information sheet and the informed consent form due to cognitive or language reasons","45 Years",{"count":116,"type":22},120,[25],"Iron is an essential micronutrient responsible for a whealth of biological processes of the human body. Iron plays a fundamental role especially in oxygen transport, by binding to hemoglobin in the blood circulation. Iron intake from the diet needs to be in balance the unavoidable losses that occur daily via different pathways. The recommended daily requirement of iron is based on the balance between absorption and losses and is calculated to maintain a balance so that the absorption equals losses. At higher altitudes, the absorption of iron may be higher due to adaptation mechanisms in response to low oxygen concentration, and to maintain a larger erytroid compartement. However, the long-term effects of altitude on iron balance are unknown. Filling this knowledge gap is important to better understand iron deficiency in populations living at high and moderate altitudes. Therefore, the investigators plan to study people that live at two different altitudes and measure iron absorption and losses over the long term. This will be useful to formulate specific recommendations for this population groups, to expand the knowledge base to better prevent iron deficiency in Switzerland but also worldwide. Participants will be asked to consume a dose of stable iron isotopes. After one year from isotope administration, the isotopes will be equally distributed in all body compartments and any change in the isotope abundance with the normal occurring body iron can be detected. From this point onwards, the investigators can observe the iron turnover and calculate iron absorption and losses per unit of time. At 4 different visits blood samples will be taken from each participant.",[28,120,121],"Iron Requirements","Altitude",[123,124,125,126],"iron absorption","altitude","stable iron isotopes","long-term iron balance","2026-01-13",{"date":129,"type":40},"2026-01-14",{"date":131,"type":40},"2025-08-22",{"date":133,"type":22},"2028-02",{"name":135,"class":47},"Diego Moretti",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":16,"sex":17,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":155,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":48},"100617182","maximizing-the-benefits-of-iron-in-ready-to-use-therapeutic-foods-for-malnourished-children-in-kenya-100617182","NCT07315295","Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya","Maximizing the Benefits of Iron in Ready-to-use Therapeutic Foods for Malnourished Children in Kenya","SAMI","Inclusion Criteria:\n\nmalnourished children:\n\n* severe acute malnutrition (SAM): WHZ \\\u003C -3.0\n* moderate acute malnutrition (MAM): WHZ \\\u003C -2.0 a\n* treated as outpatients (no acute medical conditions and a positive appetite test)\n\nhealthy children:\n\n\\- healthy: HAZ, WAZ and WHZ = 0\n\nExclusion Criteria (both groups):\n\n* Hemoglobin ≤7 g\u002FdL\n* Presence of acute medical conditions requiring inpatient management","12 Months","54 Months",{"count":147,"type":22},68,[25],"Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia. The current RUTF formulation may have an excessively high iron content. In severely acutely malnourished (SAM) children, iron cannot be properly absorbed, leading to life-threatening diarrhea. The overall aim of this project is to develop an improved RUTF treatment that addresses acute malnutrition and anemia in children, ensuring both safety and efficacy. Specifically, to assess the impact of malnutrition on fractional iron absorption (FIA) from RUTFs in children, by comparing healthy children to those with acute malnutrition and by tracking changes in FIA in malnourished children over the course of treatment.",[28,151,152,153,154],"Iron Deficiencies","Severly Acutely Malnourished Children","Malnutrition in Children","Anemia",[156,157,158,159],"Ready to use therapeutic foods (RUFTs)","Severe acute malnutrition (SAM)","Stable isotopes","Iron bioavailability","2025-12-18",{"date":162,"type":40},"2026-01-02",{"date":164,"type":22},"2025-12-23",{"date":166,"type":22},"2026-06-30",{"name":168,"class":47},"ETH Zurich",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":16,"sex":17,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":23,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":74},"100576380","the-effects-of-repeated-operational-stress-and-limited-recovery-on-resilience-capacity-100576380","NCT06784544","The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity","REP DEF","Inclusion Criteria:\n\n* Men and women aged 18 - 39 years (17 - 39 years if military personnel)\n* Weight stable in the past 2 months (± approximately 5 kg)\n* Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO) or home duty station medical support (HMS)\n* Functional exercise (i.e., step ups, box jumps, body mass movements) and\u002For aerobic exercise trained defined by self-report as performing ≥ 2 sessions\u002Fwk for previous 6 months\n* Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine not provided in the study, and dietary supplement use throughout the dietary interventions\n* Biological females must be on sustained (i.e., approximately \\>3 months) oral\u002Fhormonal contraceptive use which acts to maintain continuous hormonal levels (i.e., contains low-dose estrogen\u002Fprogesterone with no oral placebos, hormonal IUD)\n* Supervisor approval for federal civilian employees and non-HRV active duty military personnel)\n\nExclusion Criteria:\n\n* Musculoskeletal injuries that compromise exercise capability as determined by OMSO or HMS\n* Metabolic or cardiovascular abnormalities, sleep disorders (i.e., sleep apnea) gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.) as determined by OMSO or HMS\n* Abnormal or problems with blood clotting as determined by OMSO or HMS\n* History of complications with lidocaine or similar local anesthetic analogue\n* Present condition of alcoholism, anabolic steroids, or other substance abuse issues\n* Blood donation within 8-wk of beginning or completing study blood draws\n* Current diagnosis of Anemia (hemoglobin \\\u003C 13 g\u002FdL for males, hemoglobin \\\u003C 12 g\u002FdL for females) and Sickle Cell Anemia\u002FTrait as determined by OMSO or HMS\n* Pregnant, trying to become pregnant, and\u002For breastfeeding (results of urine pregnancy test or self-report for breastfeeding will be obtained before body composition testing)\n* Claustrophobia or discomfort related to having enclosed equipment around the head\n* Unwillingness or inability to consume study diets or foods provided due to personal preference or food allergies\u002Fsensitivities\n* Unwillingness or inability to adhere to study exercise restrictions and prescriptions","17 Years","39 Years",{"count":179,"type":22},24,[25],"This longitudinal study will examine the effects of repeated bouts of operational stress and limited recovery on integrated MPS, whole-body protein balance, iron absorption, and aerobic performance. Following baseline characterization measures, active adults (n=24) representative of normal weight phenotype (NW; n=12) and overweight phenotype (OW; n=12) will complete a 48h balance phase preceding two rounds of repeated 72h energy deficit exposure each immediately followed by a 48h recovery phase. NW cutoff will be defined ≤ 22% body fat for males and ≤ 32% body fat for females. OW cutoff will be defined as \\>22% body fat for males and \\>32% body fat for females. These body composition cutoffs are informed by the maximum allowable percent body fat standards outlined in current Army Regulation 600-9. Additional details for determining % body fat are outlined in the experimental procedures section of the protocol.",[183,184,28,185],"Sleep, Inadequate","Energy Deficit","High Physical Activity","2025-01-14",{"date":188,"type":40},"2025-01-20",{"date":190,"type":22},"2025-05",{"date":192,"type":22},"2025-11",{"name":194,"class":195},"United States Army Research Institute of Environmental Medicine","FED",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":81,"minAge":18,"maxAge":114,"enrollmentInfo":204,"targetDuration":4,"studyType":206,"phases":4,"briefSummary":207,"conditions":208,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":216,"leadSponsor":218,"locationsCount":74},"100514059","iron-absorption-and-requirements-in-pregnancy-and-lactation-100514059","NCT05973552","Iron Absorption and Requirements in Pregnancy and Lactation","Assessment of Iron Absorption and Requirements During Pregnancy and Lactation in Kenyan Women","PILLAR_II","Inclusion Criteria:\n\n* Providing consent to the informed consent form\n* Participation in a previous stable isotope absorption study and having received an oral dose of 15 mg 57Fe at least 12 months prior to the date of inclusion in the study\n* Positive pregnancy test and gestational age \\\u003C10 weeks based on history of last menstrual period\n* Permanent residence in the study area, and not expected to leave the study site for more than 4 weeks over the following 16 months\n* Assessment of good health by professional staff at Msambweni Hospital\n\nExclusion Criteria:\n\n* Pre-pregnancy body mass index \\>30 kg\u002Fm2\n* Blood transfusion or intravenous iron treatment within 4 months of study start\n* Major chronic infectious disease (e.g., tuberculosis, HIV+, hepatitis)\n* Major chronic non-infectious disease (e.g., Type 1 or 2 diabetes, cancer)",{"count":205,"type":22},250,"OBSERVATIONAL","Iron requirements increase significantly during pregnancy. Current recommendations for iron intake in pregnant and lactating women (PLW) are mainly based on factorial estimates and extrapolated from non-PLW. High-quality quantitative data on iron requirements in PLW are lacking, particularly in Sub- Saharan Africa where anaemia and infections are common.\n\nThe primary objective of this study is to use the stable iron isotope technique to determine iron requirements and assess iron absorption and losses in PLW living in Kenya.\n\nIn this prospective observational study, we will enrol pregnant women in the first trimester (n = 250) from a previous study cohort (n=1000) who participated in an iron absorption study at least 12 months ago and received the stable iron (Fe) isotope 57Fe. This 57Fe has now distributed and equilibrated throughout the women's body iron. Once enrolled in the present study, following Kenyan guidelines, women will receive standard prenatal care, including routine daily iron and folate supplementation. We will collect venous blood samples in each trimester and at delivery, and during the first 6 months of lactation in the mothers and infants (heel prick samples). To directly assess dietary iron absorption, in a randomly selected subset of women (n=35), oral and intravenous stable iron isotope tracers (54Fe, 58Fe) will be administered in the 2nd and 3rd trimesters.",[120,209,210,211,28],"Pregnancy","Lactation","Infancy","2023-07-31",{"date":214,"type":40},"2023-08-03",{"date":212,"type":22},{"date":217,"type":22},"2026-09-01",{"name":219,"class":47},"University of Oxford"]