[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"iron-deficiency-without-anemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:iron-deficiency-without-anemia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,85,114,142,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100623310","absorption-of-iron-from-stabilized-lactoferrin-a-study-in-women-with-iron-deficiency-100623310",false,"NCT07394972","Absorption of Iron From Stabilized Lactoferrin: A Study in Women With Iron Deficiency","Iron Absorption From Stabilized Lactoferrin: An Experimental Study in Iron Deficient Women (LOBSTER)","LOBSTER","Inclusion Criteria:\n\n* Serum ferritin \\\u003C 45 µg\u002FL (iron depleted)\n* Body weight \\\u003C 70 kg\n* Body mass index 18,5 - 24,9 kg\u002Fm2 (normal weight)\n* Hemoglobin (Hb) \\> 120 g\u002FL (nonanemic)\n* C-reactive protein (CRP) \\\u003C 5 mg\u002FL (no inflammation)\n\nExclusion Criteria:\n\n* Pregnant or lactating\n* Strictly vegan\n* Cigarette smoking (\\> 1 cigarette \u002F week)\n* Gastrointestinal or metabolic disorders affecting iron absorption or metabolism\n* Use of medication known to affect iron metabolism (oral contraceptives are allowed)\n* Intake of vitamin and mineral supplements in the 2 weeks before study start and during the study\n* Blood transfusion, blood donation, or significant blood loss during the previous 4 months\n* once enrolled, inability to follow study procedures or major illness\n* Participation in another study with investigational drug within the 30 days preceding and during the present study",true,"FEMALE","18 Years","45 Years",{"count":22,"type":23},45,"ESTIMATED","INTERVENTIONAL",[26],"NA","Lactoferrin (LF) is a natural iron-binding protein found in milk. It exists either in an iron-free state (apo-LF) or bound to iron (holo-LF). Whether LF binds iron to facilitate its absorption and\u002For to sequester iron from potential enteropathogens remains uncertain. However, while LF is a promising tool for treating iron deficiency, it is sensitive to heat during food processing and to the acidic environment of the human stomach. This degradation often causes LF to lose its functional properties before it can promote iron absorption effectively.\n\nThis study aims to evaluate whether encapsulating apo-LF (either alone or in combination with iron) can protect LF from digestion and enhance iron absorption. Using a randomized, crossover design, different encapsulation methods will be compared to determine which results in the highest iron absorption in women with iron deficiency.\n\nAll test compounds will be labeled with stable iron isotopes. Participants will consume the labeled compounds with a test meal or water in a randomized order, allowing for within subject comparisons. Fractional iron absorption will be measured 17 days after administration via the incorporation of labeled iron into red blood cells.",[29],"Iron Deficiency (Without Anemia)",[31,32,33,34,35,36,37],"Lactoferrin","Iron Deficiency","Iron Absorption","Iron Fortification","Stable Iron Isotopes","Dietary Supplements","Iron Bioavailability","RECRUITING","2026-02-11",{"date":41,"type":42},"2026-02-12","ACTUAL",{"date":44,"type":23},"2026-02-17",{"date":46,"type":23},"2026-05",{"name":48,"class":49},"Nicole Stoffel","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":71,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":50},"100599361","non-invasive-detection-of-iron-deficiency-in-obstetrics-100599361","NCT07083492","Non-invasive Detection of Iron Deficiency in Obstetrics","Point-of-care Transcutaneous Longitudinal Non-invasive Detection of Iron Deficiency in Obstetrics (PICCOLINO-Trial)","PICCOLINO","Inclusion Criteria:\n\n* any timepoint during or up to 3 months after pregnancy\n* age ≥ 18 years\n* written informed consent\n\nExclusion Criteria:\n\n* previous participation in this study\n* refusal of blood sampling\n* incapacity to give informed consent",{"count":60,"type":23},500,"OBSERVATIONAL","Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy.\n\nIn addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric complications and quality of life will be examined.",[64,65,66,67,68,69,70,29],"Iron Deficiency Anemia of Pregnancy","Iron-deficiency","Restless Leg Syndrome in Pregnancy","Restless Leg Syndrome Due to Iron Deficiency Anaemia","Postpartum Hemorrhage","Postpartum Depression","Pregnancy Anemia",[72,73,74,75],"Zinc protoporphyrin","Non-invasive detection","Obstetric anesthesia","Patient blood management","2025-07-23",{"date":78,"type":42},"2025-07-24",{"date":80,"type":42},"2022-11-15",{"date":82,"type":23},"2026-12-31",{"name":84,"class":49},"Wuerzburg University Hospital",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":93,"targetDuration":4,"studyType":24,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":50},"100579266","effect-of-chitin-and-ascorbic-acid-on-dietary-insect-iron-absorption-100579266","NCT06822062","Effect of Chitin and Ascorbic Acid on Dietary Insect Iron Absorption","The Effect of Chitin and Ascorbic Acid on Dietary Iron Absorption From Tenebrio Molitor Larvae in Young Women.","INSECTE","Inclusion Criteria:\n\n* Female aged between 18-45 years\n* Normal BMI (18.5 - 24.9 kg\u002Fm2)\n* Body weight \\\u003C 70 kg\n* Low iron status (being in the lower half of the serum ferritin distribution at screening)\n\nExclusion Criteria:\n\n* Anaemia (Hb \\\u003C 12 g\u002FdL)\n* Inflammation (CRP \\> 5.0 mg\u002FL)\n* Pregnancy or intention to become pregnant during the study or within 30 days after the discontinuation of the study intervention\n* Lactating up to 6 weeks before the study initiation\n* Chronic digestive, renal and\u002For metabolic diseases\n* Antibiotics in the last 4 weeks prior to the study and during the study\n* Mineral and vitamin supplementation in the last 2 weeks prior to the study and during the course of the study\n* Chronic medication intake (except for oral contraceptives)\n* Blood transfusion, blood donation or significant blood loss (accident, surgery) over the past 4 months\n* Earlier participation in a study using stable isotopes or in any clinical study within the last 30 days\n* Food allergies, especially known hypersensitivity to crustacea, dust mites, sea food, gluten, milk, or eggs\n* Cigarette smoking (\\> 1 cigarette per day)",{"count":94,"type":23},25,[26],"Iron is involved in many vital metabolic processes such as oxygen transport, electron transport in cells, DNA synthesis and repair, and muscle metabolism. However, iron deficiency and iron deficiency anemia continue to affect many people, particularly preschool children (\\\u003C5 years), adolescents, and pregnant and non-pregnant women of childbearing age. Iron deficiency is characterized by a lack of total iron stores in the body, which is mainly caused by insufficient dietary iron intake, physiologically increased iron requirements, poor intestinal iron absorption, or chronic blood loss. Animal foods are important sources of highly bioavailable iron in the human diet. Meeting human nutritional needs for the rapidly increasing world population while targeting food production within the planetary boundaries will require the identification of sustainable iron sources, such as edible insects. A previous iron absorption study showed that insect iron is absorbed moderately well. The present study will examine if and to which extent chitin, a polysaccharide within the insect biomass, inhibits iron absorption. In addition, the enhancing iron absorption of ascorbic acid on iron absorption from Tenebrio molitor larvae will be studied. This knowledge can support to optimize the composition of an insect-based meal to increase its iron absorption.\n\nTo distinguish iron absorption from insect biomass from other sources, insects are labeled with stable iron isotopes (Fe-57, Fe-58, Fe-54) and iron absorption in the blood is measured.",[29],[99,100,101,102,103,104],"edible insects","Tenebrio molitor","iron deficiency","iron bioavailability","chitin","ascorbic acid","2025-05-27",{"date":107,"type":42},"2025-05-31",{"date":109,"type":42},"2025-05-06",{"date":111,"type":23},"2025-12-31",{"name":113,"class":49},"Swiss Distance University of Applied Sciences",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":121,"targetDuration":123,"studyType":61,"phases":4,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":50},"100592203","iron-status-of-non-anemic-pregnant-women-in-first-trimester-100592203","NCT06990373","Iron Status of Non-anemic Pregnant Women in First Trimester","Establishment of Reference Intervals for Iron Test Panel for Pregnant Women at Hung Vuong Hospital","Inclusion Criteria:\n\n* Pregnant women attending antenatal care, carrying a single live fetus.\n* Systolic blood pressure at the time of examination \\\u003C 140 mmHg.\n* Diastolic blood pressure at the time of examination \\\u003C 90 mmHg.\n* Body temperature at the time of examination between \\>35°C and \\\u003C37.5°C.\n* Hemoglobin ≥ 11 g\u002FdL\n\nExclusion Criteria:\n\n* History of diabetes mellitus, hypertension, hemoglobinopathies, leukemia, non-hematologic cancers, systemic lupus erythematosus, Gastrointestinal diseases (Celiac disease, Crohn's disease and ulcerative colitis, Gastric diseases or prior gastrointestinal surgery, Irritable bowel syndrome, etc).\n* Currently on gastric acid-suppressing medications: Proton pump inhibitors (e.g., Omeprazole, Lansoprazole, Esomeprazole...), H2 receptor antagonists (e.g., Ranitidine, Famotidine, Cimetidine...), Positive screening for Treponema pallidum, HBsAg, or HIV.\n* Use of stimulants or tobacco smoking.",{"count":122,"type":23},600,"1 Week","This cross-sectional study aims to establish reference intervals for iron biomarkers-including serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT)-in healthy pregnant women during the first trimester. Additionally, the study will investigate the current prevalence of non-anemic iron deficiency (NAID) in this population. By applying strict inclusion and exclusion criteria to eliminate potential confounding factors, the study seeks to provide a reliable baseline for evaluating iron status and early detection of iron deficiency without anemia among pregnant women.",[29,126,127],"Reference Values","Iron Deficiency Without Anemia",[129,130,131,132],"NAID","IDWA","Iron deficiency","Pregnant","2025-05-24",{"date":135,"type":42},"2025-05-30",{"date":137,"type":42},"2025-03-12",{"date":139,"type":23},"2025-08-30",{"name":141,"class":49},"Hung Vuong Hospital",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":149,"targetDuration":4,"studyType":24,"phases":151,"briefSummary":152,"conditions":153,"keywords":154,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":163,"locationsCount":50},"100581501","assessing-the-immediate-increase-in-serum-ferritin-after-oral-iron-doses-an-experimental-study-in-iron-deficient-women-100581501","NCT06851130","Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women","INFER 2","Inclusion Criteria:\n\n* Low iron stores (SF levels \\\u003C 30 µg\u002FL),\n* no anemia (Hb \\> 120 g\u002FL)\n* no inflammation (CRP \\\u003C 5 mg\u002FL)\n* 18 to 45 years old.\n* Body weight \\\u003C70 kg\n* Normal body Mass Index (18.5-26.5 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Any chronic or acute disease\n* Consumption of mineral and vitamin supplements since screening and over the study period\n* Blood transfusion, blood donation or significant blood loss over the past 4 months,\n* Pregnant or breastfeeding,\n* Continuous\u002Flong-term use of medication during the whole studies (except for contraceptives)\n* Therapeutic iron infusion over the past 6 months,\n* Known hypersensitivity or allergy to iron supplements,\n* Intention to become pregnant over the course of the study",{"count":150,"type":23},120,[26],"Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin following the administration of a daily iron dose for two months.",[127],[155,156],"serum ferritin","oral iron supplementation","2025-05-19",{"date":159,"type":42},"2025-05-20",{"date":161,"type":42},"2025-02-25",{"date":111,"type":23},{"name":164,"class":49},"Swiss Federal Institute of Technology",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":24,"phases":175,"briefSummary":176,"conditions":177,"keywords":179,"overallStatus":192,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":50},"100577460","how-does-perimenopausal-menorrhagia-affect-womens-quality-of-life-and-cognitive-function-100577460","NCT06798584","How Does Perimenopausal Menorrhagia Affect Women's Quality of Life and Cognitive Function?","Rough Journey to Menopause: How Does Perimenopausal Menorrhagia Affect Women's Quality of Life and Cognitive Function?","MENO","Inclusion Criteria:\n\n* Undergoing natural perimenopause\n* English-speaking\n* In general good health as documented by each woman's personal report that the participant is without any past history of a chronic health condition\n\nExclusion Criteria:\n\n* Taking psychoactive drugs\n* A history of hematological disorders",{"count":174,"type":23},240,[26],"The goal of this clinical trial is to investigate how iron status and heavy bleeding during the menopausal transition affect women's cognitive function and quality of life. The main questions it aims to answer are:\n\n* What is the association between iron status, cognitive function, mood, quality of family relationships, and quality of life in perimenopausal women?\n* How does iron repletion, via supplementation, affect cognitive function, mood, quality of family relationships, and quality of life in perimenopausal women?\n\nThe investigators will compare the effect of iron supplements to a placebo (gelatin capsule) to see if iron supplements could improve iron status, cognitive function, mood, quality of family relationships, and quality of life of iron-deficient and\u002For anemic women undergoing the menopausal transition.\n\nEach participant will:\n\n* Make 2 visits (about 2 hours each - baseline and endline) to the Clinical Research Center at Purdue\n* Make a very brief visit at midpoint (about 10 minutes) for a checkup\n* Take a daily study supplement or placebo for 4 months",[178,32,29],"Iron Deficiency Anemia Treatment",[180,181,182,32,183,184,185,186,187,188,189,190,191],"Iron","Perimenopause","Iron Deficiency Anemia","Cognitive Function","Quality of Life","Mood","Quality of Family Relationships","Menopause","Perimenopausal Menorrhagia","Abnormal Uterine Bleeding","Menopause Transition","Women's Health","NOT_YET_RECRUITING","2025-02-12",{"date":195,"type":42},"2025-02-13",{"date":197,"type":23},"2025-03-01",{"date":199,"type":23},"2025-12",{"name":201,"class":49},"Purdue University"]