[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"irreversible-pulpitis-toothache\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:irreversible-pulpitis-toothache":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,77,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100627744","predicting-vital-pulp-treatment-outcomes-in-symptomatic-pulpits-using-metabolic-biomarker-100627744",false,"NCT07452614","Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker","Efficacy of Metabolic Biomarkers in Predicting Twelve-Month Outcomes of Vital Pulp Treatment in Symptomatic Teeth With Carious Pulp Exposure: A Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age range of 16-50 years.\n2. Pulp exposure during treatment of deep caries.\n3. Absence of periodontitis or systemic disease.\n4. Only one or two proximal surfaces lost with remaining walls \\> 2 mm; and\n5. Good compliance and signed informed consent forms.\n\nExclusion Criteria:\n\n1. Patients who meet any of the following criteria will be excluded:\n2. Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;\n3. Teeth with a negative response to cold testing\n4. Current pregnancy or breastfeeding;\n5. Poor compliance or inability to complete the trial.\n6. The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study.\n7. Inadequate blood sample collection after pulpal exposure.",true,"ALL","16 Years","50 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.",[28,29,30,31],"Pulp Disease, Dental","Pulpitis","Reversible Pulpitis","Irreversible Pulpitis (Toothache)",[33,34,29,35],"Vital pulp treatment","Metabolic biomarker","Carious pulp exposure","RECRUITING","2026-03-26",{"date":39,"type":40},"2026-04-01","ACTUAL",{"date":42,"type":40},"2026-02-20",{"date":44,"type":22},"2028-10",{"name":46,"class":47},"Abeer Ghalib Abdul-khaliq","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100615062","evaluation-of-laser-versus-conventional-pulpotomies-in-mature-molar-teeth-with-irreversible-pulpitis-100615062","NCT07287709","Evaluation Of Laser Versus Conventional Pulpotomies In Mature Molar Teeth With Irreversible Pulpitis","Evaluation Of Laser Versus Conventional Pulpotomies In Mature Molar Teeth With Irreversible Pulpitis (A Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Permanent molar teeth with symptomatic irreversible pulpitis.\n* The patient should be ≥ 16 to 50 years old.\n* Teeth should give positive response to cold testing and clinical diagnosis of SIP with or without periapical rarefaction.\n* Teeth will be selected only if they are restorable.\n* Patient medically healthy and free from systemic diseases. ASA I, II.\n* patients who agreed to participate in the study to attend the control visits.\n* Teeth with periapical index score (PAI) 1 and 2 will be selected\n\nExclusion Criteria:\n\n* Teeth with necrotic pulp, resorption or subgingival caries.\n* Teeth with open apices.\n* Medically compromised patients.\n* Pregnant patients.\n* Patients with uncontrollable bleeding from the radicular pulp.\n* Patients with (PAI) score 3-5 will be excluded from the study",{"count":21,"type":22},[25],"this clinical trial is evaluating the outcome of laser assisted pulpotomy compared to conventional pulpotomy in mature teeth with symptomatic irreversible pulpitis (SIP) assessed by CBCT followed by automated segmentation using Artificial intelligence (AI).",[31],[61,62,63,64,65,66,67],"Photobiomodulation,","photocoagulation,","pulpotomy,","segmentation,","irreversible pulpitis","artificial intelligence","bioceramic putty","2025-12-03",{"date":70,"type":40},"2025-12-17",{"date":72,"type":40},"2025-11-07",{"date":74,"type":22},"2026-05",{"name":76,"class":47},"Rana Hegaz",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100596520","evaluation-of-the-success-rate-of-pulpotomy-versus-to-root-canal-therapy-in-management-of-mature-first-permanent-molars-with-irreversible-pulpitis-100596520","NCT07046533","Evaluation of the Success Rate of Pulpotomy Versus to Root Canal Therapy in Management of Mature First Permanent Molars With Irreversible Pulpitis","Evaluation of the Success Rate of Full Coronal Pulpotomy as Compared to Conventional Root Canal Therapy in the Management of Mature First Permanent Molars With Irreversible Pulpitis in Children","Inclusion Criteria:\n\n1. Molars teeth with a history of spontaneous radiating pain indicated IP\n2. the pain triggered by hot\u002Fcold fluids lasted for several minutes after removing of the stimulus.\n3. Molars teeth with no prominent radiolucency at the periapical or furcation regions\n\nExclusion Criteria:\n\n1. Teeth with continuous bleeding\n2. necrosis\n3. Teeth could not be restored with direct restoration. Teeth having localized\u002Fgeneralized periodontal diseases (probing pocket depth more than 3 mm).\n\nTeeth with crack fracture. Teeth with internal\u002Fexternal root resorption. Teeth with pulp chamber\u002Fcanal calcification","9 Months","14 Months",{"count":21,"type":22},[25],"The goal of This current study compare the clinical \\& radiographic success rate between two different modalities conventional RCT and VPT using Bio-C-Repair as a pulp capping material to treat young patients with mature first permanent molars with irreversible pulpitis.",[31,90],"Dental Caries (Diagnosis)",[92,93],"randomized control trial","vital pulp therapy","NOT_YET_RECRUITING","2025-06-23",{"date":97,"type":40},"2025-07-01",{"date":97,"type":22},{"date":100,"type":22},"2026-07-01",{"name":102,"class":47},"Lamiaa Saeed Ahmed Elshiekh",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":16,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100574147","garlic-oil-as-root-filling-material-in-primary-molars-100574147","NCT06755502","Garlic Oil As Root Filling Material in Primary Molars","Evaluation of Allium Sativum As Root Filling Material for Primary Molars Indicated for Non Vital Pulp Therapy: Randomized Clinical Trials","Inclusion Criteria:\n\n1. Primary second molars which are diagnosed with irreversible pulpitis, or pulp necrosis.\n2. Presence of sinus tract.\n3. Periapical bone swelling.\n4. Continuous bleeding after amputation of the coronal pulp tissue.\n5. No pulp tissue remains when the pulp chamber is accessed.\n6. Pus discharges from the canal.\n7. Radiographically, only primary molars with at least two-thirds of the root length.\n8. Presence of inter-radicular or periapical radiolucency.\n\nExclusion Criteria:\n\n1\\. A tooth with internal root resorption will not be included. 2. Excessive tooth mobility beyond healing. 3. Carious perforation in the pulpal flour. 4. A tooth with a pathological lesion extending to the successor's tooth germ. 5. Non-restorable primary molars.\n\n\\-","4 Years","8 Years",{"count":113,"type":22},40,[25],"The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.\n\nthe study hypothesized that garlic oil mixed with zinc oxide would be the same as the gold standard filling material (metapex).\n\nThe group receiving the garlic oil with zinc oxide as root canal filling material will be compared with other similar group receiving metapex as root canal filling material in terms of clinical and radio-graphic success, and working time.",[117],"Irreversible Pulpitis (toothache)",[119,120,121,122,123],"RCT","garlic oil","natural remedies","primary molars","root canal filling material","2025-03-18",{"date":126,"type":40},"2025-03-20",{"date":128,"type":22},"2025-08-08",{"date":130,"type":22},"2026-11-08",{"name":132,"class":47},"Cairo University"]