[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"irreversible-pulpitis-with-apical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:irreversible-pulpitis-with-apical-periodontitis":58},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100614608","phase-4-comparison-of-the-pain-levels-of-single-dose-premedication-with-piroxicam-and-prednisolone-on-post-endodontic-pain-in-single-visit-root-canal-treatment-of-premolars-100614608",false,"NCT07281807","Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars","Inclusion Criteria:\n\n* Healthy patient ranging between 18-40 years\n* Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs.\n* Teeth having mature apex confirmed by periapical radiographs.\n\nExclusion Criteria:\n\n* History of systemic disorders including HIV, Hepatitis\n\n  * Pregnancy (As per Medical record\u002F Verbally)\n  * Patient using medication such as analgesics or anti-inflammatory drugs\n  * Patient allergic to lignocaine, piroxicam and prednisolone\n  * Tooth not suitable for restoration\n  * Periodontal probing depth ≥ 4mm\n  * Retreatment cases\n  * Patients having calcified canals assessed by radiographic findings",true,"ALL","18 Years","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.",[27,28],"Irreversible Pulpitis With Apical Periodontitis","Symptomatic Apical Periodontitis","NOT_YET_RECRUITING","2025-12-02",{"date":32,"type":33},"2025-12-15","ACTUAL",{"date":35,"type":21},"2026-01-01",{"date":37,"type":21},"2027-01-31",{"name":39,"class":40},"RANA AHMAD","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100579243","phase-2-to-measure-post-operative-pain-severity-by-using-two-different-intra-canal-medicaments-calcium-hydroxide-and-triple-antibiotic-paste-in-teeth-with-single-roots-and-periapical-disease-called-apical-periodontitis-100579243","NCT06821763","To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis","Effect of Calcium Hydroxide on Post Operative Pain Severity in Single Rooted Teeth with Symptomatic Apical Periodontitis","Inclusion Criteria:\n\n* Patients of both genders having age 12-45 years\n* Newly diagnosed cases fulfilling the criteria of INTERNATIONAL ASSOCIATES FOR THE STUDY OF PAIN definition of pain.\n* A Single rooted teeth (Anterior or Posterior)\n* Teeth with symptomatic apical periodontitis\n* Teeth with necrotic pulp that gave a negative response to vitality testing.\n\nExclusion Criteria:\n\n* Patients who have allergies, sensitivity or unable to take medications, periodontal disease, acute endodontic or periodontal abscess, requiring prophylactic antibiotics, systemic diseases like hypertension, diabetes, liver dysfunction renal failure and mental disabilities were excluded.\n* Pregnant ladies or patients on nursing were also excluded from the sample.\n* Teeth with anatomical difficulties such as open apices.\n* Teeth with severe dilacerations, calcified canals, occlusal interferences, chronic periodontitis, internal\u002Fexternal root resorption.\n* Patients with serious medical illness, systemic disorders, immunocompromised diseases such as AIDS or HBV.","12 Years","45 Years",{"count":51,"type":21},180,[53,54],"PHASE2","PHASE3","* The aim of this study is to compare post operative pain effectiveness between two most commonly available intra canal medicaments that are Triple Antibiotic Paste and Calcium Hydroxide during root canal treatment of single rooted teeth with symptomatic apical periodontitis.\n* Patients visiting OPD will be selected after fulfilment of inclusion criteria and randomly divided into two groups i.e group A patients receiving calcium hydroxide and group B with patients receiving Triple Antibiotic Paste as intra canal medicaments\n* Patient will be called at 48hrs 72hrs and 96hrs postoperatively.\n* Effectiveness of intra canal medicaments will be measured as no mild moderate severe on visual analogue scale(VAS).",[57,58],"Apical Periodontitis","Irreversible Pulpitis with Apical Periodontitis","2025-02-10",{"date":61,"type":33},"2025-02-12",{"date":63,"type":21},"2025-05-01",{"date":65,"type":21},"2025-11-01",{"name":67,"class":40},"Komal Ashraf Khan",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":68},"100565287","the-effect-of-eddy-sonic-versus-af-max-activation-of-bio-ceramic-sealer-on-post-operative-pain-in-teeth-with-symptomatic-irreversible-pulpitis-with-apical-periodontitis-100565287","NCT06640218","The Effect of Eddy Sonic Versus AF Max Activation of Bio-ceramic Sealer on Post-operative Pain in Teeth with Symptomatic Irreversible Pulpitis with Apical Periodontitis","Inclusion Criteria:\n\n* Age range is from 18 to 40 years old.\n* No sex predilection\n* Patients seeking root canal treatment.\n* restorable teeth.\n* Positive patient acceptance for participating in the study.\n* patients able to sign informed consent.\n* Systematically healthy patient (ASA I, Il).\n* Patient who can understand the numerical rate scale and sign an informed consent.\n* Mandibular first molar teeth with pain on bite or percussion\n* Preoperative sharp (moderate or severe) pain.\n* Vital response of pulp tissue to cold pulp tester (ethyl chloride spray).\n* widening in periodontal membrane space in radiographic appearance.\n\nExclusion Criteria:\n\n* Patients with American Association of Anesthesiologists (ASA) classifications other than ASA 1 \\& Il\n* Patients who have already ingested preoperative medication, such as analgesics, non-steroidal, or steroidal anti-inflammatory drugs, within 12 hours of the start of treatment.\n* This was done to prevent any misinterpretation of the diagnosis or post-treatment pain severity, as these drugs substantially lower post-endodontic pain (Jorge-Arajo et al.,2018).\n* Patients with NSAID allergy.\n* Patients having two or more adjacent teeth needing root canal therapy\n* Pregnant patients.\n* Patients with bleeding disorder.\n* Patients with long-term corticosteroid use.\n* Teeth having:\n\n  * Necrotic pulp.\n  * History or presence of swelling or fistulous tract.\n  * Acute\u002Fchronic periapical abscess.\n  * Mobility more than grade 1.\n  * Pocket depth of more than 5mm\n  * No possible restorability.\n  * Previous root canal treatment.\n  * Periapical radiolucency.\n  * External or internal resorption\n  * Vertical root fracture.\n* TMJ problems, bruxism, clenching or traumatic occlusion.\n* Inability to understand and perform the given instructions.",{"count":76,"type":21},30,[78],"NA","The aim of endodontic therapy for an inflamed tooth is to eliminate the source of inflammation. Relieving pain depends on the effectiveness of root canal therapy.3\n\nPostoperative pain in endodontic treatments, affecting 3-58% of patients, is often caused by peri-radicular tissue injuries. Understanding these factors helps professionals select methods and supplies to minimize discomfort.\n\n30 patients will be divided into 3 groups according to the method of activation (10 par ticipants\u002Feach). participants will be recruited from the postgrad clinic of the endodontic department faculty of oral and dental medicine, Future University in Egypt Patients with mature mandibular first permanent molar with irreversible pulpitis with apical periodontitis Intervention 1: bio-ceramic sealer activation with Eddy sonic Intervention 2: bio-ceramic sealer activation with AF max Control\u002FComparator: bio-ceramic sealer without activation The study aims to evaluate the effect of Eddy Sonic and AF max activation of bio-ceramic sealer on postoperative pain in mandibular first molars with symptomatic irreversible pulpitis with apical periodontitis",[58],"RECRUITING","2024-10-10",{"date":84,"type":33},"2024-10-15",{"date":86,"type":21},"2024-11-01",{"date":88,"type":21},"2026-04-01",{"name":90,"class":40},"Future University in Egypt"]