[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"irreversible-pulpitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:irreversible-pulpitis":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,42,70,95,126,152,172,195,220,241,267,296,322,346,372,396,421,440,463,486,508,535,558,581,606],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100640211","salvadora-persica-zinc-oxide-versus-mta-as-pulpotomy-agents-in-mature-permanent-molars-with-irreversible-pulpitis-100640211",false,"NCT07630181","Salvadora Persica-Zinc Oxide Versus MTA as Pulpotomy Agents in Mature Permanent Molars With Irreversible Pulpitis","Comparative Clinical and Radiographic Evaluation of Salvadora Persica Extract Mixed With Zn Oxide Powder Versus Mineral Trioxide Aggregate as a Pulpotomy Agent in Mature Permanent Posterior Teeth With Irreversible Pulpitis","Inclusion Criteria:\n\n* 1\\. Co-operative healthy patients both male and female with age ranging from 18-40 years. 2. Mature permanent molar teeth with caries extending deep into dentine more than two third on bite wing x ray 3. Teeth with clinical signs and symptoms of irreversible pulpitis i.e. spontaneous lingering pain that can be reproduced with a cold test 4. Teeth not painful to percussion and palpation. 5. Teeth in which hemostasis can be achieved within 5 mins. If not achieved individual will be excluded from the study 6. No peri-apical rarefaction, and inter-radicular rarefaction as seen on periapical x-ray.\n\nExclusion Criteria:\n\n* 1\\. Small carious lesion or lesions not extending deep into dentine closer to pulp 2. Grossly carious teeth with necrosed pulp 3. Teeth with swelling, abscess and sinus tract. 4. Periodontally compromised teeth 5. Immature permanent teeth with open apex 6. Fractured teeth 7. Teeth with signs of internal or external resorption 8. Patients with systemic diseases i.e. ASA classification III, IV and V will be excluded.","ALL","18 Years","40 Years",{"count":21,"type":22},78,"ESTIMATED","INTERVENTIONAL",[25],"NA","Pulpotomy has emerged as a conservative treatment option for mature permanent teeth with irreversible pulpitis, aiming to preserve pulp vitality while avoiding the limitations of conventional root canal treatment. Mineral Trioxide Aggregate (MTA) is currently considered the gold standard pulpotomy medicament because of its favorable biological properties; however, its high cost, difficult handling characteristics, and prolonged setting time limit its widespread use. Salvadora persica (Miswak), a medicinal plant with documented antibacterial and anti-inflammatory properties, may provide a cost-effective biological alternative.\n\nThis randomized controlled clinical trial aims to compare the clinical and radiographic outcomes of Salvadora persica extract mixed with zinc oxide powder versus MTA as pulpotomy agents in mature permanent posterior teeth diagnosed with irreversible pulpitis. A total of 78 patients aged 18-40 years will be randomly allocated into two equal treatment groups. Clinical outcomes, including pain, tenderness to percussion and palpation, swelling, sinus tract formation, and tooth mobility, will be evaluated alongside radiographic outcomes such as periapical\u002Finter-radicular radiolucency and internal resorption. Participants will be followed for six months after treatment.\n\nThe study seeks to determine whether Salvadora persica extract mixed with zinc oxide powder can provide outcomes comparable to MTA. If successful, this natural and economical material may offer an accessible alternative for vital pulp therapy, particularly in low-resource settings, promoting tooth preservation and reducing the need for more invasive endodontic procedures.",[28],"Irreversible Pulpitis","NOT_YET_RECRUITING","2026-06-01",{"date":32,"type":33},"2026-06-05","ACTUAL",{"date":35,"type":22},"2026-06-20",{"date":37,"type":22},"2026-12-20",{"name":39,"class":40},"Postgraduate Medical Institute, Lahore","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100639316","r-officinalis-as-pulpotomy-agent-in-permanent-teeth-with-irreversible-pulpitis-100639316","NCT07610057","R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible Pulpitis","Comparative Clinical and Radiographic Evaluation of Rosmarinus Officinalis Versus Mineral Trioxide Aggregate as Pulpotomy Medicament in Vital Mature Permanent Teeth With Irreversible Pulpitis","Inclusion Criteria\n\n* Healthy patients (ASA classification 1 and 2) of age range of 18-40 of both sexes would be included.\n* Vital mature permanent posterior teeth with deep caries approaching the pulp as seen on periapical x-ray.\n* Pain indicative of irreversible pulpitis (spontaneous pain or pain exacerbated by a cold stimulus which could last from a few seconds to hours), which a cold test could reproduce.\n* Tooth will be selected on the basis of working diagnosis i.e. successful hemostasis within 5 minutes after removal of coronal pulp.\n* Absence of clinical signs or symptoms suggesting a non-vital tooth such as tenderness to percussion or palpation, mobility, presence of abscess, soft tissue swelling or suppurating sinus.\n* Absence of radiographic changes as; furcation or periapical pathology, internal or external root resorption or calcification in the canals.\n* The tooth structure of selected teeth should be restorable after completion of the treatment\n\nExclusion Criteria:\n\n* Patients with ASA classification 3, 4 ,5 and 6 would be\n* Patients taking antibiotics within last 2 weeks.\n* Teeth with pulp necrosis, cracked tooth, internal or external resorption, calcified canals, acute or chronic apical periodontitis with an associated sinus tract or periapical radiolucency.\n* Periodontally compromised tooth.\n* Uncooperative patients or failure to obtain authorization from patients.",{"count":50,"type":22},100,[25],"This study evaluates and compares the clinical and radiographic outcomes of Rosmarinus officinalis and Mineral Trioxide Aggregate (MTA) when used as pulpotomy medicaments in vital mature permanent teeth with irreversible pulpitis. The aim is to determine the effectiveness of both materials in terms of pain reduction and periapical healing. While MTA is considered a gold standard, it has limitations such as high cost, long setting time, and potential discoloration. Therefore, this study investigates Rosmarinus officinalis as a natural, cost-effective alternative with comparable therapeutic potential. This study also provide an alternative to RCT in teeth with irreversible pulpitis",[28,54,55],"Pulpotomy","MTA Vital Tooth Pulpotomy",[57,58,59,60,61],"pulpotomy","rosemarinus officinalis","MTA","permanent teeth with irreversible pulpitis","Vital pulp theray","2026-05-21",{"date":64,"type":33},"2026-05-27",{"date":30,"type":22},{"date":67,"type":22},"2026-12-31",{"name":69,"class":40},"University of Health Sciences Lahore",{"id":71,"slug":72,"hasResults":12,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100622841","early-phase-1-comparison-of-treatment-outcome-of-pulpotomy-with-versus-without-dental-operating-microscope-in-carious-mature-permanent-teeth-100622841","NCT07388862","Comparison of Treatment Outcome of Pulpotomy With Versus Without Dental Operating Microscope in Carious Mature Permanent Teeth","Comparison of Treatment Outcome of Pulpotomy With Versus Without Dental Operating Microscope in Carious Mature Permanent Teeth : A Randomized Controlled Trial","Inclusion Criteria:\n\n* Healthy patients aged at least 18 years old with deep or extremely deep carious lesions in mature permanent teeth diagnose with asymptomatic or symptomatic irreversible pulpitis. Diagnoses are confirmed using EPT and cold tests. Pulpal and periapical diagnoses are based on terminology from the American Association of Endodontists (AAE, 2013)20.\n* Teeth are restorable with direct composite restoration.\n\nExclusion Criteria:\n\n* Teeth with subgingival caries and\u002For clinical attachment loss more than 3 mm and probing depth more than 4 mm.\n* Negative responses to pulp sensibility tests, presence of sinus tracts, swelling, non-restorable crowns, immature roots, or no pulp exposure following complete caries removal in case of pre-operative diagnosis as asymptomatic irreversible pulpitis.\n* Patients with systemic diseases involving bleeding disorders such as hemophilia, Von Willebrand disease, platelet disorders. And patients under taking all kind of anticoagulant and anti-platelet.\n* Teeth with pulpal obliteration.\n* Necrotic pulp is found after access opening\n* Bleed cannot be stopped within 8 minutes after full pulpotomy",{"count":78,"type":22},50,[80],"EARLY_PHASE1","The goal of this \\[randomized clinical trial\\] is to evaluate the treatment outcome by assessing clinical and radiographic outcomes.\n\nThe main question it aims to answer is\n\nDo using dental operating microscope incorperated with pulpotomy procedure will have a different outcome when compare with without using.\n\nParticipants will be asked to have clinical and radiographic evaluation for evaluating the outcome every year after treatment.",[28],[54,84,85],"treatment outcome","dental operating microscope","2026-03-16",{"date":88,"type":33},"2026-03-18",{"date":90,"type":22},"2026-02-21",{"date":92,"type":22},"2037-12-31",{"name":94,"class":40},"Chulalongkorn University",{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":41},"100629290","evaluation-of-bacterial-reduction-after-pulpectomy-in-primary-molars-100629290","NCT07472751","Evaluation of Bacterial Reduction After Pulpectomy in Primary Molars","Comparative Evaluation of Bacterial Reduction Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary Molars: An In Vitro and In Vivo Study","Inclusion Criteria:\n\n* Children age 4 to 6 years\n* Medically free children\n* Cooperative children\n* Restorable mandibular second primary molars with signs or symptoms of irreversible pulpitis\n* No internal root resorption on radiograph\n* No external root resorption on radiograph\n* No periapical radiolucency\n* No inter-radicular radiolucency\n\nExclusion Criteria:\n\n* Uncooperative children\n* Children with systemic disease\n* Children with physical disability\n* Children with mental disability\n* Refusal to participate\n* Inability to attend follow-up visits\n* Refusal to sign consent form\n* Previously accessed teeth\n* Mobile mandibular primary molars\n* Pain on percussion\n* Swelling on palpation or in the vestibule","4 Years","6 Years",{"count":105,"type":22},34,[25],"The primary aim of the study is to compare the bacterial reduction in pulpectomy of primary molars using a single rotary file system versus conventional manual instrumentation.",[28],[110,111,112,113,114,115,116],"Pediatric endodontics","Intracanal bacterial reduction","Endodontic treatment in children","Chemo-mechanical preparation","Pulpectomy","primary molars","Bacterial load reduction","2026-03-13",{"date":119,"type":33},"2026-03-17",{"date":121,"type":22},"2026-04",{"date":123,"type":22},"2027-10",{"name":125,"class":40},"Cairo University",{"id":127,"slug":128,"hasResults":12,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":133,"sex":17,"minAge":102,"maxAge":103,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":41},"100624904","childs-behavior-using-single-rotary-file-system-versus-manual-instrumentation-in-pulpectomy-of-primary-molars-100624904","NCT07415694","Child's Behavior Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary Molars","Evaluation of Child's Behavior Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary Molars - A Randomized Clinical Trial (RCT)","Inclusion Criteria:\n\n* Patients:\n\n  • Aged 4-6years, Medically free and Cooperative.\n* Teeth:\n\n  * Restorable mandibular second primary molars with clinical signs or symptoms of irreversible pulpitis.\n\nPre-operative Radiographic criteria:\n\n* Absence of internal or external root resorption.\n* Absence of periapical or inter-radicular radiolucencies.\n\nExclusion Criteria:\n\n* Patients:\n\n  * Uncooperative children.\n  * Children with systemic disease.\n  * Physical or mental disabilities.\n  * Refusal of participation.\n  * Unable to attend follow- up visits.\n  * Refusal to sign the informed consent.\n\nTeeth:\n\n* Previously accessed teeth.\n* Mobile mandibular primary molars.\n* Pain on percussion.\n* Swelling in the vestibule or on palpation.",true,{"count":135,"type":22},54,[25],"The primary aim is to compare the behavior of the children during using conventional manual instrumentation versus rotary instrumentation by single rotary system for pulpectomy in primary molars through a Randomized Clinical Trial.\n\nThe main question it aims to answer is:\n\nIs there a difference in the behavior of the children when using single rotary file system versus manual instrumentation in pulpectomy in primary molars?",[28],[140,141,142,143],"pulpectomy","single rotary file instrumentation","manual instrumentation","primary molar","2026-02-16",{"date":146,"type":33},"2026-02-18",{"date":148,"type":22},"2026-04-01",{"date":150,"type":22},"2027-06-01",{"name":125,"class":40},{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":133,"sex":17,"minAge":102,"maxAge":103,"enrollmentInfo":159,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":163,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":41},"100625806","postoperative-pain-after-pulpectomy-in-primary-molars-100625806","NCT07427420","Postoperative Pain After Pulpectomy in Primary Molars","Evaluation of Post Operative Pain Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary Molars","Inclusion Criteria:\n\n* • Patients:\n\n  * Aged 4-6years, Medically free and Cooperative.\n  * Teeth:\n  * Restorable mandibular second primary molars with clinical signs or symptoms of irreversible pulpitis.\n\nPre-operative Radiographic criteria:\n\n* Absence of internal or external root resorption.\n* Absence of periapical or inter-radicular radiolucencies.\n\nExclusion Criteria:\n\n* • Patients:\n\n  * Uncooperative children.\n  * Children with systemic disease.\n  * Physical or mental disabilities.\n  * Refusal of participation.\n  * Unable to attend follow- up visits.\n  * Refusal to sign the informed consent.\n\nTeeth:\n\n* Previously accessed teeth.\n* Mobile mandibular primary molars.\n* Pain on percussion.\n* Swelling in the vestibule or on palpation.",{"count":78,"type":22},[25],"To compare the post operative pain in pulpectomy of primary molars using a single rotary file system versus conventional manual instrumentation, through a Randomized Clinical Trial.\n\nThe main question it aims to answer is:\n\nIs there a difference in post operative pain when using single rotary file system versus manual instrumentation in pulpectomy of primary molars?",[28],[164,140,115,142],"single rotary file",{"date":166,"type":33},"2026-02-23",{"date":168,"type":22},"2026-04-10",{"date":170,"type":22},"2027-10-01",{"name":125,"class":40},{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":133,"sex":17,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":191,"leadSponsor":193,"locationsCount":41},"100433292","comparative-effectiveness-in-the-management-of-irreversible-pulpitis-100433292","NCT04922229","Comparative Effectiveness in the Management of Irreversible Pulpitis","Inclusion Criteria:\n\n* Maxillary or mandibular first or second mature permanent molars with carious lesions or restorations (excluding crowns), with signs and symptoms of symptomatic irreversible pulpitis (defined as spontaneous pulpal pain and cold hyperalgesia \\>30 seconds), and normal apical tissues.\n* Tooth is responsive to cold and electrical pulp testing.\n* Patients aged ≥12 years for first molars and ≥16 years for second molars.\n\nExclusion Criteria:\n\n* Evidence of Pulp Necrosis or Apical Periodontitis, preoperatively or upon inspection of an exposure site\n* Teeth that are badly broken down and\u002For are not restorable.\n* Teeth with mechanical allodynia assessed by registering bite force that is at least 50N lower than the contralateral side.\n* Teeth with radiographic evidence of internal, or external cervical, inflammatory or replacement root resorption, or with complete pulp canal obliteration.\n* Radiographic evidence of PDL space wider than three times normal width\n* Clinical evidence of swelling or sinus tract\n* Periodontal pocket probing depth ≥5 mm in any site around the tooth.\n* Clinical evidence of cracks connecting mesial and distal surfaces and\u002For extending in pulp chamber or associated with periodontal pockets ≥ 5 mm.\n* History of taking centrally acting drugs (e.g., tricyclic antidepressants), which interfere with the release of pain mediators and\u002For modify pain experience, within the previous 6 months.\n* Use of medications that affect the host response such as methotrexate, corticosteroids or cyclosporin.\n* Patients on immunosuppressive agents, chronic corticosteroid use, autoimmune disease, or other immunocompromising diseases or medications.\n* Patients who require IV sedation or general anesthesia for their dental treatment.\n* Teeth with full coverage crowns.\n* Teeth undergoing active orthodontic movement.\n* Teeth that require elective RCTx to place a post for restorative purposes.\n* Teeth with no contralateral molars with normal pulp and periapical tissues for bite and pulp testing controls.\n* Teeth in the pulpotomy group in which, following complete pulpotomy, bleeding does not stop after 10 minutes with 3-4% hypochlorite cotton pellet. These will be considered treatment failure and treated with RCTx.","12 Years","99 Years",{"count":181,"type":22},138,[25],"This project addresses a central question within the practice of dentistry: Is a pulpotomy procedure effective in the treatment of a tooth with symptomatic irreversible pulpitis and normal periapex? In addition, the project seeks to identify clinical and molecular biomarkers that are predictive of the success of pulpotomy.",[28],[54,186],"Vital Pulp Therapy","2026-02-12",{"date":189,"type":33},"2026-02-17",{"date":150,"type":22},{"date":192,"type":22},"2031-12-31",{"name":194,"class":40},"University of Alabama at Birmingham",{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":17,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":23,"phases":207,"briefSummary":208,"conditions":209,"keywords":210,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":41},"100625012","cgf-partial-pulpotomy-versus-endodontic-treatment-100625012","NCT07417098","CGF Partial Pulpotomy Versus Endodontic Treatment","Partial Pulpotomy Usung CGF Versus Endodontic Treatment in Treating Irreversibly Inflamed Mature Peramnent Molars","CGF Vs Endo","Inclusion Criteria:\n\n* Patient-based criteria: Class ASA I or II cooperative adolescents of 11 - 17 years. Based on a 10 cm modified visual analog scale (VAS), only patients who reported a preoperative pain intensity score of ≥ 7, indicative of severe pain were included.\n\nTooth-based criteria: Presence of occlusal extremely deep carious lesion with pulp exposure of mandibular first permanent molars with closed apices (i.e. class V according to Cvek's stages of root development) with sound contralateral molars to provide a reference for biomarker quantification and pulp sensibility tests. Only teeth diagnosed with symptomatic irreversible pulpitis (SIP) were included. To validate the diagnosis of SIP, the teeth with the teeth diagnosed with symptomatic irreversible pulpitis (SIP) were included. To validate the diagnosis of SIP, the teeth with the following criteria were exclusively included:\n\n1. History of sharp, spontaneous, and lingering pain that was precipitated by thermal provocation and lasted mostly for ≥ 30 seconds.\n2. Early prolonged, intense, and lingering response to cold thermal stimulus and positive response electric pulp test (EPT) at low thresholds.\n3. Normal color and appearance of the tooth surrounding gingival tissues with no evidence of gingival inflammation, swelling, abnormal tooth mobility, or sinus tract or fistula formation upon visual and palpation inspections.\n4. Preoperative periapical radiograph with evidence of caries penetrating the entire thickness of the dentin with no isolating radiopaque zone separating the lesion from the pulp indicating extremely deep caries.\n5. Normal radiographic findings in terms of intact periodontal membrane space\n\nExclusion Criteria:\n\nPatient-based criteria: Patients with a positive history of the following conditions were excluded:\n\n1. Emotional or behavioral problems and those receiving antidepressant drugs.\n2. Under treatment with antibacterial or anti-inflammatory medicaments for the last four weeks (Akbal Dincer et al., 2020).\n3. Localized or generalized gingivitis and\u002For periodontitis with loss of epithelial attachment ≥ 3mm upon probing.\n4. Poor oral hygiene with dense accumulation of calculus or dental plaque.\n5. Systemic conditions such as diabetes, bleeding, immunological disorders.\n\nTooth-based criteria:\n\n1. Teeth with abnormal structure or developmental anomalies.\n2. Persistent hemorrhage from the root canal orifices lasting longer than 10 minutes.\n3. Loss of coronal structure beyond restorability","11 Years","17 Years",{"count":206,"type":22},60,[25],"partial pulpotomy of mature molars with irrevesible pulptits using CGF in adolescents",[28],[211],"partial pulpotomy , CGF","2026-02-10",{"date":146,"type":33},{"date":215,"type":22},"2026-01-20",{"date":217,"type":22},"2028-01-25",{"name":219,"class":40},"Minia University",{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":133,"sex":17,"minAge":18,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":23,"phases":229,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100623972","effect-of-cryotherapy-on-anesthetic-success-and-pain-in-irreversible-pulpitis-100623972","NCT07403578","Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis","Effect Of Cryotherapy On Anesthetıc Success And Intraoperatıve Paın In Mandıbular Premolars Wıth Irreversıble Pulpıtıs: A Prospectıve Randomızed Clınıcal Trıal","Inclusion Criteria:\n\n* Systemically healthy patients classified as ASA I or II, aged between 18 and 60 years,\n* Presence of a restorable mandibular premolar tooth diagnosed with symptomatic irreversible pulpitis,\n* History of spontaneous pain or lingering pain elicited by thermal stimuli,\n* Positive response with lingering pain to cold testing (Endo Ice; Coltene, Altstätten, Switzerland),\n* Positive response at low current levels to electric pulp testing (Parkell Inc., USA),\n* Teeth with closed apex and no radiographic evidence of periapical pathology (intact periodontal ligament space and absence of periapical radiolucency),\n* Patients presenting with moderate or severe preoperative pain, as assessed using the visual analogue scale (VAS).\n\nExclusion Criteria:\n\n* Patients who had taken analgesic, anti-inflammatory, or opioid medication within the last 12 hours before treatment,\n* Patients with systemic conditions that may affect pain perception, inflammatory response, or healing,\n* History of antibiotic use within the previous month or requirement for antibiotic prophylaxis,\n* Teeth presenting with clinical or radiographic signs of pulp necrosis or apical periodontitis (Pain on percussion or palpation, presence of sinus tract or swelling, presence of periapical radiolucency),\n* Teeth with root resorption, immature apices, severe coronal destruction preventing proper isolation, or calcified canals,\n* Teeth that had undergone previous endodontic treatment, including pulpotomy or root canal filling,\n* Patients with neurological or psychiatric conditions that could interfere with pain perception or accurate pain reporting,\n* Inability to achieve adequate isolation with a rubberdam.","60 Years",{"count":50,"type":22},[25],"This prospective randomized clinical trial aimed to evaluate the effects of different anesthesia protocols on anesthetic success and intraoperative pain during root canal treatment of mandibular premolars diagnosed with symptomatic irreversible pulpitis. A total of 100 systemically healthy patients were randomly allocated into four groups: infiltration anesthesia alone, inferior alveolar nerve block (IANB) alone, infiltration anesthesia combined with cryotherapy, and IANB combined with cryotherapy. Cryotherapy was applied intraorally for 5 minutes immediately after anesthetic administration.\n\nThe effectiveness of anesthesia was confirmed using electric pulp testing and cold testing prior to treatment. Root canal therapy was completed in a single visit by a calibrated operator. Intraoperative pain was assessed during access cavity preparation using a visual analogue scale (VAS). Anesthetic success was defined as the presence of no or mild pain, whereas moderate or severe pain indicated anesthetic failure and required supplemental anesthesia.\n\nThe primary objective of the study was to determine whether the adjunctive use of cryotherapy improves anesthetic success and reduces intraoperative pain in mandibular premolars with symptomatic irreversible pulpitis. The null hypothesis was that no significant differences would be observed among the study groups in terms of anesthetic success or intraoperative pain intensity.",[28,232],"Cryotherapy",{"date":234,"type":33},"2026-02-11",{"date":236,"type":22},"2026-01-30",{"date":238,"type":22},"2026-12-30",{"name":240,"class":40},"TC Erciyes University",{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":248,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":252,"conditions":253,"keywords":255,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":263,"leadSponsor":265,"locationsCount":41},"100613467","phase-2-to-evaluate-post-operative-pain-using-two-different-kind-of-sealers-in-obturation-of-teeth-with-symptomatic-irreversible-pulpitis-during-second-visit-when-the-patient-is-painless-100613467","NCT07266974","To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless","Evaluation of Post -Operative Pain After Obturation Using Two Different Types of Sealers - A Randomized Clinical Trial","Inclusion Criteria:\n\n* • Patients ranging from 18 to 40 years.\n\n  * Patients whose teeth have been diagnosed with Symptomatic irreversible pulpitis.\n  * maxillary and mandibular teeth.\n  * A normal periapical condition on radiograph, or one with little to no periodontal ligament (PDL) space widening, confirming the normal periapical state.\n  * Teeth that can be restored.\n  * Teeth with healthy periodontium.\n\nExclusion Criteria:\n\n* Non-restorable teeth.\n* Patients with poor health whose systemic complications could change the course of treatment.\n* Teeth with immature roots.\n* Teeth with periapical lesions or apical periodontitis.\n* Teeth with Necrotic pulp.",{"count":206,"type":22},[250,251],"PHASE2","PHASE3","The goal of this randomized clinical trial is to evaluate pain after root canal treatment using two different kinds of sealers during obturation in 60 healthy , male and female patients ages between 18 to 40 years. The main aims is to systematically evaluate and compare post-operative pain levels in patients undergoing root canal treatment with two different types of endodontic sealers: AH plus (SEAL APEX) and bio ceramic sealer(META)\n\n• By identifying the sealer that leads to the least discomfort, this research could significantly enhance patient care, minimize recovery time, and improve overall treatment success in endodontics.\n\nParticipants in both groups will be given a visual analogue scale(VAS) to measure the pain level after the root canal treatment has been completed. They will measure pain levels at 12, 24 and 48 hours. All information will be recorded on proforma and compared.",[254,28],"Post Operative Pain, Acute",[256,257,258],"post operative pain","bioceramic sealer","irreversible pulpitis","2026-01-06",{"date":261,"type":33},"2026-01-08",{"date":148,"type":22},{"date":264,"type":22},"2026-10-01",{"name":266,"class":40},"Jaweria Gul Keyani",{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":12,"sex":17,"minAge":274,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":279,"conditions":280,"keywords":281,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":41},"100617524","clinical-and-radiographic-outcomes-of-rotary-instrumentation-in-primary-molars-100617524","NCT07319741","Clinical and Radiographic Outcomes of Rotary Instrumentation in Primary Molars","Clinical and Radiographic Evaluation of Single Visit Pulpectomy in Primary Molars for (5-7) Years Old Children Using Rotary and Manual Instrumentation: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged 5-7 years with irreversible pulpitis of primary molars.\n* History of spontaneous pain with a deep carious lesion.\n* Parents who approve to write informed consent.\n\nExclusion Criteria:\n\n* Medically compromised children.\n* Children with a history of allergic reaction to the materials used in the study.\n* Children with non-restorable teeth.\n* Teeth with resorbed roots (more than two-thirds of root length).\n* Extensive internal or external root resorption visible in periapical Radiographs.","5 Years","7 Years",{"count":277,"type":22},44,[25],"This study will evaluate the clinical and radiographic outcomes of rotary versus manual pulpectomy in children with irreversible pulpitis.A single-visit pulpectomy will be performed for all patients. Participants will be allocated to rotary instrumentation using Fanta AF Baby files or manual step-back instrumentation with K-files. Canals will be irrigated with 17% EDTA and 1% sodium hypochlorite, obturated with Metapex, and restored with glass ionomer cement and stainless-steel crowns. Primary outcomes will assess clinical success at 3, 6, 9, and 12 months, while secondary outcomes will evaluate postoperative pain and radiographic success at 6 and 12 months.",[114,28],[282,283,284,285,286,287],"Single visit pulpectomy","Rotary Instrumentation","Manual Instrumentation","Pain","swelling","radiographic outcomes","2025-12-20",{"date":259,"type":33},{"date":291,"type":22},"2026-02",{"date":293,"type":22},"2027-02",{"name":295,"class":40},"Anfal mohamed elmotaz almogtaba",{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":23,"phases":306,"briefSummary":307,"conditions":308,"keywords":310,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":41},"100605550","complete-pulpotomy-and-root-canal-treatment-patients-with-irreversible-pulpitis-with-type-2-diabetes-mellitus-100605550","NCT07163975","Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus","Success of Complete Pulpotomy and Root Canal Treatment and Quality of Life in Patients With Symptomatic Irreversible Pulpitis With Type 2 Diabetes Mellitus: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Type 2 diabetes mellitus defined by HbA1c levels 6.5% - 8% OR FPG ≥126 mg\u002FdL OR 2-hour plasma glucose ≥200 mg\u002FdL during an OGTT OR A random plasma glucose of 200 mg\u002FdL or higher in a patient with classic symptoms of hyperglycemia or hyperglycemic crisis\n* Age between 18 - 70 years.\n* Permanent mandibular posterior teeth with clinical and radiographic signs and symptoms indicative of irreversible pulpitis (PAI score ≤2)\n* Tooth showing positive response to pulp sensibility testing with no tenderness on percussion.\n* BMI\\\u003C30 Kg\u002Fm2\n\nExclusion Criteria:\n\n* Patients with immunocompromised diseases or chronic kidney disease\n* Smokers, pregnant and lactating women\n* Teeth with immature roots or retained deciduous tooth.\n* Bleeding could not be controlled in ≥5 minutes.\n* Tooth with signs and symptoms of apical periodontitis.\n* Teeth with procedural errors, cracks, fractured teeth\n* Tooth with probing depth more than 4mm.\n* Positive history of antibiotic use in the past 1 month or requiring antibiotic prophylaxis and\u002For analgesic usage in past 3 days.\n* Patients taking drugs that affect bone metabolism such as immune- suppressants, SSRIs, bisphosphonates, hormone replacement therapy","70 Years",{"count":305,"type":22},106,[25],"there is limited endodontic research on the effects of DM on pulp tissues. Diabetic human and animal histological research have demonstrated decreased wound repair, chronic pulp inflammation and reduced dentin bridge formation. To date, no human clinical trial has examined the impact of diabetes mellitus on teeth with irreversible pulpitis. Due to the paucity of data in the literature, there is a clinical dilemma whether to recommend root canal therapy or vital pulp therapy in diabetic patients with irreversible pulpitis.\n\nTo the best of our knowledge, no prospective study has evaluated the outcome of complete pulpotomy versus root canal treatment in T2DM patients with irreversible pulpitis. The aim of this study is to compare and evaluate the success rates of pulpotomy and root canal treatment in type 2 diabetes mellitus patients in mature permanent teeth presenting with clinical symptoms of irreversible pulpitis.",[309,28],"Type 2 Diabetes Mellitus (T2DM)",[57,311,258],"type 2 Diabetes Mellitus","RECRUITING","2025-09-05",{"date":315,"type":33},"2025-09-09",{"date":317,"type":33},"2025-05-01",{"date":319,"type":22},"2027-05-01",{"name":321,"class":40},"Postgraduate Institute of Dental Sciences Rohtak",{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":332,"phases":4,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":41},"100580916","bite-force-measurements-100580916","NCT06843525","Bite Force Measurements","Exploring a Neuropathic Basis for Acute Pulpal Pain- a Clinical Pilot","Inclusion Criteria:\n\n* Individuals who present for\n* a lower 1st or 2nd molar filling in an otherwise healthy tooth, i.e., does not have large decay that has already infected the nerve of the tooth, or there is increased mobility due to gum disease or a root canal treatment on a lower molar tooth and there is no history of injury to the tooth, or\n* a lower molar root canal treatment, and\n* are 18 years or older\n* capable of providing informed consent, are eligible to participate in the study, as long as they satisfy the criteria below.\n* The opposing tooth is present, symptom-free and has adequate tooth structure that allows it to make contact with the tooth it bites against, and\n* are English-speaking\n\nExclusion Criteria:\n\n* Any patient, even if satisfying the criteria above, may not take part if any of the below is true:\n* Compromised ability to guard their self-interest, for e.g., prisoners, children, pregnant women, patients with intellectual\u002Fcognitive disability are not enrolled in the study.\n* Take prescription pain medications for long-standing health conditions\n* Addiction\u002F substance dependence\n* Swelling that extends beyond the tooth in question\n* Are already taking an antibiotic to treat an infection\u002Fswelling\n* Missing complementary molar on the same or opposite side of the mouth\n* Missing more than 2 teeth in a quadrant (other than 3rd molars)\n* Any other molar in the pair either on the side of the tooth of interest or the molar pair on the other side is painful to biting pressure or upon 'tapping' the tooth with the handle of the mouth mirror\n* The patient has taken a pain medication within the last 6 hours","89 Years",{"count":331,"type":22},112,"OBSERVATIONAL","ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids. Addressing the need for non-opioid pain alternatives is crucial. Emerging evidence suggests that dental pain from pulpal and periodontal conditions (affecting the tooth's nerve and surrounding tissues) involves neuropathic mechanisms, such as mechanical allodynia (MA) and central sensitization (CS). These mechanisms can amplify pain perception, causing typically non-painful actions, like chewing, to become painful and resulting in hypersensitivity extending beyond the affected tooth. Reliably identifying these mechanisms with quantitative measures can support improved pain assessment and targeted non-opioid treatment. This minimally invasive prospective cohort study will use the FDA-approved Innobyte® device, a precise bite-force measurement tool, to evaluate periodontal health and to quantify mechanical pain thresholds in patients requiring endodontic treatment (root canal therapy).",[28,335,336],"Apical Periodontitis","Pulpal Necrosis","2025-07-22",{"date":339,"type":33},"2025-07-24",{"date":341,"type":33},"2025-05-16",{"date":343,"type":22},"2026-11-01",{"name":345,"class":40},"Rutgers, The State University of New Jersey",{"id":347,"slug":348,"hasResults":12,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":133,"sex":17,"minAge":102,"maxAge":353,"enrollmentInfo":354,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":357,"conditions":358,"keywords":361,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":4},"100587215","phase-1-comparison-of-3mixtatin-pulpotomy-and-metapex-pulpectomy-in-primary-molars-with-irreversible-pulpitis-100587215","NCT06925490","Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis","Clinical and Radiographic Evaluation of Pulpotomy Using 3Mixtatin Versus Pulpectomy Using Metapex in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis in Children Aged 4 to 9 Years: A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Children aged from 4 to 9 years with vital primary molars showing signs of irreversible pulpitis.\n* Children with spontaneous pain lasting a few seconds to several hours.\n* Pain is intensified by thermal stimulus and persists after its removal.\n* Pulp hemorrhage after performing access cavity and deroofing of pulp chamber showing reddish pink healthy pulp tissue.\n* Radicular pulp health is verified by achieving hemostasis within eight minutes of compression using a cotton pellet with 5% sodium hypochlorite.\n* Absence of peri-apical or inter-radicular radiolucency, widening of periodontal ligament space, internal or external root resorption.\n\nExclusion Criteria:\n\n* Unrestorable primary molars.\n* Primary molars with uncontrolled pulp hemorrhage or pulp necrosis.\n* Medically compromised patients who have systemic disease.\n* Uncooperative children who refuse treatment.\n* Children whose parents are unwilling to place stainless steel crowns.\n* Children whose parents or caregivers refuse to participate in the study or are unable to attend follow-up visits.","9 Years",{"count":78,"type":22},[356],"PHASE1","The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.",[28,359,360],"Primary Teeth","Pulp Disease, Dental",[362,258,363,140,57],"3Mixtatin","metapex","2025-04-25",{"date":366,"type":33},"2025-04-27",{"date":368,"type":22},"2025-06",{"date":370,"type":22},"2026-10",{"name":125,"class":40},{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":133,"sex":17,"minAge":102,"maxAge":353,"enrollmentInfo":379,"targetDuration":4,"studyType":23,"phases":381,"briefSummary":382,"conditions":383,"keywords":384,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":4},"100585624","treatment-outcomes-of-pulpotomy-versus-pulpectomy-in-vital-primary-molars-diagnosed-with-irreversible-pulpitis-100585624","NCT06904781","Treatment Outcomes of Pulpotomy Versus Pulpectomy in Vital Primary Molars Diagnosed With Irreversible Pulpitis","Treatment Outcomes of Pulpotomy Versus Pulpectomy in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis: A Non-inferiority Randomised Controlled Trial","Inclusion Criteria:\n\n1. Healthy (ASA I and II) co-operative children (Frankl Scale + and ++) between the ages of four and nine years.\n2. Participants have symptoms typical of irreversible pulpitis in one of the primary molars.\n3. The pulp of the affected primary molar is vital.\n4. Radicular pulp health is confirmed by attainment of radicular pulp haemostasis within 6 minutes of coronal pulp amputation.\n5. The affected primary molars can be restored with full coverage stainless steel crowns.\n6. Any physiologic root resorption, if present, is less than ⅓ the root length.\n\nExclusion Criteria:\n\n1. Clinical examination of affected primary molar reveals signs of pulpal infection (e.g. pathologic tooth mobility, parulis\u002Ffistula, or soft tissue swelling).\n2. Pre-operative periapical radiograph suggests presence of periapical radiolucency or pathologic root resorption.\n3. Visual examination of pulp tissue after deroofing reveals signs of necrosis (e.g. avascular\u002Fminimally bleeding pulp tissue or yellowish necrotic areas\u002Fpurulent exudate).\n4. Signs of extensive radicular pulp inflammation i.e., root pulp bleeding continues even after 6-min.\n5. Parents not willing to place full coverage crowns post-treatment.\n6. Clinical diagnosis of irreversible pulpitis between two adjacent primary molars is not sharply defined.\n7. Unable to perform clinical procedure under rubber dam",{"count":380,"type":22},80,[25],"This randomised controlled trial aims to compare treatment outcomes between pulpotomy and pulpectomy when used to treat vital primary molars diagnosed with symptomatic irreversible pulpitis. Compared to the standard pulpectomy treatment, pulpotomy is a technically simpler procedure, less time consuming, easier for young patients to tolerate, while retaining the proprioceptive sensation of the tooth - all important advantages when treating young children.",[28],[114,54,385,386],"Vital primary molars","Irreversible pulpitis","2025-04-08",{"date":389,"type":33},"2025-04-11",{"date":391,"type":22},"2025-07-01",{"date":393,"type":22},"2028-06-30",{"name":395,"class":40},"Qatar University",{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":402,"targetDuration":4,"studyType":332,"phases":4,"briefSummary":403,"conditions":404,"keywords":406,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":41},"100586689","effectiveness-of-pulpotomy-in-symptomatic-permanent-teeth-with-deep-caries-lesions-100586689","NCT06918639","Effectiveness of Pulpotomy in Symptomatic Permanent Teeth With Deep Caries Lesions","Inclusion Criteria:\n\n* Patients over 18 years of age.\n* Patients in good general health, ASA I or ASA II with no contraindications to contraindications to receive a TPV procedure under local anaesthesia.\n* Tooth with symptomatology of pulpitis, both reversible and irreversible, to be determined by history of spontaneous pain, exacerbation of pain with heat and cold confirmed by the cold test and radiating pain.\n* Tooth without signs of pulp necrosis and absence of sinus tract and abscess.\n* Tooth in occlusion with antagonist tooth and without discomfort on chewing.\n* Tooth that can be directly restored.\n* Tooth with pocket depth and mobility within normal limits.\n* Extent of the caries lesion greater than two thirds of the amelodentine distance or which tooth or the pulp has been exposed during caries removal.\n\nExclusion Criteria:\n\n* Patients with allergies or intolerance to any anaesthetic solution.\n* Pregnant patients or patients who suspect pregnancy due to the impossibility of complementary radiographic tests cannot be carried out.\n* Patients with systemic pathology that prevents the use of a vasoconstrictor or with a compromised immune system that may influence the response to treatment.\n* Tooth with an immature apex.\n* Tooth that is not restorable or not viable for preservation.\n* Tooth with negative response to thermal sensitivity test or electrical test.\n* Tooth in which haemostasis cannot be achieved after exposure of the pulp, or with a pulp, or with a haemostasis time exceeding 10 minutes, where there is no pulp bleeding or partial or complete tissue necrosis is observed.",{"count":78,"type":22},"Preservation of pulp tissue would allow it to continue to exert its defensive and physiological functions and more tooth tissue would be preserved, leading to less weakening of the tooth. In addition, root canal treatment is a more complex therapeutic process that requires the use of more instruments, more time and more visits. To date, most clinical studies that have evaluated the success of pulpotomy treatments have been conducted on teeth with immature apexes. More studies are needed to evaluate VPT success in the permanent dentition in the long term.\n\nIn accordance with the above, the main objective of the study will be to determine the success of partial or total pulpotomy treatment in permanent teeth (\\>18 adults) with a closed apex and symptoms compatible with irreversible pulpitis. At the same time, the association of factors related to the patient, the treated tooth and specific treatment factors with the success of pulpotomies will be determined. On the other hand, the patient, perception and satisfaction with the treatment received will be evaluated.\n\nAll treatments (pulpotomies and restorations) will be carried out by the principal investigator.\n\nAfter recording the preoperative data, clinical and radiographic examination, a diagnosis will be made according to the classification of Wolters and collaborators , which will also guide us in the choice of pulp treatment: PP o CP Partial pulpotomy or complete pulpotomy. The maximum pulp haemostasis time will be 10 minutes. In both treatments, in the same appointment, the definitive restoration of the tooth will be carried out.\n\nThe evaluations will be performed at one week, 3 , 6 and 12 months postoperatively. This evaluation shall be performed by an examiner who shall be different from the one performing the treatment.\n\nThe main outcome of the present study will be the determination of the success of the pulpotomies.\n\n\\- Is vital pulp therapy a highly successful treatment for teeth with irreversible pulpitis?.\n\nOutcome measure 1: Success rate of vital pulp therapy\n\n\\- Do patients feel satisfied with this conservative pulp treatment? Outcome measure 2: Patient´s satisfaction with vital pulp therapy",[28,405],"Pulpotomy of Permanent Molars",[57,407,408,409,410,411],"vitalpulptherapy","partialpulpotomy","biodentinexp","fullpulpotomy","completepulpotomy","2025-04-06",{"date":414,"type":33},"2025-04-09",{"date":416,"type":33},"2024-04-11",{"date":418,"type":22},"2027-01-01",{"name":420,"class":40},"Universidad Rey Juan Carlos",{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":428,"enrollmentInfo":429,"targetDuration":4,"studyType":23,"phases":430,"briefSummary":431,"conditions":432,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":437,"leadSponsor":439,"locationsCount":4},"100585488","post-operative-pain-following-pulpectomy-versus-pulpotomy-in-primary-molars-wit-irreversible-pulpitis-100585488","NCT06903013","Post Operative Pain Following Pulpectomy Versus Pulpotomy in Primary Molars Wit Irreversible Pulpitis","Post Operative Pain Following Pulpectomy Versus Pulpotomy in Primary Molars Wit Irreversible Pulpitis a Parallel Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy individual\n* Has primary tooth with irreversible pulpitis\n* Cooperative child\n\nExclusion Criteria:\n\n* Mentally, physically or medically compromised children\n* Uncooperative children","10 Years",{"count":78,"type":22},[25],"Study will evaluate and compare post operative pain for primary molars with irreversible pulpitis after pulpotomy and pulpuectomy",[28],"2025-03-24",{"date":435,"type":33},"2025-03-30",{"date":435,"type":22},{"date":438,"type":22},"2025-10-30",{"name":219,"class":40},{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":447,"targetDuration":102,"studyType":332,"phases":4,"briefSummary":449,"conditions":450,"keywords":4,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":41},"100580987","the-effect-of-different-risk-factors-on-the-success-rate-of-vpt-100580987","NCT06844448","The Effect of Different Risk Factors on the Success Rate of VPT","The Effect of Different Risk Factors on the Success Rate of VPT: an Observational Prospective Cohort Study","Inclusion Criteria:\n\n* Patients over 18 years of age who have at least one tooth with a pulp chamber that has been opened during a dental procedure or is likely to be opened during restoration of the tooth\n* The tooth is responsive to a sensitivity test with cold spray\n* The coronal part must be restorable\n* The periodontal depth around the tooth should be 0 according to the Dental Practicality Index Periodontal Treatment Need, i.e. the probing depth around the tooth should not be greater than 3.5 mm\n\nExclusion Criteria:\n\n* Internal\u002Fexternal resorption in the tooth\n* If the root development of the tooth is not yet complete or if it is a deciduous tooth\n* Absolute isolation cannot be performed during the procedure\n* If pulp exposure does not occur even after complete removal of caries\n* The crown of the tooth cannot be restored\n* Periodontium surrounding tooth affected by moderate\u002Fsevere marginal periodontitis (probing depth deeper than 3.5 mm)\n* Pulp exposure due to traumatic injury\n* Baseline radiograph shows signs of severe pulp palcification\n* Periapical lesion is around the root (Periapical index of the tooth \\>2)",{"count":448,"type":22},400,"This study aims to evaluate the effectiveness of various vital pulp therapy (VPT) methods, such as direct pulp capping, partial pulpotomy, and total pulpotomy, in maintaining pulp vitality following pulp exposure. It explores the success rates of these treatments compared and investigates co-factors influencing these rates, including age. This prospective cohort study involves patients over 18 with restorable teeth and exposed pulp chambers. Success is measured through clinical and radiological criteria over a follow-up period of up to four years. The study also aims to identify if there's an age threshold affecting the preference for VPT over root canal therapy.",[451,360,28,452,453],"Dental Caries Extending to Pulp","Reversible Pulpitis","Pulpitis","2025-03-03",{"date":456,"type":33},"2025-03-06",{"date":458,"type":33},"2024-06-01",{"date":460,"type":22},"2030-06-01",{"name":462,"class":40},"Semmelweis University",{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":4,"eligibilityCriteria":469,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":303,"enrollmentInfo":470,"targetDuration":4,"studyType":23,"phases":472,"briefSummary":473,"conditions":474,"keywords":477,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":482,"leadSponsor":484,"locationsCount":41},"100580818","to-compare-the-effect-of-two-instrumentation-techniques-on-the-incidence-of-post-endodontic-pain-in-patients-undergoing-root-canal-treatment-in-teeth-with-irreversible-pulpitis-100580818","NCT06842251","To COMPARE the EFFECT of TWO INSTRUMENTATION TECHNIQUES on the INCIDENCE of POST-ENDODONTIC PAIN in PATIENTS UNDERGOING ROOT CANAL TREATMENT in TEETH with IRREVERSIBLE PULPITIS","A COMPARISON of EFFECT of TWO INSTRUMENTATION TECHNIQUES on the INCIDENCE of POST-ENDODONTIC PAIN in PATIENTS UNDERGOING ROOT CANAL TREATMENT","Inclusion Criteria:1.Patients of both genders having age 18-70 years, no history of analgesics within the past 1 week ,subjects with no periapical radiolucency, teeth having completely formed tooth apex ,permanent posterior teeth with symptomatic\u002Fasymptomatic irreversible pulpitis, subjects who provided the consent for study participation\n\n\\-\n\nExclusion Criteria: Subjects with a history of trauma, previous root canal treatment, associated systemic diseases ,pregnant females, subjects on analgesics or antibiotics, complaints of tenderness and pain within the past 5 days, extreme root curvature, calcified canals ,external or internal resorption.\n\n\\-",{"count":471,"type":22},70,[25],"The aim of this study is to compare the post endodontic pain in patients presenting with irreversible pulpitis and undergoing root canal treatment with two techniques. One is rotary crown down technique and other is manual step back technique. Patients visiting OPD will be selected after fulfilment of inclusion criteria and randomly divided into two groups. In Group A rotary instrument with Crown Down approach is used and in Group B manual instrumentation with Step Back technique is used. Post endodontic pain will be graded using VAS scale at 4,12,24 and 48 hours.",[28,475,476],"Symptomatic Irreversible Pulpitis","Asymptomatic Irreversible Pulpitis",[475,476],"2025-02-18",{"date":480,"type":33},"2025-02-24",{"date":317,"type":22},{"date":483,"type":22},"2025-11-01",{"name":485,"class":40},"Urooj Fatima",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":275,"enrollmentInfo":492,"targetDuration":4,"studyType":23,"phases":493,"briefSummary":494,"conditions":495,"keywords":496,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":507,"locationsCount":41},"100573630","clinical-and-radiographic-evaluation-of-calcium-hypochlorite-versus-saline-as-root-canal-irrigants-in-pulpectomy-of-primary-molars-a-randomized-clinical-trial-100573630","NCT06748781","Clinical and Radiographic Evaluation of Calcium Hypochlorite Versus Saline As Root Canal Irrigants in Pulpectomy of Primary Molars: a Randomized Clinical Trial","Inclusion Criteria:\n\n1. Clinical Criteria:\n\n   * Children aged between 4 years and 7 years.\n   * Mandibular primary molars with deep caries lesion involving pulp.\n   * Mandibular primary molars that exhibit symptoms of irreversible pulpitis.\n   * Normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test.\n   * No history of swelling, fistula or sinus tract related to the offending molar.\n2. Radiographic criteria:\n\n   * No sign of radiolucency in periapical or furcation area.\n   * No widening of PDL space or loss of lamina dura continuity.\n   * No evidence of internal\u002Fexternal pathologic root resorption.\n\nExclusion Criteria:\n\n* Uncooperative children to avoid time waste and attrition bias.\n* Children with systemic disease as some systemic diseases may have effect on the outcome (Segura-Egea et al., 2023).\n* Lack of informed consent by the child patient's parent to be approved ethically.\n* Unable to attend follow-up visits to avoid attrition bias by decreasing number of drop off cases.\n* Refusal of participation as the parent of child has the authority of participation.\n* Teeth near exfoliation time showing root resorption.",{"count":78,"type":22},[25],"The aim of this study is to evaluate the clinical and radiographic success of Calcium Hypochlorite versus Saline as root canal irrigants in pulpectomy of primary molars.\n\nThe research question it aims to answer is:\n\nIn pulpectomy of primary molars will the use of calcium hypochlorite as root canal irrigant result in superior clinical and radiographic success to saline?",[28],[497,498,499,258,500,115,256],"calcium hypochlorite","irrigation","saline","calcium hydroxide with iodoform","2024-12-19",{"date":503,"type":33},"2024-12-27",{"date":505,"type":22},"2025-03-01",{"date":148,"type":22},{"name":125,"class":40},{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":353,"enrollmentInfo":515,"targetDuration":4,"studyType":23,"phases":517,"briefSummary":518,"conditions":519,"keywords":521,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":41},"100572214","clinical-and-radiographic-assessment-of-photobiomodulated-mta-pulpotomy-in-immature-first-permanent-molars-with-irreversible-pulpitis-100572214","NCT06730360","Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irreversible Pulpitis","Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irreversible Pulpitis: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Children aged 6 to 9 years.\n* Non-contributory medical history (healthy otherwise).\n* Presence of carious first permanent molars with the following characteristics:\n* Deep caries extending to ≥2\u002F3 of dentin.\n* Positive response to cold testing.\n* Clinical diagnosis of irreversible pulpitis (moderate or severe), with or without periapical periodontitis.\n* Restorable tooth.\n* Probing pocket depth and mobility within normal limits.\n* No signs of pulpal necrosis, including sinus tract or swelling.\n\nExclusion Criteria:\n\n* Insufficient bleeding after pulp exposure (indicating necrotic or partially necrotic pulp).\n* Presence of systemic or medical conditions that may contraindicate participation.\n* Teeth with unrestorable structure.\n* Teeth showing signs of pulpal necrosis, such as the presence of a sinus tract or swelling.",{"count":516,"type":22},72,[25],"This study evaluates the effectiveness of photobiomodulation (PBM) in conjunction with mineral trioxide aggregate (MTA) pulpotomy for treating irreversible pulpitis in immature first permanent molars. PBM, also known as low-level laser therapy (LLLT), is used to enhance healing, reduce inflammation, and manage pain in young teeth. The randomized clinical trial involves 72 children aged 6-9 years, divided into two groups: one receiving MTA pulpotomy alone and the other receiving MTA pulpotomy with PBM. Clinical and radiographic outcomes will be assessed at intervals over 15 months. This research aims to determine the combined therapy's efficacy in improving pulp healing and reducing post-operative discomfort compared to MTA alone.",[520,28],"Dental Caries",[386,522,523,524,525],"Immature permanent molars","Vital pulp therapy (VPT)","Mineral trioxide aggregate (MTA)","Photobiomodulation (PBM)","2024-12-12",{"date":528,"type":33},"2024-12-17",{"date":530,"type":33},"2024-10-10",{"date":532,"type":22},"2026-04-05",{"name":534,"class":40},"Mansoura University",{"id":536,"slug":537,"hasResults":12,"nctId":538,"briefTitle":539,"officialTitle":540,"acronym":4,"eligibilityCriteria":541,"healthyVolunteers":133,"sex":17,"minAge":542,"maxAge":543,"enrollmentInfo":544,"targetDuration":4,"studyType":23,"phases":546,"briefSummary":547,"conditions":548,"keywords":4,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":41},"100563266","assessment-of-l-prf-nanohydroxyapatite-combined-with-l-prf-using-pulpotomy-in-mature-mandibular-first-molars-100563266","NCT06613932","Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars","Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite Material Combined With L-PRF Scaffold in Vital Pulp Therapy. Treatments in Mandibular First Molars With Closed Apices \"Randomized Controlled Trial\"","Inclusion criteria:\n\nPatients should be free from any systemic disease. Patients of either gender aged from 15-30. Patients will agree to the consent and will commit to a follow-up period. Soft tissues around the tooth are normal with no swelling or sinus tract. The tooth is restorable tooth has signs and symptoms of irreversible pulpitis of the mature root The tooth doesn\\'t contain any internal or external resorption or periapical lesions.\n\nThe tooth should give a positive response to the cold test.\n\nExclusion criteria:\n\nPregnant and lactating females. Patients with Mental disturbance. Patients who could\u002Fwould not participate in a 6-month follow-up. A tooth with immature roots. Patients with necrotic pulp.• tooth with periapical lesions or infections. Soft tissue having fistula or swelling Homoeostasis after 10 minutes can not be controlled after total pulpotomy","15 Years","30 Years",{"count":545,"type":22},45,[25],"Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite material combined with L-PRF scaffold in Vital pulp Therapy. Treatments in Mandibular First Molars with Closed Apices, Randomized Controlled Trial.",[28],"2024-09-25",{"date":551,"type":33},"2024-09-26",{"date":553,"type":33},"2023-10-30",{"date":555,"type":22},"2024-10-30",{"name":557,"class":40},"Future University in Egypt",{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":4,"eligibilityCriteria":564,"healthyVolunteers":133,"sex":17,"minAge":102,"maxAge":565,"enrollmentInfo":566,"targetDuration":4,"studyType":23,"phases":567,"briefSummary":568,"conditions":569,"keywords":571,"overallStatus":312,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":41},"100505388","evaluation-of-antimicrobial-post-operative-pain-of-cinnamon-extract-versus-sodium-hypochlorite-irrigant-following-pulpectomy-of-primary-teeth-100505388","NCT05860712","Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpectomy of Primary Teeth","Evaluation Of Antimicrobial Potency Of A Novel Cinnamon Extract Irrigant Versus Sodium Hypochlorite Irrigant Following Pulpectomy Of Primary Teeth . (A Randomized Clinical Trial)","Inclusion Criteria:\n\n* Children:\n\n  1. Aged 4 to 8, in good general health, and medically free.\n  2. Cooperative patients who will comply to dental treatment .\n  3. Parents provided with written informed consent.\n  4. No previous history of antibiotics administration or last dose was taken from at least 2 weeks.\n* Teeth:\n\n  1. Carious primary molars with irreversible pulpitis.\n  2. Presence of localized swelling ,sinus and pain on percussion which indicate non vital pulp .\n  3. Presence of periapical and furcation radiolucency .\n  4. In periapical radiograph teeth have no more than 1\u002F3 of root resorption.\n\nExclusion Criteria:\n\n* Children:\n\n  1. Children with medical, physical, or mental conditions.\n  2. Severly Uncooperative children .\n* Teeth:\n\n  1. Primary molars with any congenital anomalies.\n  2. Teeth with un-restorable crowns .\n  3. Root resorbtion more than half of the root.\n\n     \\-","8 Years",{"count":5,"type":22},[25],"The aim of the study is to evaluate effectiveness of cinnamon extract versus sodium hypochlorite as root canal irrigant for in pulpectomy of primary teeth in reduction of bacterial count .",[28,570],"Caries,Dental",[572],"antimicrobial and post operative pain evaluation","2024-08-20",{"date":575,"type":33},"2024-08-22",{"date":577,"type":33},"2024-01-20",{"date":579,"type":22},"2024-11-22",{"name":125,"class":40},{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":586,"acronym":4,"eligibilityCriteria":587,"healthyVolunteers":12,"sex":17,"minAge":588,"maxAge":589,"enrollmentInfo":590,"targetDuration":4,"studyType":23,"phases":591,"briefSummary":592,"conditions":593,"keywords":594,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":605},"100554824","full-pulpotomy-procedure-of-permanent-molar-teeth-of-adults-using-calcium-silicate-based-sealer-material-100554824","NCT06504108","Full Pulpotomy Procedure of Permanent Molar Teeth of Adults Using Calcium Silicate-based Sealer Material","Evaluation Of The Efficacy Of Using Calcium-Silicate Based Sealers As A Pulp Capping Material After Adult Pulpotomy: An In-vivo Study","Inclusion Criteria:\n\n* Vital mandibular molar teeth with mature apices.\n* Teeth that respond positively to cold testing.\n* Teeth without any signs of necrosis including sinus tract or swelling.\n* Teeth with caries extending ≥ 2\u002F3 of dentine or exposing the pulp.\n* Teeth with symptomatic irreversible pulpitis with\u002Fwithout apical periodontitis.\n* Teeth without periodontal diseases or mobility.\n* Teeth without root resorption, detectable pulp chamber and root canal calcification or history of trauma.\n* Patients from both genders with age range from 20 to 45 years old.\n* Patients with good or moderate oral hygiene and without any systemic diseases.\n\nExclusion Criteria:\n\nPre-operative criteria:\n\n* Non-vital teeth.\n* Teeth with irreversible pulpitis with apical periodontitis.\n* Teeth with immature apices.\n* Teeth with Periodontal disease or mobility grade II or III.\n* Teeth that are badly decayed and need post and core placement.\n* Patients refused to continue treatment procedures or refuse to commit to periodic follow-up sessions.\n* Non-restorable teeth.\n\nIntra-operative criteria:\n\n* If hemostasis could not be achieved within 6 minutes after full pulpotomy.\n* Teeth with partial necrosis.\n* No bleeding after access cavity preparation.\n\nPost-operative criteria:\n\n* presence of Swelling.\n* presence of Sinus tract.\n* Pain on percussion after the end of the first week.\n* Pain with palpation.\n* Pain on biting after the end of first week.\n* Mobility of the tooth.\n* Fracture of tooth structure that renders the tooth non-restorable.\n* Fracture of the restoration during the evaluation.\n* Probing depth more than 3 mm.","20 Years","45 Years",{"count":21,"type":22},[25],"This clinical study aims to assess the efficacy of using calcium silicate based sealer as a capping material after complete removal of coronal pulp tissue. The study will evaluate both the clinical and radiographic changes.",[28],[57,595,258,59],"calcium silicate-based sealer","2024-07-14",{"date":598,"type":33},"2024-07-16",{"date":600,"type":22},"2024-07",{"date":602,"type":22},"2026-05",{"name":604,"class":40},"Al-Azhar University",2,{"id":607,"slug":608,"hasResults":12,"nctId":609,"briefTitle":610,"officialTitle":611,"acronym":4,"eligibilityCriteria":612,"healthyVolunteers":133,"sex":17,"minAge":428,"maxAge":613,"enrollmentInfo":614,"targetDuration":4,"studyType":23,"phases":616,"briefSummary":618,"conditions":619,"keywords":620,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":626,"leadSponsor":627,"locationsCount":4},"100553595","phase-4-comparing-mta-pulpotomy-to-root-canal-treatment-in-management-of-permanent-molars-with-irreversible-pulpitis-in-children-100553595","NCT06488131","Comparing MTA Pulpotomy to Root Canal Treatment in Management of Permanent Molars With Irreversible Pulpitis in Children","A Comparative Study Between MTA Pulpotomy and Root Canal Treatment in Management of First Permanent Molars With Irreversible Pulpitis in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Healthy male and female children, aged 10 to 14 years\n* Signs and symptoms of irreversible pulpitis in carious first permanent molar.\n\nExclusion Criteria:\n\n* Molars with immature roots\n* Non-restorable molars, with abnormal mobility or increased probing pocket depth (normal range = 1-3 mm)\n* Any indication of pulpal necrosis, such as sinus tract or swelling or no bleeding from orifices after access opening.\n* Any signs of periapical or furcal rarefaction.","14 Years",{"count":615,"type":22},62,[617],"PHASE4","Dental caries, highly prevalent amongst children, can cause pulpitis. Coronal pulpotomy provides an easier, cost-effective, conservative and biologically-driven treatment option compared to endodontic treatment in mature permanent teeth with irreversible pulpitis.\n\nThe aim of the current study is to evaluate postoperative pain, clinical and radiographic outcomes of MTA pulpotomy compared to root canal treatment in children's first permanent molars suffering from irreversible pulpitis.",[28],[621],"Endodontic Treatment, Vital Pulp Therapy","2024-06-28",{"date":624,"type":33},"2024-07-05",{"date":600,"type":22},{"date":368,"type":22},{"name":628,"class":40},"Ain Shams University"]