[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"irritable-mood\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:irritable-mood":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,89,114,144,166],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100517647","parent-management-training-to-treat-irritability-100517647",false,"NCT06020261","Parent Management Training to Treat Irritability","The Efficacy of Parent Management Training to Treat Irritability","PMT","Inclusion Criteria:\n\n* clinically significant irritability (Clinician Affective Reactivity Index 30 or greater)\n* parent or guardian willing to participate in treatment with the child\n\nExclusion Criteria:\n\n* psychiatric instability (danger to self\u002Fothers, risky substance abuse)\n* current active Post-Traumatic Stress Disorder (PTSD) or a severe active stressor (e.g. child abuse)\n* history of severe psychopathology with an established alternate treatment (e.g. autism spectrum disorder, bipolar disorder, schizophrenia, intellectual disability)\n* general medical condition that may be driving irritability or prevent generalizable physiologic measures.\n* screen positive for an intellectual disability via Wechsler Abbreviated Scale of Intelligence Second Edition (WASI II) estimated Intelligence Quotient (IQ)\\\u003C70.","ALL","10 Years","14 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to see if 12 sessions of a Parent Management Training program can treat irritability in children aged 10-14 years old. The main question it aims to answer are:\n\n* Can a Parent Management Training for parents reduce anger outbursts and cranky moods in their children?\n* Can Parent Management Training be done in an outpatient clinic and do parents like it?\n\nUp to 18 families can join this study. This study will be used to set up a larger study in the Fall of 2025.\n\nParent participants will complete 12 sessions of Parent Management Training for Irritability. Each session will be 45-55 minutes weekly. They will also participate in the assessments of their child before, during and after treatment.\n\nChild participants will do assessments before, during and after the Parent Management Training treatment.",[28,29,30],"Irritable Mood","Temper Tantrum","Anger",[32,33,34,35,36],"irritability","anger","parenting","temper outbursts","Parent Management Training","RECRUITING","2026-01-06",{"date":40,"type":41},"2026-01-07","ACTUAL",{"date":43,"type":41},"2025-06-12",{"date":45,"type":22},"2026-12-30",{"name":47,"class":48},"University of Colorado, Denver","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":76,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":88},"100471118","art-therapy-and-emotional-well-being-in-military-populations-with-posttraumatic-stress-symptoms-100471118","NCT05414708","Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms","Inclusion Criteria:\n\n* DEERS Eligible\n* Active Duty or Veteran separated within the past 10 years\n* Significant posttraumatic stress symptoms (score of \\>\u002F=31 on the PCL-5)\n\nExclusion Criteria:\n\n* History of moderate, severe, or penetrating brain injury\n* History of psychotic disorder, bipolar disorder, or active suicidal or homicidal ideation\n* History of multiple sclerosis, Huntington's disease, or Alzheimer's disease\n* History of stroke or myocardial infarction\n* History of brain tumor\n* History of seizures\n* Contradictions for MRI (for example, participants will be excluded for pregnancy, metal implants or suspected shrapnel, aneurysm\u002Fintracranial clips, cardiac pacemakers or implanted programmable devices or pumps)\n* Unable to provide informed consent\n* History of previous exposure to art therapy\n* Active substance use disorder","18 Years","64 Years",{"count":59,"type":22},40,[25],"Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members. This research hopes to learn about the effects of art therapy on emotional expression and regulation in service members as well as the neurological systems at work. If a participant chooses to be in this study, he or she will attend eleven sessions over a period of six to eight months. The first session will be an interview and self-assessment questionnaires to collect information on a variety of symptoms, experiences, and personality traits, and an MRI scan. During the MRI scan, participants will be asked to perform a task where they will be shown a series of neutral and negative images. The following eight sessions will be one-hour art therapy sessions with a certified art therapist. The tenth session will consist of the same self-assessment questionnaires and another MRI scan. The final session will consist of some of the same questionnaires from the tenth visit, as well as a qualitative interview done virtually three months after the tenth visit.",[63,64,65,66,67,68,69,28,30,70,71,72,73,74,75],"PTSD","Military Activity","Post-Traumatic Headache","Posttraumatic Stress Disorder","Posttraumatic Stress Disorder, Delayed Onset","Sleep Disturbance","Nightmare","Combat and Operational Stress Reaction","Combat Stress Disorders","Military Family","Military Operations","Emotional Regulation","Emotion Processing",[63,77,78],"Military","Art Therapy",{"date":80,"type":41},"2026-01-08",{"date":82,"type":41},"2022-02-01",{"date":84,"type":22},"2027-12",{"name":86,"class":87},"Walter Reed National Military Medical Center","FED",2,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":17,"minAge":56,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":100,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":49},"100510780","focus-groups-in-ethnically-and-racially-diverse-families-100510780","NCT05930886","Focus Groups in Ethnically and Racially Diverse Families","Focus Groups to Optimize Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children With ADHD and Emotional Dysregulation","Inclusion Criteria:\n\n* Adult parents\u002Fcaregivers self-identified as Black or Hispanic\u002FLatino\n* With a family member 6-18 years old with suspected ADHD and\u002For emotional dysregulation, or provide care for, or teach someone who meets these criteria\n* Who have sought or are interested in treatment\n* Willing to discuss child's mental health care needs and provide feedback regarding feasibility study\n* Able to attend focus groups in person\n* Able to communicate in English or Spanish\n* Agree to focus group session audio recording\n\nExclusion Criteria:\n\n* Unwilling to be recorded",true,"80 Years",{"count":99,"type":22},30,"OBSERVATIONAL","Focus groups to identify treatment needs and barriers to participation in the planned multinutrient study among racially and ethnically diverse (Black and Hispanic) communities.",[103,104,28],"Attention Deficit\u002FHyperactivity Disorder","Emotional Dysfunction","2025-04-01",{"date":107,"type":41},"2025-04-04",{"date":109,"type":41},"2023-04-15",{"date":111,"type":22},"2025-10-04",{"name":113,"class":48},"Oregon Health and Science University",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":96,"sex":17,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":49},"100554968","stop-focus-plan-and-change-predicting-parent-and-child-responses-to-a-brief-telehealth-parent-training-100554968","NCT06505980","Stop, Focus, Plan, and Change: Predicting Parent and Child Responses to a Brief, Telehealth Parent Training","Stop, Focus, Plan, and Change: A Translational Approach to Predict Parent and Child Responses to a Brief, Telehealth Parent Training","Inclusion Criteria:\n\n* Parent speaks English or Spanish\n* Parent has access to Internet\n* Parent intends to complete treatment\n* Parent reports child has elevated externalizing concerns\n\nExclusion Criteria:\n\n* Child is a ward of the state\n* Child diagnosed with severe medical or nonverbal developmental disability","3 Years","5 Years",{"count":124,"type":22},130,[25],"This study will look at who does not improve after doing a behavioral parent training program briefly through telehealth. It will also study ways to make the intervention better for those that do not improve.",[128,28,129,130],"Behavioral Problem","Parenting","Stress",[132,133,134,135],"Behavioral Concerns","Irritability","Parenting stress","Parenting practices","2025-02-28",{"date":138,"type":41},"2025-03-04",{"date":140,"type":41},"2024-10-18",{"date":142,"type":22},"2029-03-30",{"name":47,"class":48},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":152,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":155,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":49},"100526322","optimizing-research-with-diverse-families---feasibility-and-acceptability-study-fast-100526322","NCT06133231","Optimizing Research With Diverse Families - Feasibility and Acceptability Study (FAST)","A Feasibility and Acceptability Study (FAST) to Optimize Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children With ADHD and Emotional Dysregulation","FAST","Inclusion Criteria:\n\n* Children, ages 6-17 years at enrollment, with suspected or definite ADHD based on parent report in a majority of families that identify as Black or Hispanic or multicultural\n* Meet criteria on Child and Adolescent Symptom Inventory-5 (CASI-5) ADHD scale (6+ symptoms ≥ 2), occurring in \\>1 setting, plus one impairing irritability symptom (≥2) from Oppositional Defiant Disorder (ODD) or Disruptive Mood Dysregulation Disorder (DMDD) subscale\n* Able and willing to swallow up to 8 pills per day\n* Medication free for 2 weeks prior to baseline\n* Willing to use Tasso® OnDemand SST+ to collect blood at home and filter cards to provide urine samples\n* Able to communicate in English\n* Parent\u002Fcare giver identifies child as Black\u002FAfrican American or Hispanic\u002FLatina\u002Fo or more than one race (target 70-100%)\n\nExclusion Criteria:\n\n* Neurological disorders\n* Medical conditions (e.g. cancer, kidney or liver disease, diabetes, hyperthyroidism)\n* Psychiatric conditions requiring hospitalization\n* Allergy to any supplement ingredient\n* In people with a uterus: sexually active, pregnancy or suspected pregnancy\n* Abnormality of mineral metabolism","6 Years","17 Years",{"count":99,"type":22},[25],"Evaluate feasibility and acceptability of recruiting Black and Hispanic families for an open label clinical trial of multinutrients while collecting real-time parent-reported child behavior data and collecting at-home biospecimens to explore their potential as biomarkers, in a study of pediatric ADHD.",[103,104,28],"2025-01-14",{"date":160,"type":41},"2025-01-16",{"date":162,"type":41},"2024-01-06",{"date":164,"type":22},"2026-01",{"name":113,"class":48},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":17,"minAge":152,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":49},"100479895","resist-against-irritability-superiority-trial-100479895","NCT05528926","RESist Against Irritability Superiority Trial","Parent Training for the Treatment of Irritability in Children and Adolescents: a Multisite Randomized Controlled, 3-parallel-group, Evaluator-blinded, Superiority Trial","RESIST","Inclusion Criteria:\n\n* Male and female subject between 6 and 15 years-old.\n* Express informed consent f by at least one of the parents or legal representative, and oral consent of the child.\n* A confirmed K-SADS DSM-5 diagnosis of ADHD, ODD, CD, mood\u002Fanxiety disorder or DMDD, or a clinical diagnosis of IED. The request of a concomitant mental disorder allows to restrict this intervention to a clinical population.\n* A Parental-rated ARI total score of 4 or above at baseline.\n* A Clinical Global Impression-Severity score (CGI-S) of 4 or above (=at least moderately ill).\n* Persistence of irritability symptoms 6 month or above at baseline (this avoids including children with transitory irritability).\n* stable treatment regimen (pharmacological and non-pharmacological) for 2 weeks prior to inclusion and during the trial\n* RESIST-QUAL : Same inclusion criteria as above with specific informed consent form signed by the participating parent.\n\nExclusion Criteria:\n\n* Unavailability of parents or legal representative during the study period.\n* Subjects with a DSM-5 diagnosis (clinical presentation or history) that is consistent with Schizophrenia or psychotic disorders or acute manic episodes.\n* Diagnosis of Autism Spectrum Disorder (ASD) in patients who are non-verbal and with IQ lower than 70.\n* Known or estimated IQ\\\u003C70 or clinical diagnosis of intellectual disability.\n* Subjects with severe irritability that are better accounted for by another factor, e.g.: general medical condition(s) or direct effect of a substance (i.e., medication, illicit drug use), as determined by the clinical judgment of the investigator, or related to child abuse and\u002For neglect.\n* absence of informed consent give by at least one of the parents or legal representatives, and oral consent of the child\n* inability to speak and comprehend French\n* deemed unable to comply with the trial protocol\n* participation in a structured parent program during the last 6 months","15 Years",{"count":176,"type":22},270,[25],"Irritability is defined as developmentally inappropriate proneness to anger. Irritability is a symptom of several mental health conditions in children and adolescents such as attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD), depressive disorders, anxiety disorders.Irritability has been associated with poor functional outcomes across the lifespan and was found to be specifically associated with concurrent and longitudinal emotional disorders, suicidality and impaired academic and socio-professional functioning. Children with high irritability also have distinct physiological profiles with hyper-reactivity to stress and perceived threats.\n\nDespite the high prevalence and health issues related to irritability, there is little treatment research on this topic. Developing evidence-based non-pharmacological treatment options for children suffering from severe, chronic irritability is therefore a particularly important target for clinical research.",[28],[133,181,182],"Parent Management Training (PMT)","Non-Violent Resistance (NVR)","2023-08-09",{"date":185,"type":41},"2023-08-14",{"date":187,"type":41},"2023-04-25",{"date":189,"type":22},"2026-09-01",{"name":191,"class":48},"University Hospital, Montpellier"]