[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"irriversible-pulpitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:irriversible-pulpitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100638575","postoperative-pain-after-root-canal-treatment-using-different-root-canal-sealers-100638575",false,"NCT07608939","Postoperative Pain After Root Canal Treatment Using Different Root Canal Sealers","Comparison of Postoperative Pain Following Root Canal Treatment Using AH Plus, ProRoot Bio Sealer, and BC Sealer Ion+: A Randomized Clinical Trial","PO-Pain","Patient Selection Patients will be selected from individuals referred to the Dental Clinic for root canal treatment. Only mandibular first or second molars diagnosed with asymptomatic irreversible pulpitis will be included in the study. Asymptomatic irreversible pulpitis is defined as inflamed vital pulp tissue without clinical symptoms, usually caused by caries, caries excavation, or trauma.\n\nBefore treatment, written and verbal informed consent will be obtained from all participants. An online questionnaire including the Numeric Rating Scale (NRS) and the number of analgesics taken will be electronically sent to the participants. Patients will subsequently be contacted by telephone and asked to complete the questionnaire online. Submitted responses will not be modifiable after completion. The primary outcome will be postoperative pain, while secondary outcomes will include analgesic consumption and flare-up incidence.\n\nInclusion Criteria\n\n* Asymptomatic teeth showing delayed positive responses to thermal testing (EndoIce; Coltene\u002FWhaledent Inc.) and electric pulp testing (Parkell)\n* Teeth with extensive pulp exposure during caries excavation\n* Inflamed pulp tissue in which bleeding cannot be controlled within 5 minutes\n* Periodontally healthy, mature mandibular first or second molars Exclusion Criteria\n\nPatients presenting with the following conditions will be excluded from the study:\n\n* Diabetes mellitus, immunocompromised conditions, or pregnancy\n* Use of antibiotics within the last month or requirement for antibiotic prophylaxis\n* Use of analgesics within 7 days prior to treatment\n* Allergy to any material used during root canal treatment\n* Teeth suitable for vital pulp therapy in which bleeding can be controlled within 5 minutes\n* Non-vital or symptomatic teeth\n* Presence of radiographically detectable periapical lesions\n* Teeth requiring post-core restorations or prosthetic support\n* Calcified root canals, root resorption, or immature teeth","ALL","18 Years","60 Years",{"count":21,"type":22},135,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective randomized clinical trial aims to compare the effects of three different root canal sealers-AH Plus, ProRoot Bio Sealer, and BC Sealer ion+-on postoperative pain following root canal treatment in patients diagnosed with asymptomatic irreversible pulpitis.\n\nPostoperative pain is a common complication after endodontic treatment and may be influenced by microbial, chemical, and mechanical factors. The type and composition of root canal sealer may also affect tissue response, inflammation, and pain levels. AH Plus is an epoxy resin-based sealer known for its sealing ability and dimensional stability, whereas ProRoot Bio Sealer and BC Sealer ion+ are bioceramic sealers with enhanced bioactive properties. BC Sealer ion+ additionally releases both calcium and magnesium ions, which may improve tissue healing and biological performance.\n\nThe study will include patients aged 18-60 years presenting with asymptomatic irreversible pulpitis in mandibular first or second molars. Following ethical approval from the European University of Lefke Ethics Committee, approximately 135 patients will be enrolled and randomly assigned into three equal groups according to the root canal sealer used. Sample size calculation was performed using G\\*Power software with 80% statistical power and a significance level of 0.05.\n\nAll treatments will be completed in a single visit by the same experienced clinician under standardized clinical conditions. Root canal preparation will be performed using the ProTaper Universal rotary system with standardized irrigation protocols including sodium hypochlorite, EDTA, chlorhexidine, and sonic activation. Obturation will be completed using a modified single-cone technique with the assigned root canal sealer.\n\nPatients and the outcome assessor will be blinded to group allocation. Postoperative pain will be assessed using the Numeric Rating Scale (NRS) at 6, 12, 24, 48, and 72 hours, as well as on day 7 after treatment. Secondary outcomes will include analgesic consumption and flare-up incidence. All patients will be prescribed ibuprofen to use only if necessary, and analgesic intake will be recorded.\n\nThe primary objective of this study is to determine whether different root canal sealers significantly influence postoperative pain levels after root canal treatment. The null hypothesis states that there will be no statistically significant difference among AH Plus, ProRoot Bio Sealer, and BC Sealer ion+ regarding postoperative pain outcomes. Data will be analyzed using appropriate statistical methods, with a significance level set at P \\\u003C 0.05.",[28],"Irriversible Pulpitis",[30,31,32,33],"postoperative-pain","root canal sealer","bioceramic","root canal treatment","NOT_YET_RECRUITING","2026-05-27",{"date":37,"type":38},"2026-05-29","ACTUAL",{"date":40,"type":22},"2026-05-16",{"date":42,"type":22},"2026-12-31",{"name":44,"class":45},"European University of Lefke","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100633450","effect-of-instrumentation-systems-and-sealers-on-postoperative-pain-100633450","NCT07526844","Effect of Instrumentation Systems and Sealers on Postoperative Pain","Impact of TruNatomy and ProTaper Gold Ni-Ti Systems Using Resin-based or Bioceramic Sealers on Postoperative Pain After Root Canal Treatment: a Randomized Clinical Trial","POP","Inclusion Criteria\n\n* Asymptomatic teeth with delayed positive response to thermal and electric pulp testing\n* Vital teeth with signs of irreversible pulpitis\n* Mature mandibular first or second premolars\n* Periodontally healthy teeth Exclusion Criteria\n* Patients with systemic conditions (e.g., diabetes, immunocompromised status, pregnancy)\n* Antibiotic use within the past month\n* Use of analgesics within 7 days prior to treatment\n* Known allergy to materials used\n* Teeth with periapical lesions\n* Non-vital or symptomatic teeth\n* Teeth requiring post-core restorations\n* Calcified canals, root resorption, or immature teeth",{"count":55,"type":22},144,[25],"The goal of this randomized clinical trial is to evaluate whether different root canal preparation systems and sealer types affect postoperative pain after root canal treatment in adult patients (18-60 years) with asymptomatic irreversible pulpitis in mandibular premolars.\n\nThe main questions it aims to answer are:\n\nDo different instrumentation systems (TruNatomy vs ProTaper Gold) influence postoperative pain levels? Do different sealer types (AH Plus vs TotalFill BC) affect postoperative pain and analgesic consumption? Researchers will compare TruNatomy and ProTaper Gold systems combined with AH Plus or TotalFill BC sealers to determine their effect on postoperative pain.\n\nParticipants will:\n\nUndergo single-visit root canal treatment using one of the assigned file system and sealer combinations Record their pain levels using a Numerical Rating Scale (NRS) at specific time intervals (6, 12, 24, 48, 72 hours, and 7 days) Take ibuprofen only if needed and record analgesic intake Attend a follow-up visit on the 7th day",[28],[60,61,62,63],"Post Operative Pain","Irreversible Pulpitis","NiTi File","Canal Sealer","2026-04-15",{"date":66,"type":38},"2026-04-21",{"date":68,"type":22},"2026-07-01",{"date":70,"type":22},"2027-10-30",{"name":44,"class":45},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100608027","comparison-of-post-operative-pain-after-different-root-canal-irrigant-activation-methods-100608027","NCT07196215","Comparison of Post-operative Pain After Different Root Canal Irrigant Activation Methods","Comparison of Post-operative Pain After Different Root Canal Irrigant Activation Methods in Maxillary Incisors With Symptomatic Irreversible Pulpitis","Inclusion Criteria:\n\n* • Patients in good health with no systemic disease (ASA Class I or II)\n\n  * Age range is between 20 to 50 years.\n  * Patients diagnosed with symptomatic irreversible pulpitis in maxillary incisor teeth.\n  * Patients who can understand VAS.\n  * Patients who give verbal consent to participate voluntarily in the study.\n\nExclusion Criteria:\n\n* • History of systemic disorder.\n\n  * Pregnant \u002F lactating females (As per medical record\u002Fverbally)\n  * Patients who had taken preoperative drugs as anti-inflammatory analgesic or antibiotics.\n  * Patients with swelling or acute peri-apical abscess.\n  * Tooth not suitable for restoration.\n  * Periodontally compromised teeth.\n  * Retreatment cases.",true,"20 Years","50 Years",{"count":83,"type":22},72,[25],"root canal irrigation protocol",[28,87,88],"Irrigation","Activation, Patient","2025-09-26",{"date":91,"type":38},"2025-09-29",{"date":93,"type":22},"2026-01-01",{"date":95,"type":22},"2027-01-01",{"name":97,"class":45},"RANA AHMAD"]