[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ischaemic-heart-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ischaemic-heart-disease":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,59,92,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100414271","icormica---stratified-medicine-in-angina-100414271",false,"NCT04674449","iCorMicA - Stratified Medicine in Angina","International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry","iCorMicA","Inclusion Criteria:\n\n1. Age ≥18 years.\n2. A clinical plan for invasive coronary angiography.\n3. Symptoms of angina (typical or atypical) according to the Rose- and\u002For Seattle Angina questionnaires.\n4. Able to comply with study procedures.\n5. Able to provide informed consent.\n\nExclusion Criteria:\n\n1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).\n2. History of coronary artery bypass surgery.\n3. Presence of obstructive disease evident in a main coronary artery (diameter \\>2.5 mm), i.e. a coronary stenosis \\>50% and\u002For a fractional flow reserve (FFR) ≤0.80\\*.\n4. Logistical reason\\*. \\*These patients will enter a follow-up registry.","ALL","18 Years",{"count":20,"type":21},1500,"ESTIMATED","INTERVENTIONAL",[24],"NA","The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.",[27,28,29,30,31,32,33,34,35,36],"Microvascular Angina","Angina, Stable","Ischemia With No Obstructive Coronary Arteries (INOCA)","Coronary Microvascular Dysfunction (CMD)","Ischaemic Heart Disease","Non-Obstructive Coronary Atherosclerosis","Coronary Artery Disease","Vasospastic Angina","Coronary; Ischemic","Angina Attacks",[38,39,40,41,42,43,44,45],"angina","microvascular angina","ischaemia with no obstructive coronary artery disease (INOCA)","stratified medicine","clinical trial","outcomes research","prognosis","health economics","RECRUITING","2026-04-03",{"date":49,"type":50},"2026-04-09","ACTUAL",{"date":52,"type":50},"2020-12-30",{"date":54,"type":21},"2030-12-31",{"name":56,"class":57},"NHS Greater Glasgow and Clyde","OTHER",39,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":91},"100377357","machine-learning-in-quantitative-stress-echocardiography-100377357","NCT04193475","Machine Learning in Quantitative Stress Echocardiography","MLQSE","Inclusion Criteria:\n\n* Clinically suitable for stress echocardiography examination\n\nExclusion Criteria:\n\n* None","20 Years","89 Years",{"count":69,"type":21},1250,"OBSERVATIONAL","Greater diagnostic accuracy is required to find out who is at risk of a heart attack as this can reduce the requirement of more invasive downstream tests and thereby improve the patient experience and also reduce their exposure to risk. Stress echocardiography is a routine clinical test that involves using ultrasound to image the heart whilst it is under stress to assess the risk of a heart attack.\n\nThis study will focus on developing more accurate analysis tools to interpret the results of these stress echocardiographic scans. New methods will be tested to measure the function of each part of the heart muscle, using advanced analysis of the information obtained when high-frequency sound waves are bounced off the heart inside the chest. The researchers will measure and report exact heart function during stress, so that they will be able to recognise normal hearts and those with any disease. New computer methods will be developed to display any abnormality, which will make it easier for doctors to choose the best treatment for patients who are at risk.\n\nThe goals and potential benefits of this research proposal are to update the interpretation of a routinely used clinical test (stress echocardiography) to produce a reliable new method for diagnosing the precise effects of diseased arteries on the function of the heart muscle; to develop new computer graphics that adapt to show individual risks for each patient; and to implement new computer models that can be constantly updated",[73,31],"Cardiovascular Diseases",[75,76,77,78,79,80],"Chest pain","Angina","Deformation imaging","Tissue doppler imaging","Strain","Velocity","2026-02-12",{"date":83,"type":50},"2026-02-17",{"date":85,"type":50},"2019-11-22",{"date":87,"type":21},"2026-03-01",{"name":89,"class":90},"Hull University Teaching Hospitals NHS Trust","OTHER_GOV",1,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":109,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":91},"100595647","cabgprehab---a-feasibility-study-protocol-100595647","NCT07035171","CABGpreHAB - a Feasibility Study Protocol","CABGpreHAB- Home-based Multimodal Prehabilitation (CABGpreHAB) for Elective Patients Awaiting CABG-surgery - a Feasibility Study Protocol","Inclusion Criteria:\n\n* Planned to have elective isolated first-time CABG surgery.\n* 18 years or older\n* Two weeks or more before surgery\n* Speaks and understands Danish.\n* Gives written informed consent.\n\nExclusion Criteria:\n\n* Patient with unstable angina pectoris and\u002F or MI during the last two weeks.\n* Left main stem stenosis \\>50%\n* Left ventricular ejection fraction \\\u003C 35%\n* Significant ventricular arrhythmia\n* Orthopedic or neurologic preconditions precluding exercise training.\n* Inability to attend the prehabilitation program due to physical limitations.\n* Patients who have cognitive deficits that would disqualify prehabilitation.\n* Severe heart failure, NYHA Class IV\n* Lack of capacity to consent",{"count":100,"type":21},50,[24],"Patients with ischemic heart disease (IHD) awaiting coronary artery bypass graft (CABG) surgery often face challenges like advanced age, frailty, comorbidities, and physical inactivity. These factors, combined with the physiological and psychological stress of surgery, can hinder postoperative recovery. Traditionally, strategies to improve surgical outcomes focus on the intra- and postoperative periods. However, the pre-surgery waiting period offers a \"window of opportunity\" for prehabilitation, which aims to enhance patients' functional capacity through exercise, nutrition, and psychological support.\n\nThe CABGpreHAB feasibility study evaluates the feasibility of a home-based multimodal prehabilitation intervention for patients awaiting elective CABG surgery. This randomized pilot study compares the intervention plus usual care to usual care alone, assessing feasibility outcomes like recruitment, retention, attrition, fidelity, and adherence. The study aims to optimize a subsequent full-scale randomized controlled trial (RCT) and improve patient outcomes by leveraging the pre-surgery period for prehabilitation.",[31,104,105,106,107,108],"Prehabilitation","Coronary Artery Bypass","Feasibility Studies","Multimodal Intervention","Adult",[110],"Prehabilitation, CABG surgery, adult, preoperative,homebased","2025-06-25",{"date":113,"type":50},"2025-06-29",{"date":115,"type":50},"2025-06-24",{"date":117,"type":21},"2026-07-18",{"name":119,"class":57},"Rigshospitalet, Denmark",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":91},"100363586","ifr-guided-coronary-artery-bypass-grafting-surgery-100363586","NCT04014140","iFR Guided Coronary Artery Bypass Grafting Surgery","Long-term Graft Patency Outcomes of LIMA-LAD Post-CABG Surgery Based on iFR Measurements.","iCABG","INCLUSION CRITERIA\n\n1. Age of 25 to 80 years of age\n2. Willing to participate and able to understand, read and sign the informed consent form (ICF) before standard of care elective CABG surgery\n3. Undergoing isolated first-time elective CABG surgery\n4. Available pre-operative angiography data with iFR measurements done during the pre-operative angiography\n\nEXCLUSION CRITERIA\n\n1. Emergency CABG surgery\n2. Ejection Fraction≤ 40%\n3. Severe valvular heart disease","25 Years","80 Years",{"count":131,"type":21},100,"The expected outcome of better and improved patency of bypass grafts and its direct relation to pre-operative iFR measurements of stenosis as compared to direct visual physiology of stenosis in the coronary angiogram.\n\nTo establish the correlation between the use of intracoronary physiology and improved graft patency at 12 months for patients undergoing CABG surgery.\n\nIt is a minimum of 28 and a maximum of 100 patients single-centre proof or concept\u002F observational study\u002F pilot study.",[31,33,134],"Coronary Stenosis",[136,137],"Instantaneous wave-free ratio (iFR)","Coronary Artery Bypass Grafting (CABG)","2023-11-20",{"date":140,"type":50},"2023-11-21",{"date":142,"type":50},"2022-04-25",{"date":144,"type":21},"2026-08-31",{"name":146,"class":57},"Prakash Punjabi"]