[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ischemic-cerebrovascular-accident\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ischemic-cerebrovascular-accident":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100637073","carotid-endatorectomy-and-general-anesthesia-assessment-and-evaluation-of-cerebral-ischemic-damage-with-clinical-laboratory-and-imaging-parameters-100637073",false,"NCT07602400","CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters","CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters: a Single-center, Prospective, Randomized, Comparative Clinical Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* ASA 1-4\n* For planned carotid endarterectomy\n* Absence of major established neurological deficits that would not allow neurological evaluation and performance of the MoCA test\n* Patient consent to participate in the study\n\nExclusion Criteria:\n\n* Age ≤ 18 years\n* Presence of major neurological deficits that will not allow neurological evaluation and performance of the MoCA test\n* Claustrophobia and inability to enter the MRI scanner\n* Cochlear implants\n* Intracranial vascular clips\n* Neurostimulation systems\n* Pacemaker incompatible for MRI\n* Small cell and non-small cell lung cancer\n* Neuroendocrine tumors\n* Melanoma\n* Seminoma\n* Teratoma\n* Malignant pheochromocytoma\n* CNS or NM diseases\n* Schizophrenia\n* Allergy or contraindication to any anesthetic factor\n* Patient refusal to participate in the study","ALL","18 Years",{"count":19,"type":20},160,"ESTIMATED","3 Days","OBSERVATIONAL","This study is aiming to provide us with information about the neuroprotective effect of two commonly used anesthetic drugs, during carotid endarterectomy. A day before sugery, a brain MRI will be performed as well as a cognitive function assessment test. The day of the surgery each patient will receive anesthesia either by using intravenous anesthetic drug or an inhalation agent and during the intraoperative period, the Anesthesiologist will draw a small amount of blood in three different times in order to measure brain biomarkers. A day after the surgery, a second brain MRI will be performed as well as a second cognitive function assessment test and their results will be compared to the preoperative ones. The study will focus on whether there is a higher incidence of microischemic brain lesions shown in imaging tests or whether cognitive function is impaired postoperative or whether brain biomarkers indicating brain damage are elevayed with any of these drugs and thus conclude which one shows or not a neuroprotective effect, with the condition that no change in the regular anesthesia management was made and no danger was imposed on the patient.",[25,26,27],"Carotid Artery Stenosis","Endarterectomy, Carotid","Ischemic Cerebrovascular Accident",[29,30,31,32,33,34],"carotid endarterectomy","MRI brain","general anesthesia","neuroprotection","propofol","sevoflurane","NOT_YET_RECRUITING","2026-05-18",{"date":38,"type":39},"2026-05-22","ACTUAL",{"date":41,"type":20},"2026-05-30",{"date":43,"type":20},"2027-12",{"name":45,"class":46},"University Hospital of Patras","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100421083","immuno-inflammation-in-the-acute-phase-of-an-ischaemic-cerebral-accident-managed-by-decompressive-hemicraniectomy-a-case-control-study-100421083","NCT04763161","Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study","NEUTROSURGERY","Inclusion Criteria Patients:\n\n* Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC.\n\nInclusion Criteria Control:\n\n\\- For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.\n\nNon-inclusion Criteria Patients:\n\n* HD carried out in a context of acute cerebral haemorrhage\n* Pre-existing neurological disability: modified Rankin score \\> 2\n* Patient benefiting from a legal protection measure\n\nNon-inclusion Criteria Controls:\n\n* Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage.\n* Patient operated on for an osteomeningeal pathology present at the approach site.\n* Patient operated on for an infectious cranial or neuro-meningeal pathology.\n* Patient to be operated on as a result of an intracranial traumatic condition",{"count":55,"type":20},90,"The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.",[27],"2026-01-16",{"date":60,"type":39},"2026-01-20",{"date":62,"type":20},"2026-08-15",{"date":64,"type":20},"2027-03-15",{"name":66,"class":67},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":79,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100278144","population-based-brest-stroke-registry-100278144","NCT02900521","Population-based Brest Stroke Registry","The Brest Registry of Stroke","BREST","Inclusion Criteria:\n\n* Diagnostic validated for one of the following pathologies:\n* Ischemic stroke,\n* Non-traumatic intracranial hematoma\n* Cerebral venous thrombosis Diagnostic after December 31, 2007 Age \\> 15 years on the date of the diagnostic Patient domiciled at the time of the diagnostic in one of the 79 communes defined beforehand\n\nExclusion Criteria:\n\n* Age ≤ 15 years\n* Validated diagnosis (see below, § 4.2.2) of aneurysmal subarachnoid hemorrhage cerebrovascular\n* Diagnosis made before 1 January 2008\n* Unconfirmed diagnosis\n* Patient domiciled outside the previously defined area of residence","15 Years",{"count":78,"type":20},15000,"10 Years","The registry is the main objective exhaustive list of cases validated stroke brain on a geographical area defined to calculate an incidence.",[82,27,83,84,85,86,87,88,89],"Cerebral (CVAs)","Stroke","Brain Ischemia","Brain Hemorrhage","Ischemic Stroke","Hemorrhagic Stroke","Cerebrovascular Disorders","Transient Ischemic Attack (TIA)","RECRUITING","2023-05-25",{"date":93,"type":39},"2023-05-26",{"date":95,"type":39},"2008-01",{"date":97,"type":20},"2026-12",{"name":99,"class":46},"University Hospital, Brest",1]