[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ischemic-cholangiopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ischemic-cholangiopathy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100616419","phase-2-seladelpar-in-adult-liver-transplant-recipients-with-ischemic-cholangiopathy-selic-100616419",false,"NCT07305363","Seladelpar in Adult Liver Transplant Recipients With Ischemic Cholangiopathy (SELIC).","The SELIC Trial Seladelpar for the Treatment of Ischemic Cholangiopathy: An Open-Label, Single-Arm, Investigator-Initiated Study","SELIC","Inclusion Criteria:\n\n1. Adult, age ≥ 18 and \\\u003C 80 years\n2. Diagnosis of ischemic cholangiopathy defined as non-anastomotic biliary strictures confirmed by imaging (ERCP, MRI, percutaneous cholangiogram)\n3. Cholestasis noted by elevated alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT)\n4. Imaging and clinical findings present at least 4 weeks after but within 12 months of liver transplantation\n5. No recent hospitalization within 2 weeks before enrollment to ensure clinical stability\n\nExclusion Criteria:\n\n1. Decompensated liver disease, including but not limited to ascites requiring paracentesis, hepatic encephalopathy, or variceal bleeding.\n2. Pregnancy or breastfeeding.\n3. Current or recent (within 30 days) use of other investigational agents or fenofibrate.\n4. Current or recent (within 30 days) use of cyclosporine\n5. Known hypersensitivity or contraindication to seladelpar or its excipients.\n6. Severe concomitant illness (renal, cardiac, or other systemic condition) that, in the investigator's judgment, would interfere with study participation or interpretation of results.\n7. ALT \\> 150 IU\u002FL.\n8. AST \\> 150 IU\u002FL.\n9. Total bilirubin \\> 5 mg\u002FdL at screening","ALL","18 Years","79 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","A prospective, open-label, single-arm, investigator-initiated study (SELIC) to evaluate the efficacy and safety of seladelpar in adult liver transplant recipients with Ischemic cholangiopathy (IC).",[28,29],"Liver Transplant; Complications","Ischemic Cholangiopathy","NOT_YET_RECRUITING","2026-04-03",{"date":33,"type":34},"2026-04-09","ACTUAL",{"date":36,"type":22},"2026-05",{"date":38,"type":22},"2027-12",{"name":40,"class":41},"University of California, San Diego","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100497764","endoscopic-management-of-non-anastomotic-biliary-strictures-following-liver-transplantation-100497764","NCT05761483","Endoscopic Management of Non-anastomotic Biliary Strictures Following Liver Transplantation.","Endoscopic Management of Non-anastomotic Biliary Strictures Following Liver Transplantation. Registry of the Italian Society of Digestive Endoscopy.","STEBINANSIED","Inclusion Criteria:\n\n* Age \\> 18\n* Non anastomotic biliary strictures diagnosed by direct cholangiogram (T-tube) or MRCP\n* Stricture involving the hepatic hilum until secondary branches\n* Increase of liver function tests\n* Signature of the informed consent\n\nExclusion Criteria:\n\n* Previopus endoscopic or percutaneous treatments\n* Patient candidate to metal stents placement\n* Previous surgery resulting in altered anatomy",{"count":51,"type":22},40,"2 Years","OBSERVATIONAL","The study will evaluate the results of endoscopic treatment of NON-anastomotic biliary strictures following liver transplantation",[56,29,57,58,59],"Liver Transplant Disorder","Non-anastomotic Biliary Stricture","Biliary Stricture","Biliary Stents (Plastic)",[61,62,63,64],"ERCP","Biliary stents","Liver transplantation","Ischemic cholangiopathy","RECRUITING","2026-01-27",{"date":68,"type":34},"2026-01-29",{"date":70,"type":34},"2020-03-12",{"date":72,"type":22},"2028-01-01",{"name":74,"class":41},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",1]