[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ischemic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ischemic":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100479078","platelet-expression-of-fcriia-and-arterial-hemodynamics-to-predict-recurrent-stroke-in-intracranial-atherosclerosis-100479078",false,"NCT05518305","Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis","Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosi","FCG","Inclusion Criteria:\n\n* Stroke is defined as symptoms lasting \\>24 hours and associated with imaging evidence of acute ischemia in the distribution of the stenotic vessel on head CT or brain MRI. Minor stroke is defined as NIHSS\\\u003C6, as used in prior studies.\n* Eligible TIA, defined as transient neurological symptoms lasting \\\u003C24 hours, need to be: a) accompanied by DWI abnormalities in the distribution of the stenotic artery; or b) multiple (\\>1), stereotyped events associated with unequivocal ischemic symptoms (i.e. weakness, aphasia, diplopia), and attributed to the symptomatic artery. The intent of these restrictive inclusion criteria for TIA is to exclude potential stroke mimics.\n* ICAD should involve the intracranial carotid, middle cerebral, intracranial vertebral or basilar arteries. Isolated anterior and posterior cerebral artery stenosis is not included as it is uncommon in these locations and non-invasive criteria for high-grade ICAD are not well established for these vessels.\n* Stenosis 50-99% will be quantified by CTA. The criteria for 50-99% are: measured stenosis by WASID criteria (percent stenosis = (1-\\[diameter stenosis\u002Fdiameter normal\\]) x 100%.\n* Age ³30; those 30-49 years of age must also have the presence of established atherosclerotic disease in another vascular bed (coronary, extracranial carotid, peripheral) or the presence of 2 or more risk factors (hypertension, diabetes mellitus, hyperlipidemia, tobacco abuse within the last 2 years). The rationale for this criterion is to exclude non-atherosclerotic vasculopathies.\n* Provide informed consent for participation in the study.\n\nExclusion Criteria:\n\n* Other determined etiology or established cause of the acute stroke or TIA: atrial fibrillation, mitral stenosis, mechanical valve, intracardiac thrombus or vegetation, dilated cardiomyopathy or ejection fraction \\\u003C30%, proximal extracranial carotid or vertebral stenosis \\>50%.\n* Contraindications to MRI, including MR-incompatible metallic implants (i.e. certain artificial cardiac valves, penile implants, other prosthesis), implanted electronic devices (i.e. pacemaker\u002Fdefibrillator, neurostimulators, cochlear implants), other potentially mobile ferromagnetic material (i.e. shrapnel, magnetic aneurysm clips), pregnancy (women in fertile age should have a negative pregnancy test), lactation, morbid obesity, and severe claustrophobia.",true,"ALL","30 Years",{"count":21,"type":22},250,"ESTIMATED","OBSERVATIONAL","An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.",[26,27,28,29],"Stroke","TIA","Ischemic Stroke","Ischemic",[26],"RECRUITING","2026-06-09",{"date":34,"type":35},"2026-06-11","ACTUAL",{"date":37,"type":35},"2022-09-30",{"date":39,"type":22},"2027-09-30",{"name":41,"class":42},"University of California, Los Angeles","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100611186","phase-4-beacon-aa-apixaban-with-or-without-clopidogrel-in-stroke-patients-with-atrial-fibrillation-and-cerebral-atherosclerosis-100611186","NCT07237308","BEACON-AA: Apixaban With or Without Clopidogrel in Stroke Patients With Atrial Fibrillation and Cerebral Atherosclerosis","A Multicenter Prospective Randomized Study to Evaluate the Efficacy of Apixaban and Clopidogrel on the Prevention of Recurrent Ischemic Stroke in Patients With Atrial Fibrillation and Cerebral Atherosclerosis","Inclusion Criteria:\n\n1. Adults aged 19 years or older at the time of enrollment.\n2. Patients with non-valvular atrial fibrillation (NVAF) documented by electrocardiography or medical records.\n3. Acute ischemic stroke confirmed by brain MRI (diffusion-weighted and FLAIR sequences), with neurological symptoms occurring within 5 days prior to randomization.\n4. Presence of clinically significant atherosclerosis in the cerebral or aortic arteries, meeting at least one of the following criteria:\n\n   ① ≥30% stenosis in the relevant artery (the artery supplying the infarcted territory) demonstrated by CTA, MRA, or DSA - using the WASID criteria for intracranial arteries and NASCET criteria for extracranial arteries.\n\n   ② High-risk atherosclerotic plaque features in the relevant artery demonstrated by CTA, MRA, or ultrasound, such as ulceration, intraplaque hemorrhage, mobile plaque, or a large lipid core (involving ≥25% of plaque cross-sectional area) on CTA\u002FMRA, or ulceration, mobile plaque, or hypoechoic\u002Fecholucent plaque on ultrasound; or presence of branch artery occlusive disease (BAOD).\n\n   ③ Complex aortic plaque (≥4 mm in thickness, mobile, or ulcerative) identified in the ascending aorta or aortic arch by transthoracic\u002Ftransesophageal echocardiography or coronary CT angiography.\n5. Ability and willingness to provide written informed consent for participation in the study.\n\nExclusion Criteria:\n\n1. Presence of mechanical heart valves or rheumatic mitral stenosis.\n2. Requirement for antiplatelet agents other than clopidogrel.\n3. Planned percutaneous coronary intervention, coronary artery bypass graft surgery, carotid endarterectomy, or intracranial stenting within 3 months after enrollment.\n4. Presence of mural thrombus in the heart confirmed by imaging.\n5. Renal impairment with creatinine clearance ≤30 mL\u002Fmin\u002F1.73 m².\n6. Severe hepatic impairment, including acute hepatitis, chronic active hepatitis, hepatic lesions or coagulopathy, hepatic failure, or laboratory evidence of AST\u002FALT \\>2× the upper limit of normal (ULN) or total bilirubin \\>1.5× ULN.\n7. Small-vessel occlusion (lacunar infarction) according to the TOAST classification.\n8. History within the past 30 days of gastrointestinal bleeding, vascular malformation of the brain or spinal cord, recent brain, spinal, or ophthalmologic surgery or trauma, esophageal varices, or intracranial hemorrhage at any time; or chronic regular use of NSAIDs (≥3 days per week for ≥2 consecutive weeks).\n9. Ischemic stroke occurring despite concurrent use of both NOAC and antiplatelet therapy.\n10. Planned surgery or high-bleeding-risk procedure within 3 months, or presence of active bleeding at enrollment.\n11. Anemia (hemoglobin \\\u003C 8.0 g\u002FdL) or thrombocytopenia (platelet count \\\u003C 100,000\u002FµL).\n12. Pre-stroke modified Rankin Scale (mRS) ≥ 2.\n13. Severe comorbid illness or malignancy not in complete remission with an expected life expectancy \\\u003C1 year.\n14. Known hypersensitivity or allergy to apixaban or clopidogrel.\n15. Pregnant or breastfeeding women.\n16. Uncontrolled diabetes mellitus (HbA1c \\> 10.0%) or severe hypertension (systolic ≥ 220 mmHg or diastolic ≥ 120 mmHg).\n17. Concomitant use of strong CYP3A4 and P-glycoprotein inhibitors that can significantly increase apixaban exposure (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin).\n18. Concomitant use of strong CYP2C19 inducers that can reduce clopidogrel antiplatelet effect (e.g., rifampin, carbamazepine, phenytoin, phenobarbital, St. John's wort).\n19. Clinically significant mass effect due to space-occupying cerebral infarction, or patients expected to require decompressive craniectomy, including those with midline shift \\> 5 mm, loss of basal cisterns, herniation, fourth-ventricle compression, or obstructive hydrocephalus in posterior fossa infarcts.\n20. Intracranial hemorrhage or hemorrhagic transformation (PH1 or PH2) according to ECASS criteria.\n21. Participation in another interventional clinical trial within the past 30 days or concurrent participation in another interventional study (non-interventional observational or registry studies may be allowed at the investigator's discretion).\n22. Any other condition that, in the investigator's judgment, would make participation or continued involvement in the study inappropriate or infeasible.","19 Years",{"count":53,"type":22},586,"INTERVENTIONAL",[56],"PHASE4","This trial aims to compare the safety and efficacy of apixaban alone versus apixaban combined with clopidogrel in patients with acute ischemic stroke associated with non-valvular atrial fibrillation and concomitant symptomatic intracranial or extracranial atherosclerosis. Participants will be randomly assigned in a 1:1 ratio to receive apixaban monotherapy or dual therapy with clopidogrel for 30 days. The primary outcome is the incidence of symptomatic or asymptomatic recurrent ischemic lesions detected on brain MRI (DWI\u002FFLAIR) at 30 ± 5 days after initiation of study medication.",[26,29,59,60,61],"Atrial Fibrillation","Intracrnaial Arterioscelrosis","Arteriosclerosis","NOT_YET_RECRUITING","2025-11-14",{"date":65,"type":35},"2025-11-19",{"date":67,"type":22},"2025-12",{"date":69,"type":22},"2029-10",{"name":71,"class":42},"Yonsei University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":18,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":83,"studyType":23,"phases":4,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":43},"100322566","coronary-artery-disease-and-coronary-microvascular-disease-in-cardiomyopathies-registry-100322566","NCT03479580","Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry","3CRegistry","Inclusion Criteria:\n\n* Ischemic\n* Dilated\n* Hypertrophic\n* Restrictive cardiomyopathy.\n\nExclusion Criteria:\n\n* Pregnant women\n* Breastfeeding women\n* Patients under legal protection","18 Years","100 Years",{"count":82,"type":22},1600,"5 Years","Long-term prognostic value of macrovascular and microvascular coronary artery stenoses in each type of cardiomyopathy.",[86,29,87,88],"Hypertrophic","Restrictive Cardiomyopathy","Dilated Cardiomyopathies",[90,91,92,93,94,95,96],"Cardiomyopathy","Multimodal imaging","Coronary artery disease","Coronary microvascular disease","Prognosis","Atherosclerosis","Myocardial ischemia","2022-05-18",{"date":99,"type":35},"2022-05-19",{"date":101,"type":35},"2018-02-08",{"date":103,"type":22},"2028-02",{"name":105,"class":42},"University Hospital, Grenoble"]