[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"isokinetic-test\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:isokinetic-test":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100617411","clinical-and-functional-outcomes-after-acl-reconstruction-versus-primary-repair-100617411",false,"NCT07318272","Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair","Comparison of Clinical and Functional Outcomes After Anterior Cruciate Ligament Reconstruction and Primary Repair Surgery","Inclusion Criteria for the ACL Reconstruction Group\n\n* Age 18-40 years\n* History of complete ACL rupture treated with ACL reconstruction\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* At least 12 months postoperative at the time of evaluation\n* Ability to comply with all study procedures\n* Signed informed consent\n\nExclusion Criteria for the ACL Reconstruction Group\n\n* Previous surgery for partial or chronic ACL tear\n* Concomitant multi-ligament knee injuries\n* Prior surgery on the ipsilateral or contralateral knee\n* Lower extremity malalignment (e.g., significant varus\u002Fvalgus)\n* Tibial avulsion-type ACL injury\n* Neurological or musculoskeletal disorders affecting lower limb function\n* Any medical condition that may interfere with test performance or safety\n\nInclusion Criteria for the Primary ACL Repair Group\n\n* Age 18-40 years\n* Complete ACL rupture treated with arthroscopic primary ACL repair\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* Minimum 12 months postoperative at the time of assessment A-bility to follow and complete study procedures\n* Signed informed consent\n\nExclusion Criteria for the Primary ACL Repair Group\n\n* Previous surgery for partial or chronic ACL injury\n* Multi-ligament knee injuries\n* History of surgery on either knee\n* Lower extremity malalignment\n* Tibial avulsion-type ACL rupture\n* Neuromuscular or musculoskeletal diseases affecting lower limb function or balance\n* Any condition that may affect participation or compromise safety\n\nInclusion Criteria for the Healthy Control Group\n\n* Age 18-40 years\n* No significant lower-extremity malalignment (e.g., varus\u002Fvalgus deformity)\n* No history of lower-extremity injury within the past 12 months\n* No known chronic systemic disease\n* No history of knee surgery or diagnosed knee pathology\n* Ability to understand and comply with study procedures\n* Signed informed consent\n\nExclusion Criteria for the Healthy Control Group\n\n* Presence of clinically significant lower-extremity malalignment\n* Lower-extremity musculoskeletal injury within the last 12 months\n* Any chronic systemic or metabolic disease\n* History of knee injury, knee surgery, or diagnosed knee pathology\n* Neurological, vestibular, or musculoskeletal disorder affecting balance or gait\n* Inability to complete study procedures",true,"ALL","18 Years","40 Years",{"count":21,"type":22},45,"ESTIMATED","OBSERVATIONAL","The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint. Although ACL reconstruction has long been considered the gold standard among surgical interventions following ACL injury, arthroscopic primary repair techniques have recently regained interest. With advances in minimally invasive surgical procedures, refined patient selection criteria, and improved rehabilitation strategies, the clinical effectiveness of primary repair is once again being re-evaluated. However, there remains a limited body of literature directly comparing the medium- to long-term effects of these two surgical techniques on neuromuscular performance, fatigue tolerance, and functional outcomes.\n\nThe aim of this study is to comparatively investigate postoperative muscle strength and endurance, isokinetic fatigue response, muscle oxygenation, proprioception, knee stability, postural control, and patient-reported outcome measures in individuals who have undergone ACL reconstruction or primary repair. Assessments will include low- and high-velocity tests performed on the Cybex Norm isokinetic dynamometer, a 33-repetition fatigue protocol at 300°\u002Fs, muscle oxygenation analysis using Train.Red NIRS, knee laxity measurement via the GNRB arthrometer, single-leg balance and landing evaluations using the KFORCE force platform, and subjective outcome measures (IKDC, ACL-RSI).\n\nThe findings of this study are expected to provide a more comprehensive understanding of how surgical technique influences physiological, biomechanical, and functional outcomes. This knowledge may contribute to the development of individualized rehabilitation approaches and evidence-based return-to-sport criteria.",[26,27,28],"Anterior Cruciate Ligament (ACL) Tear","Anterior Cruciate Ligament Reconstruction","Isokinetic Test",[30,31,32,33,34,35,36],"ACL Injury","Anterior Cruciate Ligament","ACL Reconstruction","ACL Primary Repair","Postoperative Outcomes","Muscle Oxygenation","Isokinetic Testing","NOT_YET_RECRUITING","2025-12-28",{"date":40,"type":41},"2026-01-05","ACTUAL",{"date":43,"type":22},"2026-01-01",{"date":45,"type":22},"2027-08-30",{"name":47,"class":48},"Gazi University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":71,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100606658","muscle-architecture-vs-alfredson-protocol-in-achilles-tendinopathy-100606658","NCT07178418","Muscle Architecture vs Alfredson Protocol in Achilles Tendinopathy","The Effects of a Muscle Architecture-Based Exercise Program and the Alfredson Protocol on Muscle-Tendon Architecture and Physical Performance in Subjects With Achilles Tendinopathy","Inclusion Criteria:\n\n* Presence of pain and tenderness in the mid-portion of the Achilles tendon (2-6 cm proximal to the insertion) persisting for at least 3 months\n* Clinical diagnosis of non-insertional Achilles tendinopathy\n* Pain aggravated by physical activity\n* Palpable tenderness localized to the mid-portion of the tendon\n* Voluntary participation in the study with signed informed consent\n\nExclusion Criteria:\n\n* Diagnosis of insertional Achilles tendinopathy\n* History of surgery or fracture in the affected lower limb within the past 12 months\n* Corticosteroid injection to the Achilles tendon within the past month\n* Presence of systemic diseases (e.g., diabetes mellitus, rheumatoid arthritis)\n* Presence of neurological disorders (e.g., peripheral neuropathy, central nervous system disorders)\n* Prior experience with eccentric exercise protocols targeting the Achilles tendon\n* Acute onset of symptoms suggestive of a tendon rupture","60 Years",{"count":59,"type":22},20,"INTERVENTIONAL",[62],"NA","Achilles tendinopathy is a frequent overuse disorder caused by repetitive loading of the tendon, particularly observed in athletes and middle-aged men. It is typically characterized by mid-portion pain, stiffness in the morning, and functional limitations, with structural alterations such as thickening and disrupted collagen alignment. Chronic progression often compromises performance and quality of life.\n\nEccentric training protocols, such as the Alfredson regimen, are commonly prescribed but their standardized nature does not fully address individual variability. Alternative approaches including Heavy Slow Resistance training and progressive loading models (e.g., Silbernagel protocol) have demonstrated clinical effectiveness and higher patient adherence, yet they still apply uniform loading across the triceps surae without accounting for architectural differences.\n\nGiven the heterogeneous structure of the soleus and gastrocnemii, targeted loading strategies may be required to optimize tendon adaptation. To address this, the present study employs a muscle architecture-based exercise program tailored to the functional and structural properties of each muscle. Ultrasound imaging will be used to evaluate muscle-tendon morphology, while isokinetic dynamometry and functional performance tests will quantify outcomes. Pain (VAS) and functional capacity (VISA-A) will also be assessed.\n\nThis randomized controlled trial aims to compare the effectiveness of an architecture-specific program with the Alfredson protocol on tendon remodeling, strength, endurance, functional performance, and symptom reduction in individuals with non-insertional Achilles tendinopathy.",[65,66,67,28,68,69,70],"Achilles Tendinopathy (AT)","Eccentric Exercise Training","Muscle Architecture","Ultrasound","Balance","Anaerobic Power",[72,73,74,75,76],"Achilles tendinopathy","muscle architecture","isokinetic strength","Alfredson protocol","tendon architecture","2025-09-10",{"date":79,"type":41},"2025-09-17",{"date":81,"type":22},"2025-10-15",{"date":83,"type":22},"2026-12-31",{"name":85,"class":48},"Halic University",2,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":16,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":60,"phases":99,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100590804","proprioceptive-fatigue-adaptation-in-osteoarthritis-100590804","NCT06972186","Proprioceptive Fatigue Adaptation in Osteoarthritis","Neuromotor Adaptation to Fatigue: Changes in Lower Extremity Proprioception in Patients With Osteoarthritis","PROFA-OA","Inclusion Criteria:\n\n* Female, aged 50-65\n* Postmenopausal\n* Grade 2-3 knee osteoarthritis (Kellgren-Lawrence Scale) for OA group\n* No lower extremity surgery in the last 6 months\n* No neuromuscular or orthopedic condition affecting the lower extremities\n\nExclusion Criteria:\n\n* Severe balance disorders or vestibular disease\n* Bilateral knee prosthesis or severe osteoporosis\n* Lower extremity musculoskeletal injury in the last 6 months","FEMALE","45 Years","65 Years",{"count":59,"type":22},[62],"This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.",[102,103,28,104],"Osteoarthritis of Knee","Proprioception","Gonarthritis",[106,107,108,109],"osteoarthritis of knee","propripception","isokinetic test","gonarthritis","2025-05-06",{"date":112,"type":41},"2025-05-14",{"date":114,"type":22},"2025-06-01",{"date":116,"type":22},"2025-12-01",{"name":118,"class":48},"Kocaeli Sağlık ve Teknoloji Üniversitesi"]