[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"isthmocele\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:isthmocele":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,39,72,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100639171","impact-of-vertical-vs-transverse-closure-on-outcomes-of-laparoscopic-correction-of-isthmocele-100639171",false,"NCT07625852","Impact of Vertical vs. Transverse Closure on Outcomes of Laparoscopic Correction of Isthmocele","Inclusion Criteria:\n\n* Women aged 18-45 years.\n* Diagnosis of symptomatic isthmocele confirmed by transvaginal ultrasound (myometrial thickness at the defect \\\u003C 2.5 mm).\n* History of at least one prior cesarean section.\n* Symptoms attributable to isthmocele (e.g., abnormal uterine bleeding, pelvic pain, dysmenorrhea, secondary infertility).\n* Desire for surgical correction of isthmocele.\n* Ability to understand and provide informed consent\n\nExclusion Criteria:\n\n* Asymptomatic isthmocele.\n* Active pelvic infection or malignancy.\n* Significant medical comorbidities contraindicating laparoscopic surgery.\n* Coagulopathy.\n* Known uterine anomalies (e.g., bicornuate uterus).\n* Pregnancy at the time of recruitment.\n* Inability to comply with follow-up protocol.","FEMALE","18 Years","45 Years",{"count":19,"type":20},72,"ESTIMATED","INTERVENTIONAL",[23],"NA","Laparoscopic repair of Isthmocele aims to restore the anatomical integrity and physiological function of the lower uterine segment.\n\n* Vertical Closure: This technique involves closing the defect along the longitudinal axis of the uterus. Proponents suggest it may be more anatomically aligned with the muscle fibers of the lower uterine segment, potentially leading to stronger scar formation and reduced tension.\n* Transverse Closure: This technique involves closing the defect perpendicular to the long axis of the uterus. This approach is more commonly used during primary cesarean sections.\n\nArguments for transverse closure in isthmocele repair include familiarity for surgeons and potentially less shortening of the lower uterine segment.\n\nHowever, the actual impact of these different closure methods on long-term outcomes such as defect recurrence, scar integrity, and fertility, remains largely unexplored in a randomized controlled trial setting.",[26],"Isthmocele","NOT_YET_RECRUITING","2026-05-29",{"date":30,"type":31},"2026-06-04","ACTUAL",{"date":33,"type":20},"2026-06-01",{"date":35,"type":20},"2027-06-01",{"name":37,"class":38},"Minia University","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100639956","comparing-decidual-inclusion-vs-exclusion-in-uterine-suture-techniques-during-cesarean-section-to-improve-scar-thickness-and-reduce-isthmocele-risk-in-primiparous-women-100639956","NCT07608874","Comparing Decidual Inclusion vs. Exclusion in Uterine Suture Techniques During Cesarean Section to Improve Scar Thickness and Reduce Isthmocele Risk in Primiparous Women","The Impact of Decidual Inclusion or Sparing in a Single Unlocked Closure of a Cesarean Uterine Incision: Randomized Controlled Trial","DISSUC","Inclusion Criteria:\n\n* Singleton, term pregnancy\n* Elective cesarean section before labor onset or membrane rupture\n* Maternal age \\>18 years\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Placenta previa\n* Maternal substance abuse or infection\n* Suspected placenta accreta\n* Diabetes\n* one or more prior cesarean section\n* Vulnerable participants (e.g., mental health conditions)\n* Emergency cesarean sections",{"count":48,"type":20},374,[23],"This study compares two ways of closing the uterus during cesarean delivery. In one group, the decidual layer near the uterine cavity is included in the suture. In the other group, this layer is left out. The study will examine whether these two methods differ in how well the uterine scar heals 6 to 9 months after surgery.\n\nWomen having an elective cesarean delivery will be randomly assigned to one of the two closure methods. Scar healing will be assessed by ultrasound after delivery. The goal is to determine whether one method is associated with better cesarean scar healing and fewer scar defects.",[26,52],"Cesarean Scar Diverticula",[54,55,56,57,58,59,60,61,62],"isthmocele","Uterine closure techniques","Decidual inclusion","Decidual sparing","Cesarean section","Scar thickness","Niche formation","Sonography","Dyspareunia","2026-05-28",{"date":33,"type":31},{"date":66,"type":20},"2026-05-25",{"date":68,"type":20},"2029-05-30",{"name":70,"class":38},"Kantonsspital Baden",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":84,"conditions":85,"keywords":93,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":71},"100569246","clinical-impact-of-uterine-repair-during-cesarean-section-with-barbed-suture-on-the-incidence-of-isthmocele-100569246","NCT06691750","Clinical Impact of Uterine Repair During Cesarean Section with Barbed Suture on the Incidence of Isthmocele","Clinical Impact of Uterine Repair During Cesarean Section with Barbed Suture on the Incidence of Isthmocele and Its Ultrasound and Molecular Characteristics: a Randomized Controlled Trial","CESARIS","Inclusion Criteria:\n\n* Pregnant women who deliver at Hospital Clinic of Barcelona by a planned, intrapartum or urgent cesarean section, irrespective of their pregnancy risk.\n* Had accepted to participate in the study during the third trimester of gestation.\n* Patients who accept a 6-month follow-up visit.\n* Minimal maternal age of 18 years old.\n\nExclusion Criteria:\n\n* Patients who end up delivering in another center.\n* Patients who deliver by vaginal route.\n* Patients diagnosed with isthmocele prior to the current pregnancy.\n* Need for histerectomy in the following 6 months after delivery.\n* Patients with known allergies to any of the components of the barbed suture.",true,{"count":82,"type":20},364,[23],"Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean section. Following surgery, these patients will be followed up for clinical outcomes, ultrasound evaluation of the uterine scar, and study of the hypoxic-inflammatory environment of the uterine cavity.",[26,86,87,88,89,90,91,92],"Cesarean Scar Defect","Pelvic Pain","Spotting","Infertility","Uterine Niche","Uterine Abnormal Bleeding","Niche",[26,94,95,96,58],"Uterine niche","Cesarean scar defect","Barbed suture","RECRUITING","2025-03-10",{"date":100,"type":31},"2025-03-13",{"date":102,"type":31},"2024-11-22",{"date":104,"type":20},"2028-05",{"name":106,"class":38},"Hospital Clinic of Barcelona",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":71},"100570514","frequency-of-isthmocele-following-single--vs-double-layer-uterine-closure-100570514","NCT06708234","Frequency of Isthmocele Following Single- Vs Double-layer Uterine Closure.","Frequency of Isthmocele Following Single- Vs Double-layer Uterine Closure. a Prospective and Retrospective Multicenter Observational Study","Inclusion Criteria:\n\n* Patients undergoing elective or emergency\u002Femergency caesarean section at the centres involved.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years;\n* Pregnant women at the time of ultrasound assessment;\n* Refusal to perform transvaginal ultrasound;\n* Type of hysterorrhaphy performed during surgery not known;",{"count":115,"type":20},200,"OBSERVATIONAL","The main objective of this study is to compare the frequency of isthmocele after caesarean section according to the type of hysteroraffia performed (single or double layer suture).",[26],[54,120,121],"cesarean section","ultrasound","2024-11-24",{"date":124,"type":31},"2024-11-27",{"date":126,"type":31},"2024-05-09",{"date":128,"type":20},"2025-11",{"name":130,"class":38},"Lorenza Driul"]