[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"iugr\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:iugr":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100238477","longitudinal-study-of-intra-uterine-growth-restriction-100238477",false,"NCT02382601","Longitudinal Study of Intra-Uterine Growth Restriction","Longitudinal Study of Intra-Uterine Growth Restriction (IUGR)","Inclusion Criteria:\n\n* Patients with diagnosed SGA by an ultrasound estimated fetal weight (EFW) of less than the 10th percentile or a fetal abdominal circumference of less than the 5th percentile will be included in the study at the time of their first examination.\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years of age, and chromosomal anomalies as identified by regular aneuploidy screening.","FEMALE","18 Years","45 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","The investigation will employ a longitudinal approach in which every fetus diagnosed to be SGA (Small for Gestational Age ) will be studied at frequent intervals with sophisticated imaging techniques to assess subtle physiologic changes in the brain, heart, and placenta over time. These findings will be correlated with neurological and cardiovascular function in the newborn and early childhood. This research initiative should yield diagnostic and therapeutic templates that will improve the quality of life of IUGR babies in addition to providing important information that will better inform current diagnostic practices.",[25,26],"IUGR","Pregnancy",[26,25,28],"Small for gestational age","RECRUITING","2026-06-09",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":33},"2015-04",{"date":37,"type":21},"2028-12",{"name":39,"class":40},"University of Colorado, Denver","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":41},"100239163","effects-of-high-altitude-on-ampk-activation-100239163","NCT02391519","Effects of High Altitude on AMPK Activation","Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation","Inclusion Criteria:\n\n* Women scheduled for cesarean delivery at University of Colorado Hospital (Denver, 1600 m) and St. Anthony's Summit Medical Center (Summit County, 3000 m)\n* Cesarean delivery at a prescheduled time without any labor, typically at 39 weeks gestation\n\nExclusion Criteria:\n\n* Women will be excluded if there are co-existing medical diagnoses that are known to affect vascular parameters (i.e., diabetes mellitus, gestational diabetes, any hypertensive disorder of pregnancy, or a current smoker).\n* Women with multiple gestations and preterm deliveries will also be excluded.",true,{"count":51,"type":21},84,"Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.",[26,25,54],"Preeclampsia",[26,56,57,58],"High altitude","vasoreactivity","myometrial arteries","2026-02-10",{"date":61,"type":33},"2026-02-13",{"date":63,"type":4},"2016-01",{"date":65,"type":21},"2026-12-31",{"name":39,"class":40},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":41},"100560226","pregnancy-in-guch-patients-100560226","NCT06574386","Pregnancy in GUCH Patients","Pregnancy in GUCH Patients: Maternal-Foetal-Neonatal Aspects at Mid Term","PURE-HEART","Inclusion Criteria:\n\n* Congenital heart disease in natural history or undergoing corrective and\u002For palliative cardiothoracic surgery.\n* Chronological age \\> 18 years.\n* Single pregnancy progressing normally at a gestational age of 14 weeks + 0.\n* Correct pregnancy dating based on CRL as per ISUOG guidelines. (26)\n* Normal results of non-invasive screening tests for foetal aneuploidies.\n* Normal first-trimester ultrasound examination.\n* Informed consent of the woman.\n\nExclusion Criteria:\n\n* Maternal chromosomal abnormalities.\n* Maternal syndromic conditions.\n* Spontaneous abortion.\n* Vanishing Twin.\n* High risk for chromosomal abnormalities on screening tests performed in the 1st Trimester (Combined Test\u002FNIPT) or Major foetal structural anomalies identified during first-trimester ultrasound evaluation.",{"count":76,"type":21},70,"INTERVENTIONAL",[79],"NA","This study aims to investigate the impact of congenital heart diseases on maternal and foetal-neonatal health, the effect of pregnancy on maternal cardiac health, and the outcome of newborns\u002Fchildren born from Grown-Up Congenital Heart (GUCH) mothers with follow-up at one year, extendable to two.\n\nThe main question it aims to answer is:\n\n-Does maternal congenital heart disease affects outcomes of newborn?",[82,83,84,25,85],"Congenital Heart Disease","Pregnancy Related","Infant Development","Fetal Growth Restriction",[87,26],"GUCH","NOT_YET_RECRUITING","2024-10-18",{"date":91,"type":33},"2024-10-22",{"date":93,"type":21},"2024-11-01",{"date":95,"type":21},"2029-10-01",{"name":97,"class":40},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]