[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"jaw-muscle-over-tension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:jaw-muscle-over-tension":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":4},"100638786","efficacy-and-safety-of-ha35-gel-nighttime-occlusive-application-for-tmd-pain-100638786",false,"NCT07584642","Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Nighttime Occlusive 10% 35 kDa Hyaluronan (HA35) Gel for Temporomandibular Joint Disorder (TMD) Pain and Muscle Over-Tension","HA35-TMJ","Inclusion Criteria:\n\n* Age 18-60 years, male or female\n* Clinically diagnosed with TMD with TMJ pain and\u002For muscle over-tension\n* Baseline TMJ pain NRS score ≥3\n* History of bruxism or jaw clenching\n* Ability to complete NRS assessments independently\n* Signed written informed consent\n\nExclusion Criteria:\n\n* TMJ treatment (medication, physical therapy, injection) within 2 weeks\n* Topical analgesic\u002Fanti-inflammatory use within 24 hours\n* Skin damage, allergy, or infection in the TMJ application area\n* Severe systemic disease (cardiovascular, diabetes, autoimmune)\n* Known hypersensitivity to hyaluronan or gel components\n* Pregnant or lactating women","ALL","18 Years","60 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nighttime occlusive application of 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with temporomandibular joint disorder (TMD). Eligible participants will apply HA35 gel to the TMJ area nightly under occlusive conditions for 8-12 hours. The primary objectives are to assess rapid pain relief and muscle over-tension reduction at 60 seconds and 12 hours after application. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive intervention.",[28,29,30,31,32],"Temporomandibular Joint Disorders","TMD","Temporomandibular Joint Pain","Jaw Muscle Over-Tension","Bruxism",[34,35,36,37,29,30,38,39,40,41],"Hyaluronan","35 kDa Hyaluronan","Nighttime Occlusive","TMJ","Muscle Over-Tension","Analgesia","Non-invasive Treatment","Pilot Clinical Study","NOT_YET_RECRUITING","2026-05-07",{"date":45,"type":46},"2026-05-13","ACTUAL",{"date":48,"type":22},"2026-05-20",{"date":50,"type":22},"2026-07-20",{"name":52,"class":53},"Nakhia Impex LLC","INDUSTRY"]