[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"joint-contractures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:joint-contractures":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100627878","knee-flexionater-to-avoid-motion-restoring-surgery-100627878",false,"NCT07454356","Knee Flexionater to Avoid Motion Restoring Surgery","Comparing High Intensity Stretch Device Combined With Physical Therapy Versus Physical Therapy Alone to Prevent Motion-Restoring Surgery Following Primary Total Knee Arthroplasty: Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 40 years or older\n* Undergoing primary total knee replacement surgery\n* Knee flexion less than 105 degrees at approximately 4 weeks after surgery\n* Considered a candidate for motion-restoring surgery, with any surgery delayed until after 2 months of nonoperative treatment\n\nExclusion Criteria:\n\n* Not willing to participate\n* Diagnosis of advanced rheumatoid arthritis\n* Neurological deficit affecting the operative leg\n* Revision total knee replacement or previous major surgery on the same knee\n* Cognitive impairment\n* Prior total hip replacement on the same side (ipsilateral total hip arthroplasty)\n* Living more than 2 hours from the study site or unwilling to attend required local physical therapy visits","ALL","40 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total knee replacement surgery.\n\nSome people have difficulty bending their knee during recovery. When this happens, doctors may recommend another procedure called motion-restoring surgery to improve knee movement.\n\nThis study aims to answer two main questions. First, does adding a hydraulic high-intensity stretching device to physical therapy help people regain knee bending after surgery? Second, does using the device affect recovery, daily activities, or the chance of needing another procedure?\n\nResearchers will compare two treatment approaches. One group will receive standard physical therapy alone. The other group will receive standard physical therapy and will also use a hydraulic high-intensity stretching device called the Ermi Knee Flexionater at home.\n\nParticipants who receive the device will use it at home each day in addition to attending their physical therapy sessions. Researchers will measure how well participants can bend their knee and will ask questions about pain, daily function, and activity level. Participants will also complete simple walking and mobility tests.\n\nStudy visits will occur about four weeks after surgery when participants enroll, and again at about eight weeks, twelve weeks, six months, one year, and two years after surgery. Researchers will compare results between the two groups to see whether the stretching device improves recovery after knee replacement.",[26,27,28],"Joint Contractures","Total Knee Anthroplasty","Knee Arthrofibrosis","RECRUITING","2026-03-02",{"date":32,"type":33},"2026-03-06","ACTUAL",{"date":35,"type":33},"2025-12-09",{"date":37,"type":20},"2029-12",{"name":39,"class":40},"Ermi LLC","INDUSTRY",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":41},"100619036","incidence-and-determinants-of-joint-contractures-in-mechanically-ventilated-icu-patients-100619036","NCT07339397","Incidence and Determinants of Joint Contractures in Mechanically Ventilated ICU Patients","Incidence and Determinants of Joint Contractures in Mechanically Ventilated Intensive Care Unit Patients: a Prospective Cohort Study","ICU-CONTRACT","Inclusion Criteria:\n\n* • Adult patients aged 18 and over\n\n  * Patients on mechanical ventilation and monitored in the intensive care unit for at least 7 days\n  * Glasgow Coma Score ≤10\n  * Patients monitored immobile in the intensive care unit\n  * Situations where informed consent can be obtained from the patient's legal representative\n\nExclusion Criteria:\n\n* • Presence of pre-existing joint contracture, ankylosis, or amputation\n\n  * Patients with severe burns, fractures, or surgical reasons preventing joint movement\n  * Patients with a history of neuromuscular disease or spasticity\n  * Patients who were immobilized for ≥1 week prior to admission to the intensive care unit\n  * Hemodynamic instability situations where measurement is unreliable","18 Years",{"count":19,"type":20},"OBSERVATIONAL","This prospective observational cohort study aims to evaluate the incidence and determinants of joint contracture development in mechanically ventilated adult patients admitted to the intensive care unit (ICU). Prolonged immobilization, deep sedation, and neuromuscular blockade are common in critically ill patients and may contribute to musculoskeletal complications, including joint contractures, which can adversely affect functional outcomes and rehabilitation after ICU discharge.\n\nAdult patients who are mechanically ventilated, immobilized, and have impaired consciousness will be consecutively enrolled and followed during their ICU stay. Joint range of motion will be assessed using standardized passive range of motion (PROM) measurements performed with a goniometer at predefined intervals by trained assessors. Joint contracture will be defined as a reduction of at least 33% in passive joint range of motion compared with normal reference values.\n\nThis study is non-interventional, and all patients will receive routine ICU care and standard physiotherapy according to institutional protocols. No additional procedures or interventions will be applied for research purposes. Demographic characteristics, clinical variables, and ICU-related factors will be recorded to explore potential associations with contracture development.\n\nThe findings of this study are expected to provide prospective data on the burden of joint contractures in mechanically ventilated ICU patients and to identify modifiable risk factors that may inform future preventive and rehabilitative strategies in critical care practice.",[26,55,56,57],"Critical Illness","Mechanical Ventilation","INTANSIVE CARE",[59,60,61,62,63,64],"Joint contracture","Intensive care unit","Mechanical ventilation","Passive range of motion","Musculoskeletal complications","Physiotherapy","2026-01-13",{"date":67,"type":33},"2026-01-14",{"date":69,"type":33},"2025-12-01",{"date":71,"type":20},"2026-05",{"name":73,"class":74},"Elazıg Fethi Sekin Sehir Hastanesi","OTHER"]