[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"joint-hypermobility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:joint-hypermobility":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100615546","investigation-of-medial-longitudinal-arch-and-foot-function-in-patients-with-lipedema-100615546",false,"NCT07294014","Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema","Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema: A Cross-Sectional Study","General Inclusion Criteria (Apply to All Participants)\n\n* Female participants\n* Age 18 years or older\n* Able to read and write (literacy requirement)\n* Availability of bilateral lateral foot radiographs obtained within the past 1 year in the hospital PACS system\n* Willing and able to provide written and verbal informed consent\n\nAdditional eligibility criteria for Lipedema Group\n\n\\- Clinical diagnosis of lipedema according to Halk and Damstra criteria.\n\nAdditional eligibility criteria for Control group:\n\n* Female patients presenting with nonspecific foot pain\n* Similar age and BMI range as the lipedema group\n* No clinical diagnosis or suspicion of lipedema\n\nExclusion Criteria (Apply to all participants)\n\n* Pregnancy\n* Illiteracy\n* Inability or unwillingness to provide written and verbal informed consent\n* History of lower extremity fracture, trauma, or orthopedic surgery\n* Diagnosis of diabetes mellitus\n* Known rheumatologic disease\n* Known polyneuropathy or peripheral nerve injury affecting the lower extremities",true,"FEMALE","18 Years","65 Years",{"count":21,"type":22},32,"ESTIMATED","OBSERVATIONAL","Lipedema is a chronic adipose tissue disorder that commonly leads to joint laxity, hypermobility, and functional limitations, yet its impact on foot morphology has not been systematically examined. This case-control study aims to investigate whether patients with lipedema exhibit a higher prevalence of generalized joint hypermobility and foot structural abnormalities-specifically pes planus-compared with age- and BMI-matched controls. Using radiographic measurements (Meary angle and calcaneal inclination angle), clinical hypermobility assessment, and validated functional scales, the study seeks to determine the relationship between lipedema, hypermobility, and foot function.",[26,27,28,29],"Lipedema","Hypermobility Syndrome (Disorder)","Pes Planus","Joint Hypermobility",[31,32,33,34,35,36,37,38],"lipedema","mypermobility","foot function","pes planus","joint hyper mobility","foot morphology","Meary angle","calcaneal inclination angle","RECRUITING","2025-12-31",{"date":42,"type":43},"2026-01-02","ACTUAL",{"date":45,"type":22},"2026-01-01",{"date":47,"type":22},"2026-04-01",{"name":49,"class":50},"Marmara University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":60,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":51},"100506194","functional-instability-in-patients-suffering-from-collagen-disease-and-joint-hypermobility-100506194","NCT05871216","Functional Instability in Patients Suffering From Collagen Disease and Joint Hypermobility","Evaluation of Functional Instability Using the \"Delos Proprioceptive System\" in Patients Suffering From Collagen Disease and Joint Hypermobility","VIPIA","Inclusion Criteria:\n\n* Patients with moderate (Beighton-Horan Joint Mobility Index score from 3 to 4) or severe (Beighton-Horan Joint Mobility Index score from 5 to 9) joints hyperlaxity at the clinical evaluation\n\nExclusion Criteria:\n\n* Obesity (BMI \\> 25) and weight \\> 90 kg\n* Practice of competitive sport\n* Orthopedic (complex surgery of the spine and lower limbs), neurological (spasticity, stroke), and oncological comorbidities\n* Orthostatic \u002F walking inability\n* Absence of joints hyperlaxity at the clinical evaluation (Beighton-Horan Joint Mobility Index score from 0 to 2)","ALL","60 Years",{"count":63,"type":22},30,"A joint is considered \"hypermobile\" when it has a greater range of motion than normal for a given age, ethnicity or gender. Many people have asymptomatic hyperlaxity in multiple joints, a condition called Generalized Joint Hypermobility (GJH).\n\nConversely, hyperlaxity can be symptomatic, a condition that has been defined \"Joint Hypermobility Syndrome\" - JHS.\n\nDiagnosis of JHS is commonly performed by applying the revised Brighton criteria. Based on these criteria, an individual is diagnosed with JHS with a Beighton score \\>\u002F= 4\u002F9, and arthralgia for 3 or more months in 4 or more joints (major criteria).\n\nThe dynamic body balance test (i.e. the stability test with multiple single-leg jumps) can provide information regarding the effectiveness of the feedforward and feedback mechanisms in correcting the postural deviations necessary to achieve successful performance during daily and sporting activities. Such assessment may also be useful to demonstrate deficiencies in balance, especially in young patients with increased physical activity.\n\nThe aim of this study is to examine the postural balance of individuals with JHS by performing stability tests in monopodalic and bipodalic stance with the \"Delos Postural Proprioceptive System\"",[66,67,68,29,69],"Hypermobility Syndrome","Danlos Disease, Ehlers","Collagen Diseases","Laxity of Ligament","2025-07-18",{"date":72,"type":43},"2025-07-20",{"date":74,"type":43},"2020-10-01",{"date":76,"type":22},"2026-03-30",{"name":78,"class":50},"Istituto Ortopedico Rizzoli",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":60,"minAge":18,"maxAge":61,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":104,"locationsCount":51},"100454389","the-clinical-outcomes-of-the-modified-brostrm-vs-anatomic-reconstruction-operation-in-clai-and-gjl-100454389","NCT05196906","The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL","The Clinical Outcomes Comparing the Modified Broström vs Anatomic Reconstruction Operation in Chronic Lateral Ankle Instability and Generalized Joint Laxity","Inclusion Criteria:\n\nClinical diagnosis of lateral ankle pain and instability Beighton score ≥4 Age with 18 to 60 years\n\nExclusion Criteria:\n\nPatients with an acute or subacute ankle injury (within 3 months) Injury of the deltoid ligament Alignment of lower extremity greater than 5 degrees Fractures of the lower extremity Stage III or IV osteoarthritis Patients who refused to participate in the study",{"count":87,"type":22},100,"Investigators designed this prospective cohort study to compare the clinical outcomes of modified Broström operation and anatomical reconstruction for the treatment of CLAI and GJL.",[90,91,29],"Ankle Sprains","Instability, Joint",[93,94,95,96,97],"chronic lateral ankle instability","generalized joint laxity","re-injury","modified Brostrom operation","anatomic reconstruction","2025-04-08",{"date":100,"type":43},"2025-04-11",{"date":102,"type":43},"2020-01-01",{"date":40,"type":22},{"name":105,"class":50},"Peking University Third Hospital"]