[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"keloids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:keloids":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100633774","early-phase-1-comparison-of-effectiveness-of-intralesional-injectioms-of-5-flourouracil-alone-verses-its-cpmbination-with-cryotherapy-in-the-treatment-of-keloids-100633774",false,"NCT07531056","Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids","A Randomized Controlled Trial Comparing The Effectiveness And Safety Of iIntralesional 5 Flourouracil Monotherapy Verses 5 Flourouracil Combined With Cryotherapy; In The Treatment Of Keloid Scars","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 18 -50 years.\n* Patients having symptomatic keloids i.e., having pain, pruritus, restriction of movement, scar tension or disfigurement.\n\nExclusion Criteria\n\n:• Pregnant women or lactating women\n\n* Patients with history of hepatic, renal, cardiac diseases or chronic diarrhea.\n* Patients on immunosuppressant medications due to other diseases\n* Patients having myelosuppression checked by CBC.\n* Patient taking warfarin.\n* Patients with history of hypersensitivity to 5FU.","ALL","18 Years","50 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","The goal of this clinical trial is to learn how well intralesional 5 fluorouracil with cryotherapy works to treat keloids as compared to intralesional 5 fluorouracil alone on keloids. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* What well does cryotherapy followed by intralesional 5 fluorouracil (5FU) work to treat keloids as compared to 5 fluorouracil (5FU) alone?\n* What is participant's satisfaction when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) as compared to 5 fluorouracil (5FU) alone?\n* What skin problems do participants have when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) and 5 fluorouracil (5FU) alone? Researchers will compare cryotherapy followed by intralesional 5 fluorouracil (5FU) with 5 fluorouracil (5FU) alone to see how well both work.\n\nParticipants will be divided into two groups:\n\nFor Group A: Cryotherapy will be done at lesion site followed by intralesional 5FU every 3 weekly.\n\nFor Group B: Intralesional 5FU will be given at lesion site every 3 weekly. Keloids will be assessed at the start of trial and then after 12 weeks of treatment.",[27],"Keloids",[27,29,30],"Intralesional injectioms","5-FU","RECRUITING","2026-04-21",{"date":34,"type":35},"2026-04-24","ACTUAL",{"date":37,"type":35},"2025-12-22",{"date":39,"type":21},"2026-09-20",{"name":41,"class":42},"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100624735","a-prospective-observational-clinical-study-on-exploring-the-value-of-surgical-excision-combined-with-32p-application-in-the-treatment-of-keloids-and-the-factors-affecting-the-prognosis-of-combined-therapy-100624735","NCT07413497","A Prospective Observational Clinical Study on Exploring the Value of Surgical Excision Combined With 32P Application in the Treatment of Keloids and the Factors Affecting the Prognosis of Combined Therapy","Inclusion Criteria:\n\n1. Histological biopsy confirms the patient has keloids. Pathological diagnostic criteria include: 1. Proliferating fibroblasts: A large number of proliferating fibroblasts are usually detected in keloid tissue. 2. Disordered arrangement of collagen fibers: Collagen fibers in normal scars are generally arranged in an orderly manner, while in keloids, they are disorganized and present as thick bundles. 3. Scar tissue extending beyond the original wound boundaries: Keloid tissue often spreads beyond the scope of the initial trauma.\n2. Patients with keloids ≥3 mm in thickness and within 1 week after surgical excision.\n3. Patients have at least one measurable lesion as defined by the Vancouver Scar Scale (VSS) criteria.\n4. Patients have no other skin disorders similar to keloids.\n5. Patients are capable of understanding and signing the informed consent form.\n6. Patients are willing and able to comply with scheduled visits, treatment plans, laboratory tests, follow-up appointments, and other study procedures.\n\nExclusion Criteria:\n\n1. Difficulty in accurately assessing the patient's lesions.\n2. Patients who do not meet the indications for local excision or have received superficial radiotherapy after surgery.\n3. Dementia, intellectual impairment, or any mental illness that hinders the understanding of the informed consent form.\n4. Patients deemed inappropriate to participate in this clinical study by the investigator.\n5. Patients from whom pathological specimens cannot be obtained, or those who die or are lost to follow-up.\n6. Patients with recurrent keloids following previous treatment.\n7. Pregnant female patients. -",{"count":51,"type":21},401,"OBSERVATIONAL","Keloids are non-cancerous (benign) growths on the skin. They form after an injury, when the skin makes too much connective tissue that thickens and hardens.\n\nThese keloids cause big problems for people. They grow uncontrollably on their own, itch, hurt, and look bad. This is especially true if they're on visible areas like the head or neck-they harm both a person's physical comfort and mental well-being.\n\n32P application is a popular treatment for keloids. It's simple, easy to use, quick, and doesn't have many limits on where or when it can be used. Besides keloids, it also works for surface skin issues like hemangiomas.\n\nHere's how 32P works: When it breaks down (decays), it releases beta rays. These rays create a local effect that changes the shape and function of the affected tissue. Blood vessel cells in the area swell, get inflamed, and shrink, eventually blocking the blood vessels. Beta rays also stop two key things from growing too much: fibroblasts (cells that make connective tissue) and new blood vessels. This is how the treatment works-with very low chances of the keloid coming back and few side effects.\n\nFor these reasons, we think combining surgery with 32P application is an effective way to treat keloids. Its success rate is similar to, or even better than, surgery combined with low-dose radiation. Also, two factors matter a lot for how well the treatment works long-term: when 32P application is started, and the dose used.",[27,55],"Keloids Scars",[57,58,59,60,61],"32P","keloids","32P application","nuclide application therapy","nuclide therapy","NOT_YET_RECRUITING","2026-02-09",{"date":65,"type":35},"2026-02-17",{"date":67,"type":21},"2026-06-01",{"date":69,"type":21},"2030-06-01",{"name":71,"class":42},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]