[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"keratinized-tissue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:keratinized-tissue":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100565726","novel-soft-tissue-augmentation-technique-using-free-gingival-graft-simultaneous-with-posterior-mandibular-implant-100565726",false,"NCT06645925","Novel Soft Tissue Augmentation Technique Using Free Gingival Graft Simultaneous With Posterior Mandibular Implant","Novel Soft Tissue Augmentation Technique Using Free Gingival Graft Simultaneous With Implant Placement in Posterior Mandible: A 1-year Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults at or above the age of 18.\n* Lower Posterior missing tooth\u002F teeth with minimal KT \\< 2mm\n* Sufficient alveolar ridge length minimum 13-15 mm to IAN\n\n  •. Sufficient alveolar ridge width minimum of 6 mm\n* Patients able to tolerate surgical periodontal procedures.\n* Patients who provided an informed consent and accepted the one-year follow-up period.\n\nExclusion Criteria\n\n* Patients diagnosed with periodontal diseases (Caton et al., 2018).\n* Current or previous smokers.\n* Pregnant and lactating females.\n* Patients with medical conditions that would compromise the surgical procedures; uncontrolled diabetes mellitus, taking intravenous Bisphosphonates for treatment of osteoporosis.\n* Patients with active infection related to the site of implant.\n* Patients with parafunctional habits.\n* Patients with shallow vestibule",true,"ALL","18 Years","50 Years",{"count":21,"type":22},22,"ESTIMATED","INTERVENTIONAL",[25],"NA","Presence of keratinized tissue (KT) around dental implants, plays a crucial role in stability and health of peri-implant tissues. Several studies reported that, minimum of 2 mm keratinized tissue width is required to achieve long-term longevity. Insufficient keratinized mucosa leads to biofilm accumulation, soft tissue inflammation, eventually peri-implant mucositis and peri-implantitis. Hence, the aim of the present trial is to evaluate KTW gain, linear and volumetric changes in buccal soft tissue along with hard tissue alterations following implant restoration at sites treated either with delayed implant placement \\& simultaneous FGG or the conventional FGG protocol prior to implant placement.",[28,29,30],"Free Gingival Graft","Free Gingival Graft Volume Change","Keratinized Tissue",[32,33,34],"FGG","Delayed implant placement","Keratinized mucosa","RECRUITING","2026-01-27",{"date":38,"type":39},"2026-01-29","ACTUAL",{"date":41,"type":39},"2025-11-01",{"date":43,"type":22},"2027-12-30",{"name":45,"class":46},"Misr International University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100597320","efficacy-of-collagen-matrix-for-peri-implant-soft-tissue-phenotype-modification-100597320","NCT07056959","Efficacy of Collagen Matrix for Peri-implant Soft Tissue Phenotype Modification","Efficacy of Collagen Matrix for Peri-implant Soft Tissue Phenotype Modification: A Randomized Controlled Trial","XCM versus FGG","Inclusion Criteria:\n\n* Aged 21 or over.\n* Insufficient KM width (\\\u003C 2 mm) at the buccal aspect of implants at time of healing abutment placement, either for single anterior or posterior implants.\n* Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline).\n* Good compliance and commitment to attend follow-up review appointments.\n* Willing to provide informed consent.\n\nExclusion Criteria:\n\n* Smoking\n* Untreated localized or generalized periodontal diseases\n* Uncontrolled systemic diseases\n* Long term use of non-steroidal anti-inflammatory medications\n* History of malignancy, radiotherapy or chemotherapy\n* Collagen allergy\n* History of mucogingival surgery","21 Years",{"count":58,"type":22},30,[25],"A stable band of keratinized mucosa (KM) around dental implants is thought to minimize tissue recession and provide resistance against mechanical, chemical, and microbial challenges, thereby preserving peri-implant tissue health. Soft tissue augmentation is often employed to enhance the soft tissue phenotype in such cases. While autogenous grafts such as free gingival grafts (FGG) remain the gold standard, xenogeneic collagen matrices (XCM) have emerged as promising alternatives, offering reduced patient morbidity and surgical time. This randomized controlled clinical trial aims to compare the clinical efficacy and patient-reported outcome measures (PROMs) of XCM versus FGG for soft tissue phenotype modification when performed during healing abutment connection around dental implants, with evaluations at both short-term (6 months) and long-term (1 and 2 years) intervals.\n\nThirty participants will be recruited at Dubai Health Dental Hospital and randomly assigned to receive either XCM (test) or FGG (control) augmentation. Clinical assessments will be conducted at baseline (T0), 2 weeks (T2w), and at 1 (T1), 3 (T3), 6 (T6), 12 (T12), and 24 (T24) months post-surgery.\n\nThe primary outcome is the change in KM width, measured from the mucosal margin to the mucogingival junction. Secondary outcomes include KM thickness, supracrestal tissue height, and soft tissue dimensional changes, assessed using intraoral scans (Trios 5) and superimposed STL files. Additional measurements include peri-implant soft tissue level and phenotype.\n\nPROMs will be recorded in the first postoperative week and at the 3-year mark using a visual analog scale (VAS). Clinical indices such as plaque index, bleeding index, and probing depth will be evaluated at 6 months, 1 year, and 2 years. Marginal bone level changes and implant survival rates will also be tracked throughout the study period.",[62,30],"Keratinized Mucosa",[64,65,66],"keratinized mucosa","implants","soft tissue augmentation","2025-11-26",{"date":69,"type":39},"2025-12-04",{"date":41,"type":39},{"date":72,"type":22},"2028-06",{"name":74,"class":46},"Mohammed Bin Rashid University of Medicine and Health Sciences",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":47},"100572734","effect-of-modified-free-gingival-graft-and-conventional-free-gingival-graft-on-gingival-recession-100572734","NCT06737120","Effect of Modified Free Gingival Graft and Conventional Free Gingival Graft on Gingival Recession","Comparison of Conventional and Modified Free Gingival Graft Techniques in Treating Mandibular Incisor Gingival Recession: a Randomized Clinical Study","Inclusion Criteria:-volunteers aged between 18-65 years.\n\n* To be systemically healthy.\n* Not smoking.\n* Individuals aged 18 years and over.\n* Shallow vestibule (≤5 mm).\n* The periodontal pocket depth of the tooth\u002Fteeth to be treated should be ≤3 mm and the degree of tooth mobility should be ≤1.\n* There should be no cervical composite restoration and no caries-free lesions on the teeth to be treated.\n* Presence of Cairo Type 1 class gingival recession on the buccal surface of at most 2 of the mandibular incisors.\n\nExclusion Criteria:\n\n* pregnancy\n* untreated periodontal disease\n* parafunctional habits\n* poor oral hygiene (persistent whole mouth plaque index \\> 20%)\n* iodine allergy\n* excessive dental crowding or misalignment of teeth.","65 Years",{"count":84,"type":22},60,[25],"The aim of this clinical study is to understand whether the modified free gingival graft technique is superior to the conventional free gingival graft:\n\nWill gingival recession completely close in modified free gingival grafting areas? Will there be a significant increase in the amount of keratinized gingiva in modified free gingival grafting participants compared to traditional free gingival grafting participants? Participants will visit our clinic in the 1st, 3rd and 6th months. Necessary clinical parameter measurements will be made by the clinician.",[88,30,28],"Gingival Recession, Localized",[90,91,92],"modified free gingival graft","free gingival graft","gingival recession","NOT_YET_RECRUITING","2024-12-11",{"date":96,"type":39},"2024-12-17",{"date":98,"type":22},"2024-12-30",{"date":100,"type":22},"2025-07-30",{"name":102,"class":46},"AYSE HUMEYRA ORUC"]